Huang W, Hickson LJ, Eirin A, Kirkland JL, Lerman LO. Cellular senescence: the good, the bad and the unknown. Nat Rev Nephrol. 2022;18(10):611–27.
Article PubMed PubMed Central CAS Google Scholar
Frasca D, Romero M, Diaz A, Garcia D, Thaller S, Blomberg BB. B Cells with a Senescent-Associated Secretory Phenotype Accumulate in the Adipose Tissue of Individuals with Obesity. Int J Mol Sci. 2021;22(4).
Pawelec G. Age and immunity: What is “immunosenescence”? Exp Gerontol. 2018;105:4–9.
Article PubMed CAS Google Scholar
Dahlquist KJV, Camell CD. Aging Leukocytes and the Inflammatory Microenvironment of the Adipose Tissue. Diabetes. 2022;71(1):23–30.
Article PubMed CAS Google Scholar
Frasca D, Blomberg BB. Inflammaging decreases adaptive and innate immune responses in mice and humans. Biogerontology. 2016;17(1):7–19.
Article PubMed CAS Google Scholar
Ferrucci L, Fabbri E. Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty. Nat Rev Cardiol. 2018;15(9):505–22.
Article PubMed PubMed Central CAS Google Scholar
Camell CD, Yousefzadeh MJ, Zhu Y, Prata L, Huggins MA, Pierson M, et al. Senolytics reduce coronavirus-related mortality in old mice. Science. 2021;373(6552).
Carey A, Nguyen K, Kandikonda P, Kruglov V, Bradley C, Dahlquist KJV, et al. Age-associated accumulation of B cells promotes macrophage inflammation and inhibits lipolysis in adipose tissue during sepsis. Cell Rep. 2024;43(3): 113967.
Article PubMed PubMed Central CAS Google Scholar
Jura M, Kozak LP. Obesity and related consequences to ageing. Age (Dordr). 2016;38(1):23.
Speakman JR, de Jong JMA, Sinha S, Westerterp KR, Yamada Y, Sagayama H, et al. Total daily energy expenditure has declined over the past three decades due to declining basal expenditure, not reduced activity expenditure. Nat Metab. 2023;5(4):579–88.
Article PubMed PubMed Central Google Scholar
Tchernof MJTaA. Lipid metabolism in the elderly.pdf. Eur J Clin Nutr. 2000;54(Suppl 3):121-S125.
Camell CD. Adipose tissue microenvironments during aging: Effects on stimulated lipolysis. Biochim Biophys Acta Mol Cell Biol Lipids. 2022;1867(5): 159118.
Article PubMed PubMed Central CAS Google Scholar
Huffman DM, Barzilai N. Role of visceral adipose tissue in aging. Biochim Biophys Acta. 2009;1790(10):1117–23.
Article PubMed PubMed Central CAS Google Scholar
Nguyen HP, Lin F, Yi D, Xie Y, Dinh J, Xue P, et al. Aging-dependent regulatory cells emerge in subcutaneous fat to inhibit adipogenesis. Dev Cell. 2021;56(10):1437-51.e3.
Article PubMed PubMed Central CAS Google Scholar
Zhang YX, Ou MY, Yang ZH, Sun Y, Li QF, Zhou SB. Adipose tissue aging is regulated by an altered immune system. Front Immunol. 2023;14:1125395.
Article PubMed PubMed Central CAS Google Scholar
Man K, Kallies A, Vasanthakumar A. Resident and migratory adipose immune cells control systemic metabolism and thermogenesis. Cell Mol Immunol. 2022;19(3):421–31.
Article PubMed CAS Google Scholar
Pamir N, McMillen TS, Kaiyala KJ, Schwartz MW, LeBoeuf RC. Receptors for tumor necrosis factor-alpha play a protective role against obesity and alter adipose tissue macrophage status. Endocrinology. 2009;150(9):4124–34.
Article PubMed PubMed Central CAS Google Scholar
Wallenius V, Wallenius K, Ahrén B, et al. Interleukin-6-deficient mice develop mature-onset obesity. Nat. 2002;8:75–9.
Yunna C, Mengru H, Lei W, Weidong C. Macrophage M1/M2 polarization. Eur J Pharmacol. 2020;877: 173090.
Hu Q, Lyon CJ, Fletcher JK, Tang W, Wan M, Hu TY. Extracellular vesicle activities regulating macrophage- and tissue-mediated injury and repair responses. Acta Pharm Sin B. 2021;11(6):1493–512.
Article PubMed CAS Google Scholar
Wang N, Liang H, Zen K. Molecular mechanisms that influence the macrophage m1–m2 polarization balance. Front Immunol. 2014;5:614.
Article PubMed PubMed Central Google Scholar
Qi LYH, Zhang Y, et al. IL-10 secreted by M2 macrophage promoted tumorigenesis through interaction with JAK2 in glioma. Oncotarget. 2016;7(44):71673–85.
Article PubMed PubMed Central Google Scholar
Lumeng CN, Liu J, Geletka L, Delaney C, Delproposto J, Desai A, et al. Aging is associated with an increase in T cells and inflammatory macrophages in visceral adipose tissue. J Immunol. 2011;187(12):6208–16.
Article PubMed CAS Google Scholar
Camell CD, Sander J, Spadaro O, Lee A, Nguyen KY, Wing A, et al. Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing. Nature. 2017;550(7674):119–23.
Article PubMed PubMed Central CAS Google Scholar
Covarrubias AJ, Kale A, Perrone R, Lopez-Dominguez JA, Pisco AO, Kasler HG, et al. Senescent cells promote tissue NAD(+) decline during ageing via the activation of CD38(+) macrophages. Nat Metab. 2020;2(11):1265–83.
Article PubMed PubMed Central CAS Google Scholar
He R, Chen Y, Cai Q. The role of the LTB4-BLT1 axis in health and disease. Pharmacol Res. 2020;158: 104857.
Article PubMed CAS Google Scholar
W SE. Leukotriene receptor antagonists and related compounds. Can Respir J. 1999;6(2):189–93.
Afonso PV, Janka-Junttila M, Lee YJ, McCann CP, Oliver CM, Aamer KA, et al. LTB4 is a signal-relay molecule during neutrophil chemotaxis. Dev Cell. 2012;22(5):1079–91.
Article PubMed PubMed Central CAS Google Scholar
Li P, Oh DY, Bandyopadhyay G, Lagakos WS, Talukdar S, Osborn O, et al. LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes. Nat Med. 2015;21(3):239–47.
Article PubMed PubMed Central CAS Google Scholar
Patnode ML, Bando JK, Krummel MF, Locksley RM, Rosen SD. Leukotriene B4 amplifies eosinophil accumulation in response to nematodes. J Exp Med. 2014;211(7):1281–8.
Article PubMed PubMed Central CAS Google Scholar
Tager AM DJ, Goodarzi K, Bercury SD, von Andrian UH, Luster AD. Bltr Mediates Leukotriene B4–Induced Chemotaxis and Adhesion and Plays a Dominant Role in Eosinophil Accumulation in a Murine Model of Peritonitis. J Exp Med. 2000;192(3):439–46.
Serezani CH, Lewis C, Jancar S, Peters-Golden M. Leukotriene B4 amplifies NF-kappaB activation in mouse macrophages by reducing SOCS1 inhibition of MyD88 expression. J Clin Invest. 2011;121(2):671–82.
Article PubMed PubMed Central CAS Google Scholar
Kim ND, Chou RC, Seung E, Tager AM, Luster AD. A unique requirement for the leukotriene B4 receptor BLT1 for neutrophil recruitment in inflammatory arthritis. J Exp Med. 2006;203(4):829–35.
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