Kennedy BK, Berger SL, Brunet A, Campisi J, Cuervo AM, Epel ES, et al. Geroscience: linking aging to chronic disease. Cell. 2014;159:709–13.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fulop T, Larbi A, Dupuis G, Le Page A, Frost EH, Cohen AA, et al. Ímmunosenescence and inflamm-aging as two sides of the same coin: friends or Foes?”. Front Immunol. 1960;2018:8.

Google Scholar 

De Martinis M, Franceschi C, Monti D, Ginaldi L. Inflamm-aging and lifelong antigenic load as major determinants of aging rate and longevity. FEBS Lett. 2005;579:2035–9.

Article  PubMed  Google Scholar 

Bucci L., Ostan R., Capri S., et al. ``Inflamm-aging: handbook on immunosenesce – basic understanding and clinical applications.” Springer Science+Business Media B.V. 2009; 839–918.

Goldman DP, Cutler D, Rowe JW, et al. Substantial health and economic returns from delayed aging may warrant a new focus for medical research. Health Aff. 2013;32(10):1698–705.

Article  Google Scholar 

Voisin S, Jasques M, Landen S, Harvey NR, Haupt LM, Griffiths LR, Gancheva S, Ouni M, Jahnert M, Ashton KJ, Coffey VG, Thompson J-L M, Doering T M, Gabory A, Junien C, Caiazzo R, Verkindt H, Raverdy V, Pattou F, Froguel P, Craig JM, Blocquiaux S, Thomis M, Sharples A P, Schurmann A, Roden M, Horvath S, Eynon N. Meta-analysis of genome-wide DNA methylation and integrative omics of age in human skeletal muscle. J Cachexia Sarcopenia Muscle. 2021;12:1064–78.

Article  PubMed  PubMed Central  Google Scholar 

Zykovich A, Hubbard A, Flynn JM, Tarnopolsky M, Fraga MF, Kerksick C, Ogborn D, MacNeil L, Mooney SD, Melov S. Genome-wide DNA methylation changes with age in disease-free human skeletal muscle. Aging Cell. 2014;13:360–6.

Article  CAS  PubMed  Google Scholar 

He L, Khanal P, Morse CI, Williams A, Thomis M. Differentially methylated gene patterns between age-matched sarcopenic and non-sarcopenic women. J Cachexia Sarcopenia Muscle. 2019;10(6):1295–306.

Article  PubMed  PubMed Central  Google Scholar 

Day K, Waite LL, Thalacker-Mercer A, West A, Bamman MM, Brooks JD, Myers RM, Absher D. Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape. Genome Biol. 2013;14(9):R102.

Article  PubMed  PubMed Central  Google Scholar 

Gensous N, Bacalini MG, Pirazzini C, Marasco E, Giuliani C, Ravaioli F, Mengozzi G, Bertarelli C, Palmas MG, Franseschi C, Garagnani P. The epigenetic landscape of age-related diseases: the geroscience perspective. Biogerontology. 2018;18(4):549–59.

Article  Google Scholar 

Mangelinck A, Mann C. DNA methylation and histone variants in aging and cancer. Int Rev Cell Mol Biol. 2021;364:1–110.

Article  CAS  PubMed  Google Scholar 

Martinez P, Blasco MA. Telomere-driven diseases and telomere-targeting therapies. J Cell Biol. 2017;216:875–87.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Muraki K, Han L, Miller D, Murnane JP. Processing by MRE11 is involved in the sensitivity of subtelomeric regions to DNA double-strand breaks. Nucleic Acids Res. 2015;43:7911–30.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martinez P, Blasco MA. Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins. Nat Rev Cancer. 2011;11:161–76.

Article  CAS  PubMed  Google Scholar 

Kannengiesser C, Borie R, Renzoni EA. Pulmonary fibrosis: Genetic analysis of telomere-related genes, telomere length measurement-or both? Respirology. 2019;24:97–8.

Article  PubMed  Google Scholar 

Prasad KN, Wu M, Bondy SC. Telomere shortening during aging: Attenuation by antioxidants and anti-inflammatory agents. Mech Ageing Dev. 2017;164:61–6.

Article  CAS  PubMed  Google Scholar 

Bernabeu-Wittel M, González-Molina Á, Fernández-Ojeda R, Díez-Manglano J, Salgado F, Soto-Martín M, et al. Impact of sarcopenia and frailty in a multicenter cohort of polypathological patients. J Clin Med. 2019;8(4):535.

Article  PubMed  PubMed Central  Google Scholar 

Fouad M, Salem S, Hussein M, Zekri A, Hafez H, Desouky E, Shourman S, Impact of Global DNA Methylation in Treatment Outcome of Colorectal Cancer Patients, Frontiers Pharmacology, 2018; 9.

Marty E, Liu Y, Samuel A, Or O, Lane J. A review of sarcopenia: Enhancing awareness of an increasingly prevalent disease. Bone. 2017;105:276–86.

Article  PubMed  Google Scholar 

Tournadre A, Vial G, Capel F, Soubrier M, Boirie Y. Sarcopenia. Jt Bone Spine. 2019;86:309–14.

Article  Google Scholar 

Wou F, Conroy S. The frailty syndrome. Medicine. 2013;41:13–5.

Article  Google Scholar 

Davies B, García F, Ara I, Artalejo FR, Rodriguez-Mañas L, Walter S. Relationship between sarcopenia and frailty in the toledo study of healthy aging: A population based cross-sectional study. J Am Med Dir Assoc. 2018;19:282–6.

Article  CAS  PubMed  Google Scholar 

Fried LP, Tangen CM, Walston J, Newman AB, Hirsh C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56:M146–56.

Article  CAS  PubMed  Google Scholar 

Fontana L, Kennedy BK, Longo VD, Seals D, Melov S. Medical research: treat aging. Nature. 2014;7510:405–7.

Article  Google Scholar 

Rae MJ, Butler RN, Campisi J, et al. The demographic and biomedical case for late-life interventions in aging. Sci Transl Med. 2010;2(40):40cm21.

Article  PubMed  PubMed Central  Google Scholar 

Turner DC, Seaborne RA, Sharples AP. „Comparative transcriptome and methylome analysis in human skeletal muscle anabolism, hypertrophy and epigenetic memory. Sci Rep. 2019;9:4251.

Article  PubMed  PubMed Central  Google Scholar 

Gensous N, Bacalini MG, Franceschi C, Meskers CGM, Maier AB, Garagnani P. Age-Related DNA Methylation Changes: Potential Impact on Skeletal Muscle Aging in Humans. Front Physiol. 2019;2(10):996.

Article  Google Scholar 

Bernabeu-Wittel M, Gómez-Díaz R, González-Molina Á, Vidal-Serrano S, Díez-Manglano J, Salgado F, et al. Oxidative Stress, Telomere Shortening, and Apoptosis Associated to Sarcopenia and Frailty in Patients with Multimorbidity. J Clin Med. 2020;9(8):2669.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kameda M, Teruya T, Yanagida M, Kondoh H. Frailty markers comprise blood metabolites involved in antioxidation, cognition, and mobility. Proc Natl Acad Sci USA. 2020;117:9483–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liguori I, Russo G, Curcio F, Bulli G, Aran L, Della-Morte D, et al. Oxidative stress, aging, and diseases. Clin Interv Aging. 2018;13:757–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cederholm T. Overlaps between frailty and sarcopenia definitions. Nestle Nutr Inst Workshop Ser. 2015;83:65–9.

Article  PubMed  Google Scholar 

H. Sies Oxidative Stress: Introductory remarks., Oxidative Stress Acad. Press (1985): 1–8.

Phaniendra A, Jestadi DB, Periyasamy L. Free radicals: properties, sources, targets, and their implication in various diseases Indian. J Clin Biochem. 2015;30:11–26.

Article  CAS  Google Scholar 

G. Bjelakovic, D. Nikolova, L.L. Gluud, R.G. Simonetti, C. Gluud Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases Cochrane Database Syst. Rev. (2012); CD007176.

Liguori I, Russo G, Curcio F, Bulli G, Aran L, Della-Morte D, Gargiulo G, Testa G, Caciatore F, Bonaduce D, Abete P. Oxidative stress, aging, and diseases. Clin Interv Aging. 2018;13:757–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Belenguer-Varea Á., Tarazona-Santabalbina F.J., Avellana-Zaragoza J.A., Martínez-Reig M., Mas-Bargues C., Inglés M. „Oxidative stress and exceptional human longevity: Systematic review.“ Free Radic Biol Med., 2019, 51–63.