Senescence-associated secretory phenotypes in mesenchymal cells contribute to cytotoxic immune response in oral lichen planus

Alrashdan MS, Cirillo N, McCullough M. Oral lichen planus: a literature review and update. Arch Dermatol Res. 2016;308:539–51.

Article  PubMed  Google Scholar 

Li C, Tang X, Zheng X, Ge S, Wen H, Lin X, et al. Global prevalence and incidence estimates of oral Lichen Planus: a systematic review and Meta-analysis. JAMA Dermatol. 2020;156:172–81.

Article  PubMed  PubMed Central  Google Scholar 

Olson MA, Rogers RS, Bruce AJ. Oral lichen planus. Clin Dermatol. 2016;34:495–504.

Article  PubMed  Google Scholar 

Roopashree MR, Gondhalekar RV, Shashikanth MC, George J, Thippeswamy SH, Shukla A. Pathogenesis of oral lichen planus–a review. J Oral Pathol Med. 2010;39:729–34.

Article  PubMed  CAS  Google Scholar 

Aly EAH, Burgess P. Use of laser in the relief of malignant dysphagia: a district hospital experience. Dig Surg. 2002;19:3–8.

Article  PubMed  Google Scholar 

Cheng Y-SL, Gould A, Kurago Z, Fantasia J, Muller S. Diagnosis of oral lichen planus: a position paper of the American Academy of Oral and Maxillofacial Pathology. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;122:332–54.

Article  PubMed  Google Scholar 

Herranz N, Gil J. Mechanisms and functions of cellular senescence. J Clin Invest. 2018;128:1238–46.

Article  PubMed  PubMed Central  Google Scholar 

Gorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C, et al. Cellular Senescence: defining a path Forward. Cell. 2019;179:813–27.

Article  PubMed  CAS  Google Scholar 

Ferrucci L, Fabbri E. Inflammageing: chronic inflammation in ageing, Cardiovascular Disease, and frailty. Nat Rev Cardiol. 2018;15:505–22.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Childs BG, Gluscevic M, Baker DJ, Laberge R-M, Marquess D, Dananberg J, et al. Senescent cells: an emerging target for Diseases of ageing. Nat Rev Drug Discov. 2017;16:718–35.

Article  PubMed  PubMed Central  CAS  Google Scholar 

van Deursen JM. The role of senescent cells in ageing. Nature. 2014;509:439–46.

Article  PubMed  PubMed Central  Google Scholar 

Dissemond J. Oral lichen planus: an overview. J Dermatolog Treat. 2004;15:136–40.

Article  PubMed  Google Scholar 

Xue N, Wang Y, Cheng H, Liang H, Fan X, Zuo F, et al. Regulatory T cell therapy suppresses inflammation of oral mucosa. Front Immunol. 2022;13:1009742.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Carbone T, Nasorri F, Pennino D, Donnarumma M, Garcovich S, Eyerich K, et al. CD56 highCD16 - NK cell involvement in cutaneous lichen planus. Eur J Dermatol. 2010;20:724–30.

PubMed  CAS  Google Scholar 

Qing M, Shang Q, Yang D, Peng J, Deng J, Jiang L et al. CD8 + tissue-resident memory T cells triggered the erosion of oral lichen planus by the cytokine network. medRxiv. 2022;:2022.10.18.22281149.

Kale A, Sharma A, Stolzing A, Desprez P-Y, Campisi J. Role of immune cells in the removal of deleterious senescent cells. Immun Ageing. 2020;17:16.

Article  PubMed  PubMed Central  Google Scholar 

Rhodus NL, Cheng B, Myers S, Bowles W, Ho V, Ondrey F. A comparison of the pro-inflammatory, NF-κB-dependent cytokines: TNF-alpha, IL-1-alpha, IL-6, and IL-8 in different oral fluids from oral lichen planus patients. Clin Immunol. 2005;114:278–83.

Article  PubMed  CAS  Google Scholar 

Rhodus NL, Cheng B, Myers S, Miller L, Ho V, Ondrey F. The feasibility of monitoring NF-κB associated cytokines: TNF-α, IL-1α, IL-6, and IL-8 in whole saliva for the malignant transformation of oral lichen planus. Mol Carcinog. 2005;44:77–82.

Article  PubMed  CAS  Google Scholar 

Wang B, Varela-Eirin M, Brandenburg SM, Hernandez-Segura A, van Vliet T, Jongbloed EM, et al. Pharmacological CDK4/6 inhibition reveals a p53-dependent senescent state with restricted toxicity. EMBO J. 2022;41:e108946.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhang Y, Lin M, Zhang S, Wang Z, Jiang L, Shen J, et al. NF-kappaB-dependent cytokines in saliva and serum from patients with oral lichen planus: a study in an ethnic Chinese population. Cytokine. 2008;41:144–9.

Article  PubMed  CAS  Google Scholar 

Rhodus NL, Cheng B, Myers S, Bowles W, Ho V, Ondrey F. A comparison of the pro-inflammatory, NF-kappaB-dependent cytokines: TNF-alpha, IL-1-alpha, IL-6, and IL-8 in different oral fluids from oral lichen planus patients. Clin Immunol. 2005;114:278–83.

Article  PubMed  CAS  Google Scholar 

Rhodus NL, Cheng B, Myers S, Miller L, Ho V, Ondrey F. The feasibility of monitoring NF-kappaB associated cytokines: TNF-alpha, IL-1alpha, IL-6, and IL-8 in whole saliva for the malignant transformation of oral lichen planus. Mol Carcinog. 2005;44:77–82.

Article  PubMed  CAS  Google Scholar 

Montebugnoli L, Venturi M, Gissi DB, Leonardi E, Farnedi A, Foschini MP. Immunohistochemical expression of p16(INK4A) protein in oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;112:222–7.

Article  PubMed  CAS  Google Scholar 

Poomsawat S, Buajeeb W, Khovidhunkit S-OP, Punyasingh J. Overexpression of cdk4 and p16 in oral lichen planus supports the concept of premalignancy. J Oral Pathol Med. 2011;40:294–9.

Article  PubMed  Google Scholar 

González-Moles MA, Bascones-Ilundain C, Gil Montoya JA, Ruiz-Avila I, Delgado-Rodríguez M, Bascones-Martínez A. Cell cycle regulating mechanisms in oral lichen planus: molecular bases in epithelium predisposed to malignant transformation. Arch Oral Biol. 2006;51:1093–103.

Article  PubMed  Google Scholar 

Binet F, Cagnone G, Crespo-Garcia S, Hata M, Neault M, Dejda A et al. Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy. Science. 2020;369.

Saul D, Kosinsky RL, Atkinson EJ, Doolittle ML, Zhang X, LeBrasseur NK, et al. A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues. Nat Commun. 2022;13:4827.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Fridman AL, Tainsky MA. Critical pathways in cellular senescence and immortalization revealed by gene expression profiling. Oncogene. 2008;27:5975–87.

Article  PubMed  CAS  Google Scholar 

Purcell M, Kruger A, Tainsky MA. Gene expression profiling of replicative and induced senescence. Cell Cycle. 2014;13:3927–37.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Casella G, Munk R, Kim KM, Piao Y, De S, Abdelmohsen K, et al. Transcriptome signature of cellular senescence. Nucleic Acids Res. 2019;47:7294–305.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hernandez-Segura A, de Jong TV, Melov S, Guryev V, Campisi J, Demaria M. Unmasking transcriptional heterogeneity in senescent cells. Curr Biol. 2017;27:2652–2660e4.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Salminen A, Kauppinen A, Kaarniranta K. Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP). Cell Signal. 2012;24:835–45.

Article  PubMed  CAS  Google Scholar 

Jin S, Guerrero-Juarez CF, Zhang L, Chang I, Ramos R, Kuan C-H, et al. Inference and analysis of cell-cell communication using CellChat. Nat Commun. 2021;12:1088.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Choi YW, Kim YH, Oh SY, Suh KW, Kim Y-S, Lee G-Y, et al. Senescent Tumor cells build a Cytokine Shield in Colorectal Cancer. Adv Sci (Weinh). 2021;8:2002497.

Article  PubMed  CAS  Google Scholar 

Mukherjee T, Chatterjee B, Dhar A, Bais SS, Chawla M, Roy P, et al. A TNF-p100 pathway subverts noncanonical NF-κB signaling in inflamed secondary lymphoid organs. EMBO J. 2017;36:3501–16.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Shatrova AN, Mityushova EV, Aksenov NA, Marakhova II. CD25 expression on the surface of jurkat cells. Cell Tissue biol. 2015;9:364–70.

Article  Google Scholar 

Peter CD, Shashidara R, Jain V, Haragannavar VC, Samuel P, Nayak SR. Senescence in oral lichen planus as assessed by the immunohistochemical evaluation of senescence marker protein-30 (regucalcin). Indian J Pathol Microbiol. 2023;66:9–13.

Article  PubMed  Google Scholar 

Fujita T, Inoue H, Kitamura T, Sato N, Shimosawa T, Maruyama N. Senescence marker protein-30 (SMP30) rescues cell death by enhancing plasma membrane ca(2+)-pumping activity in Hep G2 cells. Biochem Biophys Res Commun. 1998;250:374–80.

Article  PubMed  CAS 

Comments (0)

No login
gif