The present work gained approval from the Ethics Committee of the Third Xiangya Hospital, Central South University, China. Each participant provided informed consent. The Animal Ethics Committee of the Third Xiangya Hospital, Central South University, China, approved each animal experimental protocol.

The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.