PLK1 and its substrate MISP facilitate intrahepatic cholangiocarcinoma progression by promoting lymphatic invasion and impairing E-cadherin adherens junctions

Valle JW, Lamarca A, Goyal L, Barriuso J, Zhu AX. New horizons for precision medicine in biliary tract cancers. Cancer Discov. 2017;7:943–62.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Duffy MJ, Shering S, Sherry F, McDermott E, O’Higgins N. CA 15-3: a prognostic marker in breast cancer. Int J Biol Markers. 2000;15:330–3.

Article  CAS  PubMed  Google Scholar 

Shaib Y, El-Serag HB. The epidemiology of cholangiocarcinoma. Semin Liver Dis. 2004;24:115–25.

Article  PubMed  Google Scholar 

Khan SA, Thomas HC, Davidson BR, Taylor-Robinson SD. Cholangiocarcinoma. Lancet. 2005;366:1303–14.

Article  PubMed  Google Scholar 

Blechacz B, Komuta M, Roskams T, Gores GJ. Clinical diagnosis and staging of cholangiocarcinoma. Nat Rev Gastroenterol Hepatol. 2011;8:512–22.

Article  PubMed  PubMed Central  Google Scholar 

Chaiteerakij R, Yang JD, Harmsen WS, Slettedahl SW, Mettler TA, Fredericksen ZS, et al. Risk factors for intrahepatic cholangiocarcinoma: association between metformin use and reduced cancer risk. Hepatology. 2013;57:648–55.

Article  CAS  PubMed  Google Scholar 

Fisher SB, Patel SH, Kooby DA, Weber S, Bloomston M, Cho C, et al. Lymphovascular and perineural invasion as selection criteria for adjuvant therapy in intrahepatic cholangiocarcinoma: a multi-institution analysis. HPB (Oxf). 2012;14:514–22.

Article  Google Scholar 

Tsai CY, Wang SY, Chan KM, Lee WC, Chen TC, Yeh TS, et al. Hepatectomy or/with metastatectomy for recurrent intrahepatic cholangiocarcinoma: of promise for selected patients. J Pers Med. 2022;12:540.

Article  PubMed  PubMed Central  Google Scholar 

Fidler IJ. Critical determinants of metastasis. Semin Cancer Biol. 2002;12:89–96.

Article  PubMed  Google Scholar 

Pantel K, Brakenhoff RH. Dissecting the metastatic cascade. Nat Rev Cancer. 2004;4:448–56.

Article  CAS  PubMed  Google Scholar 

Rimini M, Loi E, Fabregat-Franco C, Burgio V, Lonardi S, Niger M, et al. Next-generation sequencing analysis of cholangiocarcinoma identifies distinct IDH1-mutated clusters. Eur J Cancer. 2022;175:299–310.

Article  CAS  PubMed  Google Scholar 

Singhi AD, Nikiforova MN, Chennat J, Papachristou GI, Khalid A, Rabinovitz M, et al. Integrating next-generation sequencing to endoscopic retrograde cholangiopancreatography (ERCP)-obtained biliary specimens improves the detection and management of patients with malignant bile duct strictures. Gut. 2020;69:52–61.

Article  CAS  PubMed  Google Scholar 

Liu Z, Sun Q, Wang X. PLK1, a potential target for cancer therapy. Transl Oncol. 2017;10:22–32.

Article  PubMed  Google Scholar 

Lee SY, Jang C, Lee KA. Polo-like kinases (plks), a key regulator of cell cycle and new potential target for cancer therapy. Dev Reprod. 2014;18:65–71.

Article  PubMed  PubMed Central  Google Scholar 

Lens SM, Voest EE, Medema RH. Shared and separate functions of polo-like kinases and aurora kinases in cancer. Nat Rev Cancer. 2010;10:825–41.

Article  CAS  PubMed  Google Scholar 

van de Weerdt BC, Medema RH. Polo-like kinases: a team in control of the division. Cell Cycle. 2006;5:853–64.

Article  PubMed  Google Scholar 

Cholewa BD, Liu X, Ahmad N. The role of polo-like kinase 1 in carcinogenesis: cause or consequence? Cancer Res. 2013;73:6848–55.

Article  CAS  PubMed  Google Scholar 

Luo P, Yan H, Du J, Chen X, Shao J, Zhang Y, et al. PLK1 (polo like kinase 1)-dependent autophagy facilitates gefitinib-induced hepatotoxicity by degrading COX6A1 (cytochrome c oxidase subunit 6A1). Autophagy. 2021;17:3221–37.

Article  CAS  PubMed  Google Scholar 

Jang HR, Shin SB, Kim CH, Won JY, Xu R, Kim DE, et al. PLK1/vimentin signaling facilitates immune escape by recruiting Smad2/3 to PD-L1 promoter in metastatic lung adenocarcinoma. Cell Death Differ. 2021;28:2745–64.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vertii A, Ivshina M, Zimmerman W, Hehnly H, Kant S, Doxsey S. The centrosome undergoes Plk1-independent interphase maturation during inflammation and mediates cytokine release. Dev Cell. 2016;37:377–86.

Article  CAS  PubMed  Google Scholar 

Fu Z, Wen D. The emerging role of polo-like kinase 1 in epithelial-mesenchymal transition and tumor metastasis. Cancers. 2017;9:131.

Article  PubMed  PubMed Central  Google Scholar 

Chiappa M, Petrella S, Damia G, Broggini M, Guffanti F, Ricci F. Present and future perspective on PLK1 inhibition in cancer treatment. Front Oncol. 2022;12:903016.

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Carcer G. The mitotic cancer target polo-like kinase 1: oncogene or tumor suppressor? Genes. 2019;10:208.

Article  PubMed  PubMed Central  Google Scholar 

Kneisel L, Strebhardt K, Bernd A, Wolter M, Binder A, Kaufmann R. Expression of polo-like kinase (PLK1) in thin melanomas: a novel marker of metastatic disease. J Cutan Pathol. 2002;29:354–8.

Article  PubMed  Google Scholar 

Weichert W, Kristiansen G, Winzer KJ, Schmidt M, Gekeler V, Noske A, et al. Polo-like kinase isoforms in breast cancer: expression patterns and prognostic implications. Virchows Arch. 2005;446:442–50.

Article  CAS  PubMed  Google Scholar 

Weichert W, Schmidt M, Gekeler V, Denkert C, Stephan C, Jung K, et al. Polo-like kinase 1 is overexpressed in prostate cancer and linked to higher tumor grades. Prostate. 2004;60:240–5.

Article  CAS  PubMed  Google Scholar 

Thrum S, Lorenz J, Mossner J, Wiedmann M. Polo-like kinase 1 inhibition as a new therapeutic modality in therapy of cholangiocarcinoma. Anticancer Res. 2011;31:3289–99.

CAS  PubMed  Google Scholar 

Zhu M, Settele F, Kotak S, Sanchez-Pulido L, Ehret L, Ponting CP, et al. MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression. J Cell Biol. 2013;200:773–87.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Maier B, Kirsch M, Anderhub S, Zentgraf H, Kramer A. The novel actin/focal adhesion-associated protein MISP is involved in mitotic spindle positioning in human cells. Cell Cycle. 2013;12:1457–71.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kumeta M, Gilmore JL, Umeshima H, Ishikawa M, Kitajiri S, Horigome T, et al. Caprice/MISP is a novel F-actin bundling protein critical for actin-based cytoskeletal reorganizations. Genes Cells. 2014;19:338–49.

Article  CAS  PubMed  Google Scholar 

Vodicska B, Cerikan B, Schiebel E, Hoffmann I. MISP regulates the IQGAP1/Cdc42 complex to collectively orchestrate spindle orientation and mitotic progression. Sci Rep. 2018;8:6330.

Article  PubMed  PubMed Central  Google Scholar 

Morales EA, Arnaiz C, Krystofiak ES, Zanic M, Tyska MJ. Mitotic Spindle Positioning (MISP) is an actin bundler that selectively stabilizes the rootlets of epithelial microvilli. Cell Rep. 2022;39:110692.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang X, Zhao L, Jin Y, Wang Z, Li T, Xu H, et al. Up-regulated MISP is associated with poor prognosis and immune infiltration in pancreatic ductal adenocarcinoma. Front Oncol. 2022;12:827051.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dejana E. Endothelial cell-cell junctions: happy together. Nat Rev Mol Cell Biol. 2004;5:261–70.

Article  CAS  PubMed  Google Scholar 

Morris HT, Machesky LM. Actin cytoskeletal control during epithelial to mesenchymal transition: focus on the pancreas and intestinal tract. Br J Cancer. 2015;112:613–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Campbell HK, Maiers JL, DeMali KA. Interplay between tight junctions & adherens junctions. Exp Cell Res. 2017;358:39–44.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Harris TJ, Tepass U. Adherens junctions: from molecules to morphogenesis. Nat Rev Mol Cell Biol. 2010;11:502–14.

Article  CAS  PubMed 

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