ScRNA-seq revealed the tumor microenvironment heterogeneity related to the occurrence and metastasis in upper urinary tract urothelial carcinoma

Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Cancer J Clin. 2022;72:7–33. https://doi.org/10.3322/caac.21708.

Article  PubMed  Google Scholar 

Hassler MR, Bray F, Catto JWF, Grollman AP, Hartmann A, Margulis V, et al. Molecular characterization of upper tract urothelial carcinoma in the era of next-generation sequencing: a systematic review of the current literature. Eur Urol. 2020;78 :209–20. https://doi.org/10.1016/j.eururo.2020.05.039.

Article  CAS  PubMed  Google Scholar 

Crivelli JJ, Xylinas E, Kluth LA, Rieken M, Rink M, Shariat SF. Effect of smoking on outcomes of urothelial carcinoma: a systematic review of the literature. Eur Urol. 2014;65:742–54. https://doi.org/10.1016/j.eururo.2013.06.010.

Article  CAS  PubMed  Google Scholar 

Van Osch FH, Jochems SH, van Schooten FJ, Bryan RT, Zeegers MP. Significant role of lifetime cigarette smoking in worsening bladder cancer and upper tract urothelial carcinoma prognosis: a meta-analysis. J Urol. 2016;195:872–9. https://doi.org/10.1016/j.juro.2015.10.139.

Article  PubMed  Google Scholar 

Rouprêt M, Babjuk M, Burger M, Capoun O, Cohen D, Compérat EM, et al. European Association of Urology Guidelines on upper urinary tract urothelial carcinoma: 2020 update. Eur Urol. 2021;79:62–79. https://doi.org/10.1016/j.eururo.2020.05.042.

Article  CAS  PubMed  Google Scholar 

Laplane L, Duluc D, Bikfalvi A, Larmonier N, Pradeu T. Beyond the tumour microenvironment [published correction appears in Int J Cancer. 2021 Mar 15;148(6):E5]. Int J Cancer. 2019;145:2611–8. https://doi.org/10.1002/ijc.32343.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang C, Bruggeman LA, Hydo LM, Miller RT. Shear stress induces cell apoptosis via a c-Src-phospholipase D-mTOR signaling pathway in cultured podocytes. Exp Cell Res. 2012;318:1075–85. https://doi.org/10.1016/j.yexcr.2012.03.011.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ahn S, Park H. XIAP is essential for shear stress-enhanced Tyr-576 phosphorylation of FAK. Biochem Biophys Res Commun. 2010;399:256–61. https://doi.org/10.1016/j.bbrc.2010.07.064.

Article  CAS  PubMed  Google Scholar 

McGranahan N, Swanton C. Clonal heterogeneity and tumor evolution: past, present, and the future. Cell. 2017;168:613–28. https://doi.org/10.1016/j.cell.2017.01.018.

Article  CAS  PubMed  Google Scholar 

McGranahan N, Swanton C. Biological and therapeutic impact of intratumor heterogeneity in cancer evolution. Cancer Cell. 2015;27:15–26. https://doi.org/10.1016/j.ccell.2014.12.001.

Article  CAS  PubMed  Google Scholar 

Blanpain C. Tracing the cellular origin of cancer. Nat Cell Biol. 2013;15:126–34. https://doi.org/10.1038/ncb2657.

Article  CAS  PubMed  Google Scholar 

Lourenco AR, Ban Y, Crowley MJ, Lee SB, Ramchandani D, Du W, et al. Differential contributions of pre- and post-EMT tumor cells in breast cancer metastasis. Cancer Res. 2020;80:163–9. https://doi.org/10.1158/0008-5472.CAN-19-1427.

Article  CAS  PubMed  Google Scholar 

Davis RT, Blake K, Ma D, Gabra MBI, Hernandez GA, Phung AT, et al. Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing. Nat Cell Biol. 2020;22:310–20. https://doi.org/10.1038/s41556-020-0477-0.

Article  CAS  PubMed  Google Scholar 

Müller M, Bird TG, Nault JC. The landscape of gene mutations in cirrhosis and hepatocellular carcinoma. J Hepatol. 2020;72:990–1002. https://doi.org/10.1016/j.jhep.2020.01.019.

Article  CAS  PubMed  Google Scholar 

Rebouissou S, Nault JC. Advances in molecular classification and precision oncology in hepatocellular carcinoma. J Hepatol. 2020;72:215–29. https://doi.org/10.1016/j.jhep.2019.08.017.

Article  CAS  PubMed  Google Scholar 

Baslan T, Hicks J. Unravelling biology and shifting paradigms in cancer with single-cell sequencing. Nat Rev Cancer. 2017;17:557–69. https://doi.org/10.1038/nrc.2017.58.

Article  CAS  PubMed  Google Scholar 

Patel AP, Tirosh I, Trombetta JJ, Shalek AK, Gillespie SM, Wakimoto H, et al. Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma. Science. 2014;344:1396–401. https://doi.org/10.1126/science.1254257.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Albini A, Sporn MB. The tumour microenvironment as a target for chemoprevention. Nat Rev Cancer. 2007;7:139–47. https://doi.org/10.1038/nrc2067.

Article  CAS  PubMed  Google Scholar 

Quail DF, Joyce JA. Microenvironmental regulation of tumor progression and metastasis. Nat Med. 2013;19:1423–37. https://doi.org/10.1038/nm.3394.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hosein AN, Huang H, Wang Z, Parmar K, Du W, Huang J, et al. Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single-cell resolution. JCI Insight. 2019;5:e129212. https://doi.org/10.1172/jci.insight.129212.

Article  PubMed  Google Scholar 

Wirtz D, Konstantopoulos K, Searson PC. The physics of cancer: the role of physical interactions and mechanical forces in metastasis. Nat Rev Cancer. 2011;11:512–22. https://doi.org/10.1038/nrc3080.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Turajlic S, Swanton C. Metastasis as an evolutionary process. Science. 2016;352:169–75. https://doi.org/10.1126/science.aaf2784.

Article  CAS  PubMed  Google Scholar 

Ramaswamy S, Ross KN, Lander ES, Golub TR. A molecular signature of metastasis in primary solid tumors. Nat Genet. 2003;33:49–54. https://doi.org/10.1038/ng1060.

Article  CAS  PubMed  Google Scholar 

Chen YC, Sahoo S, Brien R, Jung S, Humphries B, Lee W, et al. Single-cell RNA-sequencing of migratory breast cancer cells: discovering genes associated with cancer metastasis. Analyst. 2019;144:7296–309. https://doi.org/10.1039/c9an01358j.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim KT, Lee HW, Lee HO, Song HJ, Jeong da E, Shin S, et al. Application of single-cell RNA sequencing in optimizing a combinatorial therapeutic strategy in metastatic renal cell carcinoma. Genome Biol. 2016;17:80. https://doi.org/10.1186/s13059-016-0945-9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Neftel C, Laffy J, Filbin MG, Hara T, Shore ME, Rahme GJ, et al. An integrative model of cellular states, plasticity, and genetics for glioblastoma. Cell. 2019;178:835–49.e21. https://doi.org/10.1016/j.cell.2019.06.024.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liang Y, Tan Y, Guan B, Guo B, Xia M, Li J, et al. Single-cell atlases link macrophages and CD8+ T-cell subpopulations to disease progression and immunotherapy response in urothelial carcinoma. Theranostics. 2022;12:7745–59. https://doi.org/10.7150/thno.77281.

Article  CAS  PubMed  PubMed Central 

Comments (0)

No login
gif