Torres J, Mehandru S, Colombel J-F, et al. Crohn’s disease. Lancet. 2017;389:1741–55.

Article  PubMed  Google Scholar 

Cosnes J, Cattan S, Blain A, et al. Long-term evolution of disease behavior of Crohn’s disease. Inflamm Bowel Dis. 2002;8:244–50.

Article  PubMed  Google Scholar 

Frøslie KF, Jahnsen J, Moum BA, et al. Mucosal healing in inflammatory bowel disease: results from a Norwegian population-based cohort. Gastroenterology. 2007;133:412–22.

Article  PubMed  Google Scholar 

Louis E, Collard A, Oger AF, et al. Behaviour of Crohn’s disease according to the Vienna classification: changing pattern over the course of the disease. Gut. 2001;49:777–82.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Soontararak S, Chow L, Johnson V, et al. Mesenchymal stem cells (MSC) derived from induced pluripotent stem cells (iPSC) equivalent to adipose-derived MSC in promoting intestinal healing and microbiome normalization in mouse inflammatory bowel disease model. Stem Cells Transl Med. 2018;7:456–67.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Xie M, Qin H, Luo Q, et al. Comparison of adipose-derived and bone marrow mesenchymal stromal cells in a murine model of Crohn’s disease. Dig Dis Sci. 2017;62:115–23.

Article  PubMed  CAS  Google Scholar 

Dhere T, Copland I, Garcia M, et al. The safety of autologous and metabolically fit bone marrow mesenchymal stromal cells in medically refractory Crohn’s disease—a phase 1 trial with three doses. Aliment Pharmacol Ther. 2016;44:471–81.

Article  PubMed  CAS  Google Scholar 

Lian L, Huang Q, Zhang L, et al. Anti-fibrogenic potential of mesenchymal stromal cells in treating fibrosis in Crohn’s disease. Dig Dis Sci. 2018;63:1821–34.

Article  PubMed  CAS  Google Scholar 

Kim H-S, Choi D-Y, Yun SJ, et al. Proteomic analysis of microvesicles derived from human mesenchymal stem cells. J Proteome Res. 2012;11:839–49.

Article  PubMed  CAS  Google Scholar 

Collino F, Deregibus MC, Bruno S, et al. Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs. PLoS One. 2010;5: e11803.

Article  PubMed  PubMed Central  Google Scholar 

Heidari N, Abbasi-Kenarsari H, Namaki S, et al. Regulation of the Th17/Treg balance by human umbilical cord mesenchymal stem cell-derived exosomes protects against acute experimental colitis. Exp Cell Res. 2022;419: 113296.

Article  PubMed  CAS  Google Scholar 

Mardpour S, Ghanian MH, Sadeghi-Abandansari H, et al. Hydrogel-mediated sustained systemic delivery of mesenchymal stem cell-derived extracellular vesicles improves hepatic regeneration in chronic liver failure. ACS Appl Mater Interfaces. 2019;11:37421–33.

Article  PubMed  CAS  Google Scholar 

Guo L, Lai P, Wang Y, et al. Extracellular vesicles derived from mesenchymal stem cells prevent skin fibrosis in the cGVHD mouse model by suppressing the activation of macrophages and B cells immune response. Int Immunopharmacol. 2020;84: 106541.

Article  PubMed  CAS  Google Scholar 

Grange C, Tritta S, Tapparo M, et al. Stem cell-derived extracellular vesicles inhibit and revert fibrosis progression in a mouse model of diabetic nephropathy. Sci Rep. 2019;9:4468.

Article  PubMed  PubMed Central  Google Scholar 

Baglio SR, Pegtel DM, Baldini N. Mesenchymal stem cell secreted vesicles provide novel opportunities in (stem) cell-free therapy. Front Physiol. 2012;3:359.

Article  PubMed  PubMed Central  Google Scholar 

Xie M, Xiong Z, Yin S, et al. Adiponectin alleviates intestinal fibrosis by enhancing AMP-activated protein kinase phosphorylation. Dig Dis Sci. 2022;67:2232–43.

Article  PubMed  CAS  Google Scholar 

Li X, Chen J, Xie M, et al. Adipose-derived mesenchymal stromal cells alleviate intestinal fibrosis: the role of tumor necrosis factor-stimulated gene 6 protein. Int Immunopharmacol. 2024;139: 112693.

Article  PubMed  CAS  Google Scholar 

Wirtz S, Neufert C, Weigmann B, et al. Chemically induced mouse models of intestinal inflammation. Nat Protoc. 2007;2:541–6.

Article  PubMed  CAS  Google Scholar 

Théry C, Witwer KW, Aikawa E, et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles. 2018;7:1535750.

Article  PubMed  PubMed Central  Google Scholar 

Scheibe K, Kersten C, Schmied A, et al. Inhibiting interleukin 36 receptor signaling reduces fibrosis in mice with chronic intestinal inflammation. Gastroenterology. 2019. https://doi.org/10.1053/j.gastro.2018.11.029.

Article  PubMed  Google Scholar 

Rieder F, Fiocchi C, Rogler G. Mechanisms, management, and treatment of fibrosis in patients with inflammatory bowel diseases. Gastroenterology. 2017. https://doi.org/10.1053/j.gastro.2016.09.047.

Article  PubMed  Google Scholar 

Holvoet T, Devriese S, Castermans K, et al. Treatment of intestinal fibrosis in experimental inflammatory bowel disease by the pleiotropic actions of a local rho kinase inhibitor. Gastroenterology. 2017;153:1054–67.

Article  PubMed  CAS  Google Scholar 

Candido J, Hagemann T. Cancer-related inflammation. J Clin Immunol. 2013;33(Suppl 1):S79–84.

Article  PubMed  Google Scholar 

Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15:550.

Article  PubMed  PubMed Central  Google Scholar 

Benjamini Y, Drai D, Elmer G, et al. Controlling the false discovery rate in behavior genetics research. Behav Brain Res. 2001;125:279–84.

Article  PubMed  CAS  Google Scholar 

Draghici S, Khatri P, Tarca AL, et al. A systems biology approach for pathway level analysis. Genome Res. 2007;17:1537–45.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Wong VW, Rustad KC, Akaishi S, et al. Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling. Nat Med. 2011;18(1):148–52.

Article  PubMed  PubMed Central  Google Scholar 

Wang K, Shi L, Linthicum W, et al. Substrate stiffness-dependent carbon nanotube-induced lung fibrogenesis. Nano Lett. 2019;19:5443–51.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhu H, Liao J, Zhou X, et al. Tenascin-C promotes acute kidney injury to chronic kidney disease progression by impairing tubular integrity via αvβ6 integrin signaling. Kidney Int. 2020;97:1017–31.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Nakamura Y, Miyaki S, Ishitobi H, et al. Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration. FEBS Lett. 2015;589:1257–65.

Article  PubMed  CAS  Google Scholar 

Vonk LA, van Dooremalen SFJ, Liv N, et al. Mesenchymal stromal/stem cell-derived extracellular vesicles promote human cartilage regeneration. Theranostics. 2018;8:906–20.

Article