The role of AMPK in macrophage metabolism, function and polarisation

Judge A, Dodd MS. Metabolism. Essays Biochem. 2020;64(4):607–47.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ross FA, MacKintosh C, Hardie DG. AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours. FEBS J. 2016;283(16):2987–3001.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Y, Chen Y. AMPK and autophagy. Adv Exp Med Biol. 2019;1206:85–108.

Article  CAS  PubMed  Google Scholar 

Carling D. AMPK signalling in health and disease. Curr Opin Cell Biol. 2017;45:31–7.

Article  CAS  PubMed  Google Scholar 

Russell FM, Hardie DG. AMP-activated protein kinase: do we need activators or inhibitors to treat or prevent cancer? Int J Mol Sci. 2020;22(1):186.

Article  PubMed  PubMed Central  Google Scholar 

Steinberg GR, Hardie DG. New insights into activation and function of the AMPK. Nat Rev Mol Cell Biol. 2023;24(4):255–72.

Article  CAS  PubMed  Google Scholar 

Yan Y, et al. Structure and physiological regulation of AMPK. Int J Mol Sci. 2018;19(11):3534.

Article  PubMed  PubMed Central  Google Scholar 

Brookens SK, Boothby MR. AMPK metabolism in the B lineage modulates humoral responses. Immunometabolism. 2021;3(2):e210011.

Article  PubMed  PubMed Central  Google Scholar 

Wang S, et al. Metabolic reprogramming of macrophages during Infections and cancer. Cancer Lett. 2019;452:14–22.

Article  CAS  PubMed  Google Scholar 

McArthur S, et al. Annexin A1 drives macrophage skewing to accelerate muscle regeneration through AMPK activation. J Clin Invest. 2020;130(3):1156–67.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Juban G, et al. AMPK activation regulates LTBP4-dependent TGF-beta1 secretion by pro-inflammatory macrophages and controls fibrosis in Duchenne muscular dystrophy. Cell Rep. 2018;25(8):2163–76.e6.

Article  CAS  PubMed  Google Scholar 

Li J, et al. Structural and biochemical insights into the allosteric activation mechanism of AMP-activated protein kinase. Chem Biol Drug Des. 2017;89(5):663–9.

Article  CAS  PubMed  Google Scholar 

Hardie DG. AMP-activated protein kinase—a journey from 1 to 100 downstream targets. Biochem J. 2022;479(22):2327–43.

Article  CAS  PubMed  Google Scholar 

Dermaku-Sopjani M, Sopjani M. Intracellular signaling of the AMP-activated protein kinase. Adv Protein Chem Struct Biol. 2019;116:171–207.

Article  CAS  PubMed  Google Scholar 

Garcia D, Shaw RJ. AMPK: mechanisms of cellular energy sensing and restoration of metabolic balance. Mol Cell. 2017;66(6):789–800.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim J, et al. AMPK activators: mechanisms of action and physiological activities. Exp Mol Med. 2016;48:e224.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Viollet B, et al. AMPK inhibition in health and disease. Crit Rev Biochem Mol Biol. 2010;45(4):276–95.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rajamohan F, et al. Probing the enzyme kinetics, allosteric modulation and activation of alpha1- and alpha2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators. Biochem J. 2016;473(5):581–92.

Article  CAS  PubMed  Google Scholar 

Steinberg GR, Carling D. AMP-activated protein kinase: the current landscape for drug development. Nat Rev Drug Discov. 2019;18(7):527–51.

Article  CAS  PubMed  Google Scholar 

Herzig S, Shaw RJ. AMPK: guardian of metabolism and mitochondrial homeostasis. Nat Rev Mol Cell Biol. 2018;19(2):121–35.

Article  CAS  PubMed  Google Scholar 

Wu S, Zou MH. AMPK, mitochondrial function, and cardiovascular disease. Int J Mol Sci. 2020;21(14):4987.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Q, et al. AMPK-Mediated regulation of lipid metabolism by phosphorylation. Biol Pharm Bull. 2018;41(7):985–93.

Article  CAS  PubMed  Google Scholar 

Hardie DG, Schaffer BE, Brunet A. AMPK: an energy-sensing pathway with multiple inputs and outputs. Trends Cell Biol. 2016;26(3):190–201.

Article  CAS  PubMed  Google Scholar 

Peixoto CA, et al. AMPK activation: role in the signaling pathways of neuroinflammation and neurodegeneration. Exp Neurol. 2017;298(Pt A):31–41.

Article  CAS  PubMed  Google Scholar 

Gonzalez A, et al. AMPK and TOR: the Yin and Yang of cellular nutrient sensing and growth control. Cell Metab. 2020;31(3):472–92.

Article  CAS  PubMed  Google Scholar 

Aslam M, Ladilov Y. Emerging role of cAMP/AMPK signaling. Cells. 2022;11(2):308.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xiao B, et al. Structure of mammalian AMPK and its regulation by ADP. Nature. 2011;472(7342):230–3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Trefts E, Shaw RJ. AMPK: restoring metabolic homeostasis over space and time. Mol Cell. 2021;81(18):3677–90.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ke R, et al. Mechanisms of AMPK in the maintenance of ATP balance during energy metabolism. Cell Biol Int. 2018;42(4):384–92.

Article  CAS  PubMed  Google Scholar 

Neumann D. Is TAK1 a direct upstream kinase of AMPK? Int J Mol Sci. 2018;19(8):2412.

Article  PubMed  PubMed Central  Google Scholar 

Ma EH, et al. The role of AMPK in T cell metabolism and function. Curr Opin Immunol. 2017;46:45–52.

Article  CAS  PubMed  Google Scholar 

Jeon SM. Regulation and function of AMPK in physiology and diseases. Exp Mol Med. 2016;48(7):e245.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Saito M, Saito M, Das BC. Involvement of AMP-activated protein kinase in neuroinflammation and neurodegeneration in the adult and developing brain. Int J Dev Neurosci. 2019;77:48–59.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mihaylova MM, Shaw RJ. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol. 2011;13(9):1016–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin SC, Hardie DG. AMPK: sensing glucose as well as cellular energy status. Cell Metab. 2018;27(2):299–313.

Article  CAS  PubMed  Google Scholar 

Pinkosky SL, et al. Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis. Nat Commun. 2016;7:13457.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li S, et al. Ca2+-stimulated AMPK-dependent phosphorylation of Exo1 protects stressed replication forks from aberrant resection. Mol Cell. 2019;74(6):1123–37.e6.

Article  CAS  PubMed 

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