Liu L, Oza S, Hogan D, Chu Y, Perin J, Zhu J, et al. Global, regional, and national causes of under-5 mortality in 2000–15: an updated systematic analysis with implications for the Sustainable Development Goals. Lancet. 2016;388:3027–35. https://doi.org/10.1016/S0140-6736(16)31593-8.

Article  PubMed  PubMed Central  Google Scholar 

Hoffman MK. Prediction and prevention of spontaneous preterm birth: ACOG Practice Bulletin, Number 234. Obstet Gynecol. 2021;138:945–6. https://doi.org/10.1097/AOG.0000000000004612.

Article  PubMed  PubMed Central  Google Scholar 

Mitha A, Chen R, Razaz N, Johansson S, Stephansson O, Altman M, et al. Neurological development in children born moderately or late preterm: national cohort study. BMJ. 2024. https://doi.org/10.1136/bmj-2023-075630.

Article  PubMed  PubMed Central  Google Scholar 

Tingleff T, Vikanes Å, Räisänen S, Sandvik L, Murzakanova G, Laine K. Risk of preterm birth in relation to history of preterm birth: a population-based registry study of 213 335 women in Norway. BJOG. 2022;129:900–7. https://doi.org/10.1111/1471-0528.17013.

Article  CAS  PubMed  Google Scholar 

Shennan A, Story L. Royal College of Obstetricians G .Cervical cerclage: green-top guideline. BJOG. 2022;129:1178–210. https://doi.org/10.1111/1471-0528.17003.

Article  CAS  PubMed  Google Scholar 

Linehan LA, Morris AG, Meaney S, O’Donoghue K. Subsequent pregnancy outcomes following second trimester miscarriage-a prospective cohort study. Eur J Obstet Gynecol Reprod Biol. 2019;237:198–203. https://doi.org/10.1016/j.ejogrb.2019.04.006.

Article  PubMed  Google Scholar 

Daskalakis G, Psarris A, Koutras A, Fasoulakis Z, Prokopakis I, Varthaliti A, et al. Maternal infection and preterm birth: from molecular basis to clinical implications. Children. 2023;10:907. https://doi.org/10.3390/children10050907.

Article  PubMed  PubMed Central  Google Scholar 

Mohanty T, Doke PP, Khuroo SR. Effect of bacterial vaginosis on preterm birth: a meta-analysis. Arch Gynecol Obstet. 2023;308:1247–55. https://doi.org/10.1007/s00404-022-06817-5.

Article  PubMed  Google Scholar 

Goodfellow L, Verwijs MC, Care A, Sharp A, Ivandic J, Poljak B, et al. Vaginal bacterial load in the second trimester is associated with early preterm birth recurrence: a nested case-control study. BJOG. 2021;128:2061–72. https://doi.org/10.1111/1471-0528.16816.

Article  CAS  PubMed  Google Scholar 

Chu DM, Seferovic M, Pace RM, Aagaard KM. The microbiome in preterm birth. Best Pract Res Clin Obstet Gynaecol. 2018;52:103–13. https://doi.org/10.1016/j.bpobgyn.2018.03.006.

Article  PubMed  Google Scholar 

Fettweis JM, Serrano MG, Brooks JP, Edwards DJ, Girerd PH, Parikh HI, et al. The vaginal microbiome and preterm birth. Nat Med. 2019;25:1012–21. https://doi.org/10.1038/s41591-019-0450-2.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kindinger LM, Bennett PR, Lee YS, Marchesi JR, Smith A, Cacciatore S, et al. The interaction between vaginal microbiota, cervical length, and vaginal progesterone treatment for preterm birth risk. Microbiome. 2017;5:6. https://doi.org/10.1186/s40168-016-0223-9.

Article  PubMed  PubMed Central  Google Scholar 

Kumar S, Kumari N, Talukdar D, Kothidar A, Sarkar M, Mehta O, et al. The vaginal microbial signatures of preterm birth delivery in Indian women. Front Cell Infect Microbiol. 2021;11: 622474. https://doi.org/10.3389/fcimb.2021.622474.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aslam S, Sayeed Saraf V, Saleem S, Saeed S, Javed S, Junjua M, et al. Lactobacillus species signature in association with term and preterm births from low-income group of Pakistan. J Matern Fetal Neonatal Med. 2022;35:2843–52. https://doi.org/10.1080/14767058.2020.1810660.

Article  CAS  PubMed  Google Scholar 

Payne MS, Newnham JP, Doherty DA, Furfaro LL, Pendal NL, Loh DE, et al. A specific bacterial DNA signature in the vagina of Australian women in midpregnancy predicts high risk of spontaneous preterm birth (the Predict1000 study). Am J Obstet Gynecol. 2021;224:206.e1-206.e23. https://doi.org/10.1080/14767058.2020.1810660.

Article  CAS  PubMed  Google Scholar 

Elovitz MA, Gajer P, Riis V, Brown AG, Humphrys MS, Holm JB, et al. Cervicovaginal microbiota and local immune response modulate the risk of spontaneous preterm delivery. Nat Commun. 2019;10:1305. https://doi.org/10.1038/s41467-019-09285-9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Blostein F, Gelaye B, Sanchez SE, Williams MA, Foxman B. Vaginal microbiome diversity and preterm birth: results of a nested case-control study in Peru. Ann Epidemiol. 2020;41:28–34. https://doi.org/10.1016/j.annepidem.2019.11.004.

Article  PubMed  Google Scholar 

Huang C, Gin C, Fettweis J, Foxman B, Gelaye B, MacIntyre DA, et al. Meta-analysis reveals the vaginal microbiome is a better predictor of earlier than later preterm birth. BMC Biol. 2023;21:199. https://doi.org/10.1186/s12915-023-01702-2.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Golob JL, Oskotsky TT, Tang AS, Roldan A, Chung V, Ha CW, et al. Microbiome preterm birth DREAM challenge: Crowdsourcing machine learning approaches to advance preterm birth research. Cell Rep Med. 2024;5: 101350. https://doi.org/10.1016/j.xcrm.2023.101350.

Article  CAS  PubMed  Google Scholar 

Liao J, Shenhav L, Urban JA, Serrano M, Zhu B, Buck GA, et al. Microdiversity of the vaginal microbiome is associated with preterm birth. Nat Commun. 2023;14:4997. https://doi.org/10.1038/s41467-023-40719-7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schuster HJ, Bos AM, Himschoot L, van Eekelen R, Matamoros SP, de Boer MA, et al. Vaginal microbiota and spontaneous preterm birth in pregnant women at high risk of recurrence. Heliyon. 2024;10: e30685. https://doi.org/10.1016/j.heliyon.2024.e30685.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alonzo Martínez MC, Cazorla E, Cánovas E, Martínez-Blanch JF, Chenoll E, Climent E, et al. Study of the vaginal microbiota in healthy women of reproductive age. Microorganisms. 2021;9:1069. https://doi.org/10.3390/microorganisms9051069.

Article  PubMed  PubMed Central  Google Scholar 

Muliyil S. Linking the vaginal microbiome to women’s health. Nat Med. 2023. https://doi.org/10.1038/d41591-023-00096-6.

Article  PubMed  Google Scholar 

Gudnadottir U, Debelius JW, Du J, Hugerth LW, Danielsson H, Schuppe-Koistinen I, et al. The vaginal microbiome and the risk of preterm birth: a systematic review and network meta-analysis. Sci Rep. 2022;12:7926. https://doi.org/10.1038/s41598-022-12007-9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hotkani ZG, Ghaedmohammadi S, Mozdoori N. Meta-analysis of race and age influence on the vaginal microbiome in pregnant and nonpregnant healthy women. Future Microbiol. 2022;17:1147–59. https://doi.org/10.2217/fmb-2021-0209.

Article  CAS  PubMed  Google Scholar 

Hugerth LW, Krog MC, Vomstein K, Du J, Bashir Z, Kaldhusdal V, et al. Defining Vaginal Community Dynamics: daily microbiome transitions, the role of menstruation, bacteriophages, and bacterial genes. Microbiome. 2024;12:153. https://doi.org/10.1186/s40168-024-01870-5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goldenberg RL, Gravett MG, Iams J, Papageorghiou AT, Waller SA, Kramer M, et al. The preterm birth syndrome: issues to consider in creating a classification system. Am J Obstet Gynecol. 2012;206:113–8. https://doi.org/10.1016/j.ajog.2011.10.865.

Article