Ozone alleviates MSU-induced acute gout pain via upregulating AMPK/GAS6/MerTK/SOCS3 signaling pathway

Dalbeth N, Gosling AL, Gaffo A, Abhishek A. Gout. Lancet (London, England). 2021;397:1843–55.

Article  CAS  PubMed  Google Scholar 

Dehlin M, Jacobsson L, Roddy E. Global epidemiology of gout: prevalence, incidence, treatment patterns and risk factors. Nat Rev Rheumatol. 2020;16:380–90.

Article  PubMed  Google Scholar 

Zhuang Z-G, Lu L-J, Peng B-G, Ma K, Cai Z-Y, Fu Z-J, Liu G-Z, Liu J-F, Liu W-T, Li X-H, et al. Expert consensus of Chinese Association for the Study of Pain on the application of ozone therapy in pain medicine. World J Clin Cases. 2021;9:2037–46.

Article  PubMed  PubMed Central  Google Scholar 

Lu L, Pan C, Chen L, Hu L, Wang C, Han Y, Yang Y, Cheng Z, Liu W-T. AMPK activation by peri-sciatic nerve administration of ozone attenuates CCI-induced neuropathic pain in rats. J Mol Cell Biol. 2017;9:132–43.

Article  CAS  PubMed  Google Scholar 

Yu Q, Yang X, Zhang C, Zhang X, Wang C, Chen L, Liu X, Gu Y, He X, Hu L, et al. AMPK activation by ozone therapy inhibits tissue factor-triggered intestinal ischemia and ameliorates chemotherapeutic enteritis. FASEB J. 2020;34:13005–21.

Article  CAS  PubMed  Google Scholar 

Wang Z, Zhao Y, Phipps-Green A, Liu-Bryan R, Ceponis A, Boyle DL, Wang J, Merriman TR, Wang W, Terkeltaub R. Differential DNA methylation of networked signaling, transcriptional, innate and adaptive immunity, and osteoclastogenesis genes and pathways in gout. Arthritis Rheumatol (Hoboken, NJ). 2020;72:802–14.

Article  CAS  Google Scholar 

Wang Y, Viollet B, Terkeltaub R, Liu-Bryan R. AMP-activated protein kinase suppresses urate crystal-induced inflammation and transduces colchicine effects in macrophages. Ann Rheum Dis. 2016;75:286–94.

Article  CAS  PubMed  Google Scholar 

Chen Y-H, Hsieh S-C, Chen W-Y, Li K-J, Wu C-H, Wu P-C, Tsai C-Y, Yu C-L. Spontaneous resolution of acute gouty arthritis is associated with rapid induction of the anti-inflammatory factors TGFβ1, IL-10 and soluble TNF receptors and the intracellular cytokine negative regulators CIS and SOCS3. Ann Rheum Dis. 2011;70:1655–63.

Article  CAS  PubMed  Google Scholar 

Wong PKK, Egan PJ, Croker BA, O’Donnell K, Sims NA, Drake S, Kiu H, McManus EJ, Alexander WS, Roberts AW, Wicks IP. SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis. J Clin Investig. 2006;116:1571–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Apel F, Zychlinsky A, Kenny EF. The role of neutrophil extracellular traps in rheumatic diseases. Nat Rev Rheumatol. 2018;14:467–75.

Article  CAS  PubMed  Google Scholar 

Dalbeth N, Choi HK, Joosten LAB, Khanna PP, Matsuo H, Perez-Ruiz F, Stamp LK. Gout. Nat Rev Dis Primers. 2019;5:69.

Article  PubMed  Google Scholar 

Yoshimura A, Naka T, Kubo M. SOCS proteins, cytokine signalling and immune regulation. Nat Rev Immunol. 2007;7:454–65.

Article  CAS  PubMed  Google Scholar 

Rothlin CV, Ghosh S, Zuniga EI, Oldstone MBA, Lemke G. TAM receptors are pleiotropic inhibitors of the innate immune response. Cell. 2007;131:1124–36.

Article  CAS  PubMed  Google Scholar 

Liu H-J, Pan X-X, Liu B-Q, Gui X, Hu L, Jiang C-Y, Han Y, Fan Y-X, Tang Y-L, Liu W-T. Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome suppression. J Neuroinflammation. 2017;14:74.

Article  PubMed  PubMed Central  Google Scholar 

Parvathy SS, Masocha W. Gait analysis of C57BL/6 mice with complete Freund’s adjuvant-induced arthritis using the CatWalk system. BMC Musculoskelet Disord. 2013;14:14.

Article  PubMed  PubMed Central  Google Scholar 

Feehan AK, Zadina JE. Morphine immunomodulation prolongs inflammatory and postoperative pain while the novel analgesic ZH853 accelerates recovery and protects against latent sensitization. J Neuroinflammation. 2019;16:100.

Article  PubMed  PubMed Central  Google Scholar 

Bardin T, Richette P. Definition of hyperuricemia and gouty conditions. Curr Opin Rheumatol. 2014;26:186–91.

Article  CAS  PubMed  Google Scholar 

Dalbeth N, Phipps-Green A, Frampton C, Neogi T, Taylor WJ, Merriman TR. Relationship between serum urate concentration and clinically evident incident gout: an individual participant data analysis. Ann Rheum Dis. 2018;77:1048–52.

Article  CAS  PubMed  Google Scholar 

Renaudin F, Orliaguet L, Castelli F, Fenaille F, Prignon A, Alzaid F, Combes C, Delvaux A, Adimy Y, Cohen-Solal M, et al. Gout and pseudo-gout-related crystals promote GLUT1-mediated glycolysis that governs NLRP3 and interleukin-1β activation on macrophages. Ann Rheum Dis. 2020;79:1506–14.

Article  CAS  PubMed  Google Scholar 

Yan CY, Ouyang SH, Wang X, Wu YP, Sun WY, Duan WJ, Liang L, Luo X, Kurihara H, Li YF, He RR. Celastrol ameliorates Propionibacterium acnes/LPS-induced liver damage and MSU-induced gouty arthritis via inhibiting K63 deubiquitination of NLRP3. Phytomedicine. 2021;80: 153398.

Article  CAS  PubMed  Google Scholar 

Lin Y, Luo T, Weng A, Huang X, Yao Y, Fu Z, Li Y, Liu A, Li X, Chen D, Pan H. Gallic acid alleviates gouty arthritis by inhibiting NLRP3 inflammasome activation and pyroptosis through enhancing Nrf2 signaling. Front Immunol. 2020;11: 580593.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen B, Li H, Ou G, Ren L, Yang X, Zeng M. Curcumin attenuates MSU crystal-induced inflammation by inhibiting the degradation of IκBα and blocking mitochondrial damage. Arthritis Res Ther. 2019;21:193.

Article  PubMed  PubMed Central  Google Scholar 

Chirumbolo S, Valdenassi L, Simonetti V, Bertossi D, Ricevuti G, Franzini M, Pandolfi S. Insights on the mechanisms of action of ozone in the medical therapy against COVID-19. Int Immunopharmacol. 2021;96: 107777.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yousefi B, Banihashemian SZ, Feyzabadi ZK, Hasanpour S, Kokhaei P, Abdolshahi A, Emadi A, Eslami M. Potential therapeutic effect of oxygen-ozone in controlling of COVID-19 disease. Med Gas Res. 2022;12:33–40.

Article  CAS  PubMed  Google Scholar 

Li L-Y, Ni J-X. Efficacy and safety of ozonated autohemotherapy in patients with hyperuricemia and gout: A phase I pilot study. Exp Ther Med. 2014;8:1423–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guedon J-MG, Longo G, Majuta LA, Thomspon ML, Fealk MN, Mantyh PW. Dissociation between the relief of skeletal pain behaviors and skin hypersensitivity in a model of bone cancer pain. Pain. 2016;157:1239–47.

Article  PubMed  PubMed Central  Google Scholar 

Gabriel AF, Marcus MAE, Honig WMM, Walenkamp GHIM, Joosten EAJ. The CatWalk method: a detailed analysis of behavioral changes after acute inflammatory pain in the rat. J Neurosci Methods. 2007;163:9–16.

Article  CAS  PubMed  Google Scholar 

Ma S, Zhao X, Zhang C, Sun P, Li Y, Lin X, Sun T, Fu Z. Ozone exposure induces metabolic disorders and NAD+ depletion through PARP1 activation in spinal cord neurons. Front Med. 2020;7: 617321.

Article  Google Scholar 

Valdenassi L, Franzini M, Ricevuti G, Rinaldi L, Galoforo AC, Tirelli U. Potential mechanisms by which the oxygen-ozone (O2–O3) therapy could contribute to the treatment against the coronavirus COVID-19. Eur Rev Med Pharmacol Sci. 2020;24:4059–61.

CAS  PubMed  Google Scholar 

O’Neill LAJ, Hardie DG. Metabolism of inflammation limited by AMPK and pseudo-starvation. Nature. 2013;493:346–55.

Article  CAS  PubMed  Google Scholar 

McWherter C, Choi Y-J, Serrano RL, Mahata SK, Terkeltaub R, Liu-Bryan R. Arhalofenate acid inhibits monosodium urate crystal-induced inflammatory responses through activation of AMP-activated protein kinase (AMPK) signaling. Arthritis Res Ther. 2018;20:204.

Article  PubMed  PubMed Central  Google Scholar 

Yue H, Yang Z, Ou Y, Liang S, Deng W, Chen H, Zhang C, Hua L, Hu W, Sun P. Tanshinones inhibit NLRP3 inflammasome activation by alleviating mitochondrial damage to protect against septic and gouty inflammation. Int Immunopharmacol. 2021;97: 107819.

Article  CAS  PubMed  Google Scholar 

Ariel A, Serhan CN. New lives given by cell death: macrophage differentiation following their encounter with apoptotic leukocytes during the resolution of inflammation. Front Immunol. 2012;3:4.

Article  PubMed  PubMed Central  Google Scholar 

Wanke F, Gutbier S, Rümmelin A, Steinberg M, Hughes LD, Koenen M, Komuczki J, Regan-Komito D, Wagage S, Hesselmann J, et al. Ligand-dependent kinase activity of MERTK drives efferocytosis in human iPSC-derived macrophages. Cell Death Dis. 2021;12:538.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Waterborg CEJ, Beermann S, Broeren MGA, Bennink MB, Koenders MI, van Lent PLEM, van den Berg WB, van der Kraan PM, van de Loo FAJ. Protective role of the MER tyrosine kinase efferocytosis in rheumatoid arthritis models. Front Immunol. 2018;9:742.

Article 

留言 (0)

沒有登入
gif