M-type pyruvate kinase 2 (PKM2) tetramerization alleviates the progression of right ventricle failure by regulating oxidative stress and mitochondrial dynamics

Simonneau G, Montani D, Celermajer DS, Denton CP, Gatzoulis MA, Krowka M, Williams PG, Souza R. Haemodynamic definitions and updated clinical classification of pulmonary hypertension. Eur Respir J. 2019;53(1):1801913. https://doi.org/10.1183/13993003.01913-2018.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Naeije R, Richter MJ, Rubin LJ. The physiological basis of pulmonary arterial hypertension. Eur Respir J. 2022;59(6):2102334. https://doi.org/10.1183/13993003.02334-2021.

Article  PubMed  PubMed Central  Google Scholar 

Abid S, Marcos E, Parpaleix A, Amsellem V, Breau M, Houssaini A, Vienney N, Lefevre M, Derumeaux G, Evans S, Hubeau C, Delcroix M, Quarck R, Adnot S, Lipskaia L. CCR2/CCR5-mediated macrophage-smooth muscle cell crosstalk in pulmonary hypertension. Eur Respir J. 2019;54(4):1802308. https://doi.org/10.1183/13993003.02308-2018.

Article  CAS  PubMed  Google Scholar 

Calvier L, Chouvarine P, Legchenko E, Hoffmann N, Geldner J, Borchert P, Jonigk D, Mozes MM, Hansmann G. PPARgamma Links BMP2 and TGFbeta1 Pathways in Vascular Smooth Muscle Cells, Regulating Cell Proliferation and Glucose Metabolism. Cell Metab. 2017;25(5):1118-34 e7. https://doi.org/10.1016/j.cmet.2017.03.011.

Article  CAS  PubMed  Google Scholar 

Tan R, You Q, Yu D, Xiao C, Adu-Amankwaah J, Cui J, Zhang T. Novel hub genes associated with pulmonary artery remodeling in pulmonary hypertension. Front Cardiovasc Med. 2022;9: 945854. https://doi.org/10.3389/fcvm.2022.945854.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lajoie AC, Lauziere G, Lega JC, Lacasse Y, Martin S, Simard S, Bonnet S, Provencher S. Combination therapy versus monotherapy for pulmonary arterial hypertension: a meta-analysis. Lancet Respir Med. 2016;4(4):291–305. https://doi.org/10.1016/S2213-2600(16)00027-8.

Article  CAS  PubMed  Google Scholar 

van de Veerdonk MC, Kind T, Marcus JT, Mauritz GJ, Heymans MW, Bogaard HJ, Boonstra A, Marques KM, Westerhof N, Vonk-Noordegraaf A. Progressive right ventricular dysfunction in patients with pulmonary arterial hypertension responding to therapy. J Am Coll Cardiol. 2011;58(24):2511–9. https://doi.org/10.1016/j.jacc.2011.06.068.

Article  PubMed  Google Scholar 

Anastasiou D, Poulogiannis G, Asara JM, Boxer MB, Jiang JK, Shen M, Bellinger G, Sasaki AT, Locasale JW, Auld DS, Thomas CJ, van der Heiden MG, Cantley LC. Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. Science. 2011;334(6060):1278–83. https://doi.org/10.1126/science.1211485.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rees ML, Subramaniam J, Li Y, Hamilton DJ, Frazier OH, Taegtmeyer H. A PKM2 signature in the failing heart. Biochem Biophys Res Commun. 2015;459(3):430–6. https://doi.org/10.1016/j.bbrc.2015.02.122.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Masaki S, Hashimoto K, Kihara D, Tsuzuki C, Kataoka N, Suzuki K. The cysteine residue at 424th of pyruvate kinase M2 is crucial for tetramerization and responsiveness to oxidative stress. Biochem Biophys Res Commun. 2020;526(4):973–7. https://doi.org/10.1016/j.bbrc.2020.03.182.

Article  CAS  PubMed  Google Scholar 

Rajala RVS. Aerobic glycolysis in the retina: functional roles of pyruvate kinase isoforms. Front Cell Dev Biol. 2020;8:266. https://doi.org/10.3389/fcell.2020.00266.

Article  PubMed  Google Scholar 

Lee YB, Min JK, Kim JG, Cap KC, Islam R, Hossain AJ, Dogsom O, Hamza A, Mahmud S, Choi DR, Kim YS, Koh YH, Kim HA, Chung WS, Suh SW, Park JB. Multiple functions of pyruvate kinase M2 in various cell types. J Cell Physiol. 2022;237(1):128–48. https://doi.org/10.1002/jcp.30536.

Article  CAS  PubMed  Google Scholar 

Irokawa H, Numasaki S, Kato S, Iwai K, Inose-Maruyama A, Ohdate T, Hwang GW, Toyama T, Watanabe T, Kuge S. Comprehensive analyses of the cysteine thiol oxidation of PKM2 reveal the effects of multiple oxidation on cellular oxidative stress response. Biochem J. 2021;478(7):1453–70. https://doi.org/10.1042/BCJ20200897.

Article  CAS  PubMed  Google Scholar 

Bertero E, Maack C. Metabolic remodelling in heart failure. Nat Rev Cardiol. 2018;15(8):457–70. https://doi.org/10.1038/s41569-018-0044-6.

Article  CAS  PubMed  Google Scholar 

Tsutsui H, Kinugawa S, Matsushima S. Oxidative stress and heart failure. Am J Physiol Heart Circ Physiol. 2011;301(6):H2181–90. https://doi.org/10.1152/ajpheart.00554.2011.

Article  CAS  PubMed  Google Scholar 

Magadum A, Singh N, Kurian AA, Munir I, Mehmood T, Brown K, Sharkar MTK, Chepurko E, Sassi Y, Oh JG, Lee P, Santos CXC, Gaziel-Sovran A, Zhang G, Cai CL, Kho C, Mayr M, Shah AM, Hajjar RJ, Zangi L. Pkm2 regulates cardiomyocyte cell cycle and promotes cardiac regeneration. Circulation. 2020;141(15):1249–65. https://doi.org/10.1161/CIRCULATIONAHA.119.043067.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hauck L, Dadson K, Chauhan S, Grothe D, Billia F. Inhibiting the Pkm2/b-catenin axis drives in vivo replication of adult cardiomyocytes following experimental MI. Cell Death Differ. 2021;28(4):1398–417. https://doi.org/10.1038/s41418-020-00669-9.

Article  CAS  PubMed  Google Scholar 

Ni L, Lin B, Hu L, Zhang R, Fu F, Shen M, Yang J, Shi D. Pyruvate kinase M2 protects heart from pressure overload-induced heart failure by phosphorylating RAC1. J Am Heart Assoc. 2022;11(11): e024854. https://doi.org/10.1161/JAHA.121.024854.

Article  PubMed  PubMed Central  Google Scholar 

Shimauchi T, Boucherat O, Yokokawa T, Grobs Y, Wu W, Orcholski M, Martineau S, Omura J, Tremblay E, Shimauchi K, Nadeau V, Breuils-Bonnet S, Paulin R, Potus F, Provencher S, Bonnet S. PARP1-PKM2 axis mediates right ventricular failure associated with pulmonary arterial hypertension. JACC Basic Transl Sci. 2022;7(4):384–403. https://doi.org/10.1016/j.jacbts.2022.01.005.

Article  PubMed  PubMed Central  Google Scholar 

Guo L, Qin G, Cao Y, Yang Y, Dai S, Wang L, Wang E. Regulation of the immune microenvironment by an NLRP3 inhibitor contributes to attenuation of acute right ventricular failure in rats with pulmonary arterial hypertension. J Inflamm Res. 2021;14:5699–711. https://doi.org/10.2147/JIR.S336964.

Article  CAS  PubMed  Google Scholar 

Tian S, Zhan D, Yu Y, Wang Y, Liu M, Tan S, Li Y, Song L, Qin Z, Li X, Liu Y, Li Y, Ji S, Wang S, Proteomic Massive Analysis and Quality Control Consortium, Zheng Y, He F, Qin J, Ding C. Quartet protein reference materials and datasets for multi-platform assessment of label-free proteomics. Genome Biol. 2023;24(1):202. https://doi.org/10.1186/s13059-023-03048-y.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Roy Stat Soc Ser B Methodol. 2018;57(1):289–300. https://doi.org/10.1111/j.2517-6161.1995.tb02031.x.

Article  Google Scholar 

Qi W, Keenan HA, Li Q, Ishikado A, Kannt A, Sadowski T, Yorek MA, Wu IH, Lockhart S, Coppey LJ, Pfenninger A, Liew CW, Qiang G, Burkart AM, Hastings S, Pober D, Cahill C, Niewczas MA, Israelsen WJ, Tinsley L, Stillman IE, Amenta PS, Feener EP, van der Heiden MG, Stanton RC, King GL. Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction. Nat Med. 2017;23(6):753–62. https://doi.org/10.1038/nm.4328.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao S, Li X, Jiang Q, Liang Q, Zhang F, Li S, Zhang R, Luan J, Zhu J, Gu X, Xiao T, Huang H, Chen S, Ning W, Yang G, Yang C, Zhou H. PKM2 promotes pulmonary fibrosis by stabilizing TGF-beta1 receptor I and enhancing TGF-beta1 signaling. Sci Adv. 2022;8(38):eabo0987. https://doi.org/10.1126/sciadv.abo0987.

Article  CAS  PubMed Central  Google Scholar 

Hsu CC, Zhang X, Wang G, Zhang W, Cai Z, Pan BS, Gu H, Xu C, Jin G, Xu X, Manne RK, Jin Y, Yan W, Shao J, Chen T, Lin E, Ketkar A, Eoff R, Xu ZG, Chen ZZ, Li HY, Lin HK. Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK. Mol Cell. 2021;81(18):3803-19 e7. https://doi.org/10.1016/j.molcel.2021.08.025.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dagda RK, Cherra SJ, Kulich SM, Tandon A, Park D, Chu CT. Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. J Biol Chem. 2009;284(20):13843–55. https://doi.org/10.1074/jbc.M808515200.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Legland D, Arganda-Carreras I, Andrey P. MorphoLibJ: integrated library and plugins for mathematical morphology with ImageJ. Bioinformatics. 2016;32(22):3532–4. https://doi.org/10.1093/bioinformatics/btw413.

Article  CAS  PubMed  Google Scholar 

Gao H, Cheng Y, Zong L, Huang L, Qiao C, Li W, Gong B, Hu J, Liu H, Wang X, Zhao C. Aspirin attenuates monocrotaline-induced pulmonary arterial hypertension in rats by suppressing the ERK/MAPK pathway. Clin Exp Hypertens. 2017;39(1):34–41. https://doi.org/10.1080/10641963.2016.1210620.

Article  CAS  PubMed  Google Scholar 

Li Q, Wang J, Zhu X, Zeng Z, Wu X, Xu Y, Xie J, Yu J. Dihydromyricetin prevents monocrotaline-induced pulmonary arterial hypertension in rats. Biomed Pharmacother. 2017;96:825–33. https://doi.org/10.1016/j.biopha.2017.10.007.

Article  CAS  PubMed  Google Scholar 

Carls

留言 (0)

沒有登入
gif