Docetaxel treatment together with CTLA-4 knockdown enhances reduction of cell viability and amplifies apoptosis stimulation of MCF-7 breast cancer cells

Akhtartavan S, Karimi M, Karimian K, Azarpira N, Khatami M, Heli H (2019) Evaluation of a self-nanoemulsifying docetaxel delivery system. Biomed Pharmacother 109:2427–2433

Article  CAS  PubMed  Google Scholar 

Alipour S, Aghebati-Maleki A, Sadeghi MR, Soltani-Zangbar MS, Khakpour A, Aghebati-Maleki L (2024) Altered miR-10a gene expression in peripheral blood mononuclear cells correlates with frequency of T regulatory cells and cytokine profile in multiple sclerosis patients. Neurosci Lett 844:138036

Article  PubMed  Google Scholar 

Alipour S, Amanallahi P, Baradaran B, Aghebati-Maleki A, Soltani-Zangbar MS, Aghebati-Maleki L (2024b) Altered gene expression of miR-155 in peripheral blood mononuclear cells of multiple sclerosis patients: correlation with TH17 frequency, inflammatory cytokine profile and autoimmunity. Mult Scler Relat Disord 89:105764

Article  CAS  PubMed  Google Scholar 

Alipour S, Kazemi T, Sadeghi MR, Heris JA, Masoumi J, Naseri B, Baghbani E, Sohrabi S, Baradaran B (2024c) Glyburide-treated human monocyte-derived dendritic cells loaded with insulin represent tolerogenic features with anti-inflammatory responses and modulate autologous T cell responses in vitro. Int Immunopharmacol 126:111230

Article  CAS  PubMed  Google Scholar 

Alipour S, Mardi A, Shajari N, Kazemi T, Sadeghi MR, Heris JA, Masoumi J, Baradaran B (2024) Unmasking the NLRP3 inflammasome in dendritic cells as a potential therapeutic target for autoimmunity, cancer, and infectious conditions. Life Sci 348:122686

Article  CAS  PubMed  Google Scholar 

Baghbani E, Noorolyai S, Shanehbandi D, Mokhtarzadeh A, Aghebati-Maleki L, Shahgoli VK, Brunetti O, Rahmani S, Shadbad MA, Baghbanzadeh A (2021) Regulation of immune responses through CD39 and CD73 in cancer: novel checkpoints. Life Sci 282:119826

Article  CAS  PubMed  Google Scholar 

Cetin B, Gumusay O, Cengiz M, Ozet A (2016) Advances of molecular targeted therapy in gastric cancer. J Gastrointest Cancer 47:125–134

Article  CAS  PubMed  Google Scholar 

Chen X, Shao Q, Hao S, Zhao Z, Wang Y, Guo X, He Y, Gao W, Mao H (2017) CTLA-4 positive breast cancer cells suppress dendritic cells maturation and function. Oncotarget 8:13703

Article  PubMed  PubMed Central  Google Scholar 

Contardi E, Palmisano GL, Tazzari PL, Martelli AM, Fala F, Fabbi M, Kato T, Lucarelli E, Donati D, Polito L (2005) CTLA-4 is constitutively expressed on tumor cells and can trigger apoptosis upon ligand interaction. Int J Cancer 117:538–550

Article  CAS  PubMed  Google Scholar 

Diaz JF, Andreu JM (1993) Assembly of purified GDP-tubulin into microtubules induced by taxol and taxotere: reversibility, ligand stoichiometry, and competition. Biochemistry 32:2747–2755

Article  CAS  PubMed  Google Scholar 

Dunbar CE, High KA, Joung JK, Kohn DB, Ozawa K, Sadelain M (2018) Gene therapy comes of age. Science 359:4672

Article  Google Scholar 

Fahad Ullah M (2019) Breast cancer: current perspectives on the disease status. Breast Cancer Metastasis and Drug Resistance: Challenges and Progress. https://doi.org/10.1007/978-3-030-20301-6_4

Article  Google Scholar 

Ghahramanipour Z, Alipour S, Masoumi J, Rostamlou A, Hatami-Sadr A, Heris JA, Naseri B, Jafarlou M, Baradaran B (2023) Regulation of dendritic cell functions by vitamins as promising therapeutic strategy for immune system disorders. Adv Biol 7:2300142

Article  CAS  Google Scholar 

Ghorbaninezhad F, Masoumi J, Bakhshivand M, Baghbanzadeh A, Mokhtarzadeh A, Kazemi T, Aghebati-Maleki L, Shotorbani SS, Jafarlou M, Brunetti O (2022) CTLA-4 silencing in dendritic cells loaded with colorectal cancer cell lysate improves autologous T cell responses in vitro. Front Immunol 13:931316–931316

Article  CAS  PubMed  PubMed Central  Google Scholar 

Giri PM, Banerjee A, Layek B (2023) A recent review on cancer nanomedicine. Cancers 15:2256

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goldhirsch A, Francis P, Castiglione-Gertsch M, Gelber RD, Coates AS (2000) Taxanes as adjuvant for breast cancer. The Lancet 356:507–508

Article  CAS  Google Scholar 

Greenwald RJ, Oosterwegel MA, van der Woude D, Kubal A, Mandelbrot DA, Boussiotis VA, Sharpe AH (2002) CTLA-4 regulates cell cycle progression during a primary immune response. Eur J Immunol 32:366–373

Article  CAS  PubMed  Google Scholar 

Hosseinkhani N, Derakhshani A, Kooshkaki O, Abdoli Shadbad M, Hajiasgharzadeh K, Baghbanzadeh A, Safarpour H, Mokhtarzadeh A, Brunetti O, Yue SC (2020) Immune checkpoints and CAR-T cells: the pioneers in future cancer therapies? Int J Mol Sci 21:8305

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hosseinkhani N, Hemmat N, Baghbani E, Baghbanzadeh A, Kazemi T, Mokhtarzadeh A, Jafarlou M, Doustvandi MA, Baradaran B (2024) Dual silencing of tumor-intrinsic VISTA and CTLA-4 stimulates T-cell mediated immune responses and inhibits MCF7 breast cancer development. Gene 896:148043

Article  CAS  PubMed  Google Scholar 

Jassim GA, Doherty S, Whitford DL, Khashan AS (2023) Psychological interventions for women with non-metastatic breast cancer. Cochrane Database of Syst Rev. https://doi.org/10.1002/14651858.CD008729.pub3

Article  Google Scholar 

Kern R, Panis C (2021) CTLA-4 expression and its clinical significance in breast cancer. Arch Immunol Ther Exp 69:1–9

Article  Google Scholar 

Lens M, Ferrucci PF, Testori A (2008) Anti-CTLA4 monoclonal antibody Ipilimumab in the treatment of metastatic melanoma: recent findings. Recent Pat Anti-Cancer Drug Discov 3:105–113

Article  CAS  Google Scholar 

Li S-Y, Liu Y, Xu C-F, Shen S, Sun R, Du X-J, Xia J-X, Zhu Y-H, Wang J (2016) Restoring anti-tumor functions of T cells via nanoparticle-mediated immune checkpoint modulation. J Control Release 231:17–28

Article  CAS  PubMed  Google Scholar 

Liang L, Ge K, Zhang F, Ge Y (2018) The suppressive effect of co-inhibiting PD-1 and CTLA-4 expression on H22 hepatomas in mice. Cell Mol Biol Lett 23:1–11

Article  Google Scholar 

Lotfinejad P, Asghari Jafarabadi M, Abdoli Shadbad M, Kazemi T, Pashazadeh F, Sandoghchian Shotorbani S, Jadidi Niaragh F, Baghbanzadeh A, Vahed N, Silvestris N (2020) Prognostic role and clinical significance of tumor-infiltrating lymphocyte (TIL) and programmed death ligand 1 (PD-L1) expression in triple-negative breast cancer (TNBC): a systematic review and meta-analysis study. Diagnostics 10:704

Article  PubMed  PubMed Central  Google Scholar 

Mao H, Zhang L, Yang Y, Zuo W, Bi Y, Gao W, Deng B, Sun J, Shao Q, Qu X (2010) New insights of CTLA-4 into its biological function in breast cancer. Curr Cancer Drug Targets 10:728–736

Article  CAS  PubMed  Google Scholar 

Moudry P, Chroma K, Bursac S, Volarevic S, Bartek J (2022) RNA-interference screen for p53 regulators unveils a role of WDR75 in ribosome biogenesis. Cell Death Differ 29:687–696

Article  CAS  PubMed  Google Scholar 

Organization, W. H. (2022). "Current and future burden of breast cancer: global statistics for 2020 and 2040." from https://www.iarc.who.int/news-events/current-and-future-burden-of-breast-cancer-global-statistics-for-2020-and-2040/#:~:text=Breast%20cancer%20is%20the%20most,between%20countries%20and%20world%20regions.

Postow MA, Callahan MK, Wolchok JD (2015) Immune checkpoint blockade in cancer therapy. J Clin Oncol 33:1974

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ralph C, Elkord E, Burt DJ, O’Dwyer JF, Austin EB, Stern PL, Hawkins RE, Thistlethwaite FC (2010) Modulation of lymphocyte regulation for cancer therapy: a phase II trial of Tremelimumab in advanced gastric and esophageal adenocarcinomaanti-CTLA4 in gastric and esophageal adenocarcinoma. Clin Cancer Res 16:1662–1672

Article  CAS  PubMed  Google Scholar 

Romero D (2016) PD-1 says goodbye, TIM-3 says hello. Nat Rev Clin Oncol 13:203–203

Article  Google Scholar 

Shadbad MA, Hajiasgharzadeh K, Derakhshani A, Silvestris N, Baghbanzadeh A, Racanelli V, Baradaran B (2021) From melanoma development to RNA-modified dendritic cell vaccines: highlighting the lessons from the past. Front Immunol 12:623639

Article  CAS  PubMed  PubM

Comments (0)

No login
gif