Carrillo-Galvez AB et al (2020) GARP promotes the proliferation and therapeutic resistance of bone sarcoma cancer cells through the activation of TGF-beta. Cell Death Dis 11(11):985. https://doi.org/10.1038/s41419-020-03197-z

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chen S et al (2021) Wild-type IDH1 inhibits the tumor growth through degrading HIF-alpha in renal cell carcinoma. Int J Biol Sci 17(5):1250–1262. https://doi.org/10.7150/ijbs.54401

Article  PubMed  PubMed Central  CAS  Google Scholar 

Delgoffe GM (2016) Filling the tank: keeping antitumor T cells metabolically fit for the long haul. Cancer Immunol Res 4(12):1001–1006. https://doi.org/10.1158/2326-6066.CIR-16-0244

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ding X, Lu D, Fan J (2021) A natural product phillygenin suppresses osteosarcoma growth and metastasis by regulating the SHP-1/JAK2/STAT3 signaling. Biosci Biotechnol Biochem 85(2):307–314. https://doi.org/10.1093/bbb/zbaa007

Article  PubMed  Google Scholar 

Ding XC et al (2021) The relationship between expression of PD-L1 and HIF-1alpha in glioma cells under hypoxia. J Hematol Oncol 14(1):92. https://doi.org/10.1186/s13045-021-01102-5

Article  PubMed  PubMed Central  CAS  Google Scholar 

Dong Z et al (2017) Forsythiae fructus: a review on its phytochemistry, quality control. Pharm Pharmacokinet Mol. https://doi.org/10.3390/molecules22091466

Article  Google Scholar 

Du B et al (2019) Phillygenin exhibits anti-inflammatory activity through modulating multiple cellular behaviors of mouse lymphocytes. Immunopharmacol Immunotoxicol 41(1):76–85. https://doi.org/10.1080/08923973.2018.1547742

Article  PubMed  CAS  Google Scholar 

Fu XT et al (2019) Tumor-associated macrophages modulate resistance to oxaliplatin via inducing autophagy in hepatocellular carcinoma. Cancer Cell Int 19:71. https://doi.org/10.1186/s12935-019-0771-8

Article  PubMed  PubMed Central  Google Scholar 

Ge Y et al (2020) Decursin promotes HIF-1alpha proteasomal degradation and immune responses in hypoxic tumour microenvironment. Phytomedicine 78:153318. https://doi.org/10.1016/j.phymed.2020.153318

Article  PubMed  CAS  Google Scholar 

Gong J, Zhou S, Yang S (2019) Vanillic acid suppresses HIF-1alpha expression via inhibition of mTOR/p70S6K/4E-BP1 and Raf/MEK/ERK pathways in human colon cancer HCT116 cells. Int J Mol Sci. https://doi.org/10.3390/ijms20030465

Article  PubMed  PubMed Central  Google Scholar 

Hsieh CH et al (2020) TESC promotes TGF-alpha/EGFR-FOXM1-mediated tumor progression in cholangiocarcinoma. Cancers (Basel). https://doi.org/10.3390/cancers12051105

Article  PubMed  PubMed Central  Google Scholar 

Hu N et al (2020) Phillygenin inhibits LPS-induced activation and inflammation of LX2 cells by TLR4/MyD88/NF-kappaB signaling pathway. J Ethnopharmacol 248:112361. https://doi.org/10.1016/j.jep.2019.112361

Article  PubMed  CAS  Google Scholar 

Huang YN et al (2021) Dextran sulfate effects EMT of human gastric cancer cells by reducing HIF-1alpha/ TGF-beta. J Cancer 12(11):3367–3377. https://doi.org/10.7150/jca.55550

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lai KC et al (2019) Casticin promotes immune responses, enhances macrophage and NK cell activities, and increases survival rates of leukemia BALB/c mice. Am J Chin Med 47(1):223–236. https://doi.org/10.1142/S0192415X19500113

Article  PubMed  CAS  Google Scholar 

Lan H et al (2021) Tumor-associated macrophages promote oxaliplatin resistance via METTL3-mediated m(6)A of TRAF5 and necroptosis in colorectal cancer. Mol Pharm 18(3):1026–1037. https://doi.org/10.1021/acs.molpharmaceut.0c00961

Article  PubMed  CAS  Google Scholar 

Lee JH et al (2022) Histone deacetylase 6 plays an important role in TGF-beta-induced murine Treg cell differentiation by regulating cell proliferation. Sci Rep 12(1):22550. https://doi.org/10.1038/s41598-022-27230-7

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lei R et al (2019) HIF-1alpha promotes the keloid development through the activation of TGF-beta/Smad and TLR4/MyD88/NF-kappaB pathways. Cell Cycle 18(23):3239–3250. https://doi.org/10.1080/15384101.2019.1670508

Article  PubMed  PubMed Central  CAS  Google Scholar 

Li H et al (2020) Phillygenin, a MELK inhibitor, inhibits cell survival and epithelial-mesenchymal transition in pancreatic cancer cells. Onco Targets Ther 13:2833–2842. https://doi.org/10.2147/OTT.S238958

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lin Y, Yang P (2021) Phillygenin inhibits the inflammation and apoptosis of pulmonary epithelial cells by activating PPARgamma signaling via downregulation of MMP8. Mol Med Rep. https://doi.org/10.3892/mmr.2021.12415

Article  PubMed  PubMed Central  Google Scholar 

Liu Y et al (2022) Platycodin D sensitizes KRAS-mutant colorectal cancer cells to cetuximab by inhibiting the PI3K/Akt signaling pathway. Front Oncol 12:1046143. https://doi.org/10.3389/fonc.2022.1046143

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ma C et al (2023) Phillygenin inhibited M1 macrophage polarization and reduced hepatic stellate cell activation by inhibiting macrophage exosomal miR-125b-5p. Biomed Pharmacother 159:114264. https://doi.org/10.1016/j.biopha.2023.114264

Article  PubMed  CAS  Google Scholar 

Musumeci G et al (2015) Enhanced expression of CD31/platelet endothelial cell adhesion molecule 1 (PECAM1) correlates with hypoxia inducible factor-1 alpha (HIF-1alpha) in human glioblastoma multiforme. Exp Cell Res 339(2):407–416. https://doi.org/10.1016/j.yexcr.2015.09.007

Article  PubMed  CAS  Google Scholar 

Ning T et al (2021) Exosomal miR-208b related with oxaliplatin resistance promotes Treg expansion in colorectal cancer. Mol Ther 29(9):2723–2736. https://doi.org/10.1016/j.ymthe.2021.04.028

Article  PubMed  PubMed Central  CAS  Google Scholar 

Rong W et al (2022) Chrysin inhibits hepatocellular carcinoma progression through suppressing programmed death ligand 1 expression. Phytomedicine 95:153867. https://doi.org/10.1016/j.phymed.2021.153867

Article  PubMed  CAS  Google Scholar 

Shephard MT, Merkhan MM, Forsyth NR (2022) Human mesenchymal stem cell secretome driven T cell immunomodulation is IL-10 dependent. Int J Mol Sci. https://doi.org/10.3390/ijms232113596

Article  PubMed  PubMed Central  Google Scholar 

Song J et al (2022) MiR-192-5p/RB1/NF-kappaBp65 signaling axis promotes IL-10 secretion during gastric cancer EMT to induce Treg cell differentiation in the tumour microenvironment. Clin Transl Med 12(8):e992. https://doi.org/10.1002/ctm2.992

Article  PubMed  PubMed Central  CAS  Google Scholar 

Su Q et al (2019) Sanguinarine inhibits epithelial-mesenchymal transition via targeting HIF-1alpha/TGF-beta feed-forward loop in hepatocellular carcinoma. Cell Death Dis 10(12):939. https://doi.org/10.1038/s41419-019-2173-1

Article  PubMed  PubMed Central  CAS  Google Scholar 

Tan J et al (2022) The role of NFATc1/c-myc/PKM2/IL-10 axis in activating cervical cancer tumor-associated M2 macrophage polarization to promote cervical cancer progression. Exp Cell Res 413(2):113052.