C.R. Bartram, A. de Klein, A. Hagemeijer, T. van Agthoven, A.G. van Kessel, D. Bootsma, G. Grosveld, M.A. Ferguson-Smith, T. Davies, M. Stone, Translocation of c-ab1 oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia. Nature 306(5940), 277–280 (1983)
Article CAS PubMed Google Scholar
B.J. Druker, F. Guilhot, S.G. O’Brien, I. Gathmann, H. Kantarjian, N. Gattermann, M.W.N. Deininger, R.T. Silver, J.M. Goldman, R.M. Stone, F. Cervantes, A. Hochhaus, B.L. Powell, J.L. Gabrilove, P. Rousselot, J. Reiffers, J.J. Cornelissen, T. Hughes, H. Agis, T. Fischer, G. Verhoef, J. Shepherd, G. Saglio, A. Gratwohl, J.L. Nielsen, J.P. Radich, B. Simonsson, K. Taylor, M. Baccarani, C. So, L. Letvak, R.A. Larson, IRIS Investigators, Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N. Engl. J. Med. 355(23), 2408–2417 (2006)
H. de Lavallade, J.F. Apperley, J.S. Khorashad, D. Milojkovic, A.G. Reid, M. Bua, R. Szydlo, E. Olavarria, J. Kaeda, J.M. Goldman, D. Marin, Imatinib for newly diagnosed patients with chronic myeloid leukemia: incidence of sustained responses in an intention-to-treat analysis. J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol. 26(20), 3358–3363 (2008)
M. Baccarani, M.W. Deininger, G. Rosti, A. Hochhaus, S. Soverini, J.F. Apperley, F. Cervantes, R.E. Clark, J.E. Cortes, F. Guilhot, H. Hjorth-Hansen, T.P. Hughes, H.M. Kantarjian, D.-W. Kim, R.A. Larson, J.H. Lipton, F.-X. Mahon, G. Martinelli, J. Mayer, M.C. Müller, D. Niederwieser, F. Pane, J.P. Radich, P. Rousselot, G. Saglio, S. Saußele, C. Schiffer, R. Silver, B. Simonsson, J.-L. Steegmann, J.M. Goldman, R. Hehlmann, European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013. Blood 122(6), 872–884 (2013)
Article CAS PubMed PubMed Central Google Scholar
S. Soverini, S. Branford, F.E. Nicolini, M. Talpaz, M.W.N. Deininger, G. Martinelli, M.C. Müller, J.P. Radich, N.P. Shah, Implications of BCR-ABL1 kinase domain-mediated resistance in chronic myeloid leukemia. Leuk Res. 38(1), 10–20 (2014)
Article CAS PubMed Google Scholar
T. Schindler, W. Bornmann, P. Pellicena, W.T. Miller, B. Clarkson, J. Kuriyan, Structural mechanism for STI-571 inhibition of abelson tyrosine kinase. Science 289(5486), 1938–1942 (2000)
Article CAS PubMed Google Scholar
B. Nagar, W.G. Bornmann, P. Pellicena, T. Schindler, D.R. Veach, W.T. Miller, B. Clarkson, J. Kuriyan, Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571). Cancer Res. 62(15), 4236–4243 (2002)
A.S. Corbin, A. Agarwal, M. Loriaux, J. Cortes, M.W. Deininger, B.J. Druker, Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity. J. Clin. Invest. 121(1), 396–409 (2011)
Article CAS PubMed Google Scholar
S.M. Graham, H.G. Jørgensen, E. Allan, C. Pearson, M.J. Alcorn, L. Richmond, T.L. Holyoake, Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood 99(1), 319–325 (2002)
Article CAS PubMed Google Scholar
X. Jiang, Y. Zhao, C. Smith, M. Gasparetto, A. Turhan, A. Eaves, C. Eaves, Chronic myeloid leukemia stem cells possess multiple unique features of resistance to BCR-ABL targeted therapies. Leukemia 21(5), 926–935 (2007)
Article CAS PubMed Google Scholar
H. Herrmann, I. Sadovnik, S. Cerny-Reiterer, T. Rülicke, G. Stefanzl, M. Willmann, G. Hoermann, M. Bilban, K. Blatt, S. Herndlhofer, M. Mayerhofer, B. Streubel, W.R. Sperr, T.L. Holyoake, C. Mannhalter, P. Valent, Dipeptidylpeptidase IV (CD26) defines leukemic stem cells (LSC) in chronic myeloid leukemia. Blood 123(25), 3951–3962 (2014)
Article CAS PubMed Google Scholar
F. Pellicano, M.T. Scott, G.V. Helgason, L.E.M. Hopcroft, E.K. Allan, M. Aspinall-O’Dea, M. Copland, A. Pierce, B.J.P. Huntly, A.D. Whetton, T.L. Holyoake, The antiproliferative activity of kinase inhibitors in chronic myeloid leukemia cells is mediated by FOXO transcription factors. Stem. Cells Dayt. Ohio 32(9), 2324–2337 (2014)
C. Hurtz, K. Hatzi, L. Cerchietti, M. Braig, E. Park, Y. Kim, S. Herzog, P. Ramezani-Rad, H. Jumaa, M.C. Müller, W.-K. Hofmann, A. Hochhaus, B.H. Ye, A. Agarwal, B.J. Druker, N.P. Shah, A.M. Melnick, M. Müschen, BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia. J. Exp. Med. 208(11), 2163–2174 (2011)
Article CAS PubMed PubMed Central Google Scholar
L. Jin, Y. Tabe, S. Konoplev, Y. Xu, C.E. Leysath, H. Lu, S. Kimura, A. Ohsaka, M.-B. Rios, L. Calvert, H. Kantarjian, M. Andreeff, M. Konopleva, CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells. Mol. Cancer Ther. 7(1), 48–58 (2008)
Article CAS PubMed Google Scholar
H. Xie, C. Peng, J. Huang, B.E. Li, W. Kim, E.C. Smith, Y. Fujiwara, J. Qi, G. Cheloni, P.P. Das, M. Nguyen, S. Li, J.E. Bradner, S.H. Orkin, Chronic myelogenous leukemia- initiating cells require polycomb group protein EZH2. Cancer Discov. 6(11), 1237–1247 (2016)
Article CAS PubMed PubMed Central Google Scholar
M.A. Gonzalez, I.M. Olivas, A.E. Bencomo-Alvarez, A.J. Rubio, C. Barreto-Vargas, J.L. Lopez, S.K. Dang, J.P. Solecki, E. McCall, G. Astudillo, V.V. Velazquez, K. Schenkel, K. Reffell, M. Perkins, N. Nguyen, J.N. Apaflo, E. Alvidrez, J.E. Young, J.J. Lara, D. Yan, A. Senina, J. Ahmann, K.E. Varley, C.C. Mason, C.A. Eide, B.J. Druker, M. Nurunnabi, O. Padilla, S. Bajpeyi, A.M. Eiring, Loss of G0/G1 switch gene 2 (G0S2) promotes disease progression and drug resistance in chronic myeloid leukaemia (CML) by disrupting glycerophospholipid metabolism. Clin. Transl. Med. 12(12), e1146 (2022)
Article CAS PubMed PubMed Central Google Scholar
Y. Wang, Y. Liu, S.N. Malek, P. Zheng, Y. Liu, Targeting HIF1α eliminates cancer stem cells in hematological malignancies. Cell. Stem. Cell. 8(4), 399–411 (2011)
Article CAS PubMed PubMed Central Google Scholar
Y.-H. Wang, W.J. Israelsen, D. Lee, V.W.C. Yu, N.T. Jeanson, C.B. Clish, L.C. Cantley, M.G. Vander Heiden, D.T. Scadden, Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis. Cell. 158(6), 1309–1323 (2014)
Article CAS PubMed PubMed Central Google Scholar
Y. Saito, R.H. Chapple, A. Lin, A. Kitano, D. Nakada, AMPK protects leukemia-initiating cells in myeloid leukemias from metabolic stress in the bone marrow. Cell. Stem. Cell. 17(5), 585–596 (2015)
Article CAS PubMed PubMed Central Google Scholar
L. Liu, R. Chen, S. Huang, Y. Wu, G. Li, Q. Liu, D. Yin, Y. Liang, Knockdown of SOD1 sensitizes the CD34+ CML cells to imatinib therapy. Med. Oncol. Northwood Lond. Engl. 28(3), 835–839 (2011)
Y. Chen, Y. Hu, H. Zhang, C. Peng, S. Li, Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia. Nat. Genet. 41(7), 783–792 (2009)
Article CAS PubMed PubMed Central Google Scholar
A. Hattori, M. Tsunoda, T. Konuma, M. Kobayashi, T. Nagy, J. Glushka, F. Tayyari, D. McSkimming, N. Kannan, A. Tojo, A.S. Edison, T. Ito, Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia. Nature 545(7655), 500–504 (2017)
Article CAS PubMed PubMed Central Google Scholar
S. Raffel, M. Falcone, N. Kneisel, J. Hansson, W. Wang, C. Lutz, L. Bullinger, G. Poschet, Y. Nonnenmacher, A. Barnert, C. Bahr, P. Zeisberger, A. Przybylla, M. Sohn, M. Tönjes, A. Erez, L. Adler, P. Jensen, C. Scholl, S. Fröhling, S. Cocciardi, P. Wuchter, C. Thiede, A. Flörcken, J. Westermann, G. Ehninger, P. Lichter, K. Hiller, R. Hell, C. Herrmann, A.D. Ho, J. Krijgsveld, B. Radlwimmer, A. Trumpp, BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation. Nature 551(7680), 384–388 (2017)
Article CAS PubMed Google Scholar
P. Gulati, L.D. Gaspers, S.G. Dann, M. Joaquin, T. Nobukuni, F. Natt, S.C. Kozma, A.P. Thomas, G. Thomas, Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34. Cell. Metab. 7(5), 456–465 (2008)
Article CAS PubMed PubMed Central Google Scholar
F. Mercan, H. Lee, S. Kolli, A.M. Bennett, Novel role for SHP-2 in nutrient-responsive control of S6 kinase 1 signaling. Mol. Cell. Biol. 33(2), 293–306 (2013)
Article CAS PubMed PubMed Central Google Scholar
K. Sato, A. Suematsu, T. Nakashima, S. Takemoto-Kimura, K. Aoki, Y. Morishita, H. Asahara, K. Ohya, A. Yamaguchi, T. Takai, T. Kodama, T.A. Chatila, H. Bito, H. Takayanagi, Regulation of osteoclast differentiation and function by the CaMK-CREB pathway. Nat. Med. 12(12), 1410–1416 (2006)
Comments (0)