Trained immunity alleviates the progression of melanoma during sepsis-associated immunoparalysis

M. Singer, C.S. Deutschman, C.W. Seymour, M. Shankar-Hari, D. Annane, M. Bauer, R. Bellomo, G.R. Bernard, J.D. Chiche, C.M. Coopersmith, R.S. Hotchkiss, M.M. Levy, J.C. Marshall, G.S. Martin, S.M. Opal, G.D. Rubenfeld, T. van der Poll, J.L. Vincent, D.C. Angus, The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 315(8), 801–810 (2016)

Article  CAS  PubMed  PubMed Central  Google Scholar 

B.G. Chousterman, F.K. Swirski, G.F. Weber, Cytokine storm and sepsis disease pathogenesis. Semin Immunopathol. 39(5), 517–528 (2017)

Article  CAS  PubMed  Google Scholar 

J. Blazkova, F. Gao, M.H. Marichannegowda, J.S. Justement, V. Shi, E.J. Whitehead, R.F. Schneck, E.D. Huiting, K. Gittens, M. Cottrell, E. Benko, C. Kovacs, J. Lack, M.C. Sneller, S. Moir, A.S. Fauci, T.W. Chun, Distinct mechanisms of long-term virologic control in two HIV-infected individuals after treatment interruption of anti-retroviral therapy. Nat. Med. 27(11), 1893–1898 (2021)

Article  CAS  PubMed  Google Scholar 

A. Roquilly, C. Jacqueline, M. Davieau, A. Molle, A. Sadek, C. Fourgeux, P. Rooze, A. Broquet, B. Misme-Aucouturier, T. Chaumette, M. Vourc’h, R. Cinotti, N. Marec, V. Gauttier, H.E.G. McWilliam, F. Altare, J. Poschmann, J.A. Villadangos, K. Asehnoune, Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis. Nat. Immunol. 21(6), 636–648 (2020)

Article  CAS  PubMed  Google Scholar 

N. Bruse, G.P. Leijte, P. Pickkers, M. Kox, New frontiers in precision medicine for sepsis-induced immunoparalysis. Expert Rev. Clin. Immunol. 15(3), 251–263 (2019)

Article  CAS  PubMed  Google Scholar 

I.J. Jensen, C.S. Winborn, M.G. Fosdick, P. Shao, M.M. Tremblay, Q. Shan, S.K. Tripathy, C.M. Snyder, H.H. Xue, T.S. Griffith, J.C. Houtman, V.P. Badovinac, Polymicrobial sepsis influences NK-cell-mediated immunity by diminishing NK-cell-intrinsic receptor-mediated effector responses to viral ligands or infections. PLoS Pathog. 14(10), e1007405 (2018)

Article  PubMed  PubMed Central  Google Scholar 

F.V. Sjaastad, S.A. Condotta, J.A. Kotov, K.A. Pape, C. Dail, D.B. Danahy, T.A. Kucaba, L.T. Tygrett, K.A. Murphy, J. Cabrera-Perez, T.J. Waldschmidt, V.P. Badovinac, T.S. Griffith, Polymicrobial sepsis chronic immunoparalysis is defined by diminished Ag-Specific T cell-Dependent B cell responses. Front. Immunol. 9, 2532 (2018)

Article  PubMed  PubMed Central  Google Scholar 

R.S. Hotchkiss, G. Monneret, D. Payen, Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat. Rev. Immunol. 13(12), 862–874 (2013)

Article  CAS  PubMed  PubMed Central  Google Scholar 

X. Liu, L. Yin, S. Shen, Y. Hou, Inflammation and Cancer: Paradoxical Roles in Tumorigenesis and Implications in Immunotherapies (Genes & Diseases, 2021)

Z. Liu, P. Mahale, E.A. Engels, Sepsis and risk of cancer among elderly adults in the united States. Clin. Infect. Dis. 68(5), 717–724 (2019)

Article  CAS  PubMed  Google Scholar 

J.M. Mota, C.A. Leite, L.E. Souza, P.H. Melo, D.C. Nascimento, V.M. de-Deus-Wagatsuma, J. Temporal, F. Figueiredo, H. Noushmehr, J.C. Alves-Filho, F.Q. Cunha, E.M. Rego, Post-Sepsis state induces tumor-Associated macrophage accumulation through CXCR4/CXCL12 and favors tumor progression in mice. Cancer Immunol. Res. 4(4), 312–322 (2016)

Article  CAS  PubMed  Google Scholar 

S. Yende, G. D’Angelo, J.A. Kellum, L. Weissfeld, J. Fine, R.D. Welch, L. Kong, M. Carter, D.C. Angus, I.M.S.I. Gen, Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis. Am. J. Respir Crit. Care Med. 177(11), 1242–1247 (2008)

Article  PubMed  PubMed Central  Google Scholar 

M. Philip, A. Schietinger, CD8(+) T cell differentiation and dysfunction in cancer. Nat. Rev. Immunol. 22(4), 209–223 (2022)

Article  CAS  PubMed  Google Scholar 

D.B. Danahy, S.P. Kurup, C.S. Winborn, I.J. Jensen, J.T. Harty, T.S. Griffith, V.P. Badovinac, Sepsis-Induced state of immunoparalysis is defined by diminished CD8 T Cell-Mediated antitumor immunity. J. Immunol. 203(3), 725–735 (2019)

Article  CAS  PubMed  Google Scholar 

L. Cassetta, K. Bruderek, J. Skrzeczynska-Moncznik, O. Osiecka, X. Hu, I.M. Rundgren, A. Lin, K. Santegoets, U. Horzum, A. Godinho-Santos, G. Zelinskyy, T. Garcia-Tellez, S. Bjelica, B. Taciak, A.O. Kittang, B. Hoing, S. Lang, M. Dixon, V. Muller, J.S. Utikal, D. Karakoc, K.B. Yilmaz, E. Gorka, L. Bodnar, O.E. Anastasiou, C. Bourgeois, R. Badura, M. Kapinska-Mrowiecka, M. Gotic, M. Ter Laan, E. Kers-Rebel, M. Krol, J.F. Santibanez, M. Muller-Trutwin, U. Dittmer, A.E. de Sousa, G. Esendagli, G. Adema, K. Lore, E. Ersvaer, V. Umansky, J.W. Pollard, J. Cichy, S. Brandau, Differential expansion of Circulating human MDSC subsets in patients with cancer, infection and inflammation. J. Immunother Cancer. 8(2), (2020).

X. Zhou, D. Fang, H. Liu, X. Ou, C. Zhang, Z. Zhao, S. Zhao, J. Peng, S. Cai, Y. He, J. Xu, PMN-MDSCs accumulation induced by CXCL1 promotes CD8(+) T cells exhaustion in gastric cancer. Cancer Lett. 532, 215598 (2022)

Article  CAS  PubMed  Google Scholar 

F. Venet, G. Monneret, Advances in the Understanding and treatment of sepsis-induced immunosuppression. Nat. Rev. Nephrol. 14(2), 121–137 (2018)

Article  CAS  PubMed  Google Scholar 

K. Taniguchi, M. Karin, IL-6 and related cytokines as the critical lynchpins between inflammation and cancer. Semin Immunol. 26(1), 54–74 (2014)

Article  CAS  PubMed  Google Scholar 

Y. Li, Y. Xu, X. Liu, X. Yan, Y. Lin, Q. Tan, Y. Hou, mTOR inhibitor INK128 promotes wound healing by regulating MDSCs. Stem Cell. Res. Ther. 12(1), 170 (2021)

Article  CAS  PubMed  PubMed Central  Google Scholar 

W.J.M. Mulder, J. Ochando, L.A.B. Joosten, Z.A. Fayad, M.G. Netea, Therapeutic targeting of trained immunity. Nat. Rev. Drug Discov. 18(7), 553–566 (2019)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Y. Pan, J. Li, X. Xia, J. Wang, Q. Jiang, J. Yang, H. Dou, H. Liang, K. Li, Hou, beta-glucan-coupled superparamagnetic iron oxide nanoparticles induce trained immunity to protect mice against sepsis. Theranostics. 12(2), 675–688 (2022)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Z. Sun, J. Qu, X. Xia, Y. Pan, X. Liu, H. Liang, H. Dou, Y. Hou, 17beta-Estradiol promotes LC3B-associated phagocytosis in trained immunity of female mice against sepsis. Int. J. Biol. Sci. 17(2), 460–474 (2021)

Article  CAS  PubMed  PubMed Central  Google Scholar 

L. Lu, Q. Guo, L. Zhao, Overview of oroxylin A: A promising flavonoid compound. Phytother Res. 30(11), 1765–1774 (2016)

Article  CAS  PubMed  Google Scholar 

L. Yin, Z. Bing, Y. Zheng, Y. Pan, Y. Dong, J. Wang, R. Luo, Y. Zhao, H. Dou, Y. Hou, Oroxylin A-induced Trained Immunity Promotes LC3-associated Phagocytosis in Macrophage in Protecting Mice against Sepsis (Inflammation, 2024)

H. Li, N. Lu, X. Yu, X. Liu, P. Hu, Y. Zhu, L. Shen, J. Xu, Z. Li, Q. Guo, H. Hui, Oroxylin A, a natural compound, mitigates the negative effects of TNFalpha-treated acute myelogenous leukemia cells. Carcinogenesis. 39(10), 1292–1303 (2018)

Article  CAS  PubMed  Google Scholar 

L. Yin, X. Liu, J. Wu, J. Yang, J. Wang, H. Dou, Y. Hou, LS-007 inhibits melanoma growth via inducing apoptosis and cell cycle arrest and regulating macrophage polarization. Melanoma Res. 32(6), 419–427 (2022)

Article  CAS  PubMed  Google Scholar 

H. Movassagh, M. Prunicki, A. Kaushik, X. Zhou, D. Dunham, E.M. Smith, Z. He, G.R. Aleman Muench, M. Shi, A.K. Weimer, S. Cao, S. Andorf, A. Feizi, M.P. Snyder, P. Soroosh, E.D. Mellins, K.C. Nadeau, Proinflammatory polarization of monocytes by particulate air pollutants is mediated by induction of trained immunity in pediatric asthma. Allergy. 78(7), 1922–1933 (2023)

Article  CAS  PubMed  Google Scholar 

E. Jentho, C. Ruiz-Moreno, B. Novakovic, I. Kourtzelis, W.L. Megchelenbrink, R. Martins, T. Chavakis, M.P. Soares, L. Kalafati, J. Guerra, F. Roestel, P. Bohm, M. Godmann, T. Grinenko, A. Eugster, M. Beretta, L.A.B. Joosten, M.G. Netea, M. Bauer, H.G. Stunnenberg, S. Weis, Trained Innate Immunity, long-lasting Epigenetic Modulation, and Skewed Myelopoiesis by Heme (Proc Natl Acad Sci U S A, 2021). 118(42)

R.M. Rodriguez, B. Suarez-Alvarez, C. Lopez-Larrea, Therapeutic epigenetic reprogramming of trained immunity in myeloid cells. Trends Immunol. 40(1), 66–80 (2019)

Article  CAS  PubMed  Google Scholar 

S.C. Cheng, J. Quintin, R.A. Cramer, K.M. Shepardson, S. Saeed, V. Kumar, E.J. Giamarellos-Bourboulis, J.H. Martens, N.A. Rao, A. Aghajanirefah, G.R. Manjeri, Y. Li, D.C. Ifrim, R.J. Arts, B.M. van der Veer, P.M. Deen, C. Logie, L.A. O’Neill, P. Willems, F.L. van de Veerdonk, J.W. van der Meer, A. Ng, L.A. Joosten, C. Wijmenga, H.G. Stunnenberg, R.J. Xavier, M.G. Netea, mTOR- and HIF-1alpha-mediated aerobic Glycolysis as metabolic basis for trained immunity. Science. 345(6204), 1250684 (2014)

Article  PubMed  PubMed Central  Google Scholar 

V. Bronte, S. Brandau, S.H. Chen, M.P. Colombo, A.B. Frey, T.F. Greten, S. Mandruzzato, P.J. Murray, A. Ochoa, S. Ostrand-Rosenberg, P.C. Rodriguez, A. Sica, V. Umansky, R.H. Vonderheide, D.I. Gabrilovich, Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards. Nat. Commun. 7, 12150 (2016)

Article  CAS 

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