J. Muto, K. Shirabe, K. Sugimachi, Y. Maehara, Review of angiogenesis in hepatocellular carcinoma. Hepatol. Res. 45(1), 1–9 (2015)

Article  PubMed  Google Scholar 

H. Sung, J. Ferlay, R.L. Siegel, M. Laversanne, I. Soerjomataram, A. Jemal, F. Bray, Global Cancer statistics 2020: GLOBOCAN estimates of incidence and Mortality Worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 71(3), 209–249 (2021)

Article  PubMed  Google Scholar 

J.M. Llovet, S. Ricci, V. Mazzaferro, P. Hilgard, E. Gane, J.F. Blanc, de A.C. Oliveira, A. Santoro, J.L. Raoul, A. Forner et al., Sorafenib in advanced hepatocellular carcinoma. N Engl. J. Med. 359(4), 378–390 (2008)

Article  CAS  PubMed  Google Scholar 

X.F. Ding, C. Luo, K.Q. Ren, J. Zhang, J.L. Zhou, X. Hu, R.S. Liu, Y. Wang, X. Gao, J. Zhang, Characterization and expression of a human KCTD1 gene containing the BTB domain, which mediates transcriptional repression and homomeric interactions. DNA Cell. Biol. 27(5), 257–265 (2008)

Article  CAS  PubMed  Google Scholar 

X. Ding, C. Luo, J. Zhou, Y. Zhong, X. Hu, F. Zhou, K. Ren, L. Gan, A. He, J. Zhu et al., The interaction of KCTD1 with transcription factor AP-2alpha inhibits its transactivation. J. Cell. Biochem. 106(2), 285–295 (2009)

Article  CAS  PubMed  Google Scholar 

L. Pirone, G. Smaldone, R. Spinelli, M. Barberisi, F. Beguinot, L. Vitagliano, C. Miele, Di S. Gaetano, G.A. Raciti, E. Pedone, KCTD1: a novel modulator of adipogenesis through the interaction with the transcription factor AP2alpha. Biochim. Biophys. Acta Mol. Cell. Biol. Lipids. 1864(12), 158514 (2019)

Article  CAS  PubMed  Google Scholar 

A.G. Marneros, AP-2beta/KCTD1 control Distal Nephron differentiation and protect against Renal Fibrosis. Dev. Cell. 54(3), 348–366e345 (2020)

Article  CAS  PubMed  PubMed Central  Google Scholar 

D. Hanahan, R.A. Weinberg, The hallmarks of cancer. Cell. 100(1), 57–70 (2000)

Article  CAS  PubMed  Google Scholar 

S. Tan, L. Xia, P. Yi, Y. Han, L. Tang, Q. Pan, Y. Tian, S. Rao, L. Oyang, J. Liang et al., Exosomal miRNAs in tumor microenvironment. J. Exp. Clin. Cancer Res. 39(1), 67 (2020)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Y. Wang, A. Moh-Moh-Aung, T. Wang, M. Fujisawa, T. Ohara, K.I. Yamamoto, M. Sakaguchi, T. Yoshimura, A. Matsukawa, Exosomal delivery of miR-200b-3p suppresses the growth of hepatocellular carcinoma cells by targeting ERG- and VEGF-mediated angiogenesis. Gene. 931, 148874 (2024)

Article  CAS  PubMed  Google Scholar 

F.J. Slack, A.M. Chinnaiyan, The role of non-coding RNAs in Oncology. Cell. 179(5), 1033–1055 (2019)

Article  CAS  PubMed  PubMed Central  Google Scholar 

L. Yang, J. Qiu, Y. Xiao, X. Hu, Q. Liu, L. Chen, W. Huang, X. Li, L. Li, J. Zhang et al., AP-2β inhibits hepatocellular carcinoma invasion and metastasis through slug and snail to suppress epithelial-mesenchymal transition. Theranostics. 8(13), 3707–3721 (2018)

Article  CAS  PubMed  PubMed Central  Google Scholar 

O. Menyhart, A. Nagy, B. Gyorffy, Determining consistent prognostic biomarkers of overall survival and vascular invasion in hepatocellular carcinoma. R Soc. Open. Sci. 5(12), 181006 (2018)

Article  CAS  PubMed  PubMed Central  Google Scholar 

W. Huang, Z. Zhong, C. Luo, Y. Xiao, L. Li, X. Zhang, L. Yang, K. Xiao, Y. Ning, L. Chen et al., The miR-26a/AP-2alpha/Nanog signaling axis mediates stem cell self-renewal and temozolomide resistance in glioma. Theranostics. 9(19), 5497–5516 (2019)

Article  CAS  PubMed  PubMed Central  Google Scholar 

W. Huang, C. Chen, Z. Liang, J. Qiu, X. Li, X. Hu, S. Xiang, X. Ding, J. Zhang, AP-2alpha inhibits hepatocellular carcinoma cell growth and migration. Int. J. Oncol. 48(3), 1125–1134 (2016)

Article  CAS  PubMed  Google Scholar 

X. Ding, Z. Yang, F. Zhou, F. Wang, X. Li, C. Chen, X. Li, X. Hu, S. Xiang, J. Zhang, Transcription factor AP-2alpha regulates acute myeloid leukemia cell proliferation by influencing Hoxa gene expression. Int. J. Biochem. Cell. Biol. 45(8), 1647–1656 (2013)

Article  CAS  PubMed  Google Scholar 

Y. Wu, Y. Xiao, X. Ding, Y. Zhuo, P. Ren, C. Zhou, J. Zhou, A miR-200b/200c/429-Binding site polymorphism in the 3′ untranslated region of the AP-2α gene is Associated with Cisplatin Resistance. Plos One. 6(12), e29043 (2011)

Article  CAS  PubMed  PubMed Central  Google Scholar 

X. Ding, C. Fan, J. Zhou, Y. Zhong, R. Liu, K. Ren, X. Hu, C. Luo, S. Xiao, Y. Wang et al., GAS41 interacts with transcription factor AP-2beta and stimulates AP-2beta-mediated transactivation. Nucleic Acids Res. 34(9), 2570–2578 (2006)

Article  CAS  PubMed  PubMed Central  Google Scholar 

F. Wang, W. Huang, X. Hu, C. Chen, X. Li, J. Qiu, Z. Liang, J. Zhang, L. Li, X. Wang et al., Transcription factor AP-2beta suppresses cervical cancer cell proliferation by promoting the degradation of its interaction partner beta-catenin. Mol. Carcinog. 56(8), 1909–1923 (2017)

Article  CAS  PubMed  Google Scholar 

L. Hu, L. Chen, L. Yang, Z. Ye, W. Huang, X. Li, Q. Liu, J. Qiu, X. Ding, KCTD1 mutants in scalp–ear–nipple syndrome and AP–2α P59A in Char syndrome reciprocally abrogate their interactions, but can regulate Wnt/β–catenin signaling. Mol. Med. Rep. 22(5), 3895–3903 (2020)

CAS  PubMed  PubMed Central  Google Scholar 

C. Chen, Z. Liang, W. Huang, X. Li, F. Zhou, X. Hu, M. Han, X. Ding, S. Xiang, Eps8 regulates cellular proliferation and migration of breast cancer. Int. J. Oncol. 46(1), 205–214 (2015)

Article  CAS  PubMed  Google Scholar 

D.I. Gabrilovich, S. Ostrand-Rosenberg, V. Bronte, Coordinated regulation of myeloid cells by tumours. Nat. Rev. Immunol. 12(4), 253–268 (2012)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Z.W. Zhu, H. Friess, L. Wang, M. Abou-Shady, A. Zimmermann, A.D. Lander, M. Korc, J. Kleeff, M.W. Buchler, Enhanced glypican-3 expression differentiates the majority of hepatocellular carcinomas from benign hepatic disorders. Gut. 48(4), 558–564 (2001)

Article  CAS  PubMed  PubMed Central  Google Scholar 

L. Zhou, J. Liu, F. Luo, Serum tumor markers for detection of hepatocellular carcinoma. World J. Gastroenterol. 12(8), 1175–1181 (2006)

Article  CAS  PubMed  PubMed Central  Google Scholar 

J.P. Piret, D. Mottet, M. Raes, C. Michiels, CoCl2, a chemical inducer of hypoxia-inducible factor-1, and hypoxia reduce apoptotic cell death in hepatoma cell line HepG2. Ann. N Y Acad. Sci. 973(1), 443–447 (2002)

Article  CAS  PubMed  Google Scholar 

D. Chilov, G. Camenisch, I. Kvietikova, U. Ziegler, M. Gassmann, R.H. Wenger, Induction and nuclear translocation of hypoxia-inducible factor-1 (HIF-1): heterodimerization with ARNT is not necessary for nuclear accumulation of HIF-1alpha. J. Cell. Sci. 112(Pt 8), 1203–1212 (1999)

Article  CAS  PubMed  Google Scholar 

G.L. Semenza, Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer. 3(10), 721–732 (2003)

Article  CAS  PubMed  Google Scholar 

C.A. Corzo, T. Condamine, L. Lu, M.J. Cotter, J.I. Youn, P. Cheng, H.I. Cho, E. Celis, D.G. Quiceno, T. Padhya et al., HIF-1alpha regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment. J. Exp. Med. 207(11), 2439–2453 (2010)

Article  CAS  PubMed  PubMed Central  Google Scholar