Evaluating boron neutron capture therapy as a potential treatment for unresectable gastrointestinal stromal tumors

Joensuu H, Fletcher C, Dimitrijevic S, Silberman S, Roberts P, Demetri G. Management of malignant gastrointestinal stromal tumours. Lancet Oncol. 2002;3:655–64.

Article  CAS  PubMed  Google Scholar 

Søreide K, Sandvik OM, Søreide JA, Giljaca V, Jureckova A, Bulusu VR. Global epidemiology of gastrointestinal stromal tumours (GIST): a systematic review of population-based cohort studies. Cancer Epidemiol. 2016;40:39–46.

Article  PubMed  Google Scholar 

Diamantis A, Samara AA, Baloyiannis I, Symeonidis D, Diamantis AM, Tolia M, et al. Gastrointestinal stromal tumor (GIST) and synchronous intra-abdominal liposarcoma: a report of two rare cases and literature review. Int J Surg Oncol. 2021;2021:2626635.

PubMed  PubMed Central  Google Scholar 

Radu P, Zurzu M, Paic V, Bratucu M, Garofil D, Tigora A, et al. Interstitial cells of cajal-origin, distribution and relationship with gastrointestinal tumors. Medicina. 2023;59:63.

Article  Google Scholar 

Iwatsuki M, Harada K, Iwagami S, Eto K, Ishimoto T, Baba Y, et al. Neoadjuvant and adjuvant therapy for gastrointestinal stromal tumors. Ann Gastroenterol Surg. 2019;3:43–9.

Article  PubMed  Google Scholar 

Antonescu CR, Besmer P, Guo T, Arkun K, Hom G, Koryotowski B, et al. Acquired resistance to imatinib in gastrointestinal stromal tumor occurs through secondary gene mutation. Clin Cancer Res. 2005;11:4182–90.

Article  CAS  PubMed  Google Scholar 

Verweij J, Casali PG, Zalcberg J, LeCesne A, Reichardt P, Blay JY, et al. Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: randomised trial. Lancet. 2004;364:1127–34.

Article  CAS  PubMed  Google Scholar 

Kelly CM, Gutierrez Sainz L, Chi P. The management of metastatic GIST: current standard and investigational therapeutics. J Hematol Oncol. 2021;14:2.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mei L, Du W, Idowu M, von Mehren M, Boikos SA. Advances and challenges on management of gastrointestinal stromal tumors. Front Oncol. 2018;8:135.

Article  PubMed  PubMed Central  Google Scholar 

Jin WH, Seldon C, Butkus M, Sauerwein W, Giap HB. A review of boron neutron capture therapy: its history and current challenges. Int J Part Ther. 2022;9:71–82.

Article  PubMed  PubMed Central  Google Scholar 

Coderre JA, Morris GM. The radiation biology of boron neutron capture therapy. Radiat Res. 1999;151:1–18.

Article  CAS  PubMed  Google Scholar 

Suzuki M. Boron neutron capture therapy (BNCT): a unique role in radiotherapy with a view to entering the accelerator-based BNCT era. Int J Clin Oncol. 2020;25:43–50.

Article  PubMed  Google Scholar 

Mishima Y, Honda C, Ichihashi M, Obara H, Hiratsuka J, Fukuda H, et al. Treatment of malignant melanoma by single thermal neutron capture therapy with melanoma-seeking 10B-compound. Lancet. 1989;2:388–9.

Article  CAS  PubMed  Google Scholar 

Wongthai P, Hagiwara K, Miyoshi Y, Wiriyasermkul P, Wei L, Ohgaki R, et al. Boronophenylalanine, a boron delivery agent for boron neutron capture therapy, is transported by ATB0,+, LAT1 and LAT2. Cancer Sci. 2015;106:279–86.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hirose K, Konno A, Hiratsuka J, Yoshimoto S, Kato T, Ono K, et al. Boron neutron capture therapy using cyclotron- based epithermal neutron source and borofalan (10B) for recurrent or locally advanced head and neck cancer (JHN002): an open-label phase II trial. Radiother Oncol. 2021;155:182–7.

Article  CAS  PubMed  Google Scholar 

Michiue H, Kitamatsu M, Fukunaga A, Tsuboi N, Fujimura A, Matsushita H, et al. Self-assembling A6K peptide nanotubes as a mercaptoundecahydrododecaborate (BSH) delivery system for boron neutron capture therapy (BNCT). J Control Release. 2021;330:788–96.

Article  CAS  PubMed  Google Scholar 

Iguchi Y, Michiue H, Kitamatsu M, Hayashi Y, Takenaka F, Nishiki T, et al. Tumor-specific delivery of BSH-3R for boron neutron capture therapy and positron emission tomography imaging in a mouse brain tumor model. Biomaterials. 2015;56:10–7.

Article  CAS  PubMed  Google Scholar 

Michiue H, Sakurai Y, Kondo N, Kitamatsu M, Bin F, Nakajima K, et al. The acceleration of boron neutron capture therapy using multi-linked mercaptoundecahydrododecaborate (BSH) fused cell-penetrating peptide. Biomaterials. 2014;35:3396–405.

Article  CAS  PubMed  Google Scholar 

Shima T, Taniguchi K, Tokumaru Y, Inomata Y, Arima J, Lee SW, et al. Glucose transporter-1 inhibition overcomes imatinib resistance in gastrointestinal stromal tumor cells. Oncol Rep. 2022;47:7.

Article  PubMed  Google Scholar 

Arima J, Taniguchi K, Yamamoto M, Watanabe T, Suzuki Y, Hamamoto H, et al. Anti-tumor effect of boron neutron capture therapy in pelvic human colorectal cancer in a mouse model. Biomed Pharmacother. 2022;154: 113632.

Article  CAS  PubMed  Google Scholar 

Kiśluk J, Zińczuk J, Kemona A, Guzińska-Ustymowicz K, Żurawska J, Kędra B. Expression of CD117, DOG-1, and IGF-1R in gastrointestinal stromal tumours—an analysis of 70 cases from 2004 to 2010. Prz Gastroenterol. 2016;11:115–22.

PubMed  Google Scholar 

Bonner WM, Redon CE, Dickey JS, Nakamura AJ, Sedelnikova OA, Solier S, et al. GammaH2AX and cancer. Nat Rev Cancer. 2008;8:957–67.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fernandes-Alnemri T, Litwack G, Alnemri ES. CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme. J Biol Chem. 1994;269:30761–4.

Article  CAS  PubMed  Google Scholar 

Nicholson DW, Ali A, Thornberry NA, Vaillancourt JP, Ding CK, Gallant M, et al. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature. 1995;376:37–43.

Article  CAS  PubMed  Google Scholar 

Muzio M, Chinnaiyan AM, Kischkel FC, O’Rourke K, Shevchenko A, Ni J, et al. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death–inducing signaling complex. Cell. 1996;85:817–27.

Article  CAS  PubMed  Google Scholar 

Boldin MP, Goncharov TM, Goltsev YV, Wallach D. Involvement of Mach, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell. 1996;85:803–15.

Article  CAS  PubMed  Google Scholar 

Satoh MS, Lindahl T. Role of poly (ADP-ribose) formation in DNA repair. Nature. 1992;356:356–8.

Article  CAS  PubMed  Google Scholar 

Wei MC, Zong WX, Cheng EH, Lindsten T, Panoutsakopoulou V, Ross AJ, et al. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science. 2001;292:727–30.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Detta A, Cruickshank GS. L-amino acid transporter-1 and boronophenylalanine-based boron neutron capture therapy of human brain tumors. Cancer Res. 2009;69:2126–32.

Article  CAS  PubMed  Google Scholar 

Haller F, Löbke C, Ruschhaupt M, Schulten HJ, Schwager S, Gunawan B, et al. Increased KIT signalling with up-regulation of cyclin D correlates to accelerated proliferation and shorter disease-free survival in gastrointestinal stromal tumours (GISTs) with KIT exon 11 deletions. J Pathol. 2008;216:225–35.

Article  CAS  PubMed  Google Scholar 

Watanabe T, Sanada Y, Hattori Y, Suzuki M. Correlation between the expression of LAT1 in cancer cells and the potential efficacy of boron neutron capture therapy. J Radiat Res. 2023;64:91–8.

Article  CAS  PubMed 

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