Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cnacers in 185 countries. CA Cancer J Clin. 2024;74:229–63.

Article  PubMed  Google Scholar 

Petryszyn P, Chapelle N, Matysiak-Budnik T. Gastric cancer: where are we heading? Dig Dis. 2020;38:280–5.

Article  PubMed  Google Scholar 

International Agency for Research on Cancer (IARC). Working Group on the Evaluation of Carcinogenic Risks to Humans Helicobacter pylori. In: Schistosomes, liver flukes and Helicobacter pylori: views and expert opinions of the IARC working group on the evaluation of carcinogenic risks to humans. Lyon, France: IARC; 1994. p. 177–240.

Google Scholar 

Uemura N, Okamoto S, Yamamoto S, Matsumura N, Yamaguchi S, Yamakido M, et al. Helicobacter pylori infection and the development of gastric cancer. N Engl J Med. 2001;345:784–9.

Article  CAS  PubMed  Google Scholar 

Nardone G, Rocco A, Malfertheiner P. Helicobacter pylori and molecular events in precancerous gastric lesions. Aliment Pharmacol Ther. 2004;20:261–70.

Article  CAS  PubMed  Google Scholar 

Sadjadi A, Derakhshan MH, Yazdanbod A, Boreiri M, Paraeian M, Babaei M, et al. Neglected role of hookah and opium in gastric carcinogenesis: a cohort study on risk factors and attributable fractions. Int J Cancer. 2014;134:181–8.

Article  PubMed  Google Scholar 

Ladeiras-Lopes R, Pereira AK, Nogueira A, Pinheiro-Torres T, Pinto I, Santos-Pereira R, et al. Smoking and gastric cancer: systematic review and meta-analysis of cohort studies. Cancer Causes Control. 2008;19:689–701.

Article  PubMed  Google Scholar 

Ma K, Baloch Z, He TT, Xia X. Alcohol consumption and gastric cancer risk: a meta-analysis. Med Sci Monit. 2017;23:238–46.

Article  PubMed  PubMed Central  Google Scholar 

Tatemichi M, Hanada GS, Nishimoto IN, Kowalski LP, Iriya K, Rodriques JJ, Tsugane S. Ethnic difference in serology of Helicobacter pylori CagA between Japanese and non-Japanese Brazilians for non-cardia gastric cancer. Cancer Sci. 2003;94:64–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Suzuki G, Cullings H, Fujiwara S, Hattori N, Matsuura S, Hakoda M, et al. Low-positive antibody titer against Helicobacter pylori cytotoxin-associated gene A (CagA) may predict future gastric cancer better than simple seropositivity against H. pylori CagA or against H. pylori. Cancer Epidemiol Biomarkers Prev. 2007;16:1224–8.

Article  CAS  PubMed  Google Scholar 

Watanabe M, Kato J, Inoue I, Yoshimura N, Yoshida T, Mukoubayashi C, et al. Development of gastric cancer in nonatrophic stomach with highly active inflammation identified by serum levels of pepsinogen and Helicobacter pylori antibody together with endoscopic rugal hyperplastic gastritis. Int J Cancer. 2012;131:2632–42.

Article  CAS  PubMed  Google Scholar 

Inoue M, Sawada N, Goto A, Shimazu T, Yamaji T, Iwasaki M, et al. High-negative anti-Helicobacter pylori IgG antibody titers and long-term risk of gastric cancer: results from a large-scale population-based cohort study in Japan. Cancer Epidemiol Biomarkers Prev. 2020;29:420–6.

Article  CAS  PubMed  Google Scholar 

Mülder DT, Hahn AI, Huang RJ, Zhou MJ, Blake B, Omofuma O, et al. Prevalence of gastric precursor lesions in countries with differentiated gastric cancer burden: a systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2024;22(8):1605–17.

Article  PubMed  Google Scholar 

Fontham ETH, Ruiz B, Perez A, Hunter F, Correa P. Determinants of Helicobacter pylori infection and chronic gastritis. Am J Gastroenterol. 1995;90:1094–101.

CAS  PubMed  Google Scholar 

Karnes WE Jr, Samloff IM, Siurala M, Kekki M, Sipponen P, Kim SW, Walsh JH. Positive serum antibody and negative tissue staining for Helicobacter pylori in subjects with atrophic body gastritis. Gastroenterol. 1991;101(1):167–74.

Article  Google Scholar 

Robles C, Rudzite D, Polaka I, Sjomina O, Tzivian L, Kikuste I, et al. Assessment of serum pepsinogen with Gastrin-17 in gastric cancer risk assessment-results from the GISTAR Pilot study. Diagnostics. 2022;12:1746.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Park JY, Polaka I, Parshutin S, Kikuste I, Isajevs S, Santare D, et al. Trial Profile: pilot study of the multicentre randomized trial of H. pylori eradication and pepsinogen testing for prevention of gastric cancer mortality (the GISTAR Pilot study). Microb Health Dis. 2019;1: e165.

Google Scholar 

Leja M, Park JY, Murillo R, Liepniece-Karele I, Isajevs S, Kikuste I, et al. Multicentric randomized study of Helicobacter pylori eradication and pepsinogen testing for prevention of gastric cancer mortality: the GISTAR study. BMJ Open. 2017;7: e016999.

Article  PubMed  PubMed Central  Google Scholar 

Leja M, Camargo MC, Polaka I, Isajevs S, Liepniece-Karele I, Janciauskas D, et al. Detection of gastric atrophy by circulating pepsinogens: a comparison of three assays. Helicobacter. 2017. https://doi.org/10.1111/hel.12393.

Article  PubMed  PubMed Central  Google Scholar 

Dixon MF, Genta RM, Yardley JH, Correa P. Classification and grading of gastritis. The updated Sydney system. International workshop on the histopathology of gastritis, Houston 1994. Am J Surg Pathol. 1996;20:1161–81.

Article  CAS  PubMed  Google Scholar 

Rugge M, Correa P, Mario FD, El-Omar E, Fiocca R, Geboes K, et al. OLGA staging for gastritis: a tutorial. Dig Liver Dis. 2008;40:650–8.

Article  CAS  PubMed  Google Scholar 

Miki K. Gastric cancer screening by combined assay for serum anti-Helicobacter pylori IgG antibody and serum pepsinogen levels – “ABC method.” Proc Jpn Acad Ser B Phys Biol Sci. 2011;87:405–14.

Article  PubMed  PubMed Central  Google Scholar 

Tu H, Sun L, Dong Z, et al. Serum anti-Helicobacter pylori immunoglobulin G titer correlates with grade of histological gastritis, mucosal bacterial density, and levels of serum biomarkers. Scand J Gastroenterol. 2014;49(3):259–66.

Article  CAS  PubMed  Google Scholar 

Gong Y, Wei W, Yuan Y. Association between abnormal gastric function risk and Helicobacter pylori infection assessed by ELISA and 14C-urea breath test. Diagn Microbiol Infect Dis. 2014;80(4):316–20.

Article  PubMed  Google Scholar 

Nomura AM, Lee J, Stemmermann GN, Nomura RY, Perez-Perez GI, Blaser MJ. Helicobacter pylori CagA seropositivity and gastric carcinoma risk in a Japanese American population. J Infec Dis. 2002;186(8):1138–44.

Article  Google Scholar 

Tatemichi M, Sasazuki S, Inoue M, Tsugane S, Japan Public Health Center Study Group. Different etiological role of Helicobacter pylori infection in carcinogenesis between differentiated and undifferentiated gastric cancers: a nested case-control study using IgG titer against Hp surface antigen. Acta Oncol. 2008;47(3):360–5.

Article  CAS  PubMed  Google Scholar 

Tatemichi M, Sasazuki S, Inoue M, Tsugane S, Japan Public Health Center Study Group. Clinical significance of IgG antibody titer against Helicobacter pylori. Helicobacter. 2009;14:231–6.

Article  CAS  PubMed  Google Scholar 

Lim JH, Han A, Cho SJ, Hahn S, Kim SG. Nomogram prediction for gastric cancer development. Clin Transl Gastroenterol. 2025;13:10.

Google Scholar 

Nam JH, Choi IJ, Kook MC, Lee JY, Cho SJ, Nam SY, Kim CG. OLGA and OLGIM stage distribution according to age and Helicobacter pylori status in the Korean population. Hellicobacter. 2014;19:81–9.

Article  Google Scholar 

Yoshida T, Kato J, Inoue I, et al. Cancer development based on chronic active gastritis and resulting gastric atrophy as assessed by serum levels of pepsinogen and Helicobacter pylori antibody titer. Int J Cancer. 2014;134(6):1445–57.

Article  CAS  PubMed  Google Scholar 

Watanabe Y, Kurata JH, Mizuno S, Mukai M, Inokuchi H, Miki K, et al. Helicobacter pylori infection and gastric cancer. A nested case–control study in a rural area of Japan. Dig Dis Sci. 1997;42(7):1383–7.

Article  CAS  PubMed  Google Scholar