Design, synthesis and evaluation of imidazo[1,2-a]pyrazin-8(7H)-one derivatives as acetylcholinesterase inhibitors and antioxidants

Toro PMJ, Parra PDR, Pacheco MNV, Galarza AGA. Enfermedad de Alzheimer. Recimundo. 2022;6:68–76.

Article  Google Scholar 

Gustavsson A, Norton N, Fast T, Frölich L, Georges J, Holzapfel D, et al. Global estimates on the number of persons across the Alzheimer’s disease continuum. Alzh Dement. 2023;19:658–70.

Article  Google Scholar 

Woźniak K, Gardian-Baj M, Jung M, Hedesz P, Jung M, Żuk-Łapan A, et al. Alzheimer’s disease-a comprehensive review. J Educ Health Sport. 2024;56:195–209.

Article  Google Scholar 

Grossberg G, Urganus A, Schein J, Bungay R, Cloutier M, Gauthier-Loiselle M, et al. A real-world assessment of healthcare costs associated with agitation in Alzheimer’s dementia. J Med Econ. 2023;27:99–108.

Article  PubMed  Google Scholar 

Wilson RS, Segawa E, Boyle PA, Anagnos SE, Hizel LP, Bennett DA. The natural history of cognitive decline in Alzheimer’s disease. Psychol Aging. 2012;27:1008–17.

Article  PubMed  PubMed Central  Google Scholar 

Woodward MC. Drug treatment of Alzheimer’s disease: what has changed in 30 years? J Pharm Pract Res. 2024;53:314–19.

Article  Google Scholar 

Hampel H, Mesulam MM, Cuello AC, Farlow MR, Giacobini E, Grossberg GT, et al. The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease. Brain. 2018;141:1917–1933.

Article  PubMed  PubMed Central  Google Scholar 

Hua KY, Zhao WJ. Current study on diagnosis and treatment of Alzheimer’s disease by targeting amyloid b-protein. Folia Neuropathol. 2022;61:8–15.

Article  Google Scholar 

Iliyasu MO, Musa SA, Oladele SB, Iliya AI. Amyloid-beta aggregation implicates multiple pathways in Alzheimer’s disease: Understanding the mechanisms. Front. Neurosci. 2023;17:1081938.

Article  PubMed  PubMed Central  Google Scholar 

Twarowski B, Herbet M. Inflammatory Processes in Alzheimer’s Disease-Pathomechanism, Diagnosis and Treatment: A Review. Int J Mol Sci. 2023;24:6518.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abdelazim AM, Abomughaid MM. Oxidative stress: an overview of past research and future insights. All Life. 2024;17:2316092.

Article  Google Scholar 

Tian S, Huang Z, Meng Q, Liu Z. Multi-target drug design of anti-Alzheimer’s disease based on tacrine. Mini-Rev Med Chem. 2021;21:2039–64.

Article  CAS  PubMed  Google Scholar 

Kou X, Shi X, Pang Z, Yang A, Shen R, Zhao L. A review on the natural components applied as lead compounds for potential multi-target anti-AD theranostic agents. Curr Med Chem. 2023;30:4586–604.

Article  CAS  PubMed  Google Scholar 

Siemers E. Drug development in AD: point of view from the industry. JPAD-J Prev Alzheim. 2015;2:216–18.

CAS  Google Scholar 

Maniam S. Screening techniques for drug discovery in Alzheimer’s disease. ACS Omega. 2024;9:6059–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pravin N, Jozwiak K. Effects of linkers and substitutions on multitarget directed ligands for Alzheimer’s diseases: Emerging paradigms and strategies. Int J Mol Sci. 2022;23:6085.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kasus-Jacobi A, Washburn JL, Laurence RB, Pereira HA. Selecting multitarget peptides for Alzheimer’s disease. Biomolecules. 2022;12:1386.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carreiras MC, Mendes E, Perry MJ, Francisco AP, Marco-Contelles J. The multifactorial nature of Alzheimer’s disease for developing potential therapeutics. Curr Top Med Chem. 2013;13:1745–70.

Article  CAS  PubMed  Google Scholar 

Rosini M, Simoni E, Caporaso R, Minarini A. Multitarget strategies in Alzheimer’s disease: Benefits and challenges on the road to therapeutics. Future Med Chem. 2016;8:697–711.

Article  CAS  PubMed  Google Scholar 

Atali S, Dorandish S, Devos J, Williams A, Price D, Taylor J, et al. Interaction of amyloid beta with humanin and acetylcholinesterase is modulated by ATP. FEBS Open Bio. 2020;10:2805–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Elsbaey M, Igarashi Y, Ibrahim MAA, Elattar E. Click-designed vanilloid-triazole conjugates as dual inhibitors of AChE and Aβ aggregation. RSC Adv. 2023;13:2871–83.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kulshreshtha A, Piplani P. Current pharmacotherapy and putative disease-modifying therapy for Alzheimer’s disease. Neurol Sci. 2016;37:1403–35.

Article  PubMed  Google Scholar 

Anand A, Patience AA, Sharma N, Khurana N. The present and future of pharmacotherapy of Alzheimer’s disease: A comprehensive review. Eur J Pharmacol. 2017;815:364–75.

Article  CAS  PubMed  Google Scholar 

Benek O, Korabecny J, Soukup O. A perspective on multi-target drugs for Alzheimer’s disease. Trends Pharmacol Sci. 2020;41:434–45.

Article  CAS  PubMed  Google Scholar 

Oliveira C, Cagide F, Teixeira J, Amorim R, Sequeira L, Mesiti F, et al. Hydroxybenzoic acid derivatives as dual-target ligands: Mitochondriotropic antioxidants and cholinesterase inhibitors. Front Chem. 2018;6:126.

Article  PubMed  PubMed Central  Google Scholar 

Zhang C, Wang L, Xu Y, Huang Y, Huang J, Zhu J, et al. Discovery of novel dual RAGE/SERT inhibitors for the potential treatment of the comorbidity of Alzheimer’s disease and depression. Eur J Med Chem. 2022;236:114347.

Article  CAS  PubMed  Google Scholar 

Mao F, Wang H, Ni W, Zheng X, Wang M, Bao K, et al. Design, synthesis, and biological evaluation of orally available first-generation dual-target selective inhibitors of acetylcholinesterase (AChE) and phosphodiesterase 5 (PDE5) for the treatment of Alzheimer’s disease. ACS Chem Neurosci. 2017;9:328–45.

Article  PubMed  Google Scholar 

Dai R, Sun Y, Su R, Gao H. Anti-Alzheimer’s disease potential of traditional chinese medicinal herbs as inhibitors of BACE1 and AChE enzymes. Biomed Pharmacother. 2022;154:113576.

Article  CAS  PubMed  Google Scholar 

Karaca, Osmaniye D, Sağlık BN, Levent S, Ilgın S, Özkay Y, et al. Synthesis of novel benzothiazole derivatives and investigation of their enzyme inhibitory effects against Alzheimer’s disease. RSC Adv. 2022;12:23626–36.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yao H, Uras G, Zhang P, Xu S, Yin Y, Liu J, et al. Discovery of novel tacrine–pyrimidone hybrids as potent dual AChE/GSK-3 inhibitors for the treatment of Alzheimer’s disease. J Med Chem. 2021;64:7483–506.

Article  CAS  PubMed  Google Scholar 

Soliman AM, Ghorab WM, Lotfy DM, Karam HM, Ghorab MM, Ramadan LA. Novel iodoquinazolinones bearing sulfonamide moiety as potential antioxidants and neuroprotectors. Sci Rep-UK. 2023;13:15546.

Article  CAS  Google Scholar 

Skrzypek A, Matysiak J, Karpinska M, Czarnecka K, Krecisz P, Stary D, et al. Biological evaluation and molecular docking of novel 1,3,4-thiadiazole-resorcinol conjugates as multifunctional cholinesterases inhibitors. Bioorg Chem. 2021;107:104617.

Article  CAS  PubMed  Google Scholar 

Gul Q, Karim N, Shoaib M, Zahoor M, Rahman MU, Bilal H, et al. Vanillin derivatives as antiamnesic agents in scopolamine-in

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