Chung Kian Fan. Increasing utility of FeNO as a biomarker of type-2 inflammation in severe asthma. Lancet Respiratory Med. 2021;9(10):1083–4.

Article  CAS  Google Scholar 

American Thoracic Society, European Respiratory Society. ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. Am J Respri Crit Med. 2005;171(8):912–30.

Article  Google Scholar 

Dweik RA, Boggs PB, Erzurum SC, Irvin CG, Leigh MW, Lundberg JO, Olin AC, Plummer AL, Taylor. DR. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FeNO) for clinical applications. AM J RESP CRIT CARE. 2011;184(5):602–15.

Article  CAS  Google Scholar 

Bjermer L, Alving K, Diamant Z, Magnussen H, Pavord I, Piacentini G, Price D, Roche N, Sastre J, Thomas M. Usmani, O. current evidence and future research needs for FeNO measurement in respiratory diseases. RESP MED. 2014;108(6):830–41.

Article  Google Scholar 

Global Initiative For Asthma. Global strategy for asthma management and prevention [EB/OL]. [2022-05-04]. http://www.ginasthma.org

Wise J. Use clinical tests to diagnose asthma and to avoid overdiagnosis, says NICE. BMJ. 2015;350:h522.

Article  PubMed  Google Scholar 

Lung Function Cooperation Group, Group R, Branch of Science, Chinese Medical Association. A series of guidelines for pulmonary function and noninvasive airway inflammation in children (7): exhaled nitric oxide monitoring. Clin J Appl Clin Pediatr. 2017;32(21):1622–7.

Google Scholar 

Horváth I, Barnes PJ, Loukides S, Sterk PJ, Högman M, Olin AC, Amann A, Antus B, Baraldi E, Bikov A et al. A European respiratory Society technical standard: exhaled biomarkers in lung disease. EUR RESPIR J, 2017;49 (4).

Paredi P, Kharitonov SA, Meah S, Barnes PJ, Usmani OS. A novel approach to partition central and peripheral airway nitric oxide. Chest. 2014;145(1):113–9.

Article  PubMed  Google Scholar 

You S, Zhang J, Bai Y, Ji L, Wang H. Normal values of nasal NO and exhaled NO in young Chinese people aged 9–22 years. World J Otorhinolaryngol Head Neck Surg. 2016;2(1):22–7.

Article  PubMed  PubMed Central  Google Scholar 

Buchvald F, Baraldi E, Carraro S, Gaston B, De Jongste J, Pijnenburg MW, Silkoff PE, Bisgaard H. Measurements of exhaled nitric oxide in healthy subjects age 4 to 17 years. J ALLERGY CLIN IMMUN. 2005;115(6):1130–6.

Article  PubMed  CAS  Google Scholar 

Malmberg LP, Petäys T, Haahtela T, Laatikainen T, Jousilahti P, Vartiainen E, Mäkelä MJ. Exhaled nitric oxide in healthy nonatopic school-age children: determinants and height-adjusted reference values. PEDIATR PULM. 2006;41(7):635–42.

Article  CAS  Google Scholar 

Kovesi T, Kulka R, Dales R. Exhaled nitric oxide concentration is affected by age, height, and race in healthy 9- to 12-year-old children. Chest. 2007;133(1):169–75.

Article  PubMed  Google Scholar 

Hervás D, Milán JM, Garde J. Differences in exhaled nitric oxide in atopic children. ALLERGOL IMMUNOPATH. 2008;36(6):331–5.

Article  Google Scholar 

Banovcin P, Jesenak M, Michnova Z, Babusikova E, Nosal S, Mikler J, Fabry J. Barreto, M. factors attributable to the level of exhaled nitric oxide in asthmatic children. EUR J MED RES. 2009;14(Suppl 4):9–13.

Article  PubMed  PubMed Central  Google Scholar 

Janahi I, Saadoon A, Tuffaha A, Panneerselvam B. Effects of age, gender, and environmental exposures on exhaled nitric oxide level in healthy 12 to 18 years Qatari children. ANN THORAC MED. 2012;7(2):98–103.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Rouatbi S, Alqodwa A, Ben Mdella S, Saad B. Fraction of exhaled nitric oxide (FeNO) norms in healthy north African children 5–16 years old. PEDIATR PULM. 2012;48(10):981–95.

Article  Google Scholar 

Zhang H, Shu L, Cai X, Wang Z, Jiao X, Liu F, Hou P, Wang L, Shan L, Chen N, et al. Gender and age affect the levels of exhaled nitric oxide in healthy children. EXP THER MED. 2013;5(4):1174–8.

Article  PubMed  PubMed Central  CAS  Google Scholar 

See KC, Christiani DC. Normal values and thresholds for the clinical interpretation of exhaled nitric oxide levels in the US general population: results from the National Health and Nutrition Examination Survey 2007–2010. Chest. 2013;143(1):107–16.

Article  PubMed  Google Scholar 

Menou A, Babeanu D, Paruit HN, Ordureau A, Guillard S, Chambellan A. Normal values of offline exhaled and nasal nitric oxide in healthy children and teens using chemiluminescence. J BREATH RES. 2017;11(3):036008.

Article  PubMed  CAS  Google Scholar 

Paraskakis E, Brindicci C, Fleming L, Krol R, Kharitonov SA, Wilson NM, Barnes PJ, Bush A. Measurement of bronchial and alveolar nitric oxide production in normal children and children with asthma. AM J RESP CRIT CARE. 2006;174(3):260–7.

Article  CAS  Google Scholar 

Sepponen A, Lehtimäki L, Huhtala H, Kaila M, Kankaanranta H, Moilanen E. Alveolar and bronchial nitric oxide output in healthy children. PEDIATR PULM. 2008;43(12):1242–8.

Article  Google Scholar 

Puckett JL, Taylor RW, Leu SY, Guijon OL, Aledia AS, Galant SP. George, SC. Clinical patterns in asthma based on proximal and distal airway nitric oxide categories. Respir Res. 2010;11:47.

Article  PubMed  PubMed Central  Google Scholar 

Linkosalo L, Lehtimäki L, Holm K, Kaila M, Moilanen E. Relation of bronchial and alveolar nitric oxide to exercise-induced bronchoconstriction in atopic children and adolescents. Volume 23. PEDIAT ALLERG IMM-UK; 2011. pp. 360–6. 4.

Corcuera-Elosegui P, Sardón-Prado O, Aldasoro-Ruiz A, Korta-Murua J, Mintegui-Aramburu J, Emparanza-Knorr J, Pérez-Yarza E. Inflammatory patterns in Asthmatic Children based on alveolar nitric. Oxide Determ ARCH BRONCONEUMOL. 2015;51(6):279–84.

Article  Google Scholar 

Högman M, Thornadtsson A, Liv P, Hua-Huy T, Dinh-Xuan AT, Tufvesson E, Dressel H, Janson C, Koskela K, Oksa P, Sauni R, et al. Effects of growth and aging on the reference values of pulmonary nitric oxide dynamics in healthy subjects. J BREATH RES. 2017;11(4):047103.

Article  PubMed  Google Scholar 

Latzin P, Beck J, Griese M. Exhaled nitric oxide in healthy children: variability and a lack of correlation with atopy. Volume 13. PEDIAT ALLERG IMM-UK; 2002. pp. 37–46. 1.

Olin AC, Rosengren A, Thelle DS, Lissner L, Bake B, Toren K. Height, age, and atopy are associated with fraction of exhaled nitric oxide in a large adult general population sample. Chest. 2006;130(5):1319–25.

Article  PubMed  Google Scholar 

Brody DJ, Zhang X, Kit BK, Dillon CF. Reference values and factors associated with exhaled nitric oxide: U.S. youth and adults. Respir Med. 2013;107(11):1682–91.

Article  PubMed  Google Scholar 

Avital A, Uwyyed K, Berkman N, Bar-Yishay E, Godfrey S. Springer, C. exhaled nitric oxide is age-dependent in asthma. PEDIATR PULM. 2003;36(5):433–8.

Article  Google Scholar 

Taylor DR, Mandhane P, Greene JM, Hancox RJ, Filsell S, McLachlan CR, Williamson AJ, Cowan JO, Smith AD. Sears, MR. factors affecting exhaled nitric oxide measurements: the effect of sex. Respir Res. 2007;8:82.

Article  PubMed  PubMed Central  Google Scholar 

Travers J, Marsh S, Aldington S, Williams M, Shirtcliffe P, Pritchard A, Weatherall M, Beasley R. Reference ranges for exhaled nitric oxide derived from a random community survey of adults. AM J RESP CRIT CARE. 2007;176(3):238–42.

Article  CAS  Google Scholar 

Chen X, Liu F, Niu Z, Mao S, Tang H, Li N, Chen G, Liu S, Lu Y, Xiang H. The association between short-term exposure to ambient air pollution and fractional exhaled nitric oxide level: a systematic review and meta-analysis of panel studies. ENVIRON POLLUT. 2020;265:114833. (Pt A).

Article  PubMed  CAS  Google Scholar 

von Mutius E, Schwartz J, Neas LM, Dockery D, Weiss ST. Relation of body mass index to asthma and atopy in children: the National Health and Nutrition Examination Study III. Thorax. 2001;56(11):835–8.

Article  Google Scholar 

Carpio C, Villasante C, Galera R, Romero D, de Cos A, Hernanz A, García-Río F. Systemic inflammation and higher perception of dyspnea mimicking asthma in obese subjects. J ALLERGY CLIN IMMUN. 2016;137(3):718–e264.

Article  PubMed  Google Scholar 

Cetlin AA, Gutierrez MR, Bettiol H, Barbieri MA, Vianna EO. Influence of asthma definition on the asthma-obesity relationship. BMC Public Health, 2012, 12 844.

Leung TF, Li CY, Lam CW, Au CS, Yung E, Chan IH, Wong GW, Fok TF. The relation between obesity and asthmatic airway inflammation. Volume 15. PEDIAT ALLERG IMM-UK; 2004. pp. 344–50. 4.

Lin W, Huang W, Zhu T, Hu M, Brunekreef B, Zhang Y, Liu X, Cheng H, Gehring U, Li C, et al. Acute respiratory inflammation in children and black carbon in ambient air before and during the 2008 Beijing olympics. ENVIRON HEALTH PERSP. 2011;119(10):1507–12.

Article  CAS  Google Scholar 

Feelisch M, Fernandez BO, Bryan NS, Garcia-Saura MF, Bauer S, Whitlock DR, Ford PC, Janero DR, Rodriguez J, Ashrafian H. Tissue processing of nitrite in hypoxia: an intricate interplay of nitric oxide-generating and -scavenging systems. J BIOL CHEM. 2008;283(49):33927–34.

Article  PubMed