Microbes little helpers and suppliers for therapeutic asthma approaches

The Global Asthma Report. Int J Tuberc Lung Dis 2022;26:S1-S102.

Kemp A: First and only biologic approved in the EU in patients with severe asthma with no phenotype or biomarker limitations. https://www.astrazeneca.com/media-centre/press-releases/2022/tezspire-approved-in-the-eu-for-the-treatment-of-severe-asthma.html#:~:text=Tezspire%20is%20the%20first%20and,TSLP)%2C%20an%20epithelial%20cytokine. 2022. Accessed 10 Jan 2024.

Shevyrev D, Tereshchenko V. Treg heterogeneity, function, and homeostasis. Front Immunol. 2020;10:3100.

Article  PubMed  PubMed Central  Google Scholar 

Dehzad N, Bopp T, Reuter S, Klein M, Martin H, Ulges A, et al. Regulatory T cells more effectively suppress Th1-induced airway inflammation compared with Th2. J Immunol. 2011;186:2238–44.

Article  CAS  PubMed  Google Scholar 

Martin H, Reuter S, Dehzad N, Heinz A, Bellinghausen I, Saloga J, et al. CD4-mediated regulatory T-cell activation inhibits the development of disease in a humanized mouse model of allergic airway disease. J Allergy Clin Immunol. 2012;129:521-528.e7.

Article  CAS  PubMed  Google Scholar 

Jartti T, Bønnelykke K, Elenius V, Feleszko W. Role of viruses in asthma. Semin Immunopathol. 2020;42:61–74.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Strachan DP. Hay fever, hygiene, and household size. BMJ. 1989;299:1259–60.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sender R, Fuchs S, Milo R. Revised estimates for the number of human and bacteria cells in the body. PLoS Biol. 2016;14: e1002533.

Article  PubMed  PubMed Central  Google Scholar 

Belkaid Y, Hand TW. Role of the microbiota in immunity and inflammation. Cell. 2014;157:121–41.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Iacob S, Iacob DG, Luminos LM. Intestinal microbiota as a host defense mechanism to infectious threats. Front Microbiol. 2018;9:3328.

Article  PubMed  Google Scholar 

Asnicar F, Berry SE, Valdes AM, Nguyen LH, Piccinno G, Drew DA, et al. Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals. Nat Med. 2021;27:321–32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bäckhed F, Ding H, Wang T, Hooper LV, Koh GY, Nagy A, et al. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A. 2004;101:15718–23.

Article  PubMed  PubMed Central  Google Scholar 

Rowland I, Gibson G, Heinken A, Scott K, Swann J, Thiele I, et al. Gut microbiota functions: metabolism of nutrients and other food components. Eur J Nutr. 2018;57:1–24.

Article  CAS  PubMed  Google Scholar 

Morais LH, Schreiber HL IV, Mazmanian SK. The gut microbiota–brain axis in behaviour and brain disorders. Nat Rev Microbiol. 2021;19:241–55.

Article  CAS  PubMed  Google Scholar 

Schroeder BO, Bäckhed F. Signals from the gut microbiota to distant organs in physiology and disease. Nat Med. 2016;22:1079–89.

Article  CAS  PubMed  Google Scholar 

Mills S, Shanahan F, Stanton C, Hill C, Coffey A, Ross RP. Movers and shakers. Gut Microbes. 2013;4:4–16.

Article  PubMed  PubMed Central  Google Scholar 

Citorik RJ, Mimee M, Lu TK. Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases. Nat Biotechnol. 2014;32:1141–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu SX, Li YH, Dai WK, Li XS, Qiu CZ, Ruan ML, et al. Fecal microbiota transplantation induces remission of infantile allergic colitis through gut microbiota re-establishment. World J Gastroenterol. 2017;23:8570–81.

Article  PubMed  PubMed Central  Google Scholar 

Hwang IY, Koh E, Wong A, March JC, Bentley WE, Lee YS, et al. Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models. Nat Commun. 2017;8:15028.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Börner RA, Kandasamy V, Axelsen AM, Nielsen AT, Bosma EF. Genome editing of lactic acid bacteria: opportunities for food, feed, pharma and biotech. FEMS Microbiol Lett. 2019. https://doi.org/10.1093/femsle/fny291.

Article  PubMed  Google Scholar 

Turnbaugh PJ, Ley RE, Hamady M, Fraser-Liggett CM, Knight R, Gordon JI. The human microbiome project. Nature. 2007;449:804–10.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Segal LN, Alekseyenko AV, Clemente JC, Kulkarni R, Wu B, Chen H, et al. Enrichment of lung microbiome with supraglottic taxa is associated with increased pulmonary inflammation. Microbiome. 2013;1:19.

Article  PubMed  PubMed Central  Google Scholar 

Charlson ES, Bittinger K, Haas AR, Fitzgerald AS, Frank I, Yadav A, et al. Topographical continuity of bacterial populations in the healthy human respiratory tract. Am J Respir Crit Care Med. 2011;184:957–63.

Article  PubMed  PubMed Central  Google Scholar 

Noval Rivas M, Crother TR, Arditi M. The microbiome in asthma. Curr Opin Pediatr. 2016;28:764–71.

Article  CAS  PubMed  Google Scholar 

Dickson RP, Erb-Downward JR, Freeman CM, McCloskey L, Falkowski NR, Huffnagle GB, et al. Bacterial topography of the healthy human lower respiratory tract. MBio. 2017;8:e02287-e2316.

Article  PubMed  PubMed Central  Google Scholar 

Hilty M, Burke C, Pedro H, Cardenas P, Bush A, Bossley C, et al. Disordered microbial communities in asthmatic airways. PLoS ONE. 2010;5: e8578.

Article  PubMed  PubMed Central  Google Scholar 

Pang Z, Wang G, Gibson P, Guan X, Zhang W, Zheng R, et al. Airway microbiome in different inflammatory phenotypes of asthma: a cross-sectional study in Northeast China. Int J Med Sci. 2019;16:477–85.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Proctor LM, Creasy HH, Fettweis JM, Lloyd-Price J, Mahurkar A, Zhou W, et al. The integrative human microbiome project. Nature. 2019;569:641–8.

Article  Google Scholar 

Pérez-Losada M, Authelet KJ, Hoptay CE, Kwak C, Crandall KA, Freishtat RJ. Pediatric asthma comprises different phenotypic clusters with unique nasal microbiotas. Microbiome. 2018;6:179.

Article  PubMed  PubMed Central  Google Scholar 

Santee CA, Nagalingam NA, Faruqi AA, DeMuri GP, Gern JE, Wald ER, et al. Nasopharyngeal microbiota composition of children is related to the frequency of upper respiratory infection and acute sinusitis. Microbiome. 2016. https://doi.org/10.1186/s40168-016-0179-9.

Article  PubMed  PubMed Central  Google Scholar 

Abdel-Aziz MI, Thorsen J, Hashimoto S, Vijverberg SJH, Neerincx AH, Brinkman P, et al. Oropharyngeal microbiota clusters in children with asthma or wheeze associate with allergy, blood transcriptomic immune pathways, and exacerbation risk. Am J Respir Crit Care Med. 2023;208:142–54.

Article  CAS  PubMed  Google Scholar 

Marian GN, Laura M, Xavier P, Rafaela F, Vicente PB, Miguel G, et al. Severity-related changes of bronchial microbiome in chronic obstructive pulmonary disease. J Clin Microbiol. 2014;52:4217–23.

Article  Google Scholar 

Boutin S, Graeber SY, Weitnauer M, Panitz J, Stahl M, Clausznitzer D, et al. Comparison of microbiomes from different niches of upper and lower airways in children and adolescents with cystic fibrosis. PLoS ONE. 2015;10: e0116029.

Article  PubMed  PubMed Central  Google Scholar 

Herbst T, Sichelstiel A, Schär C, Yadava K, Bürki K, Cahenzli J, et al. Dysregulation of allergic airway inflammation in the absence of microbial colonization. Am J Respir Crit Care Med. 2011;184:198–205.

Article  CAS  PubMed  Google Scholar 

Russell SL, Gold MJ, Hartmann M, Willing BP, Thorson L, Wlodarska M, et al. Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma. EMBO Rep. 2012;13:440–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Russell SL, Gold MJ, Willing BP, Thorson L, McNagny KM, Finlay BB. Perinatal antibiotic treatment affects murine microbiota, immune responses and allergic asthma. Gut Microbes. 2013;4:158–64.

Article  PubMed  PubMed Central  Google Scholar 

Borbet TC, Pawline MB, Zhang X, Wipperman MF, Reuter S, Maher T, et al. Influence of the early-life gut microbiota on the immune responses to an inhaled allergen. Mucosal Immunol. 2022;15:1000.

Article  CAS  PubMed  PubMed Central 

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