PTK2-associated gene signature could predict the prognosis of IPF

American Thoracic Society. Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement. American Thoracic Society (ATS), and the European Respiratory Society (ERS). Am J Respir Crit Care Med. 2000;161(2 Pt 1):646–664.

Maher TM, Wells AU, Laurent GJ. Idiopathic pulmonary fibrosis: multiple causes and multiple mechanisms? Eur Respir J. 2007;30(5):835–9.

Article  CAS  PubMed  Google Scholar 

Blackwell TS, Tager AM, Borok Z, Moore BB, Schwartz DA, Anstrom KJ, Bar-Joseph Z, Bitterman P, Blackburn MR, Bradford W, et al. Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report. Am J Respir Crit Care Med. 2014;189(2):214–22.

Article  PubMed  PubMed Central  Google Scholar 

King TE Jr, Tooze JA, Schwarz MI, Brown KR, Cherniack RM. Predicting survival in idiopathic pulmonary fibrosis: scoring system and survival model. Am J Respir Crit Care Med. 2001;164(7):1171–81.

Article  PubMed  Google Scholar 

Rosas IO, Ren P, Avila NA, Chow CK, Franks TJ, Travis WD, McCoy JP Jr, May RM, Wu HP, Nguyen DM, et al. Early interstitial lung disease in familial pulmonary fibrosis. Am J Respir Crit Care Med. 2007;176(7):698–705.

Article  PubMed  PubMed Central  Google Scholar 

Salisbury ML, Xia M, Zhou Y, Murray S, Tayob N, Brown KK, Wells AU, Schmidt SL, Martinez FJ, Flaherty KR. Idiopathic pulmonary fibrosis: gender-age-physiology index stage for predicting future lung function decline. Chest. 2016;149(2):491–8.

Article  PubMed  PubMed Central  Google Scholar 

Konishi S, Arita M, Ito I, Tachibana H, Takaiwa T, Fukuda Y, Watanabe N, Tsubouchi K, Masuda G, Tanaka M, et al. Composite physiologic index, percent forced vital capacity and percent diffusing capacity for carbon monoxide could be predictors of pirfenidone tolerability in patients with idiopathic pulmonary fibrosis. Intern Med. 2015;54(22):2835–41.

Article  CAS  PubMed  Google Scholar 

Guiot J, Moermans C, Henket M, Corhay JL, Louis R. Blood biomarkers in idiopathic pulmonary fibrosis. Lung. 2017;195(3):273–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tatler AL, Jenkins G. TGF-beta activation and lung fibrosis. Proc Am Thorac Soc. 2012;9(3):130–6.

Article  CAS  PubMed  Google Scholar 

Desmouliere A, Geinoz A, Gabbiani F, Gabbiani G. Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J Cell Biol. 1993;122(1):103–11.

Article  CAS  PubMed  Google Scholar 

Phan SH. The myofibroblast in pulmonary fibrosis. Chest. 2002;122(6 Suppl):286S-289S.

Article  PubMed  Google Scholar 

Peng X, Kraus MS, Wei H, Shen TL, Pariaut R, Alcaraz A, Ji G, Cheng L, Yang Q, Kotlikoff MI, et al. Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice. J Clin Invest. 2006;116(1):217–27.

Article  CAS  PubMed  Google Scholar 

Zhang J, Fan G, Zhao H, Wang Z, Li F, Zhang P, Zhang J, Wang X, Wang W. Targeted inhibition of focal adhesion kinase attenuates cardiac fibrosis and preserves heart function in adverse cardiac remodeling. Sci Rep. 2017;7:43146.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kinoshita K, Aono Y, Azuma M, Kishi J, Takezaki A, Kishi M, Makino H, Okazaki H, Uehara H, Izumi K, et al. Antifibrotic effects of focal adhesion kinase inhibitor in bleomycin-induced pulmonary fibrosis in mice. Am J Respir Cell Mol Biol. 2013;49(4):536–43.

Article  CAS  PubMed  Google Scholar 

Yu WK, Chen WC, Su VY, Shen HC, Wu HH, Chen H, Yang KY. Nintedanib inhibits endothelial mesenchymal transition in bleomycin-induced pulmonary fibrosis via focal adhesion kinase activity reduction. Int J Mol Sci. 2022;23(15):8193.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tepede A, Yogaratnam D. Nintedanib for idiopathic pulmonary fibrosis. J Pharm Pract. 2019;32(2):199–206.

Article  PubMed  Google Scholar 

Meltzer EB, Barry WT, D’Amico TA, Davis RD, Lin SS, Onaitis MW, Morrison LD, Sporn TA, Steele MP, Noble PW. Bayesian probit regression model for the diagnosis of pulmonary fibrosis: proof-of-principle. BMC Med Genomics. 2011;4:70.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cecchini MJ, Hosein K, Howlett CJ, Joseph M, Mura M. Comprehensive gene expression profiling identifies distinct and overlapping transcriptional profiles in non-specific interstitial pneumonia and idiopathic pulmonary fibrosis. Respir Res. 2018;19(1):153.

Article  PubMed  PubMed Central  Google Scholar 

DePianto DJ, Chandriani S, Abbas AR, Jia G, N’Diaye EN, Caplazi P, Kauder SE, Biswas S, Karnik SK, Ha C, et al. Heterogeneous gene expression signatures correspond to distinct lung pathologies and biomarkers of disease severity in idiopathic pulmonary fibrosis. Thorax. 2015;70(1):48–56.

Article  PubMed  Google Scholar 

Huang Y, Ma SF, Vij R, Oldham JM, Herazo-Maya J, Broderick SM, Strek ME, White SR, Hogarth DK, Sandbo NK, et al. A functional genomic model for predicting prognosis in idiopathic pulmonary fibrosis. BMC Pulm Med. 2015;15:147.

Article  PubMed  PubMed Central  Google Scholar 

Molyneaux PL, Willis-Owen SAG, Cox MJ, James P, Cowman S, Loebinger M, Blanchard A, Edwards LM, Stock C, Daccord C, et al. Host-microbial interactions in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2017;195(12):1640–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Herazo-Maya JD, Noth I, Duncan SR, Kim S, Ma SF, Tseng GC, Feingold E, Juan-Guardela BM, Richards TJ, Lussier Y, et al. Peripheral blood mononuclear cell gene expression profiles predict poor outcome in idiopathic pulmonary fibrosis. Sci Transl Med. 2013;5(205): 205ra136.

Article  PubMed  PubMed Central  Google Scholar 

Hunninghake GW, Gadek JE, Lawley TJ, Crystal RG. Mechanisms of neutrophil accumulation in the lungs of patients with idiopathic pulmonary fibrosis. J Clin Invest. 1981;68(1):259–69.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nuovo GJ, Hagood JS, Magro CM, Chin N, Kapil R, Davis L, Marsh CB, Folcik VA. The distribution of immunomodulatory cells in the lungs of patients with idiopathic pulmonary fibrosis. Mod Pathol. 2012;25(3):416–33.

Article  CAS  PubMed  Google Scholar 

Mercer PF, Chambers RC. Innate immune signaling and stem cell renewal in idiopathic pulmonary fibrosis. Nat Med. 2016;22(11):1210–2.

Article  CAS  PubMed  Google Scholar 

O’Dwyer DN, Armstrong ME, Trujillo G, Cooke G, Keane MP, Fallon PG, Simpson AJ, Millar AB, McGrath EE, Whyte MK, et al. The Toll-like receptor 3 L412F polymorphism and disease progression in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2013;188(12):1442–50.

Article  CAS  PubMed  Google Scholar 

Gilani SR, Vuga LJ, Lindell KO, Gibson KF, Xue J, Kaminski N, Valentine VG, Lindsay EK, George MP, Steele C, et al. CD28 down-regulation on circulating CD4 T-cells is associated with poor prognoses of patients with idiopathic pulmonary fibrosis. PLoS ONE. 2010;5(1): e8959.

Article  PubMed  PubMed Central  Google Scholar 

Bray F, Ferlay J, Laversanne M, Brewster DH, Gombe Mbalawa C, Kohler B, Pineros M, Steliarova-Foucher E, Swaminathan R, Antoni S, et al. Cancer incidence in five continents: inclusion criteria, highlights from Volume X and the global status of cancer registration. Int J Cancer. 2015;137(9):2060–71.

Article  CAS  PubMed  Google Scholar 

Hutchinson J, Fogarty A, Hubbard R, McKeever T. Global incidence and mortality of idiopathic pulmonary fibrosis: a systematic review. Eur Respir J. 2015;46(3):795–806.

Article  PubMed  Google Scholar 

Herazo-Maya JD, Sun J, Molyneaux PL, Li Q, Villalba JA, Tzouvelekis A, Lynn H, Juan-Guardela BM, Risquez C, Osorio JC, et al. Validation of a 52-gene risk profile for outcome prediction in patients with idiopathic pulmonary fibrosis: an international, multicentre, cohort study. Lancet Respir Med. 2017;5(11):857–68.

Article  PubMed  PubMed Central  Google Scholar 

Juan Guardela BM, Sun J, Zhang T, Xu B, Balnis J, Huang Y, Ma SF, Molyneaux PL, Maher TM, Noth I, et al. 50-gene risk profiles in peripheral blood predict COVID-19 outcomes: a retrospective, multicenter cohort study. EBioMedicine. 2021;69: 103439.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou Y, Huang X, Hecker L, Kurundkar D, Kurundkar A, Liu H, Jin TH, Desai L, Bernard K, Thannickal VJ. Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis. J Clin Invest. 2013;123(3):1096–108.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu F, Mih JD, Shea BS, Kho AT, Sharif AS, Tager AM, Tschumperlin DJ. Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression. J Cell Biol. 2010;190(4):693–706.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang X, Yang N, Fiore VF, Barker TH, Sun Y, Morris SW, Ding Q, Thannickal VJ, Zhou Y. Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransduction. Am J Respir Cell Mol Biol. 2012;47(3):340–8.

Article  CAS  PubMed  PubMed Central 

Comments (0)

No login
gif