The malignant transformation of an atypical angiocentric glioma, MYB-altered

Bandopadhayay P, Ramkissoon LA, Jain P, Bergthold G, Wala J, Zeid R et al (2016) MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism. Nat Genet 48:273–282

CAS  PubMed  PubMed Central  Google Scholar 

Tatevossian RG, Tang B, Dalton J, Forshew T, Lawson AR, Ma J et al (2010) MYB upregulation and genetic aberrations in a subset of pediatric low-grade gliomas. Acta Neuropathol 120:731–743

PubMed  PubMed Central  Google Scholar 

Ramkissoon LA, Horowitz PM, Craig JM, Ramkissoon SH, Rich BE, Schumacher SE et al (2013) Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1. Proc Natl Acad Sci USA 110:8188–8193

CAS  PubMed  PubMed Central  Google Scholar 

Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D et al (2021) The 2021 WHO classification of tumors of the central nervous system: a summary. Neuro Oncol 23:1231–1251

CAS  PubMed  PubMed Central  Google Scholar 

Li JY, Langford LA, Adesina A, Bodhireddy SR, Wang M, Fuller GN (2012) The high mitotic count detected by phospho-histone H3 immunostain does not alter the benign behavior of angiocentric glioma. Brain Tumor Pathol 29:68–72

PubMed  Google Scholar 

Kuncman W, Braun M, Kuncman Ł, Kupnicki P, Piotrowski M, Jesionek-Kupnicka D et al (2018) A malignant astrocytoma with uncommon angiocentric features and dot-like EMA expression. Contemp Oncol (Pozn) 22:205–208

PubMed  Google Scholar 

McCracken JA, Gonzales MF, Phal PM, Drummond KJ (2016) Angiocentric glioma transformed into anaplastic ependymoma: review of the evidence for malignant potential. J Clin Neurosci 34:47–52

PubMed  Google Scholar 

Miyahara H, Toyoshima Y, Natsumeda M, Uzuka T, Aoki H, Nakayama Y et al (2011) Anaplastic astrocytoma with angiocentric ependymal differentiation. Neuropathology 31:292–298

PubMed  Google Scholar 

Aguilar HN, Hung RW, Mehta V, Kotylak T (2012) Imaging characteristics of an unusual, high-grade angiocentric glioma: a case report and review of the literature. J Radiol Case Rep 6:1–10

PubMed  PubMed Central  Google Scholar 

Wefers AK, Stichel D, Schrimpf D, Coras R, Pages M, Tauziède-Espariat A et al (2020) Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course. Acta Neuropathol 139:193–209

PubMed  Google Scholar 

Suh YY, Lee K, Shim Y-M, Phi JH, Park C-K, Kim S-K et al (2023) MYB/MYBL1::QKI fusion-positive diffuse glioma. J Neuropathol Exp Neurol 82:250–260

PubMed  PubMed Central  Google Scholar 

Moreira DC, Qaddoumi I, Spiller S, Bouldin TW, Davidson A, Saba-Silva N, Chiang J (2024) Comprehensive analysis of MYB/MYBL1-altered pediatric-type diffuse low-grade glioma. Neuro Oncol 26(7):1327–1334

CAS  PubMed  PubMed Central  Google Scholar 

Chiang J, Harreld JH, Tinkle CL, Moreira DC, Li X, Acharya S et al (2019) A single-center study of the clinicopathologic correlates of gliomas with a MYB or MYBL1 alteration. Acta Neuropathol 138:1091–1092

CAS  PubMed  PubMed Central  Google Scholar 

Trkova K, Sumerauer D, Krskova L, Vicha A, Koblizek M, Votava T et al (2023) DIPG-like MYB-altered diffuse astrocytoma with durable response to intensive chemotherapy. Childs Nerv Syst 39:2509–2513

PubMed  PubMed Central  Google Scholar 

Reisz Z, Radics BL, Nemes P, Laxton R, Kaizer L, Gabor KM et al (2023) Case report: brainstem angiocentric glioma presenting in a toddler child-diagnostic and therapeutic challenges. Pathol Oncol Res 29:1611231

PubMed  PubMed Central  Google Scholar 

Lake JA, Donson AM, Prince E, Davies KD, Nellan A, Green AL et al (2020) Targeted fusion analysis can aid in the classification and treatment of pediatric glioma, ependymoma, and glioneuronal tumors. Pediatr Blood Cancer 67:e28028

CAS  PubMed  Google Scholar 

D’Aronco L, Rouleau C, Gayden T, Crevier L, Décarie J-C, Perreault S et al (2017) Brainstem angiocentric gliomas with MYB-QKI rearrangements. Acta Neuropathol 134:667–669

PubMed  PubMed Central  Google Scholar 

Nikolaus M, Koch A, Stenzel W, Elezkurtaj S, Sahm F, Tietze A et al (2022) Atypical NMDA receptor expression in a diffuse astrocytoma, MYB- or MYBL1-altered as a trigger for autoimmune encephalitis. Acta Neuropathol 144:385–389

CAS  PubMed  PubMed Central  Google Scholar 

Appay R, Tauziède-Espariat A, Silva K, Fritih R, Scavarda D, Delteil C et al (2021) Low grade glioma with MYBL1 alteration: case report of an uncommon pediatric neoplasm. Ann Pathol 41:129–133

PubMed  Google Scholar 

Lu J-Q, Patel S, Wilson BA, Pugh J, Mehta V (2013) Malignant glioma with angiocentric features. J Neurosurg Pediatr 11:350–355

PubMed  Google Scholar 

Comments (0)

No login
gif