Leung DW, Cachianes G, Kuang W-J, Goeddel DV, Ferrara N (1989) Vascular endothelial growth factor is a secreted Angiogenic Mitogen. Science 246(4935):1306–1309
Article CAS PubMed Google Scholar
Carmeliet P, Jain RK (2011) Molecular mechanisms and clinical applications of angiogenesis. Nature 473(7347):298–307. https://doi.org/10.1038/nature10144
Article CAS PubMed PubMed Central Google Scholar
Shibuya M, Yamaguchi S, Yamane A, Ikeda T, Tojo A, Matsushime H, Sato M (1990) Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family. Oncogene 5(4):519–524
Terman BI, Carrion ME, Kovacs E, Rasmussen BA, Eddy RL, Shows TB (1991) Identification of a new endothelial cell growth factor receptor tyrosine kinase. Oncogene 6(9):1677–1683
Aprelikova O, Pajusola K, Partanen J, Armstrong E, Alitalo R, Bailey SK, McMahon J, Wasmuth J, Huebner K, Alitalo K (1992) FLT4, a Novel Class III receptor tyrosine kinase in chromosome 5q33-qter1. Cancer Res 52(3):746–748
Shibuya M (2001) Structure and dual function of vascular endothelial growth factor receptor-1 (Flt-1). Int J Biochem Cell Biol 33(4):409–420. https://doi.org/10.1016/s1357-2725(01)00026-7
Article CAS PubMed Google Scholar
Iljin K, Karkkainen MJ, Lawrence EC, Kimak MA, Uutela M, Taipale J, Pajusola K, Alhonen L, HalmekytÖ M, Finegold DN, Ferrell RE, Alitalo K (2001) VEGFR3 gene structure, regulatory region, and sequence polymorphisms. FASEB J 15(6):1028–1034. https://doi.org/10.1096/fsb2fj000383com
Article CAS PubMed Google Scholar
Wang XR, Bove A, Ma B (2020) Molecular bases of VEGFR-2-Mediated physiological function and pathological role. Front Cell Dev Biology 8. https://doi.org/10.3389/fcell.2020.599281
Shalaby F, Rossant J, Yamaguchi TP, Gertsenstein M, Wu XF, Breitman ML, Schuh AC (1995) Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature 376(6535):62–66. https://doi.org/10.1038/376062a0
Article CAS PubMed Google Scholar
Fong G-H, Rossant J, Gertsenstein M, Breitman ML (1995) Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 376(6535):66–70. https://doi.org/10.1038/376066a0
Article CAS PubMed Google Scholar
Salmeri M, Motta C, Anfuso CD, Amodeo A, Scalia M, Toscano MA, Alberghina M, Lupo G (2013) VEGF receptor-1 involvement in pericyte loss induced by scherichia coli in an in vitro model of blood brain barrier. Cell Microbiol 15(8):1367–1384. https://doi.org/10.1111/cmi.12121
Article CAS PubMed Google Scholar
Ebos JML, Bocci G, Man S, Thorpe PE, Hicklin DJ, Zhou D, Jia X, Kerbel RS (2004) A naturally occurring Soluble Form of Vascular endothelial growth factor receptor 2 detected in mouse and human Plasma1. Mol Cancer Res 2(6):315–326. https://doi.org/10.1158/1541-7786.315.2.6
Article CAS PubMed Google Scholar
Singh N, Tiem M, Watkins R, Cho YK, Wang Y, Olsen T, Uehara H, Mamalis C, Luo L, Oakey Z, Ambati BK (2013) Soluble vascular endothelial growth factor receptor 3 is essential for corneal alymphaticity. Blood 121(20):4242–4249. https://doi.org/10.1182/blood-2012-08-453043
Article CAS PubMed PubMed Central Google Scholar
Kendall RL, Thomas KA (1993) Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor. Proceedings of the National Academy of Sciences 90 (22):10705–10709
Heydarian M, McCaffrey T, Florea L, Yang Z, Ross MM, Zhou W, Maynard SE (2009) Novel splice variants of sFlt1 are upregulated in preeclampsia. Placenta 30(3):250–255. https://doi.org/10.1016/j.placenta.2008.12.010
Article CAS PubMed Google Scholar
Kendall RL, Wang G, Thomas KA (1996) Identification of a natural soluble form of the vascular endothelial growth factor receptor, FLT-1, and its heterodimerization with KDR. Biochem Biophys Res Commun 226(2):324–328. https://doi.org/10.1006/bbrc.1996.1355
Article CAS PubMed Google Scholar
Michaelson IC (1948) The mode of development of the vascular system of the retina, with some observations on its significance for certain retinal diseases. In
Senger DR, Galli SJ, Dvorak AM, Perruzzi CA, Harvey VS, Dvorak HF (1983) Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 219(4587):983–985. https://doi.org/10.1126/science.6823562
Article CAS PubMed Google Scholar
Thomas CP, Andrews JI, Liu KZ (2007) Intronic polyadenylation signal sequences and alternate splicing generate human soluble fltl variants and regulate the abundance of soluble Flt1 in the placenta. FASEB J 21(14):3885–3895. https://doi.org/10.1096/fj.07-8809com
Article CAS PubMed Google Scholar
Shibuya M (2011) Vascular endothelial growth factor (VEGF) and its receptor (VEGFR) signaling in angiogenesis:a crucial target for Anti- and pro-angiogenic therapies. Genes Cancer 2(12):1097–1105. https://doi.org/10.1177/1947601911423031
Article CAS PubMed PubMed Central Google Scholar
Wakiya K, Begue A, Stehelin D, Shibuya M (1996) A cAMP response element and an ets Motif are involved in the transcriptional regulation of < em > flt-1 tyrosine kinase (vascular endothelial growth factor receptor 1) gene *. J Biol Chem 271(48):30823–30828. https://doi.org/10.1074/jbc.271.48.30823
Article CAS PubMed Google Scholar
Chappell JC, Taylor SM, Ferrara N, Bautch VL (2009) Local Guidance of emerging Vessel Sprouts requires Soluble Flt-1. Dev Cell 17(3):377–386. https://doi.org/10.1016/j.devcel.2009.07.011
Article CAS PubMed PubMed Central Google Scholar
Rahimi N (2006) VEGFR-1 and VEGFR-2: two non-identical twins with a unique physiognomy. Front Bioscience: J Virtual Libr 11:818
Shinkai A, Ito M, Anazawa H, Yamaguchi S, Shitara K, Shibuya M (1998) Mapping of the sites involved in Ligand Association and Dissociation at the Extracellular Domain of the kinase insert domain-containing receptor for vascular endothelial growth factor *. J Biol Chem 273(47):31283–31288. https://doi.org/10.1074/jbc.273.47.31283
Article CAS PubMed Google Scholar
Byrne AM, Bouchier-Hayes DJ, Harmey JH (2005) Angiogenic and cell survival functions of vascular endothelial growth factor (VEGF). J Cell Mol Med 9(4):777–794. https://doi.org/10.1111/j.1582-4934.2005.tb00379.x
Article CAS PubMed PubMed Central Google Scholar
Hyde CAC, Giese A, Stuttfeld E, Saliba JA, Villemagne D, Schleier T, Binz HK, Ballmer-Hofer K (2012) Targeting Extracellular domains D4 and D7 of vascular endothelial growth factor receptor 2 reveals allosteric receptor Regulatory sites. Mol Cell Biol 32(19):3802–3813. https://doi.org/10.1128/MCB.06787-11
Article CAS PubMed PubMed Central Google Scholar
Di Stasi R, Diana D, De Rosa L, Fattorusso R, D’Andrea LD (2019) Biochemical and conformational characterization of recombinant VEGFR2 domain 7. Mol Biotechnol 61(11):860–872. https://doi.org/10.1007/s12033-019-00211-4
Article CAS PubMed Google Scholar
Gille H, Kowalski J, Yu L, Chen H, Pisabarro MT, Davis-Smyth T, Ferrara N (2000) A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3′-kinase activation and endothelial cell migration. EMBO J 19(15):4064–4073. https://doi.org/10.1093/emboj/19.15.4064
Article CAS PubMed PubMed Central Google Scholar
Hiratsuka S, Minowa O, Kuno J, Noda T, Shibuya M (1998) Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice. Proc Natl Acad Sci U S A 95(16):9349–9354. https://doi.org/10.1073/pnas.95.16.9349
Comments (0)