Teblick A, Gunst J, Langouche L, Van den Berghe G (2022) Novel insights in endocrine and metabolic pathways in sepsis and gaps for future research. Clin Sci 136(11):861–878

Article  CAS  Google Scholar 

Vanhorebeek I, Latronico N, Van den Berghe G (2020) ICU-acquired weakness. Intensive Care Med 46(4):637–653

Article  PubMed  PubMed Central  Google Scholar 

Gunst J, Casaer MP, Preiser JC, Reignier J, Van den Berghe G (2023) Toward nutrition improving outcome of critically ill patients: how to interpret recent feeding RCTs? Crit Care 27(1):43

Article  PubMed  PubMed Central  Google Scholar 

Gunst J, De Bruyn A, Van den Berghe G (2019) Glucose control in the ICU. Curr Opin Anaesthesiol 32(2):156–162

Article  PubMed  PubMed Central  Google Scholar 

Preiser JC, van Zanten AR, Berger MM, Biolo G, Casaer MP, Doig GS, Griffiths RD, Heyland DK, Hiesmayr M, Iapichino G et al (2015) Metabolic and nutritional support of critically ill patients: consensus and controversies. Crit Care 19:35

Article  PubMed  PubMed Central  Google Scholar 

Hofmaenner DA, Arina P, Kleyman A, Page Black L, Salomao R, Tanaka S, Guirgis FW, Arulkumaran N, Singer M (2023) Association between hypocholesterolemia and mortality in critically ill patients with sepsis: a systematic review and meta-analysis. Crit Care Explor 5(2):e0860

Article  PubMed  PubMed Central  Google Scholar 

Nogueira AC, Kawabata V, Biselli P, Lins MH, Valeri C, Seckler M, Hoshino W, Junior LG, Bernik MM, de Andrade Machado JB et al (2008) Changes in plasma free fatty acid levels in septic patients are associated with cardiac damage and reduction in heart rate variability. Shock 29(3):342–348

Article  CAS  PubMed  Google Scholar 

Mesotten D, Swinnen JV, Vanderhoydonc F, Wouters PJ, Van den Berghe G (2004) Contribution of circulating lipids to the improved outcome of critical illness by glycemic control with intensive insulin therapy. J Clin Endocrinol Metab 89(1):219–226

Article  CAS  PubMed  Google Scholar 

Lind L, Lithell H (1994) Impaired glucose and lipid metabolism seen in intensive care patients is related to severity of illness and survival. Clin Intensive Care 5(3):100–105

CAS  PubMed  Google Scholar 

Tanaka S, Labreuche J, Drumez E, Harrois A, Hamada S, Vigue B, Couret D, Duranteau J, Meilhac O (2017) Low HDL levels in sepsis versus trauma patients in intensive care unit. Ann Intensive Care 7(1):60

Article  PubMed  PubMed Central  Google Scholar 

Chiarla C, Giovannini I, Giuliante F, Zadak Z, Vellone M, Ardito F, Clemente G, Murazio M, Nuzzo G (2010) Severe hypocholesterolemia in surgical patients, sepsis, and critical illness. J Crit Care 25(2):361

Article  Google Scholar 

Coombes EJ, Shakespeare PG, Batstone GF (1980) Lipoprotein changes after burn injury in man. J Trauma 20(11):971–975

Article  CAS  PubMed  Google Scholar 

Giovannini I, Boldrini G, Chiarla C, Giuliante F, Vellone M, Nuzzo G (1999) Pathophysiologic correlates of hypocholesterolemia in critically ill surgical patients. Intensive Care Med 25(7):748–751

Article  CAS  PubMed  Google Scholar 

Gordon BR, Parker TS, Levine DM, Saal SD, Wang JC, Sloan BJ, Barie PS, Rubin AL (2001) Relationship of hypolipidemia to cytokine concentrations and outcomes in critically ill surgical patients. Crit Care Med 29(8):1563–1568

Article  CAS  PubMed  Google Scholar 

Bakalar B, Hyspler R, Pachl J, Zadak Z (2003) Changes in cholesterol and its precursors during the first days after major trauma. Wien Klin Wochenschr 115(21–22):775–779

Article  CAS  PubMed  Google Scholar 

Ilias I, Vassiliadi DA, Theodorakopoulou M, Boutati E, Maratou E, Mitrou P, Nikitas N, Apollonatou S, Dimitriadis G, Armaganidis A et al (2014) Adipose tissue lipolysis and circulating lipids in acute and subacute critical illness: effects of shock and treatment. J Crit Care 29:1130

Article  Google Scholar 

Dimopoulou I, Nikitas N, Orfanos SE, Theodorakopoulou M, Vassiliadi D, Ilias I, Ikonomidis I, Boutati E, Maratou E, Tsangaris I et al (2011) Kinetics of adipose tissue microdialysis-derived metabolites in critically ill septic patients: associations with sepsis severity and clinical outcome. Shock 35(4):343–348

Article  CAS  PubMed  Google Scholar 

Dunham CM, Fealk MH, Sever WE 3rd (2003) Following severe injury, hypocholesterolemia improves with convalescence but persists with organ failure or onset of infection. Crit Care 7(6):R145-153

Article  PubMed  PubMed Central  Google Scholar 

van Leeuwen HJ, Heezius EC, Dallinga GM, van Strijp JA, Verhoef J, van Kessel KP (2003) Lipoprotein metabolism in patients with severe sepsis. Crit Care Med 31(5):1359–1366

Article  PubMed  Google Scholar 

Goossens C, Weckx R, Derde S, Vander Perre S, Derese I, Van Veldhoven PP, Ghesquiere B, Van den Berghe G, Langouche L (2021) Altered cholesterol homeostasis in critical illness-induced muscle weakness: effect of exogenous 3-hydroxybutyrate. Crit Care 25(1):252

Article  PubMed  PubMed Central  Google Scholar 

Jafurulla M, Chattopadhyay A (2013) Membrane lipids in the function of serotonin and adrenergic receptors. Curr Med Chem 20(1):47–55

Article  CAS  PubMed  Google Scholar 

Dunser MW, Ruokonen E, Pettila V, Ulmer H, Torgersen C, Schmittinger CA, Jakob S, Takala J (2009) Association of arterial blood pressure and vasopressor load with septic shock mortality: a post hoc analysis of a multicenter trial. Crit Care 13(6):R181

Article  PubMed  PubMed Central  Google Scholar 

Levels JH, Abraham PR, van den Ende A, van Deventer SJ (2001) Distribution and kinetics of lipoprotein-bound endotoxin. Infect Immun 69(5):2821–2828

Article  CAS  PubMed  PubMed Central  Google Scholar 

Parker TS, Levine DM, Chang JC, Laxer J, Coffin CC, Rubin AL (1995) Reconstituted high-density lipoprotein neutralizes gram-negative bacterial lipopolysaccharides in human whole blood. Infect Immun 63(1):253–258

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vreugdenhil AC, Snoek AM, van’t Veer C, Greve JW, Buurman WA (2001) LPS-binding protein circulates in association with apoB-containing lipoproteins and enhances endotoxin-LDL/VLDL interaction. J Clin Invest 107(2):225–234

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kallio KA, Buhlin K, Jauhiainen M, Keva R, Tuomainen AM, Klinge B, Gustafsson A, Pussinen PJ (2008) Lipopolysaccharide associates with pro-atherogenic lipoproteins in periodontitis patients. Innate Immun 14(4):247–253

Article  CAS  PubMed  Google Scholar 

Yu B, Hailman E, Wright SD (1997) Lipopolysaccharide binding protein and soluble CD14 catalyze exchange of phospholipids. J Clin Invest 99(2):315–324

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vitols S, Gahrton G, Bjorkholm M, Peterson C (1985) Hypocholesterolaemia in malignancy due to elevated low-density-lipoprotein-receptor activity in tumour cells: evidence from studies in patients with leukaemia. Lancet 2(8465):1150–1154

Article  CAS  PubMed  Google Scholar 

Tan JT, Prosser HC, Dunn LL, Vanags LZ, Ridiandries A, Tsatralis T, Lecce L, Clayton ZE, Yuen SC, Robertson S et al (2016) High-density lipoproteins rescue diabetes-impaired angiogenesis via scavenger receptor class B type I. Diabetes 65(10):3091–3103

Article  CAS  PubMed  Google Scholar 

Tsatralis T, Ridiandries A, Robertson S, Vanags LZ, Lam YT, Tan JT, Ng MK, Bursill CA (2016) Reconstituted high-density lipoproteins promote wound repair and blood flow recovery in response to ischemia in aged mice. Lipids Health Dis 15(1):150

Article  PubMed  PubMed Central  Google Scholar 

Peeters B, Meersseman P, Vander Perre S, Wouters PJ, Vanmarcke D, Debaveye Y, Billen J, Vermeersch P, Langouche L, Van den Berghe G (2018) Adrenocortical function during prolonged critical illness and beyond: a prospective observational study. Intensive Care Med 44(10):1720–1729

Article  CAS  PubMed  PubMed Central  Google Scholar 

Muscaritoli M, Pradelli L (2021) Medium-chain triglyceride (MCT) content of adult enteral tube feeding formulas and clinical outcomes. A systematic review. Front Nutr 8:697529

Article  PubMed  PubMed Central  Google Scholar 

Calder PC, Adolph M, Deutz NE, Grau T, Innes JK, Klek S, Lev S, Mayer K, Michael-Titus AT, Pradelli L et al (2018) Lipids in the intensive care unit: recommendations from the ESPEN Expert Group. Clin Nutr 37(1):1–18

Article  CAS  PubMed  Google Scholar 

Ali Abdelhamid Y, Cousins CE, Sim JA, Bellon MS, Nguyen NQ, Horowitz M, Chapman MJ, Deane AM (2015) Effect of critical illness on triglyceride absorption. JPEN J Parenter Enteral Nutr 39(8):966–972

Article  CAS  PubMed  Google Scholar 

Levels JHM, Pajkrt D, Schultz M, Hoek FJ, van Tol A, Meijers JCM, van Deventer SJH (2007) Alterations in lipoprotein homeostasis during human experimental endotoxemia and clinical sepsis. Bba-Mol Cell Biol L 1771(12):1429–1438

CAS