Afshin A, Forouzanfar MH, Reitsma MB, Sur P, Estep K, Lee A, Marczak L, Mokdad AH, Moradi-Lakeh M, Naghavi M, Salama JS, Vos T, Abate KH, Abbafati C, Ahmed MB, Al-Aly Z, Alkerwi A, Al-Raddadi R, Amare AT, Amberbir A, Amegah AK, Amini E, Amrock SM, Anjana RM, Ärnlöv J, Asayesh H, Banerjee A, Barac A, Baye E, Bennett DA, Beyene AS, Biadgilign S, Biryukov S, Bjertness E, Boneya DJ, Campos-Nonato I, Carrero JJ, Cecilio P, Cercy K, Ciobanu LG, Cornaby L, Damtew SA, Dandona L, Dandona R, Dharmaratne SD, Duncan BB, Eshrati B, Esteghamati A, Feigin VL, Fernandes JC, Fürst T, Gebrehiwot TT, Gold A, Gona PN, Goto A, Habtewold TD, Hadush KT, Hafezi-Nejad N, Hay SI, Horino M, Islami F, Kamal R, Kasaeian A, Katikireddi SV, Kengne AP, Kesavachandran CN, Khader YS, Khang YH, Khubchandani J, Kim D, Kim YJ, Kinfu Y, Kosen S, Ku T, Defo BK, Kumar GA, Larson HJ, Leinsalu M, Liang X, Lim SS, Liu P, Lopez AD, Lozano R, Majeed A, Malekzadeh R, Malta DC, Mazidi M, McAlinden C, McGarvey ST, Mengistu DT, Mensah GA, Mensink GBM, Mezgebe HB, Mirrakhimov EM, Mueller UO, Noubiap JJ, Obermeyer CM, Ogbo FA, Owolabi MO, Patton GC, Pourmalek F, Qorbani M, Rafay A, Rai RK, Ranabhat CL, Reinig N, Safiri S, Salomon JA, Sanabria JR, Santos IS, Sartorius B, Sawhney M, Schmidhuber J, Schutte AE, Schmidt MI, Sepanlou SG, Shamsizadeh M, Sheikhbahaei S, Shin MJ, Shiri R, Shiue I, Roba HS, Silva DAS, Silverberg JI, Singh JA, Stranges S, Swaminathan S, Tabarés-Seisdedos R, Tadese F, Tedla BA, Tegegne BS, Terkawi AS, Thakur JS, Tonelli M, Topor-Madry R, Tyrovolas S, Ukwaja KN, Uthman OA, Vaezghasemi M, Vasankari T, Vlassov VV, Vollset SE, Weiderpass E, Werdecker A, Wesana J, Westerman R, Yano Y, Yonemoto N, Yonga G, Zaidi Z, Zenebe ZM, Zipkin B, Murray CJL (2017) Health effects of overweight and obesity in 195 countries over 25 years. N Engl J Med 377(1):13–27. https://doi.org/10.1056/NEJMoa1614362

Article  PubMed  Google Scholar 

Alex L, Russo I, Holoborodko V, Frangogiannis NG (2018) Characterization of a mouse model of obesity-related fibrotic cardiomyopathy that recapitulates features of human heart failure with preserved ejection fraction. Am J Physiol Heart Circ Physiol 315(4):H934–H949. https://doi.org/10.1152/ajpheart.00238.2018

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bartkowiak K, Bartkowiak M, Jankowska-Steifer E, Ratajska A, Kujawa M, Aniolek O, Niderla-Bielinska J (2024) Metabolic syndrome and cardiac vessel remodeling associated with vessel rarefaction: a possible underlying mechanism may result from a poor angiogenic response to altered VEGF signaling pathways. J Vasc Res. https://doi.org/10.1159/000538361

Article  PubMed  Google Scholar 

Berger C, Kloting N (2021) Leptin receptor compound heterozygosity in humans and animal models. Int J Mol Sci. https://doi.org/10.3390/ijms22094475

Article  PubMed  PubMed Central  Google Scholar 

Bouloumie A, Drexler HC, Lafontan M, Busse R (1998) Leptin, the product of Ob gene, promotes angiogenesis. Circ Res 83(10):1059–1066. https://doi.org/10.1161/01.res.83.10.1059

Article  CAS  PubMed  Google Scholar 

Broderick TL, Parrott CR, Wang D, Jankowski M, Gutkowska J (2012) Expression of cardiac GATA4 and downstream genes after exercise training in the db/db mouse. Pathophysiology 19(3):193–203. https://doi.org/10.1016/j.pathophys.2012.06.001

Article  CAS  PubMed  Google Scholar 

Broderick TL, Sennott JM, Gutkowska J, Jankowski M (2019) Anti-inflammatory and angiogenic effects of exercise training in cardiac muscle of diabetic mice. Diabetes Metab Syndr Obes 12:565–573. https://doi.org/10.2147/dmso.S197127

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen JX, Zeng H, Reese J, Aschner JL, Meyrick B (2012) Overexpression of angiopoietin-2 impairs myocardial angiogenesis and exacerbates cardiac fibrosis in the diabetic db/db mouse model. Am J Physiol Heart Circ Physiol 302(4):H1003-1012. https://doi.org/10.1152/ajpheart.00866.2011

Article  CAS  PubMed  Google Scholar 

Chen W, Sun Q, Ju J, Chen W, Zhao X, Zhang Y, Yang Y (2018) Effect of Astragalus polysaccharides on cardiac dysfunction in db/db mice with respect to oxidant stress. Biomed Res Int 2018:8359013. https://doi.org/10.1155/2018/8359013

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cheng HS, Perez-Cremades D, Zhuang R, Jamaiyar A, Wu W, Chen J, Tzani A, Stone L, Plutzky J, Ryan TE, Goodney PP, Creager MA, Sabatine MS, Bonaca MP, Feinberg MW (2023) Impaired angiogenesis in diabetic critical limb ischemia is mediated by a miR-130b/INHBA signaling axis. JCI Insight. https://doi.org/10.1172/jci.insight.163041

Article  PubMed  PubMed Central  Google Scholar 

Chou E, Suzuma I, Way KJ, Opland D, Clermont AC, Naruse K, Suzuma K, Bowling NL, Vlahos CJ, Aiello LP, King GL (2002) Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic States: a possible explanation for impaired collateral formation in cardiac tissue. Circulation 105(3):373–379. https://doi.org/10.1161/hc0302.102143

Article  CAS  PubMed  Google Scholar 

Claesson-Welsh L (2016) VEGF receptor signal transduction—a brief update. Vascul Pharmacol 86:14–17. https://doi.org/10.1016/j.vph.2016.05.011

Article  CAS  PubMed  Google Scholar 

Dham D, Roy B, Gowda A, Pan G, Sridhar A, Zeng X, Thandavarayan RA, Palaniyandi SS (2021) 4-Hydroxy-2-nonenal, a lipid peroxidation product, as a biomarker in diabetes and its complications: challenges and opportunities. Free Radic Res 55(5):547–561. https://doi.org/10.1080/10715762.2020.1866756

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dobrzynska MM, Gajowik A, Radzikowska J, Tyrkiel EJ, Jankowska-Steifer EA (2015) Male-mediated F1 effects in mice exposed to bisphenol A, either alone or in combination with X-irradiation. Mutat Res Genet Toxicol Environ Mutagen 789–790:36–45. https://doi.org/10.1016/j.mrgentox.2015.06.015

Article  CAS  PubMed  Google Scholar 

Fahed G, Aoun L, Bou Zerdan M, Allam S, Bou Zerdan M, Bouferraa Y, Assi HI (2022) Metabolic syndrome: updates on pathophysiology and management in 2021. Int J Mol Sci. https://doi.org/10.3390/ijms23020786

Article  PubMed  PubMed Central  Google Scholar 

Farooqi IS, Wangensteen T, Collins S, Kimber W, Matarese G, Keogh JM, Lank E, Bottomley B, Lopez-Fernandez J, Ferraz-Amaro I, Dattani MT, Ercan O, Myhre AG, Retterstol L, Stanhope R, Edge JA, McKenzie S, Lessan N, Ghodsi M, De Rosa V, Perna F, Fontana S, Barroso I, Undlien DE, O’Rahilly S (2007) Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor. N Engl J Med 356(3):237–247. https://doi.org/10.1056/NEJMoa063988

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fellmann L, Nascimento AR, Tibiriça E, Bousquet P (2013) Murine models for pharmacological studies of the metabolic syndrome. Pharmacol Ther 137(3):331–340. https://doi.org/10.1016/j.pharmthera.2012.11.004

Article  CAS  PubMed  Google Scholar 

Flaht-Zabost A, Gula G, Ciszek B, Czarnowska E, Jankowska-Steifer E, Madej M, Niderla-Bielinska J, Radomska-Lesniewska D, Ratajska A (2014) Cardiac mouse lymphatics: developmental and anatomical update. Anat Rec 297(6):1115–1130. https://doi.org/10.1002/ar.22912

Article  Google Scholar 

Garonna E, Botham KM, Birdsey GM, Randi AM, Gonzalez-Perez RR, Wheeler-Jones CP (2011) Vascular endothelial growth factor receptor-2 couples cyclo-oxygenase-2 with pro-angiogenic actions of leptin on human endothelial cells. PLoS ONE 6(4):e18823. https://doi.org/10.1371/journal.pone.0018823

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goddard LM, Iruela-Arispe ML (2013) Cellular and molecular regulation of vascular permeability. Thromb Haemost 109(3):407–415. https://doi.org/10.1160/TH12-09-0678

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gogiraju R, Hubert A, Fahrer J, Straub BK, Brandt M, Wenzel P, Munzel T, Konstantinides S, Hasenfuss G, Schafer K (2019) Endothelial leptin receptor deletion promotes cardiac autophagy and angiogenesis following pressure overload by suppressing Akt/mTOR signaling. Circ Heart Fail 12(1):e005622. https://doi.org/10.1161/CIRCHEARTFAILURE.118.005622

Article  CAS  PubMed  Google Scholar 

Gogiraju R, Witzler C, Shahneh F, Hubert A, Renner L, Bochenek ML, Zifkos K, Becker C, Thati M, Schafer K (2023) Deletion of endothelial leptin receptors in mice promotes diet-induced obesity. Sci Rep 13(1):8276. https://doi.org/10.1038/s41598-023-35281-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gonzalez-Perez RR, Xu Y, Guo S, Watters A, Zhou W, Leibovich SJ (2010) Leptin upregulates VEGF in breast cancer via canonic and non-canonical signalling pathways and NFkappaB/HIF-1alpha activation. Cell Signal 22(9):1350–1362. https://doi.org/10.1016/j.cellsig.2010.05.003

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guleria RS, Singh AB, Nizamutdinova IT, Souslova T, Mohammad AA, Kendall JA Jr, Baker KM, Pan J (2013) Activation of retinoid receptor-mediated signaling ameliorates diabetes-induced cardiac dysfunction in Zucker diabetic rats. J Mol Cell Cardiol 57:106–118. https://doi.org/10.1016/j.yjmcc.2013.01.017

Article  CAS