Ambesi-Impiombato FS, Coon HG (1979) Thyroid cells in culture. Int Rev Cytol Supplement 10:163–72. https://doi.org/10.1016/S0074-7696(08)60619-1

Article  CAS  Google Scholar 

Bonde AK, Tischler V, Kumar S, Soltermann A, Schwendener RA (2012) Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors. BMC Cancer 12:35. https://doi.org/10.1186/1471-2407-12-35

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bozza WP, Zhang Y, Zhang B (2018) Cytokeratin 8/18 protects breast cancer cell lines from TRAIL-induced apoptosis. Oncotarget 9:23264–23273. https://doi.org/10.18632/oncotarget.25297

Article  PubMed  PubMed Central  Google Scholar 

Calvello R, Lofrumento DD, Perrone MG, Cianciulli A, Salvatore R, Vitale P, De Nuccio F, Giannotti L, Nicolardi G, Panaro MA, Scilimati A (2017) Highly selective cyclooxygenase-1 inhibitors P6 and mofezolac counteract inflammatory state both in vitro and in vivo models of neuroinflammation. Front Neurol 8:251. https://doi.org/10.3389/fneur.2017.00251

Article  PubMed  PubMed Central  Google Scholar 

Cano A, Perez-Moreno MA, Rodrigo I, Locascio A, Blanco MJ, del Barrio MG, Portillo F, Nieto MA (2000) The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol 2000(2):76–83

Article  Google Scholar 

Cao C, Chen Y, Masood R, Sinha UK, Kobielak A (2012) a-Catulin marks the invasion front of squamous cell carcinoma and is important for tumor cell metastasis. Mol Cancer Res 10:892–903. https://doi.org/10.1158/1541-7786.MCR-12-0169

Article  CAS  PubMed  PubMed Central  Google Scholar 

De Vitis S, Treglia AS, Ulianich L, Turco S, Terrazzano G, Lombardi A, Miele C, Garbi C, Beguinot F, Di Jeso B (2011) Tyr phosphatase-mediated P-ERK inhibition suppresses senescence in EIA + v-raf transformed cells, which, paradoxically, are apoptosis-protected in a MEK-dependent manner. Neoplasia 2:120–30. https://doi.org/10.1593/neo.101152

Article  CAS  Google Scholar 

De Wever O, Pauwels P, De Craene B et al (2008) Molecular and pathological signatures of epithelial-mesenchymal transitions at the cancer invasion front. Histochem Cell Biol 130:481–494. https://doi.org/10.1007/s00418-008-0464-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Deeken-Draisey A, Guang-Yu Yang GY, Juehua Gao J, Alexiev BA (2018) Anaplastic thyroid carcinoma: an epidemiologic, histologic, immunohistochemical, and molecular single-institution study. Hum Pathol 82:140–148. https://doi.org/10.1016/j.humpath.2018.07.027

Article  CAS  PubMed  Google Scholar 

Di Jeso B, Arvan P (2016) Thyroglobulin from molecular and cellular biology to clinical endocrinology. Endocr Rev 37:2–36. https://doi.org/10.1210/er.2015-1090

Article  CAS  PubMed  Google Scholar 

Di Jeso B, Liguoro D, Ferranti P, Marinaccio M, Acquaviva R, Formisano S, Consiglio E (1992) Modulation of the carbohydrate moiety of thyroglobulin by thyrotropin and calcium in Fisher rat thyroid line-5 cells. J Biol Chem 267:1938–1944

Article  PubMed  Google Scholar 

Di Jeso B, Feliciello A, Pacifico F, Iannelli A, D’Armiento F, Liguoro D, Giuliano P, Ferulano G, Avvedimento EV (1995) Inhibition of c-ras reactivates thyroglobulin synthesis in middle-T transformed thyroid cells. Cell Growth Differ 6:1315–1319

PubMed  Google Scholar 

Di Jeso B, Formisano S, Ulianich L (1997) Perturbation of cellular calcium delays the secretion and alters the glycosylation of thyroglobulin in FRTL-5 cells. Biochem Biophys Res Commun 234:133–136. https://doi.org/10.1006/bbrc.1997.6601

Article  PubMed  Google Scholar 

Di Jeso B, Pereira R, Consiglio E, Formisano S, Satrustegui J, Sandoval IV (1998) Demonstration of a Ca2+ requirement for thyroglobulin dimerization and export to the Golgi complex. Eur J Biochem 252:583–90. https://doi.org/10.1046/j.1432-1327.1998.2520583.x

Article  PubMed  Google Scholar 

Fagin JA, Wells SA Jr (2016) Biologic and clinical perspectives on thyroid cancer. N Engl J Med 375:1054–1067. https://doi.org/10.1056/NEJMc1613118

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fagin JA, Matsuo K, Karmakar A, Chen DL, Tang SH, Koeffler HP (1993) High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas. J Clin Invest 91:179–184. https://doi.org/10.1172/JCI116168

Article  CAS  PubMed  PubMed Central  Google Scholar 

Haddad RI, Lydiatt WM, Ball DW, Busaidy NL, Byrd D, Callender G et al (2015) Anaplastic thyroid carcinoma, Version 2.2015. J Natl Compr Cancer Netw 13:1140–1150. https://doi.org/10.6004/jnccn.2015.0139

Article  CAS  Google Scholar 

Jeon MJ, Chun SM, Kim D, Kwon H, Jang EK, Kim TY, Kim WB, Shong YK, Jang SJ, Song DE, Kim WG (2016) Genomic alterations of anaplastic thyroid carcinoma detected by targeted massive parallel sequencing in a BRAF (V600E) mutation-prevalent area. Thyroid 26:683–690. https://doi.org/10.1089/thy.2015.0506

Article  CAS  PubMed  Google Scholar 

Kahlert C, Lahes S, Radhakrishnan P, Dutta S, Mogler C, Herpel E, Brand K, Steinert G, Schneider M, Mollenhauer M, Reissfelder C, Klupp F, Fritzmann J, Wunder C, Benner A, Kloor M, Huth C, Contin P, Ulrich A, Koch M, Weitz J (2011) Overexpression of ZEB2 at the invasion front of colorectal cancer is an independent prognostic marker and regulates tumor invasion in vitro. Clin Cancer Res 17:7654–7663. https://doi.org/10.1158/1078-0432.CCR-10-2816

Article  CAS  PubMed  Google Scholar 

Kalluri R, Weimberg RA (2009) The basics of epithelial-mesenchymal transition. J Clin Invest 119:1420–1428. https://doi.org/10.1172/JCI39104

Article  CAS  PubMed  PubMed Central  Google Scholar 

Karamitopoulou E, Zlobec I, Born D et al (2012) Tumour budding is a strong and independent prognostic factor in pancreatic cancer. Eur J Cancer 49:1032–1039. https://doi.org/10.1016/j.ejca.2012.10.022

Article  PubMed  Google Scholar 

Kunstman JW, Juhlin CC, Goh G, Brown TC, Stenman A, Healy JM, Rubinstein JC, Choi M, Kiss N, Nelson-Williams C et al (2015) Characterization of the mutational landscape of anaplastic thyroid cancer via whole-exome sequencing. Hum Mol Genet 24:2318–2329. https://doi.org/10.1093/hmg/ddu749

Article  CAS  PubMed  PubMed Central  Google Scholar 

Landa I, Ibrahimpasic T, Boucai L, Sinha R, Knauf JA, Shah RH, Dogan S, Ricarte-Filho JC, Krishnamoorthy GP, Xu B et al (2016) Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers. J Clin Invest 126:1052–1066. https://doi.org/10.1172/JCI85271

Article  PubMed  PubMed Central  Google Scholar 

Lee J, Di Jeso B, Arvan P (2011) Maturation of thyroglobulin protein region I. J Biol Chem 286:33045–33052. https://doi.org/10.1074/jbc.M111.281337

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liang F, Cao W, Wang Y et al (2013) The prognostic value of tumor budding in invasive breast cancer. Pathol Res Pract 209:269–275. https://doi.org/10.1016/j.prp.2013.01.009

Article  PubMed  Google Scholar 

Lugli A, Karamitopoulou E, Zlobec I (2012) Tumour budding: a promising parameter in colorectal cancer. Br J Cancer 106:1713–1717. https://doi.org/10.1038/bjc.2012.127

Article  CAS  PubMed  PubMed Central  Google Scholar 

Miettinen M, Franssila KO (2000) Variable expression of keratins and nearly uniform lack of thyroid transcription factor 1 in thyroid anaplastic carcinoma. Hum Pathol 31:1139–1145. https://doi.org/10.1053/hupa.2000.16667

Article  CAS  PubMed  Google Scholar 

Molinaro E, Romei C, Biagini A, Sabini E, Agate L, Mazzeo S, Materazzi G, Sellari-Franceschini S, Ribechini A, Torregrossa L, Basolo F, Vitti P, Elisei R (2017) Anaplastic thyroid carcinoma: from clinicopathology to genetics and advanced therapies. Nat Rev Endocrinol 13:644–660. https://doi.org/10.1038/nrendo.2017.76

Article  CAS  PubMed