Weller M et al (2015) Glioma. Nat Rev Dis Prim 1:15017
Ostrom QT et al (2019) CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2012–2016. Neuro Oncol 21(Suppl 5):v1–v100
Article PubMed PubMed Central Google Scholar
Stupp R et al (2005) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352(10):987–996
Article PubMed CAS Google Scholar
Stupp R et al (2009) Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol 10(5):459–466
Article PubMed CAS Google Scholar
Hanif F et al (2017) Glioblastoma multiforme: a review of its epidemiology and pathogenesis through clinical presentation and treatment. Asian Pac J Cancer Prev 18(1):3–9
PubMed PubMed Central Google Scholar
Verhaak RG et al (2010) Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 17(1):98–110
Article PubMed PubMed Central CAS Google Scholar
Brennan CW et al (2013) The somatic genomic landscape of glioblastoma. Cell 155(2):462–477
Article PubMed PubMed Central CAS Google Scholar
Cancer Genome Atlas Research (2008) Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455(7216):1061–1068
Louis DN et al (2016) The 2016 World Health Organization classification of tumors of the central nervous system: a summary. Acta Neuropathol 131(6):803–820
Louis DN et al (2021) The 2021 WHO classification of tumors of the central nervous system: a summary. Neuro Oncol 23(8):1231–1251
Article PubMed PubMed Central CAS Google Scholar
Gonzalez-Castro LN, Wesseling P (2021) The cIMPACT-NOW updates and their significance to current neuro-oncology practice. Neurooncol Pract 8(1):4–10
Ma S et al (2020) Prognostic impact of CDKN2A/B deletion, TERT mutation, and EGFR amplification on histological and molecular IDH-wildtype glioblastoma. Neurooncol Adv 2(1):vdaa126
PubMed PubMed Central Google Scholar
Gil J, Peters G (2006) Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all. Nat Rev Mol Cell Biol 7(9):667–677
Article PubMed CAS Google Scholar
Kim WY, Sharpless NE (2006) The regulation of INK4/ARF in cancer and aging. Cell 127(2):265–275
Article PubMed CAS Google Scholar
Lu VM et al (2020) The prognostic significance of CDKN2A homozygous deletion in IDH-mutant lower-grade glioma and glioblastoma: a systematic review of the contemporary literature. J Neurooncol 148(2):221–229
Article PubMed CAS Google Scholar
Park JW et al (2021) The prognostic significance of p16 expression pattern in diffuse gliomas. J Pathol Transl Med 55(2):102–111
Appay R et al (2019) CDKN2A homozygous deletion is a strong adverse prognosis factor in diffuse malignant IDH-mutant gliomas. Neuro Oncol 21(12):1519–1528
PubMed PubMed Central CAS Google Scholar
Reis GF et al (2015) CDKN2A loss is associated with shortened overall survival in lower-grade (World Health Organization Grades II-III) astrocytomas. J Neuropathol Exp Neurol 74(5):442–452
Article PubMed CAS Google Scholar
Romagosa C et al (2011) p16(Ink4a) overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors. Oncogene 30(18):2087–2097
Article PubMed CAS Google Scholar
Milde-Langosch K et al (2001) Overexpression of the p16 cell cycle inhibitor in breast cancer is associated with a more malignant phenotype. Breast Cancer Res Treat 67(1):61–70
Article PubMed CAS Google Scholar
Lee CT et al (1999) Overexpression of the cyclin-dependent kinase inhibitor p16 is associated with tumor recurrence in human prostate cancer. Clin Cancer Res 5(5):977–983
Gutiontov SI et al (2021) CDKN2A loss-of-function predicts immunotherapy resistance in non-small cell lung cancer. Sci Rep 11(1):20059
Article PubMed PubMed Central CAS Google Scholar
Parkin J, Cohen B (2001) An overview of the immune system. Lancet 357(9270):1777–1789
Article PubMed CAS Google Scholar
de Padilla CML, Niewold TB (2016) The type I interferons: basic concepts and clinical relevance in immune-mediated inflammatory diseases. Gene 576(1):14–21
Ferrantini M, Capone I, Belardelli F (2007) Interferon-alpha and cancer: mechanisms of action and new perspectives of clinical use. Biochimie 89(6–7):884–893
Article PubMed CAS Google Scholar
Vidal P (2020) Interferon α in cancer immunoediting: from elimination to escape. Scand J Immunol 91(5):e12863
Tarhini AA, Gogas H, Kirkwood JM (2012) IFN-α in the treatment of melanoma. J Immunol 189(8):3789–3793
Article PubMed CAS Google Scholar
Kankuri-Tammilehto M et al (2023) Long-term outcome with prolonged use of interferon-alpha administered intermittently for metastatic renal cell carcinoma: a phase II study. Anticancer Res 43(6):2645–2657
Article PubMed CAS Google Scholar
Guo J et al (2019) Empowering therapeutic antibodies with IFN-α for cancer immunotherapy. PLoS ONE 14(8):e0219829
Article PubMed PubMed Central CAS Google Scholar
Guo C et al (2023) Adjuvant temozolomide chemotherapy with or without interferon Alfa among patients with newly diagnosed high-grade gliomas: a randomized clinical trial. JAMA Netw Open 6(1):e2253285
Fujita M et al (2010) Role of type 1 IFNs in antiglioma immunosurveillance–using mouse studies to guide examination of novel prognostic markers in humans. Clin Cancer Res 16(13):3409–3419
Article PubMed PubMed Central CAS Google Scholar
Yu R, Zhu B, Chen D (2022) Type I interferon-mediated tumor immunity and its role in immunotherapy. Cell Mol Life Sci 79(3):191
Article PubMed PubMed Central CAS Google Scholar
Rafique I, Kirkwood JM, Tarhini AA (2015) Immune checkpoint blockade and interferon-α in melanoma. Semin Oncol 42(3):436–447
Article PubMed PubMed Central CAS Google Scholar
Aricò E et al (2019) Type I interferons and cancer: an evolving story demanding novel clinical applications. Cancers (Basel) 11(12):1943
Tarhini AA et al (2012) Differing patterns of circulating regulatory T cells and myeloid-derived suppressor cells in metastatic melanoma patients receiving anti-CTLA4 antibody and interferon-α or TLR-9 agonist and GM-CSF with peptide vaccination. J Immunother 35(9):702–710
Article PubMed PubMed Central CAS Google Scholar
Al Shboul S et al (2021) Kinomics platform using GBM tissue identifies BTK as being associated with higher patient survival. Life Sci Alliance 4(12):e202101054
Article PubMed PubMed Central CAS Google Scholar
Kononen J et al (1998) Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat Med 4(7):844–847
Article PubMed CAS Google Scholar
Purkait S et al (2013) CDKN2A deletion in pediatric versus adult glioblastomas and predictive value of p16 immunohistochemistry. Neuropathology 33(4):405–412
Article PubMed CAS Google Scholar
Jubb A, Boyle S (2020) Visualizing genome reorganization using 3D DNA FISH. Methods Mol Biol 2148:85–95
Comments (0)