Peak oxygen uptake in older adults with heart failure: a systematic review and meta-analysis

Savarese G, Becher PM, Lund LH, Seferovic P, Rosano GMC, Coats AJS. Global burden of heart failure: a comprehensive and updated review of epidemiology. Cardiovasc Res. 2023;118(17):3272–87. https://doi.org/10.1093/cvr/cvac013.

Article  CAS  PubMed  Google Scholar 

Letnes JM, Nes BM, Wisløff U. Age-related decline in peak oxygen uptake: cross-sectional vs. longitudinal findings. A review. Int J Cardiol Cardiovasc Risk Prev. 2023;16:200171. https://doi.org/10.1016/j.ijcrp.2023.200171.

Alpert CM, Smith MA, Hummel SL, Hummel EK. Symptom burden in heart failure: assessment, impact on outcomes, and management. Heart Fail Rev. 2017;22(1):25–39. https://doi.org/10.1007/s10741-016-9581-4.

Article  PubMed  PubMed Central  Google Scholar 

Del Buono MG, Arena R, Borlaug BA, Carbone S, Canada JM, Kirkman DL, et al. Exercise intolerance in patients with heart failure: JACC state-of-the-art review. J Am Coll Cardiol. 2019;73(17):2209–25. https://doi.org/10.1016/j.jacc.2019.01.072.

Article  PubMed  Google Scholar 

Haykowsky MJ, Ezekowitz JA, Armstrong PW. Therapeutic exercise for individuals with heart failure: special attention to older women with heart failure. J Card Fail. 2004;10(2):165–73. https://doi.org/10.1016/j.cardfail.2003.08.014.

Article  CAS  PubMed  Google Scholar 

Forman DE, Berman AD, McCabe CH, Baim DS, Wei JY. PTCA in the elderly: the “Young-Old” versus the “Old-Old.” J Am Geriatr Soc. 1992;40(1):19–22. https://doi.org/10.1111/j.1532-5415.1992.tb01823.x.

Article  CAS  PubMed  Google Scholar 

Haykowsky MJ, Kitzman DW. Exercise physiology in heart failure and preserved ejection fraction. Heart Fail Clin. 2014;10(3):445–52. https://doi.org/10.1016/j.hfc.2014.04.001.

Article  PubMed  PubMed Central  Google Scholar 

Downes MJ, Brennan ML, Williams HC, Dean RS. Development of a critical appraisal tool to assess the quality of cross-sectional studies (AXIS). BMJ Open. 2016;6(12). https://doi.org/10.1136/bmjopen-2016-011458.

Article  PubMed  PubMed Central  Google Scholar 

Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315(7109):629–34. https://doi.org/10.1136/bmj.315.7109.629.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bhella PS, Prasad A, Heinicke K, Hastings JL, Arbab-Zadeh A, Adams-Huet B, et al. Abnormal haemodynamic response to exercise in heart failure with preserved ejection fraction. Eur J Heart Fail. 2011;13(12):1296–304. https://doi.org/10.1093/eurjhf/hfr133.

Article  PubMed  PubMed Central  Google Scholar 

Hearon CM Jr, Sarma S, Dias KA, Hieda M, Levine BD. Impaired oxygen uptake kinetics in heart failure with preserved ejection fraction. Heart. 2019;105(20):1552–8. https://doi.org/10.1136/heartjnl-2019-314797.

Article  CAS  PubMed  Google Scholar 

Sarma S, Howden E, Lawley J, Samels M, Levine BD. Central command and the regulation of exercise heart rate response in heart failure with preserved ejection fraction. Circulation. 2021;143(8):783–9. https://doi.org/10.1161/circulationaha.120.048338.

Article  PubMed  Google Scholar 

Fu TC, Wang CH, Hsu CC, Cherng WJ, Huang SC, Wang JS. Suppression of cerebral hemodynamics is associated with reduced functional capacity in patients with heart failure. Am J Physiol Heart Circ Physiol. 2011;300(4):H1545–55. https://doi.org/10.1152/ajpheart.00867.2010.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Parovic M, Okwose NC, Bailey K, Velicki L, Fras Z, Seferovic PM, et al. NT-proBNP is a weak indicator of cardiac function and haemodynamic response to exercise in chronic heart failure. ESC Heart Fail. 2019;6(2):449–54. https://doi.org/10.1002/ehf2.12424.

Article  PubMed  PubMed Central  Google Scholar 

Olson TP, Johnson BD, Borlaug BA. Impaired pulmonary diffusion in heart failure with preserved ejection fraction. JACC Heart Fail. 2016;4(6):490–8. https://doi.org/10.1016/j.jchf.2016.03.001.

Article  PubMed  PubMed Central  Google Scholar 

Peeters P, Mets T. The 6-minute walk as an appropriate exercise test in elderly patients with chronic heart failure. J Gerontol A Biol Sci Med Sci. 1996;51(4):M147–51. https://doi.org/10.1093/gerona/51a.4.m147.

Article  CAS  PubMed  Google Scholar 

Toth MJ, Gottlieb SS, Fisher ML, Poehlman ET. Skeletal muscle atrophy and peak oxygen consumption in heart failure. Am J Cardiol. 1997;79(9):1267–9. https://doi.org/10.1016/s0002-9149(97)00098-2.

Article  CAS  PubMed  Google Scholar 

Kitzman DW, Little WC, Brubaker PH, Anderson RT, Hundley WG, Marburger CT, et al. Pathophysiological characterization of isolated diastolic heart failure in comparison to systolic heart failure. JAMA. 2002;288(17):2144–50. https://doi.org/10.1001/jama.288.17.2144.

Article  PubMed  Google Scholar 

Nishio K, Mukae S, Aoki S, Itoh S, Konno N, Ozawa K, et al. Congestive heart failure is associated with the rate of bone loss. J Intern Med. 2003;253(4):439–46. https://doi.org/10.1046/j.1365-2796.2003.01130.x.

Article  CAS  PubMed  Google Scholar 

Witte KK, Desilva R, Chattopadhyay S, Ghosh J, Cleland JG, Clark AL. Are hematinic deficiencies the cause of anemia in chronic heart failure? Am Heart J. 2004;147(5):924–30. https://doi.org/10.1016/j.ahj.2003.11.007.

Article  PubMed  Google Scholar 

Borlaug BA, Melenovsky V, Russell SD, Kessler K, Pacak K, Becker LC, et al. Impaired chronotropic and vasodilator reserves limit exercise capacity in patients with heart failure and a preserved ejection fraction. Circulation. 2006;114(20):2138–47. https://doi.org/10.1161/circulationaha.106.632745.

Article  PubMed  Google Scholar 

Miller MS, Vanburen P, Lewinter MM, Lecker SH, Selby DE, Palmer BM, et al. Mechanisms underlying skeletal muscle weakness in human heart failure: alterations in single fiber myosin protein content and function. Circ Heart Fail. 2009;2(6):700–6. https://doi.org/10.1161/circheartfailure.109.876433.

Article  PubMed  PubMed Central  Google Scholar 

Munkvik M, Rehn TA, Slettaløkken G, Hasic A, Hallén J, Sjaastad I, et al. Training effects on skeletal muscle calcium handling in human chronic heart failure. Med Sci Sports Exerc. 2010;42(5):847–55. https://doi.org/10.1249/MSS.0b013e3181c29ec1.

Article  CAS  PubMed  Google Scholar 

Phan TT, Shivu GN, Abozguia K, Davies C, Nassimizadeh M, Jimenez D, et al. Impaired heart rate recovery and chronotropic incompetence in patients with heart failure with preserved ejection fraction. Circ Heart Fail. 2010;3(1):29–34. https://doi.org/10.1161/circheartfailure.109.877720.

Article  PubMed  Google Scholar 

Beale L, Silberbauer J, Guy L, Carter H, Doust J, Brickley G. Limitations to high intensity exercise prescription in chronic heart failure patients. Eur J Cardiovasc Nurs. 2011;10(3):167–73. https://doi.org/10.1016/j.ejcnurse.2010.06.002.

Article  PubMed  Google Scholar 

Savage PA, Shaw AO, Miller MS, VanBuren P, LeWinter MM, Ades PA, et al. Effect of resistance training on physical disability in chronic heart failure. Med Sci Sports Exerc. 2011;43(8):1379–86. https://doi.org/10.1249/MSS.0b013e31820eeea1.

Article  PubMed  PubMed Central  Google Scholar 

Sandri M, Kozarez I, Adams V, Mangner N, Höllriegel R, Erbs S, et al. Age-related effects of exercise training on diastolic function in heart failure with reduced ejection fraction: the Leipzig Exercise Intervention in Chronic Heart Failure and Aging (LEICA) Diastolic Dysfunction Study. Eur Heart J. 2012;33(14):1758–68. https://doi.org/10.1093/eurheartj/ehr469.

Article  PubMed  Google Scholar 

Rullman E, Andersson DC, Melin M, Reiken S, Mancini DM, Marks AR, et al. Modifications of skeletal muscle ryanodine receptor type 1 and exercise intolerance in heart failure. J Heart Lung Transplant. 2013;32(9):925–9. https://doi.org/10.1016/j.healun.2013.06.026.

Article  PubMed  PubMed Central  Google Scholar 

Comments (0)

No login
gif