Establishment of primary and immortalized fibroblasts reveals resistance to cytotoxic agents and loss of necroptosis-inducing ability in long-lived Damaraland mole-rats

Bennett NC, Jarvis JUM. The social structure and reproductive biology of colonies of the mole-rat, Cryptomys damarensis (Rodentia, Bathyergidae). J Mammal. 1988;69:293–302. https://doi.org/10.2307/1381379.

Article  Google Scholar 

Jarvis JUM, Bennett NC. Eusociality has evolved independently in two genera of bathyergid mole-rats - but occurs in no other subterranean mammal. Behav Ecol Sociobiol. 1993;33:253–60 (https://www.jstor.org/stable/4600876).

Article  Google Scholar 

Bennett NC, Jarvis JUM. Cryptomys damarensis. Mammalian species. 2004;756:1–5. https://doi.org/10.1644/756.

Article  Google Scholar 

McNab BK. The metabolism of fossorial rodents: a study of convergence. Ecology. 1966;47:712–33. https://doi.org/10.2307/1934259.

Article  Google Scholar 

Lovegrove BG. The metabolism of social subterranean rodents: adaptation to aridity. Oecologia. 1986;69:551–5. https://doi.org/10.1007/BF00410361.

Article  CAS  PubMed  Google Scholar 

Yap KN, Wong HS, Ramanathan C, Rodriguez-Wagner CA, Roberts MD, Freeman DA, Buffenstein R, Zhang Y. Naked mole-rat and Damaraland mole-rat exhibit lower respiration in mitochondria, cellular and organismal levels. Biochim Biophys Acta Bioenerg. 2022;1863: 148582. https://doi.org/10.1016/j.bbabio.2022.148582.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Scantlebury M, Speakman JR, Oosthuizen MK, Roper TJ, Bennett NC. Energetics reveals physiologically distinct castes in a eusocial mammal. Nature. 2006;440:795–7. https://doi.org/10.1038/nature04578.

Article  CAS  PubMed  Google Scholar 

Buffenstein R, Craft W. The idiosyncratic physiological traits of the naked mole-rat; a resilient animal model of aging, longevity, and healthspan BT - the extraordinary biology of the naked mole-rat. In: Buffenstein R, Park TJ, Holmes MM, editors. Cham: Springer International Publishing; 2021. p. 221–54. https://doi.org/10.1007/978-3-030-65943-1_8

Streicher S, Boyles JG, Oosthuizen MK, Bennett NC. Body temperature patterns and rhythmicity in free-ranging subterranean Damaraland mole-rats. Fukomys damarensis PLoS One. 2011;6: e26346. https://doi.org/10.1371/journal.pone.0026346.

Article  CAS  PubMed  Google Scholar 

Buffenstein R. Ecophysiological responses to a subterranean habitat; a Bathyergid perspective. Mammalia. 1996;60:591–606. https://doi.org/10.1515/mamm.1996.60.4.591.

Article  Google Scholar 

Zhang SY, Pamenter ME. Ventilatory, metabolic, and thermoregulatory responses of Damaraland mole rats to acute and chronic hypoxia. J Comp Physiol B. 2019;189:319–34. https://doi.org/10.1007/s00360-019-01206-y.

Article  PubMed  Google Scholar 

Ivy CM, Sprenger RJ, Bennett NC, van Jaarsveld B, Hart DW, Kirby AM, Yaghoubi D, Storey KB, Milsom WK, Pamenter ME. The hypoxia tolerance of eight related African mole-rat species rivals that of naked mole-rats, despite divergent ventilatory and metabolic strategies in severe hypoxia. Acta Physiol. 2020;228: e13436. https://doi.org/10.1111/apha.13436.

Article  CAS  Google Scholar 

Buffenstein R, Skinner DC, Yahav S, Moodley GP, Cavaleros M, Zachen D, Ross FP, Pettifor JM. Effect of oral cholecalciferol supplementation at physiological and supraphysiological doses in naturally vitamin D3-deficient subterranean Damara mole rats (Cryptomys damarensis). J Endocrinol. 1991;131:197–202. https://doi.org/10.1677/joe.0.1310197.

Article  CAS  PubMed  Google Scholar 

Pitcher T, Buffenstein R, Keegan JD, Moodley GP, Yahav S. Dietary calcium content, calcium balance and mode of uptake in a subterranean mammal, the Damara mole-rat. J Nutr. 1992;122:108–14. https://doi.org/10.1093/jn/122.1.108.

Article  CAS  PubMed  Google Scholar 

Lewis KN, Buffenstein R. Chapter 6 - The naked mole-rat: a resilient rodent model of aging, longevity, and healthspan. In: Kaeberlein MR, Martin GMBT-H of the B of A (Eighth E, editors. San Diego: Academic Press; 2016 179–204. https://doi.org/10.1016/B978-0-12-411596-5.00006-X

Smith ESJ, Park TJ, Lewin GR. Independent evolution of pain insensitivity in African mole-rats: origins and mechanisms. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2020;206:313–25. https://doi.org/10.1007/s00359-020-01414-w.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wong HS, Freeman DA, Zhang Y. Not just a cousin of the naked mole-rat: Damaraland mole-rats offer unique insights into biomedicine. Comp Biochem Physiol B Biochem Mol Biol. 2022;262: 110772. https://doi.org/10.1016/j.cbpb.2022.110772.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Buffenstein R, Smith M, Amoroso VG, Patel TT, Ross M, Bassanpal S, Park TJ, Delaney MA, Adams CR, Arroyo J, Fortman J. A new laboratory research model: the Damaraland mole-rat and its managed care. J Am Assoc Lab Anim Sci. 2024. https://doi.org/10.30802/AALAS-JAALAS-24-052

Hulbert AJ, Pamplona R, Buffenstein R, Buttemer WA. Life and death: metabolic rate, membrane composition, and life span of animals. Physiol Rev. 2007;87:1175–213. https://doi.org/10.1152/physrev.00047.2006.

Article  CAS  PubMed  Google Scholar 

Ruby JG, Smith M, Buffenstein R. Five years later, with double the demographic data, naked mole-rat mortality rates continue to defy Gompertzian laws by not increasing with age. Geroscience. 2024. https://doi.org/10.1007/s11357-024-01201-4.

Article  PubMed  PubMed Central  Google Scholar 

Fang X, Seim I, Huang Z, Gerashchenko MV, Xiong Z, Turanov AA, Zhu Y, Lobanov AV, Fan D, Yim SH, Yao X, Ma S, Yang L, et al. Adaptations to a subterranean environment and longevity revealed by the analysis of mole rat genomes. Cell Rep. 2014;8:1354–64. https://doi.org/10.1016/j.celrep.2014.07.030.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Buffenstein R, Ruby JG. Opportunities for new insight into aging from the naked mole-rat and other non-traditional models. Nat Aging. 2021;1:3–4. https://doi.org/10.1038/s43587-020-00012-4.

Article  PubMed  Google Scholar 

Oka K, Yamakawa M, Kawamura Y, Kutsukake N, Miura K. The naked mole-rat as a model for healthy aging. Annu Rev Anim Biosci. 2023;11:207–26. https://doi.org/10.1146/annurev-animal-050322-074744.

Article  PubMed  Google Scholar 

Ruby JG, Smith M, Buffenstein R. Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age. Elife. 2018;7: e31157. https://doi.org/10.7554/eLife.31157.

Article  PubMed  PubMed Central  Google Scholar 

O’Connor TP, Lee A, Jarvis JUM, Buffenstein R. Prolonged longevity in naked mole-rats: age-related changes in metabolism, body composition and gastrointestinal function. Comp Biochem Physiol A Mol Integr Physiol. 2002;133:835–42. https://doi.org/10.1016/s1095-6433(02)00198-8.

Article  PubMed  Google Scholar 

Buffenstein R. Negligible senescence in the longest living rodent, the naked mole-rat: insights from a successfully aging species. J Comp Physiol B. 2008;178:439–45. https://doi.org/10.1007/s00360-007-0237-5.

Article  PubMed  Google Scholar 

Can E, Smith M, Boukens BJ, Coronel R, Buffenstein R, Riegler J. Naked mole-rats maintain cardiac function and body composition well into their fourth decade of life. Geroscience. 2022;44:731–46. https://doi.org/10.1007/s11357-022-00522-6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Edrey YH, Park TJ, Kang H, Biney A, Buffenstein R. Endocrine function and neurobiology of the longest-living rodent, the naked mole-rat. Exp Gerontol. 2011;46:116–23. https://doi.org/10.1016/j.exger.2010.09.005.

Article  CAS  PubMed  Google Scholar 

Voigt C, Bennett NC. Gene expression pattern of Kisspeptin and RFamide-related peptide (Rfrp) in the male Damaraland mole-rat hypothalamus. J Chem Neuroanat. 2021;118: 102039. https://doi.org/10.1016/j.jchemneu.2021.102039.

Article  CAS  PubMed  Google Scholar 

Hart DW, Bennett NC, Voigt C. Social stress is unlikely to play a major role in reproductive suppression of female subordinate naked mole-rats and Damaraland mole-rats. Biol Lett. 2022;18:20220292. https://doi.org/10.1098/rsbl.2022.0292.

Article  PubMed  PubMed Central  Google Scholar 

Faulkes CG, Bennett NC. Social evolution in African mole-rats – a comparative overview BT - the extraordinary biology of the naked mole-rat. In: Buffenstein R, Park TJ, Holmes MM, editors. Cham: Springer International Publishing; 2021. p. 1–33. https://doi.org/10.1007/978-3-030-65943-1_1

Houslay TM, Vullioud P, Zöttl M, Clutton-Brock TH. Benefits of cooperation in captive Damaraland mole-rats. Behav Ecol. 2020;31:711–8. https://doi.org/10.1093/beheco/araa015.

Article  Google Scholar 

Thorley J, Bensch HM, Finn K, Clutton-Brock T, Zöttl M. Damaraland mole-rats do not rely on helpers for reproduction or survival. Evol

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