Mechanisms and consequences of sex differences in immune responses

Mauvais-Jarvis, F. et al. Sex and gender: modifiers of health, disease, and medicine. Lancet 396, 565–582 (2020).

Article  PubMed  PubMed Central  Google Scholar 

Klein, S. L. & Flanagan, K. L. Sex differences in immune responses. Nat. Rev. Immunol. 16, 626–638 (2016).

Article  CAS  PubMed  Google Scholar 

Haupt, S., Caramia, F., Klein, S. L., Rubin, J. B. & Haupt, Y. Sex disparities matter in cancer development and therapy. Nat. Rev. Cancer 21, 393–407 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Laffont, S. & Guery, J. C. Deconstructing the sex bias in allergy and autoimmunity: from sex hormones and beyond. Adv. Immunol. 142, 35–64 (2019).

Article  CAS  PubMed  Google Scholar 

Melk, A. et al. Equally interchangeable? How sex and gender affect transplantation. Transplantation 103, 1094–1110 (2019).

Article  PubMed  Google Scholar 

Klein, S. L. & Morgan, R. The impact of sex and gender on immunotherapy outcomes. Biol. Sex. Differ. 11, 24 (2020).

Article  PubMed  PubMed Central  Google Scholar 

Fish, E. N. The X-files in immunity: sex-based differences predispose immune responses. Nat. Rev. Immunol. 8, 737–744 (2008).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Migeon, B. R. Why females are mosaics, X-chromosome inactivation, and sex differences in disease. Gend. Med. 4, 97–105 (2007).

Article  PubMed  Google Scholar 

Oktenli, C. et al. Study of autoimmunity in Klinefelter’s syndrome and idiopathic hypogonadotropic hypogonadism. J. Clin. immunol. 22, 137–143 (2002).

Article  CAS  PubMed  Google Scholar 

Cacciari, E. et al. Serum immunoglobulins and lymphocyte subpopulations derangement in Turner’s syndrome. J. Immunogenet. 8, 337–344 (1981).

Article  CAS  PubMed  Google Scholar 

Gravholt, C. H. Turner syndrome in adulthood. Horm. Res. 64, 86–93 (2005).

CAS  PubMed  Google Scholar 

Schmiedel, B. J. et al. Impact of genetic polymorphisms on human immune cell gene expression. Cell 175, 1701–1715.e6 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Itoh, Y. et al. The X-linked histone demethylase Kdm6a in CD4+ T lymphocytes modulates autoimmunity. J. Clin. Invest. 129, 3852–3863 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Souyris, M. et al. TLR7 escapes X chromosome inactivation in immune cells. Sci. Immunol. 3, eaap8855 (2018).

Article  PubMed  Google Scholar 

Fink, A. L., Engle, K., Ursin, R. L., Tang, W. Y. & Klein, S. L. Biological sex affects vaccine efficacy and protection against influenza in mice. Proc. Natl Acad. Sci. USA 115, 12477–12482 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

van der Made, C. I. et al. Presence of genetic variants among young men with severe COVID-19. JAMA 324, 663–673 (2020).

Article  PubMed  Google Scholar 

Cheng, M. I. et al. The X-linked epigenetic regulator UTX controls NK cell-intrinsic sex differences. Nat. Immunol. 24, 780–791 (2023).

Article  CAS  PubMed  Google Scholar 

Sharma, S. & Eghbali, M. Influence of sex differences on microRNA gene regulation in disease. Biol. Sex. Differ. 5, 3 (2014).

Article  PubMed  PubMed Central  Google Scholar 

Malmhall, C., Weidner, J. & Radinger, M. MicroRNA-155 expression suggests a sex disparity in innate lymphoid cells at the single-cell level. Cell Mol. Immunol. 17, 544–546 (2020).

Article  PubMed  Google Scholar 

Arnold, A. P. & Chen, X. What does the “four core genotypes” mouse model tell us about sex differences in the brain and other tissues? Front. Neuroendocrinol. 30, 1–9 (2009).

Article  PubMed  Google Scholar 

Golden, L. C. et al. Parent-of-origin differences in DNA methylation of X chromosome genes in T lymphocytes. Proc. Natl Acad. Sci. USA 116, 26779–26787 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Case, L. K. et al. The Y chromosome as a regulatory element shaping immune cell transcriptomes and susceptibility to autoimmune disease. Genome Res. 23, 1474–1485 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Krementsov, D. N. et al. Genetic variation in chromosome Y regulates susceptibility to influenza A virus infection. Proc. Natl Acad. Sci. USA 114, 3491–3496 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Thompson, D. J. et al. Genetic predisposition to mosaic Y chromosome loss in blood. Nature 575, 652–657 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Weinstein, Y., Ran, S. & Segal, S. Sex-associated differences in the regulation of immune responses controlled by the MHC of the mouse. J. Immunol. 132, 656–661 (1984).

Article  CAS  PubMed  Google Scholar 

Eidinger, D. & Garrett, T. J. Studies of the regulatory effects of the sex hormones on antibody formation and stem cell differentiation. J. Exp. Med. 136, 1098–1116 (1972).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bjornstrom, L. & Sjoberg, M. Mechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genes. Mol. Endocrinol. 19, 833–842 (2005).

Article  PubMed  Google Scholar 

Cvoro, A. et al. Distinct roles of unliganded and liganded estrogen receptors in transcriptional repression. Mol. Cell 21, 555–564 (2006).

Article  CAS  PubMed  Google Scholar 

Blanquart, E., Laffont, S. & Guery, J. C. Sex hormone regulation of innate lymphoid cells. Biomed. J. 44, 144–156 (2021).

Article  CAS  PubMed  Google Scholar 

Kovats, S. Estrogen receptors regulate innate immune cells and signaling pathways. Cell Immunol. 294, 63–69 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Notas, G., Kampa, M. & Castanas, E. G protein-coupled estrogen receptor in immune cells and its role in immune-related diseases. Front. Endocrinol. 11, 579420 (2020).

Article  Google Scholar 

Phiel, K. L., Henderson, R. A., Adelman, S. J. & Elloso, M. M. Differential estrogen receptor gene expression in human peripheral blood mononuclear cell populations. Immunol. Lett. 97, 107–113 (2005).

Article  CAS  PubMed  Google Scholar 

Brundin, P. M. A. et al. Expression of sex hormone receptor and immune response genes in peripheral blood mononuclear cells during the menstrual cycle. Front. Endocrinol. 12, 721813 (2021).

Article  Google Scholar 

Fox, H. S., Bond, B. L. & Parslow, T. G. Estrogen regulates the IFN-gamma promoter. J. Immunol. 146, 4362–4367 (1991).

Article  CAS  PubMed  Google Scholar 

Stein, B. & Yang, M. X. Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-κB and C/EBPβ. Mol. Cell Biol. 15, 4971–4979 (1995).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang, C. et al. Membrane estrogen receptor regulates experimental autoimmune encephalomyelitis through up-regulation of programmed death 1. J. Immunol. 182, 3294–3303 (2009).

Article  CAS  PubMed  Google Scholar 

Wang, C. et al. GPR30 contributes to estrogen-induced thymic atrophy. Mol. Endocrinol. 22, 636–648 (2008).

Article  CAS  PubMed  Google Scholar 

Tan, I. J., Peeva, E. & Zandman-Goddard, G. Hormonal modulation of the immune system – a spotlight on the role of progestogens. Autoimmun. Rev. 14, 536–542 (2015).

Article  CAS  PubMed  Google Scholar 

Griekspoor, A., Zwart, W., Neefjes, J. & Michalides, R. Visualizing the action of steroid hormone receptors in living cells. Nucl. Recept. Signal. 5, e003 (2007).

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