Vankadari N, Shepherd DC, Carter SD, Ghosal D. Three-dimensional insights into human enveloped viruses in vitro and in situ. Biochem Soc Trans. 2022;50(1):95–105.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cheng N, Liu M, Li W, Sun BY, Liu D, Wang G, Shi J, Li L. Protein post-translational modification in SARS-CoV-2 and host interaction. Front Immunol. 2022;13:1068449.

Article  CAS  PubMed  Google Scholar 

Chaudhuri S, Symons JA, Deval J. Innovation and trends in the development and approval of antiviral medicines: 1987–2017 and beyond. Antiviral Res. 2018;155:76–88.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Namasivayam V, Palaniappan S, Vanangamudi M. Repurposing drugs targeting epidemic viruses. Drug Discov Today. 2022;27(7):1874–94.

Article  CAS  PubMed  Google Scholar 

Boldescu V, Behnam MAM, Vasilakis N, Klein CD. Broad-spectrum agents for flaviviral infections: dengue, Zika and beyond. Nat Rev Drug Discov. 2017;16(8):565–86.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Perera N, Brun J, Alonzi DS, Tyrrell BE, Miller JL, Zitzmann N. Antiviral effects of deoxynojirimycin (DNJ)-based iminosugars in dengue virus-infected primary dendritic cells. Antiviral Res. 2022;199: 105269.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kaufmann SHE, Dorhoi A, Hotchkiss RS, Bartenschlager R. Host-directed therapies for bacterial and viral infections. Nat Rev Drug Discov. 2018;17(1):35–56.

Article  CAS  PubMed  Google Scholar 

Zheng Y, Li S, Song K, Ye J, Li W, Zhong Y, Feng Z, Liang S, Cai Z, Xu K. A broad antiviral strategy: inhibitors of human DHODH pave the way for host-targeting antivirals against emerging and re-emerging viruses. Viruses. 2022;14(5):928.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kumar N, Sharma S, Kumar R, Tripathi BN, Barua S, Ly H, Rouse BT. Host-directed antiviral therapy. Clin Microbiol Rev. 2020;33(3):168–90.

Article  Google Scholar 

Watanabe Y, Bowden TA, Wilson IA, Crispin M. Exploitation of glycosylation in enveloped virus pathobiology. Biochim Biophys Acta Gen Subj. 2019;1863(10):1480–97.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dhara D, Dhara A, Bennett J, Murphy PV. Cyclisations and strategies for stereoselective synthesis of piperidine iminosugars. Chem Rec. 2021;21(11):2958–79.

Article  CAS  PubMed  Google Scholar 

Conforti I, Marra A. Iminosugars as glycosyltransferase inhibitors. Org Biomol Chem. 2021;19(25):5439–75.

Article  CAS  PubMed  Google Scholar 

Miller JL, Tyrrell BE, Zitzmann N. Mechanisms of antiviral activity of iminosugars against dengue virus. Adv Exp Med Biol. 2018;1062:277–301.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Evans DeWald L, Starr C, Butters T, Treston A, Warfield KL. Iminosugars: a host-targeted approach to combat Flaviviridae infections. Antiviral Res. 2020;184: 104881.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ferjancic Z, Bihelovic F, Vulovic B, Matovic R, Trmcic M, Jankovic A, Pavlovic M, Djurkovic F, Prodanovic R, Djurdjevic Djelmas A, et al. Development of iminosugar-based glycosidase inhibitors as drug candidates for SARS-CoV-2 virus via molecular modelling and in vitro studies. J Enzyme Inhib Med Chem. 2024;39(1):2289007.

Article  PubMed  Google Scholar 

Miglani V, Sharma P, Kumar Narula A. Investigation of iminosugars as antiviral agents against SARS-CoV-2 main protease: inhibitor design and optimization, molecular docking, and molecular dynamics studies to explore potential inhibitory effect of 1-deoxynojirmycin series. Curr Comput Aided Drug Des. 2023.

Tyrrell BE, Sayce AC, Warfield KL, Miller JL, Zitzmann N. Iminosugars: promising therapeutics for influenza infection. Crit Rev Microbiol. 2017;43(5):521–45.

Article  CAS  PubMed  Google Scholar 

Li Y, Liu D, Wang Y, Su W, Liu G, Dong W. The importance of glycans of viral and host proteins in enveloped virus infection. Front Immunol. 2021;12: 638573.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schön K, Lepenies B, Goyette-Desjardins G. Impact of protein glycosylation on the design of viral vaccines. Adv Biochem Eng Biotechnol. 2021;175:319–54.

PubMed  Google Scholar 

Wang Q, Groenendyk J, Michalak M. Glycoprotein quality control and endoplasmic reticulum stress. Molecules. 2015;20(8):13689–704.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rey FA, Lok SM. Common features of enveloped viruses and implications for immunogen design for next-generation vaccines. Cell. 2018;172(6):1319–34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mehta A, Ouzounov S, Jordan R, Simsek E, Lu X, Moriarty RM, Jacob G, Dwek RA, Block TM. Imino sugars that are less toxic but more potent as antivirals, in vitro, compared with N-n-nonyl DNJ. Antiviral Chem Chemother. 2002;13(5):299–304.

Article  CAS  Google Scholar 

Liu H, Chen C, Liao S, Sohaii DK, Cruz CRY, Burdo TH, Cradick TJ, Mehta A, Barrero C, Florez M, et al. Strategic self-limiting production of infectious HIV particles by CRISPR in permissive cells. Mol Ther Nucleic Acids. 2023;32:1010–25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sadat MA, Moir S, Chun TW, Lusso P, Kaplan G, Wolfe L, Memoli MJ, He M, Vega H, Kim LJY, et al. Glycosylation, hypogammaglobulinemia, and resistance to viral infections. N Engl J Med. 2014;370(17):1615–25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dobrica MO, Lazar C, Branza-Nichita N. N-glycosylation and N-glycan processing in HBV biology and pathogenesis. Cells. 2020;9(6):1404.

Article  PubMed  PubMed Central  Google Scholar 

Pralow A, Hoffmann M, Nguyen-Khuong T, Pioch M, Hennig R, Genzel Y, Rapp E, Reichl U. Comprehensive N-glycosylation analysis of the influenza A virus proteins HA and NA from adherent and suspension MDCK cells. FEBS J. 2021;288(16):4869–91.

Article  CAS  PubMed  Google Scholar 

Galan MC, Benito-Alifonso D, Watt GM. Carbohydrate chemistry in drug discovery. Org Biomol Chem. 2011;9(10):3598–610.

Article  CAS  PubMed  Google Scholar 

Karade SS, Hill ML, Kiappes JL, Manne R, Aakula B, Zitzmann N, Warfield KL, Treston AM, Mariuzza RA. N-substituted valiolamine derivatives as potent inhibitors of endoplasmic reticulum α-glucosidases I and II with antiviral activity. J Med Chem. 2021;64(24):18010–24.

Article  CAS  PubMed  Google Scholar 

Karade SS, Kolesnikov A, Treston AM, Mariuzza RA. Identification of endoplasmic reticulum α-glucosidase I from a thermophilic fungus as a platform for structure-guided antiviral drug design. Biochemistry. 2022;61(10):822–32.

Article  CAS  PubMed  Google Scholar 

Chapel C, Garcia C, Bartosch B, Roingeard P, Zitzmann N, Cosset F-L, Dubuisson J, Dwek RA, Trepo C, Zoulim F, et al. Reduction of the infectivity of hepatitis C virus pseudoparticles by incorporation of misfolded glycoproteins induced by glucosidase inhibitors. J Gen Virol. 2007;88(4):1133–43.

Article  CAS  PubMed  Google Scholar 

Tani H, Komoda Y, Matsuo E, Suzuki K, Hamamoto I, Yamashita T, Moriishi K, Fujiyama K, Kanto T, Hayashi N, et al. Replication-competent recombinant vesicular stomatitis virus