Chindamo, G. et al. Bone diseases: current approach and future perspectives in drug delivery systems for bone targeted therapeutics. Nanomaterials 10, 875 (2020).

Gu, W., Wu, C., Chen, J. & Xiao, Y. Nanotechnology in the targeted drug delivery for bone diseases and bone regeneration. Int. J. Nanomed. 8, 2305–2317 (2013).

Article  Google Scholar 

Rodan, G. A. & Martin, T. J. Therapeutic approaches to bone diseases. Science 289, 1508–1514 (2000).

Article  CAS  PubMed  Google Scholar 

Bartl, R., Frisch, B., Bartl, R. & Frisch, B. Biology of bone. Osteoporosis: Diagnosis, Prevention, Therapy 7–28 (Springer Berlin Heidelberg, 2009).

Acs, G. & Khurana, J. S. in Essentials of Anatomic Pathology 433–462 (Springer, 2002).

Oryan, A. & Sahvieh, S. Effects of bisphosphonates on osteoporosis: focus on zoledronate. Life Sci. 264, 118681 (2021).

Article  CAS  PubMed  Google Scholar 

Li, H., Xiao, Z., Quarles, L. D. & Li, W. Osteoporosis: mechanism, molecular target and current status on drug development. Curr. Med. Chem. 28, 1489–1507 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sikon, A. & Batur, P. Profile of teriparatide in the management of postmenopausal osteoporosis. in International Journal of Women’s Health 37–44 (International Federation of Gynecology and Obstetrics, 2010).

Quattrocchi, E. & Kourlas, H. Teriparatide: a review. Clin. Ther. 26, 841–854 (2004).

Article  CAS  PubMed  Google Scholar 

Papapoulos, S. et al. The effect of 8 or 5 years of denosumab treatment in postmenopausal women with osteoporosis: results from the FREEDOM Extension study. Osteoporos. Int. 26, 2773–2783 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Morizio, P., Burkhart, J. I. & Ozawa, S. Denosumab: a unique perspective on adherence and cost-effectiveness compared with oral bisphosphonates in osteoporosis patients. Ann. Pharmacother. 52, 1031–1041 (2018).

Article  CAS  PubMed  Google Scholar 

Fujiwara, S. et al. Systematic review of raloxifene in postmenopausal Japanese women with osteoporosis or low bone mass (osteopenia). Clin. Interv. Aging 9, 1879–1893 (2014).

Krum, S. A. & Brown, M. Unraveling estrogen action in osteoporosis. Cell Cycle 7, 1348–1352 (2008).

Article  CAS  PubMed  Google Scholar 

Abbasi, M. et al. Strategies toward rheumatoid arthritis therapy; the old and the new. J. Cell. Physiol. 234, 10018–10031 (2019).

Article  CAS  PubMed  Google Scholar 

Conaghan, P. G., Cook, A. D., Hamilton, J. A. & Tak, P. P. Therapeutic options for targeting inflammatory osteoarthritis pain. Nat. Rev. Rheumatol. 15, 355–363 (2019).

Article  PubMed  Google Scholar 

Weber, A. E., Bolia, I. K. & Trasolini, N. A. Biological strategies for osteoarthritis: from early diagnosis to treatment. Int. Orthop. 45, 335–344 (2021).

Article  PubMed  Google Scholar 

Kuźnik, A., Październiok-Holewa, A., Jewula, P. & Kuźnik, N. Bisphosphonates—much more than only drugs for bone diseases. Eur. J. Pharmacol. 866, 172773 (2020).

Article  PubMed  Google Scholar 

Clark-Price, S. Nonsteroidal anti-inflammatory drugs and corticosteroids. in Pain Management in Veterinary Practice 69–84 (Wiley, 2013).

Lazzarini, L., Lipsky, B. A. & Mader, J. T. Antibiotic treatment of osteomyelitis: what have we learned from 30 years of clinical trials? Int. J. Infect. Dis. 9, 127–138 (2005).

Article  CAS  PubMed  Google Scholar 

Fu, Q. et al. A nanoagent for concurrent therapy of breast cancer bone metastasis and cancer-induced bone pain through SLC7A11 interruption and photodynamic therapy. Chin. Chem. Lett. 35, 108506 (2024).

Article  CAS  Google Scholar 

Yang, Y., Yang, W., Zhang, R. & Wang, Y. Peripheral mechanism of cancer-induced bone pain. Neurosc. Bull. 40, 815–830 (2023).

Davila, D., Antoniou, A. & Chaudhry, M. A. Evaluation of osseous metastasis in bone scintigraphy. Semin. Nucl. Med. 45, 3–15 (2015).

Article  PubMed  Google Scholar 

Yin, J. J., Pollock, C. B. & Kelly, K. Mechanisms of cancer metastasis to the bone. Cell Res. 15, 57–62 (2005).

Article  CAS  PubMed  Google Scholar 

Zajączkowska, R., Kocot-Kępska, M., Leppert, W. & Wordliczek, J. Bone pain in cancer patients: mechanisms and current treatment. Int. J. Mol. Sci. 20, 6047 (2019).

Falk, S. & Dickenson, A. H. Pain and nociception: mechanisms of cancer-induced bone pain. J. Clin. Oncol. 32, 1647–1654 (2014).

Article  CAS  PubMed  Google Scholar 

van den Beuken-van Everdingen, M. H., Hochstenbach, L. M., Joosten, E. A., Tjan-Heijnen, V. C. & Janssen, D. J. Update on prevalence of pain in patients with cancer: systematic review and meta-analysis. J. Pain. Symptom Manag. 51, 1070–1090.e1079 (2016).

Article  Google Scholar 

Anderson, R. L. et al. A framework for the development of effective anti-metastatic agents. Nat. Rev. Clin. Oncol. 16, 185–204 (2019).

Article  PubMed  Google Scholar 

Choi, J. H. & Ro, J. Y. The 2020 WHO classification of tumors of bone: an updated review. Adv. Anat. Pathol. 28, 119–138 (2021).

Article  CAS  PubMed  Google Scholar 

Sbaraglia, M., Bellan, E. & Dei Tos, A. P. The 2020 WHO classification of soft tissue tumours: news and perspectives. Pathologica 113, 70–84 (2021).

Article  PubMed  Google Scholar 

Svensson, E., Christiansen, C. F., Ulrichsen, S. P., Rørth, M. R. & Sørensen, H. T. Survival after bone metastasis by primary cancer type: a Danish population-based cohort study. BMJ open 7, e016022 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Chu, G. et al. Bone tumor segmentation on bone scans using context information and random forests. Med. Image Comput. Comput. Assist. Interv. 17, 601–608 (2014).

PubMed  Google Scholar 

Kong, P. et al. Skeletal-related events and overall survival of patients with bone metastasis from nonsmall cell lung cancer—a retrospective analysis. Medicine 96, e9327 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Hong, S., Youk, T., Lee, S. J., Kim, K. M. & Vajdic, C. M. Bone metastasis and skeletal-related events in patients with solid cancer: a Korean nationwide health insurance database study. PLoS One 15, e0234927 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schulman, K. L. & Kohles, J. Economic burden of metastatic bone disease in the U.S. Cancer 109, 2334–2342 (2007).

Article  PubMed  Google Scholar 

Phanphaisarn, A. et al. Prevalence and survival patterns of patients with bone metastasis from common cancers in Thailand. Asian Pac. J. Cancer Prev. 17, 4335–4340 (2016).

PubMed  Google Scholar 

Hernandez, R. K. et al. Incidence of bone metastases in patients with solid tumors: analysis of oncology electronic medical records in the United States. BMC Cancer 18, 44 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Portales, F. et al. Bone metastases in gastrointestinal cancer. Clin. Exp. Metastasis 32, 7–14 (2015).

Article  CAS  PubMed  Google Scholar 

Nguyen, D. X., Bos, P. D. & Massagué, J. Metastasis: from dissemination to organ-specific colonization. Nat. Rev. Cancer 9, 274–284 (2009).

Article  CAS  PubMed  Google Scholar 

Vinay, R. & KusumDevi, V. Potential of targeted drug delivery system for the treatment of bone metastasis. Drug Deliv. 23, 21–29 (2016).

Article  CAS  PubMed  Google Scholar 

Wu, Y. et al. Calcium-based biomaterials: unveiling features and expanding applications in osteosarcoma treatment. Bioact. Mater. 32, 385–399 (2024).

CAS  PubMed  Google Scholar 

Clapham, D. E. Calcium signaling. Cell 131, 1047–1058 (2007).

Article  CAS