Aye completed her undergraduate studies in chemistry at Oxford UK (2000–2004), and doctoral research in organic chemistry with Prof. David Evans at Harvard (2004–2009). She then switched her research discipline to life science and received her postdoctoral training with Prof. JoAnne Stubbe at MIT (2009–2012). Science in the Aye lab seeks to understand non-canonical cell signaling processes. Her laboratory is most well-known for investigations into electrophile signaling, a nuanced communication mode whereby on-target engagement between specific reactive metabolites and target proteins, orchestrates precision responses at cellular/organismal levels. Contributions from her laboratory have been recognized by several honors; recent examples include: 2024 Klaus Grohe award in drug discovery, 2022 Tetrahedron young investigator award, 2021 International Chemical Biology Society Global Lectureship Award for distinguished investigators in chemical biology, 2021 ACS Arthur Cope Scholar, and 2020 ACS Eli Lilly award in biological chemistry.