Deng H, Liu R, Ellmeier W, Choe S, Unutmaz D, Burkhart M, et al. Identification of a major co-receptor for primary isolates of HIV-1. Nature. 1996;381(6584):661–6.
Article CAS PubMed Google Scholar
Dragic T, Litwin V, Allaway GP, Martin SR, Huang Y, Nagashima KA, et al. HIV-1 entry into CD4 + cells is mediated by the chemokine receptor CC-CKR-5. Nature. 1996;381(6584):667.
Article CAS PubMed Google Scholar
Zaitseva M, Blauvelt A, Lee S, Lapham CK, Kiaus-Kovrun V, Mostowski H, et al. Expression and function of CCR5 and CXCR4 on human Langerhans cells and macrophages: implications for HIV primary infection. Nat Med. 1997;3:1369–75.
Article CAS PubMed Google Scholar
Carrington M, Kissner T, Gerrard B, Ivanov S, O’Brien SJ, Dean M. Novel alleles of the chemokine-receptor gene CCR5. Am J Hum Genet. 1997;61(6):1261–7.
Article CAS PubMed PubMed Central Google Scholar
An P, Martin MP, Nelson GW, Carrington M, Smith MW, Gong K, et al. Influence of CCR5 promoter haplotypes on AIDS progression in African–Americans. Aids. 2000;14(14):2117–22.
Article CAS PubMed Google Scholar
Claireaux M, Robinot R, Kervevan J, Patgaonkar M, Staropoli I, Brelot A, et al. Low CCR5 expression protects HIV-specific CD4 + T cells of elite controllers from viral entry. Nat Commun. 2022;13(1):521.
Article CAS PubMed PubMed Central Google Scholar
Ansari-Lari MA, Liu X-M, Metzker ML, Rut AR, Gibbs RA. The extent of genetic variation in the CCR5 gene. Nat Genet. 1997;16(3):221–2.
Article CAS PubMed Google Scholar
Ometto L, Bertorelle R, Mainardi M, Giurisato M, Chieco-Bianchi L, De Rossi A. Analysis of the CC chemokine receptor 5 m303 mutation in infants born to HIV-1-seropositive mothers. Aids. 1999;13(7):871.
Article CAS PubMed Google Scholar
Quillent C, Oberlin E, Braun J, Rousset D, Gonzalez-Canali G, Métais P, et al. HIV-1-resistance phenotype conferred by combination of two separate inherited mutations of CCR5 gene. The Lancet. 1998;351(9095):14–8.
Hutter G, Nowak D, Mossner M, Ganepola S, Allers K, Schneider T, et al. editors. Treatment of HIV-1 infection by allogeneic CCR5-D32/D32 stem cell transplantation: a promising approach [abstract# 719]. 15th Conference on Retroviruses and Opportunistic Infections; 2008.
Maeda K, Das D, Nakata H, Mitsuya H. CCR5 inhibitors: emergence, success, and challenges. Expert Opin Emerg Drugs. 2012;17(2):135–45.
Article CAS PubMed Google Scholar
Tan Q, Zhu Y, Li J, Chen Z, Han GW, Kufareva I, et al. Structure of the CCR5 chemokine receptor–HIV entry inhibitor maraviroc complex. Science. 2013;341(6152):1387–90.
Article CAS PubMed Google Scholar
Kayongo A, Gonzalo-Gil E, Gümüşgöz E, Niwaha AJ, Semitala F, Kalyesubula R, et al. Brief report: identification of elite and viremic controllers from a large urban HIV ambulatory center in Kampala, Uganda. J Acquir Immune Defic Syndr. 2018;79(3):394.
Article PubMed PubMed Central Google Scholar
Laeyendecker O, Redd AD, Lutalo T, Gray RH, Wawer M, Ssempijja V, et al. Frequency of long-term nonprogressors in HIV-1 seroconverters from Rakai Uganda. J Acquir Immune Defic Syndr. 2009;52(3):316.
Article PubMed PubMed Central Google Scholar
Walker WE, Kurscheid S, Joshi S, Lopez CA, Goh G, Choi M, et al. Increased levels of macrophage inflammatory proteins result in resistance to R5-tropic HIV-1 in a subset of elite controllers. J Virol. 2015;89(10):5502–14.
Article CAS PubMed PubMed Central Google Scholar
Walker BD, Yu XG. Unravelling the mechanisms of durable control of HIV-1. Nat Rev Immunol. 2013;13(7):487–98.
Article CAS PubMed Google Scholar
Sáez-Cirión A, Lacabaratz C, Lambotte O, Versmisse P. HIV controllers exhibit potent CD8 T cell capacity to 3 suppress HIV infection ex vivo and peculiar CTL 4 activation phenotype.
Lissina A, Chakrabarti LA, Takiguchi M, Appay V. TCR clonotypes: molecular determinants of T-cell efficacy against HIV. Curr Opin Virol. 2016;16:77–85.
Article CAS PubMed Google Scholar
Pereyra F, Jia X, McLaren P, Telenti A, de Bakker P, Walker B. The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. Science (80-)[Internet]. 2010 Dec 10; 330 (6010): 1551–7.
Ferre AL, Hunt PW, McConnell DH, Morris MM, Garcia JC, Pollard RB, et al. HIV controllers with HLA-DRB1* 13 and HLA-DQB1* 06 alleles have strong, polyfunctional mucosal CD4 + T-cell responses. J Virol. 2010;84(21):11020–9.
Article CAS PubMed PubMed Central Google Scholar
Amanya SB. VARIATIONS IN TRIM5α AND CYCLOPHILIN A GENES AMONG HIV-1 ELITE CONTROLLERS AND NON CONTROLLERS IN UGANDA. Makerere University; 2019.
Ganser-Pornillos BK, Pornillos O. Restriction of HIV-1 and other retroviruses by TRIM5. Nat Rev Microbiol. 2019;17(9):546–56.
Article CAS PubMed PubMed Central Google Scholar
Javanbakht H, An P, Gold B, Petersen DC, O’Huigin C, Nelson GW, et al. Effects of human TRIM5α polymorphisms on antiretroviral function and susceptibility to human immunodeficiency virus infection. Virology. 2006;354(1):15–27.
Article CAS PubMed Google Scholar
Gonzalo-Gil E, Rapuano PB, Ikediobi U, Leibowitz R, Mehta S, Coskun AK, et al. Transcriptional down-regulation of ccr5 in a subset of HIV + controllers and their family members. Elife. 2019;8:e44360.
Article CAS PubMed PubMed Central Google Scholar
Salem A-H, Batzer MA. Distribution of the HIV resistance CCR5-∆32 allele among Egyptians and Syrians. Mutat Research/Fundamental Mol Mech Mutagen. 2007;616(1–2):175–80.
Barmania F, Potgieter M, Pepper MS. Mutations in CC chemokine receptor type 5 (CCR5) in south african individuals. Int J Infect Dis. 2013;17(12):e1148–e53.
Article CAS PubMed Google Scholar
McDermott DH, Zimmerman PA, Guignard F, Kleeberger CA, Leitman SF, Murphy PM. CCR5 promoter polymorphism and HIV-1 disease progression. The Lancet. 1998;352(9131):866.
Mummidi S, Ahuja SS, Gonalez E, Anderson SA, Santiago EN, Stephan KT, et al. Genealogy of the CCR5 locus and chemokine system gene variants associated with altered rates of HIV-1 disease progression. Nat Med. 1998;4:786–93.
Article CAS PubMed Google Scholar
Zimmerman PA, Buckler-White A, Alkhatib G, Spalding T, Kubofcik J, Combadiere C, et al. Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5: studies in populations with contrasting clinical phenotypes, defined racial background, and quantified risk. Mol Med. 1997;3(1):23–36.
Article CAS PubMed PubMed Central Google Scholar
Mehlotra RK. CCR5 promoter polymorphism – 2459G > A: forgotten or ignored? Cells. 2019;8(7):651.
Article CAS PubMed PubMed Central Google Scholar
Kostrikis LG, Neumann AU, Thomson B, Korber BT, McHardy P, Karanicolas R, et al. A polymorphism in the regulatory region of the CC-chemokine receptor 5 gene influences perinatal transmission of human immunodeficiency virus type 1 to african-american infants. J Virol. 1999;73(12):10264–71.
Article CAS PubMed PubMed Central Google Scholar
John GC, Bird T, Overbaugh J, Nduati R, Mbori-Ngacha D, Rostron T, et al. CCR5 promoter polymorphisms in a kenyan perinatal human immunodeficiency virus type 1 cohort: association with increased 2-year maternal mortality. J Infect Dis. 2001;184(1):89–92.
Article CAS PubMed Google Scholar
Singh KK, Hughes MD, Chen J, Phiri K, Rousseau C, Kuhn L, et al. Associations of chemokine receptor polymorphisms with HIV-1 mother-to-child transmission in sub-saharan Africa: possible modulation of genetic effects by antiretrovirals. J Acquir Immune Defic Syndr. 2008;49(3):259.
Article CAS PubMed PubMed Central Google Scholar
Gabagaya G, Rukundo G, Amone A, Wavamunno P, Namale-Matovu J, Lubega I, et al. Prevalence of undetectable and suppressed viral load in HIV-infected pregnant women initiating option B + in Uganda: an observational study nested within a randomized controlled trial. BMC Infect Dis. 2021;21(1):1–7.
Price H, Lacap P, Tuff J, Wachihi C, Kimani J, Ball TB, et al. A Trim5alpha exon 2 polymorphism is associated with protection from HIV-1 infection in Pumwani sexworker cohort. AIDS. 2010;24(12):1813.
Article CAS PubMed Google Scholar
Chakrabarti LA, Simon V. Immune mechanisms of HIV control. Curr Opin Immunol. 2010;22(4):488–96.
Article CAS PubMed PubMed Central Google Scholar
Pereyra F, Addo MM, Kaufmann DE, Liu Y, Miura T, Rathod A, et al. Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy. J Infect Dis. 2008;197(4):563–71.
Meijerink H, Indrati AR, van Crevel R, Joosten I, Koenen H, van der Ven AJ. The number of CCR5 expressing CD4 + T lymphocytes is lower in HIV-infected long-term non-progressors with viral control compared to normal progressors: a cross-sectional study. BMC Infect Dis. 2014;14(1):1–9.
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