Lundberg, I. E. et al. Idiopathic inflammatory myopathies. Nat. Rev. Dis. Prim. 7, 86 (2021).
McHugh, N. J. & Tansley, S. L. Autoantibodies in myositis. Nat. Rev. Rheumatol. 14, 290–302 (2018).
Article CAS PubMed Google Scholar
Sato, S. et al. Autoantibodies to a 140-kd polypeptide, CADM-140, in Japanese patients with clinically amyopathic dermatomyositis. Arthritis Rheum. 52, 1571–1576 (2005).
Article CAS PubMed Google Scholar
Sontheimer, R. D. Would a new name hasten the acceptance of amyopathic dermatomyositis (dermatomyositis siné myositis) as a distinctive subset within the idiopathic inflammatory dermatomyopathies spectrum of clinical illness? J. Am. Acad. Dermatol. 46, 626–636 (2002).
Mammen, A. L., Allenbach, Y., Stenzel, W. & Benveniste, O. 239th ENMC International Workshop: classification of dermatomyositis, Amsterdam, the Netherlands, 14–16 December 2018. Neuromuscul. Disord. 30, 70–92 (2020).
Muro, Y., Sugiura, K., Hoshino, K., Akiyama, M. & Tamakoshi, K. Epidemiologic study of clinically amyopathic dermatomyositis and anti-melanoma differentiation-associated gene 5 antibodies in central Japan. Arthritis Res. Ther. 13, R214 (2011).
Article CAS PubMed Google Scholar
Nishina, N., Sato, S., Masui, K., Gono, T. & Kuwana, M. Seasonal and residential clustering at disease onset of anti-MDA5-associated interstitial lung disease. RMD Open. 6, e001202 (2020).
So, H. et al. Seasonal effect on disease onset and presentation in anti-MDA5 positive dermatomyositis. Front. Med. 9, 837024 (2022).
Toquet, S. et al. The seasonality of dermatomyositis associated with anti-MDA5 antibody: an argument for a respiratory viral trigger. Autoimmun. Rev. 20, 102788 (2021).
Article CAS PubMed Google Scholar
Tonutti, A. et al. Anti-MDA5 antibody linking COVID-19, type I interferon, and autoimmunity: a case report and systematic literature review. Front. Immunol. 13, 937667 (2022).
Article CAS PubMed Google Scholar
Kitajima, T. et al. Antimelanoma differentiation-associated gene 5 antibody-positive interstitial lung disease after vaccination with COVID-19 mRNA vaccines. J. Rheumatol. 49, 1158–1162 (2022).
Article CAS PubMed Google Scholar
Kondo, Y. et al. COVID-19 shares clinical features with anti-melanoma differentiation-associated protein 5 positive dermatomyositis and adult Still’s disease. Clin. Exp. Rheumatol. 39, 631–638 (2021).
Jin, Q. et al. Peripheral lymphocyte count defines the clinical phenotypes and prognosis in patients with anti‐MDA5‐positive dermatomyositis. J. Intern. Med. 293, 494–507 (2023).
Article CAS PubMed Google Scholar
Fiorentino, D., Chung, L., Zwerner, J., Rosen, A. & Casciola-Rosen, L. The mucocutaneous and systemic phenotype of dermatomyositis patients with antibodies to MDA5 (CADM-140): a retrospective study. J. Am. Acad. Dermatol. 65, 25–34 (2011).
Kurtzman, D. J. B. & Vleugels, R. A. Anti-melanoma differentiation-associated gene 5 (MDA5) dermatomyositis: a concise review with an emphasis on distinctive clinical features. J. Am. Acad. Dermatol. 78, 776–785 (2018).
Article CAS PubMed Google Scholar
Combalia, A., Giavedoni, P., Tamez, L., Grau-Junyent, J. M. & Mascaró, J. M. Jr. Bosentan for cutaneous ulcers in anti-MDA5 dermatomyositis. JAMA Dermatol. 154, 371–373 (2018).
Min, H. K. et al. Refractory digital ulcers treated by botulinum toxin and endothelin receptor-1 antagonist in anti-MDA5-antibody-positive dermatomyositis. J. Clin. Neurol. 16, 160 (2020).
Narang, N. S., Casciola-Rosen, L., Li, S., Chung, L. & Fiorentino, D. F. Cutaneous ulceration in dermatomyositis: association with anti-melanoma differentiation-associated gene 5 antibodies and interstitial lung disease. Arthritis Care Res. 67, 667–672 (2015).
Chanprapaph, K., Udompanich, S., Visessiri, Y., Ngamjanyaporn, P. & Suchonwanit, P. Nonscarring alopecia in systemic lupus erythematosus: a cross-sectional study with trichoscopic, histopathologic, and immunopathologic analyses. J. Am. Acad. Dermatol. 81, 1319–1329 (2019).
Yang, H. et al. Differential clinical associations of anti–nuclear matrix protein 2 autoantibodies in patients with idiopathic inflammatory myopathies. Arthritis Rheumatol. 70, 1288–1297 (2018).
Article CAS PubMed Google Scholar
Hall, J. C. et al. Anti-melanoma differentiation-associated protein 5-associated dermatomyositis: expanding the clinical spectrum. Arthritis Care Res. 65, 1307–1315 (2013).
Valenzuela, A., Chung, L., Casciola-Rosen, L. & Fiorentino, D. Identification of clinical features and autoantibodies associated with calcinosis in dermatomyositis. JAMA Dermatol. 150, 724–729 (2014).
Rathore, U., Haldule, S. & Gupta, L. Psoriasiform rashes as the first manifestation of anti-MDA5 associated myositis. Rheumatology 60, 3483–3483 (2021).
Nombel, A., Fabien, N. & Coutant, F. Dermatomyositis with anti-MDA5 antibodies: bioclinical features, pathogenesis and emerging therapies. Front. Immunol. 12, 773352 (2021).
Article CAS PubMed Google Scholar
Xie, H. et al. Risk factors for mortality in patients with anti-MDA5 antibody-positive dermatomyositis: a meta-analysis and systematic review. Semin. Arthritis Rheum. 62, 152231 (2023).
Article CAS PubMed Google Scholar
Gono, T. et al. Clinical manifestation and prognostic factor in anti-melanoma differentiation-associated gene 5 antibody-associated interstitial lung disease as a complication of dermatomyositis. Rheumatology 49, 1713–1719 (2010).
Article CAS PubMed Google Scholar
Chen, F., Wang, D., Shu, X., Nakashima, R. & Wang, G. Anti-MDA5 antibody is associated with A/SIP and decreased T cells in peripheral blood and predicts poor prognosis of ILD in Chinese patients with dermatomyositis. Rheumatol. Int. 32, 3909–3915 (2012).
Article CAS PubMed Google Scholar
Ceribelli, A. et al. Prevalence and clinical significance of anti-MDA5 antibodies in European patients with polymyositis/dermatomyositis. Clin. Exp. Rheumatol. 32, 891–897 (2014).
Chen, Z. et al. Utility of anti-melanoma differentiation-associated gene 5 antibody measurement in identifying patients with dermatomyositis and a high risk for developing rapidly progressive interstitial lung disease: a review of the literature and a meta-analysis. Arthritis Care Res. 65, 1316–1324 (2013).
Zuo, Y. et al. Clinical significance of radiological patterns of HRCT and their association with macrophage activation in dermatomyositis. Rheumatology 59, 2829–2837 (2020).
Article CAS PubMed Google Scholar
Chino, H. et al. Radiological and pathological correlation in anti-MDA5 antibody-positive interstitial lung disease: rapidly progressive perilobular opacities and diffuse alveolar damage. Intern. Med. 55, 2241–2246 (2016).
Chino, H. et al. Interstitial lung disease with anti-melanoma differentiation-associated protein 5 antibody: rapidly progressive perilobular opacity. Intern. Med. 58, 2605–2613 (2019).
Chen, X. et al. Clinical, radiological and pathological features of anti-MDA5 antibody-associated interstitial lung disease. RMD Open. 9, e003150 (2023).
Zhou, M. et al. Noninvasive positive pressure ventilator deteriorates the outcome of pneumomediastinum in anti-MDA5 antibody-positive clinically amyopathic dermatomyositis. Clin. Rheumatol. 39, 1919–1927 (2020).
Abe, K. et al. Prognosis of spontaneous pneumomediastinum occurring in dermatomyositis or polymyositis patients with interstitial lung disease according to antimelanoma differentiation-associated gene 5 antibody status: a retrospective cohort study. RMD Open. 9, e002770 (2023).
Ma, X. et al. Clinical and serological features of patients with dermatomyositis complicated by spontaneous pneumomediastinum. Clin. Rheumatol. 35, 489–493 (2016).
Zhou, S. et al. Myocardial involvement is not rare in anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis/clinically amyopathic dermatomyositis: a retrospective study. Front. Immunol. 13, 928861 (2022).
Article CAS PubMed Google Scholar
Li, S. et al. The spectrum and clinical significance of myositis-specific autoantibodies in Chinese patients with idiopathic inflammatory myopathies. Clin. Rheumatol. 38, 2171–2179 (2019).
Sakamoto, R. et al. Myxovirus resistance protein 1-expressing fatal myocarditis in a patient with anti-MDA5 antibody-positive dermatomyositis. Rheumatology 60, e450–e452 (2021).
Roeser, A. et al. Successful outcome under multiple therapy in two ca
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