Astragaloside promotes the secretion of MSC-derived exosomal miR-146a-5p by regulating TRAF6/NF-κB pathway to attenuate inflammation in high glucose-impaired endothelial cells

Abdalla M, Sabbineni H, Prakash R, Ergul A, Fagan SC, Somanath PR (2015) The Akt inhibitor, triciribine, ameliorates chronic hypoxia-induced vascular pruning and TGFbeta-induced pulmonary fibrosis. Br J Pharmacol 172(16):4173–4188

Article  CAS  PubMed  PubMed Central  Google Scholar 

Asami T, Ishii M, Fujii H, Namkoong H, Tasaka S, Matsushita K et al (2013) Modulation of murine macrophage TLR7/8-mediated cytokine expression by mesenchymal stem cell-conditioned medium. Mediators Inflamm 2013:264260

Article  PubMed  PubMed Central  Google Scholar 

Auyeung KK, Han QB, Ko JK (2016) Astragalus membranaceus: A Review of its Protection Against Inflammation and Gastrointestinal Cancers. Am J Chin Med 44(1):1–22

Article  PubMed  Google Scholar 

Cade WT (2008) Diabetes-related microvascular and macrovascular diseases in the physical therapy setting. Phys Ther 88(11):1322–1335

Article  PubMed  PubMed Central  Google Scholar 

Ceriello A (2010) Point: postprandial glucose levels are a clinically important treatment target. Diabetes Care 33(8):1905–1907

Article  PubMed  PubMed Central  Google Scholar 

Chen HX, Liang FC, Gu P, Xu BL, Xu HJ, Wang WT et al (2020) Exosomes derived from mesenchymal stem cells repair a Parkinson’s disease model by inducing autophagy. Cell Death Dis 11(4):288

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Q, Su Y, Ju Y, Ma K, Li W, Li W (2018) Astragalosides IV protected the renal tubular epithelial cells from free fatty acids-induced injury by reducing oxidative stress and apoptosis. Biomed Pharmacother 108:679–686

Article  CAS  PubMed  Google Scholar 

Ding J, Wang X, Chen B, Zhang J, Xu J (2019) Exosomes Derived from Human Bone Marrow Mesenchymal Stem Cells Stimulated by Deferoxamine Accelerate Cutaneous Wound Healing by Promoting Angiogenesis. BioMed Res Int 2019:1–12

Google Scholar 

Ding J, Zhang Y, Cai X, Zhang Y, Yan S, Wang J et al (2021) Extracellular vesicles derived from M1 macrophages deliver miR-146a-5p and miR-146b-5p to suppress trophoblast migration and invasion by targeting TRAF6 in recurrent spontaneous abortion. Theranostics 11(12):5813–5830

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fu J, Wang Z, Huang L, Zheng S, Wang D, Chen S et al (2014) Review of the botanical characteristics, phytochemistry, and pharmacology of Astragalus membranaceus (Huangqi). Phytother Res 28(9):1275–1283

Article  CAS  PubMed  Google Scholar 

Grassi D, Desideri G, Necozione S, Ruggieri F, Blumberg JB, Stornello M, Ferri C (2012) Protective effects of flavanol-rich dark chocolate on endothelial function and wave reflection during acute hyperglycemia. Hypertension 60(3):827–832

Article  CAS  PubMed  Google Scholar 

Gui D, Huang J, Guo Y, Chen J, Chen Y, Xiao W et al (2013) Astragaloside IV ameliorates renal injury in streptozotocin-induced diabetic rats through inhibiting NF-κB-mediated inflammatory genes expression. Cytokine 61(3):970–977

Article  CAS  PubMed  Google Scholar 

Hua T, Yang M, Song H, Kong E, Deng M, Li Y et al (2022) Huc-MSCs-derived exosomes attenuate inflammatory pain by regulating microglia pyroptosis and autophagy via the miR-146a-5p/TRAF6 axis. J Nanobiotech 20(1):324

Article  CAS  Google Scholar 

Kilchert C, Wittmann S, Vasiljeva L (2016) The regulation and functions of the nuclear RNA exosome complex. Nat Rev Mol Cell Biol 17(4):227–239

Article  CAS  PubMed  Google Scholar 

Kong LY, Liang MY, Liu JP, Lai P, Ye JS, Zhang ZX et al (2020) Mesenchymal Stem Cell-derived Exosomes Rescue Oxygen-Glucose Deprivation-induced Injury in Endothelial Cells. Curr Neurovasc Res 17(2):155–163

Article  CAS  PubMed  Google Scholar 

Li L, Hou X, Xu R, Liu C, Tu M (2017) Research review on the pharmacological effects of astragaloside IV. Fundam Clin Pharmacol 31(1):17–36

Article  CAS  PubMed  Google Scholar 

Li Y, Shen Z, Jiang X, Wang Y, Yang Z, Mao Y et al (2022) Mouse mesenchymal stem cell-derived exosomal miR-466f-3p reverses EMT process through inhibiting AKT/GSK3β pathway via c-MET in radiation-induced lung injury. J Exp Clin Cancer Res 41(1):128

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li YE, Ajoolabady A, Dhanasekaran M, Ren J (2022) Tissue repair strategies: What we have learned from COVID-19 in the application of MSCs therapy. Pharmacol Res 182:106334

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mao W, Fan Y, Wang X, Feng G, You Y, Li H et al (2022) Phloretin ameliorates diabetes-induced endothelial injury through AMPK-dependent anti-EndMT pathway. Pharmacol Res 179:106205

Article  CAS  PubMed  Google Scholar 

Mathieu M, Martin-Jaular L, Lavieu G, Thery C (2019) Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication. Nat Cell Biol 21(1):9–17

Article  CAS  PubMed  Google Scholar 

Mayourian J, Ceholski DK, Gorski PA, Mathiyalagan P, Murphy JF, Salazar SI et al (2018) Exosomal microRNA-21-5p Mediates Mesenchymal Stem Cell Paracrine Effects on Human Cardiac Tissue Contractility. Circ Res 122(7):933–944

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rajendran S, Seetharaman S, Dharmarajan A, Kuppan K (2021) Microvascular cells: A special focus on heterogeneity of pericytes in diabetes associated complications. Int J Biochem Cell Biol 134:105971

Article  CAS  PubMed  Google Scholar 

Ranjbaran M, Kianian F, Kadkhodaee M, Seifi B, Ashabi G, Akhondzadeh F et al (2022) Mesenchymal stem cells and their conditioned medium as potential therapeutic strategies in managing comorbid anxiety in rat sepsis induced by cecal ligation and puncture. Iran J Basic Med Sci 25(6):690–697

PubMed  PubMed Central  Google Scholar 

Rusca N, Monticelli S (2011) MiR-146a in Immunity and Disease. Mol Biol Int 2011:437301

Article  PubMed  PubMed Central  Google Scholar 

Sanz AB, Sanchez-Niño MD, Ramos AM, Moreno JA, Santamaria B, Ruiz-Ortega M et al (2010) NF-kappaB in renal inflammation. J Am Soc Nephrol 21(8):1254–1262

Article  CAS  PubMed  Google Scholar 

Sha Z, Liu W, Jiang T, Zhang K, Yu Z (2023) Astragaloside IV induces the protective effect of bone marrow mesenchymal stem cells derived exosomes in acute myocardial infarction by inducing angiogenesis and inhibiting apoptosis. Biotechnol Genet Eng Rev, 1–18

Shiue SJ, Rau RH, Shiue HS, Hung YW, Li ZX, Yang KD, Cheng JK (2019) Mesenchymal stem cell exosomes as a cell-free therapy for nerve injury-induced pain in rats. Pain 160(1):210–223

Article  CAS  PubMed  Google Scholar 

Song G, Li L, Yang Y (2021) MicroRNA-329-3p alleviates high glucose-induced endothelial cell injury via inhibition of the TLR4/TRAF6/NF-κB signaling pathway. Exp Ther Med 21(1):29

CAS  PubMed  Google Scholar 

Sun L, Li W, Li W, Xiong L, Li G, Ma R (2014) Astragaloside IV prevents damage to human mesangial cells through the inhibition of the NADPH oxidase/ROS/Akt/NF-κB pathway under high glucose conditions. Int J Mol Med 34(1):167–176

Article  CAS  PubMed  Google Scholar 

Wang G, Yuan J, Cai X, Xu Z, Wang J, Ocansey DKW et al (2020) HucMSC-exosomes carrying miR-326 inhibit neddylation to relieve inflammatory bowel disease in mice. Clin Transl Med 10(2):e113

Article  PubMed  PubMed Central  Google Scholar 

Wang Q, Ou K, Zeng C, Fang Y (2022) 5-Bromo-3,4-dihydroxybenzaldehyde attenuates endothelial cells injury from high glucose-induced damage. Biomed Pharmacother 155:113793

Article  CAS  PubMed  Google Scholar 

Xiong W, Huang XL, Li CY, Wang XL, Lan HW, Wang TT et al (2022) Astragaloside IV - mediated endothelial progenitor cell exosomes promote autophagy and inhibit apoptosis in hyperglycemic damaged endothelial cells via miR-21/PTEN axis. Folia Histochem Cytobiol 60(4):323–334

Comments (0)

No login
gif