Billing LJ, Larraufie P, Lewis J, Leiter A, Li J, Lam B, Yeo GSH, Goldspink DA, Kay RG, Gribble FM, Reimann F (2019) Single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice–identification of selective stimuli for insulin-like peptide-5 and glucagon-like peptide-1 co-expressing cells. Mol Metab 29:158–169. https://doi.org/10.1016/j.molmet.2019.09.001

Article  PubMed  PubMed Central  CAS  Google Scholar 

Busslinger GA, Weusten BL, Bogte A, Begthel H, Brosens LA, & Clevers H (2021) Human gastrointestinal epithelia of the esophagus, stomach, and duodenum resolved at single-cell resolution. Cell Reports, 34(10). https://doi.org/10.1016/j.celrep.2021.108819

Chen YJ, Finkbeiner SR, Weinblatt D, Emmett MJ, Tameire F, Yousefi M, Yang C, Maehr R, Zhou Q, Shemer R, Dor Y, Li C, Spence JR, Stanger BZ (2014) De novo formation of insulin-producing “neo-β cell islets” from intestinal crypts. Cell Rep 6:1046–1058. https://doi.org/10.1016/j.celrep.2014.02.013

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cordell B, Bell G, Tischer E, Denoto FM, Ullrich A, Pictet R, Rutter WJ, Goodman HM (1979) Isolation and characterization of a cloned rat insulin gene. Cell 18:533–543

Article  PubMed  CAS  Google Scholar 

Darwich AS, Aslam U, Ashcroft DM, Rostami-Hodjegan A (2014) Meta-analysis of the turnover of intestinal epithelia in preclinical animal species and humans. Drug Metab Dispos 42:2016–2022. https://doi.org/10.1016/j.celrep.2014.02.013

Article  PubMed  CAS  Google Scholar 

Douville JM, Cheung DY, Herbert KL, Moffatt T, Wigle JT (2011) Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21CIP1/WAF1 and p16INK4a in vascular endothelial cells. PloS one 6:e29099. https://doi.org/10.1371/journal.pone.0029099

Article  PubMed  PubMed Central  CAS  Google Scholar 

Drucker DJ (2016) Evolving concepts and translational relevance of enteroendocrine cell biology. J Clin Endocrinol Metab 101:778–786. https://doi.org/10.1210/jc.2015-3449

Article  PubMed  CAS  Google Scholar 

Egerod KL, Engelstoft MS, Grunddal KV, Nøhr MK, Secher A, Sakata I, Pedersen J, Windeløv JA, Füchtbauer EM, Olsen J, Sundler F, Christensen JP, Wierup N, Olsen JV, Holst JJ, Zigman JM, Poulsen SS, Schwartz TW (2012) A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin. Endocrinology 153:5782–5795. https://doi.org/10.1210/en.2012-1595

Article  PubMed  PubMed Central  CAS  Google Scholar 

Fawkner-Corbett D, Antanaviciute A, Parikh K, Jagielowicz M, Gerós AS, Gupta T, Ashley N, Khamis D, Fowler D, Morrissey E, Cunningham C, Johnson PRV, Koohy H, Simmons A (2021) Spatiotemporal analysis of human intestinal development at single-cell resolution. Cell 184(3):810–826

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gribble FM, Reimann F (2019) Function and mechanisms of enteroendocrine cells and gut hormones in metabolism. Nat Rev Endocrinol 15:226–237

Article  PubMed  CAS  Google Scholar 

Gunawardene AR, Corfe BM, Staton CA (2011) Classification and functions of enteroendocrine cells of the lower gastrointestinal tract. Int J Exp Pathol 92(4):219–231. https://doi.org/10.1111/j.1365-2613.2011.00767.x

Article  PubMed  PubMed Central  CAS  Google Scholar 

Habib AM, Richards P, Cairns LS, Rogers GJ, Bannon CA, Parker HE, Morley TC, Yeo GS, Reimann F, Gribble FM (2012) Overlap of endocrine hormone expression in the mouse intestine revealed by transcriptional profiling and flow cytometry. Endocrinology 153:3054–3065. https://doi.org/10.1210/en.2011-2170

Article  PubMed  PubMed Central  CAS  Google Scholar 

Karra E, Batterham RL (2010) The role of gut hormones in the regulation of body weight and energy homeostasis. Mol Cell Endocrinol 316(2):120–128. https://doi.org/10.1016/j.mce.2009.06.010

Article  PubMed  CAS  Google Scholar 

Kimmel RA, Onder L, Wilfinger A, Ellertsdottir E, Meyer D (2011) Requirement for Pdx1 in specification of latent endocrine progenitors in zebrafish. BMC Biol 9:1–15. https://doi.org/10.1186/1741-7007-9-75

Article  CAS  Google Scholar 

Kuhre RE, Wewer Albrechtsen NJ, Deacon CF, Balk-Møller E, Rehfeld JF, Reimann F, Gribble FM, Holst JJ (2016) Peptide production and secretion in GLUTag, NCI-H716, and STC-1 cells: a comparison to native L-cells. J Mol Endocrinol 56:201–211. https://doi.org/10.1530/JME-15-0293

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kuroda A, Rauch TA, Todorov I, Ku HT, Al-Abdullah IH, Kandeel F, Mullen Y, Pfeifer GP, Ferreri K (2009) Insulin gene expression is regulated by DNA methylation. PLoS ONE 4(9):e6953. https://doi.org/10.1371/journal.pone.0006953

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lee E, Ryu GR, Moon SD, Ko SH, Ahn YB, Song KH (2014) Reprogramming of enteroendocrine K cells to pancreatic β-cells through the combined expression of Nkx6. 1 and Neurogenin3, and reaggregation in suspension culture. Biochem Biophys Res Commun 443:1021–1027. https://doi.org/10.1016/j.bbrc.2013.12.093

Article  PubMed  CAS  Google Scholar 

Li H, Helena E (2001) Persistent expression of Hlxb9 in the pancreatic epithelium impairs pancreatic development. Dev Biol 240:247–253. https://doi.org/10.1006/dbio.2001.0440

Article  PubMed  CAS  Google Scholar 

Liberzon A, Ridner G, Walker MD (2004) Role of intrinsic DNA binding specificity in defining target genes of the mammalian transcription factor PDX1. Nucleic Acids Res 32:54–64. https://doi.org/10.1093/nar/gkh156

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lockshin RA, Zahra Z, Tilly JL (1998) When cells die: a comprehensive evaluation of apoptosis and programmed cell death. New York: Wiley-Liss, 504 pp. ISBN 0–471–16569–7

May CL, Kaestner KH (2010) Gut endocrine cell development. Mol Cell Endocrinol 323:70. https://doi.org/10.1016/j.mce.2009.12.009

Article  PubMed  CAS  Google Scholar 

McCarthy T, Green BD, Calderwood D, Gillespie A, Cryan JF, Giblin L (2015) STC-1 cells. The impact of food bioactives on health: in vitro and ex vivo models 211–220. https://doi.org/10.1007/978-3-319-16104-4_19

Miki T, Minami K, Shinozaki H, Matsumura K, Saraya A, Ikeda H, Yamada Y, Holst JJ, Seino S (2005) Distinct effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 on insulin secretion and gut motility. Diabetes 54:1056–1063. https://doi.org/10.2337/diabetes.54.4.1056

Article  PubMed  CAS  Google Scholar 

Moran-Ramos S, Tovar AR, Torres N (2012) Diet: friend or foe of enteroendocrine cells: how it interacts with enteroendocrine cells. Adv Nutr 3:8–20. https://doi.org/10.3945/an.111.000976

Article  PubMed  PubMed Central  CAS  Google Scholar 

Nakashima K, Kanda Y, Hirokawa Y, Kawasaki F, Matsuki M, Kaku K (2009) MIN6 is not a pure beta cell line but a mixed cell line with other pancreatic endocrine hormones. Endocrine J 56(1):45–53. https://doi.org/10.1507/endocrj.K08E-172

Article  CAS  Google Scholar 

Nishimura W, Kondo T, Salameh T, El Khattabi I, Dodge R, Bonner-Weir S, Sharma A (2006) A switch from MafB to MafA expression accompanies differentiation to pancreatic β-cells. Dev Biol 293:526–539. https://doi.org/10.1016/j.ydbio.2006.02.028

Article  PubMed  PubMed Central  CAS  Google Scholar 

Permuth-Wey J, Chen YA, Fisher K, McCarthy S, Qu X, Lloyd MC, Kasprzak A, Fournier M, Williams VL, Ghia KM, Yoder SJ, Hall L, Georgeades C, Olaoye F, Husain K, Springett GM, Chen DT, Yeatman T, Centeno BA, Klapman J, Coppola D, Malafa M (2015) A genome-wide investigation of microRNA expression identifies biologically-meaningful microRNAs that distinguish between high-risk and low-risk intraductal papillary mucinous neoplasms of the pancreas. PLoS ONE 10:e0116869. https://doi.org/10.1371/journal.pone.0116869

Article  PubMed  PubMed Central  CAS  Google Scholar 

Perry B, Wang Y (2012) Appetite regulation and weight control: the role of gut hormones. Nutr Diabetes 2(1):e26–e26. https://doi.org/10.1038/nutd.2011.21

Article  PubMed  PubMed Central