Armenian SH, Lacchetti C, Barac A, et al. Prevention and monitoring of cardiac dysfunction in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline. J Clin Oncol: Off J Am Soc Clin Oncol. 2017;35:893–911.

Article  Google Scholar 

Asselin BL, Devidas M, Chen L, et al. Cardioprotection and Safety of dexrazoxane in patients treated for newly diagnosed T-cell acute lymphoblastic leukemia or advanced-stage lymphoblastic non-Hodgkin lymphoma: a report of the Children’s Oncology Group Randomized Trial Pediatric Oncology Group 9404. J Clin Oncol: Off J Am Soc Clin Oncol. 2016;34:854–62.

Article  CAS  Google Scholar 

Cardinale D, Colombo A, Bacchiani G, et al. Early detection of anthracycline cardiotoxicity and improvement with heart failure therapy. Circulation. 2015;131:1981–8.

Article  CAS  PubMed  Google Scholar 

Catanzaro MP, Weiner A, Kaminaris A, et al. Doxorubicin-induced cardiomyocyte death is mediated by unchecked mitochondrial fission and mitophagy. FASEB J: Off Publ Fed Am Soc Exp Biol. 2019;33:11096–108.

Article  CAS  Google Scholar 

Chang HM, Okwuosa TM, Scarabelli T, Moudgil R, Yeh ETH. Cardiovascular complications of cancer therapy: best practices in diagnosis, prevention, and management: part 2. J Am Coll Cardiol. 2017;70:2552–65.

Article  PubMed  PubMed Central  Google Scholar 

Dalby KN, Tekedereli I, Lopez-Berestein G, Ozpolat B. Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer. Autophagy. 2010;6:322–9.

Article  CAS  PubMed  Google Scholar 

Davis JL. A practical system for narcotic control within the OR/PACU. J Post Anesth Nurs. 1989;4:32–5.

CAS  PubMed  Google Scholar 

Gu J, Song ZP, Gui DM, Hu W, Chen YG, Zhang DD. Resveratrol attenuates doxorubicin-induced cardiomyocyte apoptosis in lymphoma nude mice by heme oxygenase-1 induction. Cardiovasc Toxicol. 2012;12:341–9.

Article  CAS  PubMed  Google Scholar 

Gu J, Hu W, Song ZP, Chen YG, Zhang DD, Wang CQ. Resveratrol-induced autophagy promotes survival and attenuates doxorubicin-induced cardiotoxicity. Int Immunopharmacol. 2016;32:1–7.

Article  PubMed  Google Scholar 

Gu J, Fan YQ, Zhang HL, et al. Resveratrol suppresses doxorubicin-induced cardiotoxicity by disrupting E2F1 mediated autophagy inhibition and apoptosis promotion. Biochem Pharmacol. 2018;150:202–13.

Article  CAS  PubMed  Google Scholar 

Levy JMM, Towers CG, Thorburn A. Targeting autophagy in cancer. Nat Rev Cancer. 2017;17:528–42.

Article  CAS  PubMed  Google Scholar 

Li DL, Wang ZV, Ding G, et al. Doxorubicin blocks cardiomyocyte autophagic flux by inhibiting lysosome acidification. Circulation. 2016;133:1668–87.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li M, Sala V, De Santis MC, et al. Phosphoinositide 3-kinase gamma inhibition protects from anthracycline cardiotoxicity and reduces tumor growth. Circulation. 2018;138:696–711.

Article  CAS  PubMed  Google Scholar 

Lipshultz SE, Scully RE, Lipsitz SR, et al. Assessment of dexrazoxane as a cardioprotectant in doxorubicin-treated children with high-risk acute lymphoblastic leukaemia: long-term follow-up of a prospective, randomised, multicentre trial. Lancet Oncol. 2010;11:950–61.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mariño G, Pietrocola F, Kong Y, et al. Dimethyl α-ketoglutarate inhibits maladaptive autophagy in pressure overload-induced cardiomyopathy. Autophagy. 2014;10:930–2.

Article  PubMed  PubMed Central  Google Scholar 

Nakai A, Yamaguchi O, Takeda T, et al. The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med. 2007;13:619–24.

Article  CAS  PubMed  Google Scholar 

Pasquier B. SAR405, a PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells. Autophagy. 2015;11:725–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ronan B, Flamand O, Vescovi L, et al. A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy. Nat Chem Biol. 2014;10:1013–9.

Article  CAS  PubMed  Google Scholar 

Shirakabe A, Zhai P, Ikeda Y, et al. Drp1-dependent mitochondrial autophagy plays a protective role against pressure overload-induced mitochondrial dysfunction and heart failure. Circulation. 2016;133:1249–63.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Song E, Da Eira D, Jani S, et al. Cardiac autophagy deficiency attenuates ANP production and disrupts myocardial-adipose cross talk, leading to increased fat accumulation and metabolic dysfunction. Diabetes. 2021;70:51–61.

Article  CAS  PubMed  Google Scholar 

Sun X, Meng H, Xiao J, Liu F, Du J, Zeng H. Pretreatment of 3-MA prevents doxorubicin-induced cardiotoxicity through inhibition of autophagy initiation. Toxicology. 2023;490:153512.

Article  CAS  PubMed  Google Scholar 

Tebbi CK, London WB, Friedman D, et al. Dexrazoxane-associated risk for acute myeloid leukemia/myelodysplastic syndrome and other secondary malignancies in pediatric Hodgkin’s disease. J Clin Oncol: Off J Am Soc Clin Oncol. 2007;25:493–500.

Article  CAS  Google Scholar 

Valentim L, Laurence KM, Townsend PA, et al. Urocortin inhibits Beclin1-mediated autophagic cell death in cardiac myocytes exposed to ischaemia/reperfusion injury. J Mol Cell Cardiol. 2006;40:846–52.

Article  CAS  PubMed  Google Scholar 

Vejpongsa P, Yeh ET. Topoisomerase 2β: a promising molecular target for primary prevention of anthracycline-induced cardiotoxicity. Clin Pharmacol Ther. 2014;95:45–52.

Article  CAS  PubMed  Google Scholar 

Vrooman LM, Neuberg DS, Stevenson KE, et al. The low incidence of secondary acute myelogenous leukaemia in children and adolescents treated with dexrazoxane for acute lymphoblastic leukaemia: a report from the Dana-Farber Cancer Institute ALL Consortium. Eur J Cancer (Oxford, England: 1990). 2011;47:1373–9.

Article  CAS  Google Scholar 

Wang Y, Lu X, Wang X, et al. atg7-based autophagy activation reverses doxorubicin-induced cardiotoxicity. Circ Res. 2021;129:e166–82.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xie Z, Klionsky DJ. Autophagosome formation: core machinery and adaptations. Nat Cell Biol. 2007;9:1102–9.

Article  CAS  PubMed  Google Scholar 

Xu Z, Jin Y, Gao Z, et al. Autophagic degradation of CCN2 (cellular communication network factor 2) causes cardiotoxicity of sunitinib. Autophagy. 2022;18:1152–73.

Article  CAS  PubMed  Google Scholar 

Zhang S, Liu X, Bawa-Khalfe T, et al. Identification of the molecular basis of doxorubicin-induced cardiotoxicity. Nat Med. 2012;18:1639–42.

Article  PubMed  Google Scholar