Evered L, Silbert B, Knopman DS, Scott DA, DeKosky ST, Rasmussen LS, et al. Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery 2018. Anesthesiology. 2018;129:872–9. https://doi.org/10.1097/ALN.0000000000002334.

Article  CAS  PubMed  Google Scholar 

Edwards ML, Bause GS. From dental to mental institutions: an american dentist and a british psychiatrist highlight insanity following nitrous-oxide administration. J Anesth Hist. 2018;4:133–4. https://doi.org/10.1016/j.janh.2018.02.002.

Article  PubMed  Google Scholar 

Bedford PD. Adverse cerebral effects of anaesthesia on old people. Lancet. 1955;269:259–63. https://doi.org/10.1016/s0140-6736(55)92689-1.

Article  CAS  PubMed  Google Scholar 

Evered L, Scott DA, Silbert B, Maruff P. Postoperative cognitive dysfunction is independent of type of surgery and anesthetic. Anesth Analg. 2011;112:1179–85. https://doi.org/10.1213/ANE.0b013e318215217e.

Article  PubMed  Google Scholar 

Inouye SK, Marcantonio ER, Kosar CM, Tommet D, Schmitt EM, Travison TG, et al. The short-term and long-term relationship between delirium and cognitive trajectory in older surgical patients. Alzheimers Dement. 2016;12:766–75. https://doi.org/10.1016/j.jalz.2016.03.005.

Article  PubMed  PubMed Central  Google Scholar 

Moller JT, Cluitmans P, Rasmussen LS, Houx P, Rasmussen H, Canet J, et al. Long-term postoperative cognitive dysfunction in the elderly ISPOCD1 study. ISPOCD investigators. International study of post-operative cognitive dysfunction. Lancet. 1998;351:857–61. https://doi.org/10.1016/s0140-6736(97)07382-0.

Article  CAS  PubMed  Google Scholar 

Androsova G, Krause R, Winterer G, Schneider R. Biomarkers of postoperative delirium and cognitive dysfunction. Front Aging Neurosci. 2015;7:112. https://doi.org/10.3389/fnagi.2015.00112.

Article  PubMed  PubMed Central  Google Scholar 

Monk TG, Weldon BC, Garvan CW, Dede DE, van der Aa MT, Heilman KM, et al. Predictors of cognitive dysfunction after major noncardiac surgery. Anesthesiology. 2008;108:18–30. https://doi.org/10.1097/01.anes.0000296071.19434.1e.

Article  PubMed  Google Scholar 

Price CC, Garvan CW, Monk TG. Type and severity of cognitive decline in older adults after noncardiac surgery. Anesthesiology. 2008;108:8.

Article  PubMed  Google Scholar 

Steinmetz J, Christensen KB, Lund T, Lohse N, Rasmussen LS, Group I. Long-term consequences of postoperative cognitive dysfunction. Anesthesiology. 2009;110:548–55. https://doi.org/10.1097/ALN.0b013e318195b569.

Article  PubMed  Google Scholar 

Pluvinage JV, Wyss-Coray T. Systemic factors as mediators of brain homeostasis, ageing and neurodegeneration. Nat Rev Neurosci. 2020;21:93–102. https://doi.org/10.1038/s41583-019-0255-9.

Article  CAS  PubMed  Google Scholar 

Capuron L, Miller AH. Immune system to brain signaling: neuropsychopharmacological implications. Pharmacol Ther. 2011;130:226–38. https://doi.org/10.1016/j.pharmthera.2011.01.014.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dantzer R, O’Connor JC, Freund GG, Johnson RW, Kelley KW. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci. 2008;9:46–56. https://doi.org/10.1038/nrn2297.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cunningham C, Campion S, Lunnon K, Murray CL, Woods JF, Deacon RM, et al. Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease. Biol Psychiatry. 2009;65:304–12. https://doi.org/10.1016/j.biopsych.2008.07.024.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gisondi P, Sala F, Alessandrini F, Avesani V, Zoccatelli G, Beltramello A, et al. Mild cognitive impairment in patients with moderate to severe chronic plaque psoriasis. Dermatology. 2014;228:78–85. https://doi.org/10.1159/000357220.

Article  PubMed  Google Scholar 

Sung CE, Huang RY, Cheng WC, Kao TW, Chen WL. Association between periodontitis and cognitive impairment: Analysis of national health and nutrition examination survey (NHANES) III. J Clin Periodontol. 2019;46:790–8. https://doi.org/10.1111/jcpe.13155.

Article  PubMed  Google Scholar 

Xue L, Zou X, Yang XQ, Peng F, Yu DK, Du JR. Chronic periodontitis induces microbiota-gut-brain axis disorders and cognitive impairment in mice. Exp Neurol. 2020;326:113176. https://doi.org/10.1016/j.expneurol.2020.113176.

Article  CAS  PubMed  Google Scholar 

Yamanaka D, Kawano T, Nishigaki A, Aoyama B, Tateiwa H, Shigematsu-Locatelli M, et al. Preventive effects of dexmedetomidine on the development of cognitive dysfunction following systemic inflammation in aged rats. J Anesth. 2017;31:25–35. https://doi.org/10.1007/s00540-016-2264-4.

Article  PubMed  Google Scholar 

Labrenz F, Wrede K, Forsting M, Engler H, Schedlowski M, Elsenbruch S, et al. Alterations in functional connectivity of resting state networks during experimental endotoxemia - An exploratory study in healthy men. Brain Behav Immun. 2016;54:17–26. https://doi.org/10.1016/j.bbi.2015.11.010.

Article  PubMed  Google Scholar 

Biesmans S, Bouwknecht JA, Ver Donck L, Langlois X, Acton PD, De Haes P, et al. Peripheral Administration of Tumor Necrosis Factor-Alpha Induces Neuroinflammation and Sickness but Not Depressive-Like Behavior in Mice. Biomed Res Int. 2015;2015:716920. https://doi.org/10.1155/2015/716920.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Song L, Quan X, Su L, Wang K, Wang H, Wu L, et al. Inflammation and behavioral symptoms in preoperational glioma patients: Is depression, anxiety, and cognitive impairment related to markers of systemic inflammation? Brain Behav. 2020;10: e01771. https://doi.org/10.1002/brb3.1771.

Article  PubMed  PubMed Central  Google Scholar 

Myint AM, Schwarz MJ, Steinbusch HW, Leonard BE. Neuropsychiatric disorders related to interferon and interleukins treatment. Metab Brain Dis. 2009;24:55–68. https://doi.org/10.1007/s11011-008-9114-5.

Article  CAS  PubMed  Google Scholar 

van den Boogaard M, Kox M, Quinn KL, van Achterberg T, van der Hoeven JG, Schoonhoven L, et al. Biomarkers associated with delirium in critically ill patients and their relation with long-term subjective cognitive dysfunction; indications for different pathways governing delirium in inflamed and noninflamed patients. Crit Care. 2011;15:R297. https://doi.org/10.1186/cc10598.

Article  PubMed  PubMed Central  Google Scholar 

Mooijaart SP, Sattar N, Trompet S, Lucke J, Stott DJ, Ford I, et al. Circulating interleukin-6 concentration and cognitive decline in old age: the PROSPER study. J Intern Med. 2013;274:77–85. https://doi.org/10.1111/joim.12052.

Article  CAS  PubMed  Google Scholar 

Serantes R, Arnalich F, Figueroa M, Salinas M, Andres-Mateos E, Codoceo R, et al. Interleukin-1beta enhances GABAA receptor cell-surface expression by a phosphatidylinositol 3-kinase/Akt pathway: relevance to sepsis-associated encephalopathy. J Biol Chem. 2006;281:14632–43. https://doi.org/10.1074/jbc.M512489200.

Article  CAS  PubMed  Google Scholar 

Riera Romo M, Perez-Martinez D, Castillo Ferrer C. Innate immunity in vertebrates: an overview. Immunology. 2016;148:125–39. https://doi.org/10.1111/imm.12597.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang Q, Raoof M, Chen Y, Sumi Y, Sursal T, Junger W, et al. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature. 2010;464:104–7. https://doi.org/10.1038/nature08780.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Andersson U, Tracey KJ. HMGB1 is a therapeutic target for sterile inflammation and infection. Annu Rev Immunol. 2011;29:139–62. https://doi.org/10.1146/annurev-immunol-030409-101323.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lotze MT, Tracey KJ. High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nat Rev Immunol. 2005;5:331–42. https://doi.org/10.1038/nri1594.

Article  CAS  PubMed  Google Scholar 

Huang C, Irwin MG, Wong GTC, Chang RCC. Evidence of the impact of systemic inflammation on neuroinflammation from a non-bacterial endotoxin animal model. J Neuroinflammation. 2018;15:147. https://doi.org/10.1186/s12974-018-1163-z.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hovens IB, Schoemaker RG, van der Zee EA, Heineman E, Nyakas C, van Leeuwen BL. Surgery-induced behavioral changes in aged rats. Exp Gerontol. 2013;48:1204–11. https://doi.org/10.1016/j.exger.2013.07.011.

Article  PubMed  Google Scholar 

Terrando N, Eriksson LI, Ryu JK, Yang T, Monaco C, Feldmann M, et al. Resolving postoperative neuroinflammation and cognitive decline. Ann Neurol. 2011;70:986–95. https://doi.org/10.1002/ana.22664.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hovens IB, van Leeuwen BL, Nyakas C, Heineman E, van der Zee EA, Schoemaker RG. Prior infection exacerbates postoperative cognitive dysfunction in aged rats. Am J Physiol Regul Integr Comp Physiol. 2015;309:R148-59. https://doi.org/10.1152/ajpregu.00002.2015.