Arya A et al (2015) NAP (davunetide) protects primary hippocampus culture by modulating expression profile of antioxidant genes during limiting oxygen conditions. Free Radic Res 49:440–452

Article  CAS  PubMed  Google Scholar 

Bassan M et al (1999) Complete sequence of a novel protein containing a femtomolar-activity-dependent neuroprotective peptide. J Neurochem 72:1283–1293

Article  CAS  PubMed  Google Scholar 

Blaj C et al (2017) ADNP is a therapeutically inducible repressor of WNT signaling in colorectal cancer. Clin Cancer Res 23:2769–2780

Article  CAS  PubMed  Google Scholar 

Bosnjak ZJ et al (2012) Ketamine induces toxicity in human neurons differentiated from embryonic stem cells via mitochondrial apoptosis pathway. Curr Drug Saf 7:106–119

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brown BP et al (2015) In vivo and in vitro ketamine exposure exhibits a dose-dependent induction of activity-dependent neuroprotective protein in rat neurons. Neuroscience 290:31–40

Article  CAS  PubMed  Google Scholar 

Burzomato V, Frugier G, Pérez-Otaño I, Kittler JT, Attwell D (2010) The receptor subunits generating NMDA receptor mediated currents in oligodendrocytes. J Physiol (Lond) 588:3403–3414

Article  CAS  PubMed  Google Scholar 

Buxbaum Grice AS et al (2024) Transient peripheral blood transcriptomic response to ketamine treatment in children with ADNP syndrome. Transl Psychiatry 14:307

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cho H et al (2023) Adnp-mutant mice with cognitive inflexibility, CaMKIIα hyperactivity, and synaptic plasticity deficits. Mol Psychiatry 28:3548–3562

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cull-Candy S, Brickley S, Farrant M (2001) NMDA receptor subunits: diversity, development and disease. Curr Opin Neurobiol 11:327–335

Article  CAS  PubMed  Google Scholar 

D’Incal CP et al (2023) Chromatin remodeler activity-dependent neuroprotective protein (ADNP) contributes to syndromic autism. Clin Epigenetics 15:45

Article  PubMed  PubMed Central  Google Scholar 

D’Incal CP et al (2024a) Loss-of-function of activity-dependent neuroprotective protein (ADNP) by a splice-acceptor site mutation causes Helsmoortel-Van der Aa syndrome. Eur J Hum Genet 32:630–638. https://doi.org/10.1038/s41431-024-01556-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

D’Incal C et al (2024b) ADNP dysregulates methylation and mitochondrial gene expression in the cerebellum of a Helsmoortel-Van der Aa syndrome autopsy case. Acta Neuropathol Commun 12:62

Article  PubMed  PubMed Central  Google Scholar 

D’Incal CP et al (2024c) Tracing the invisible mutant ADNP protein in Helsmoortel-Van der Aa syndrome patients. Sci Rep 14:14710

Article  PubMed  PubMed Central  Google Scholar 

D’Incal CP et al. (2025) A novel Adnp frameshift variant disrupts Wnt signaling leading to chromatocytoskeletal defects and autism-related behavior in mice. https://doi.org/10.2139/ssrn.5353802

Darke S, Duflou J, Farrell M, Peacock A, Lappin J (2021) Characteristics and circumstances of death related to the self-administration of ketamine. Addiction 116:339–345

Article  PubMed  Google Scholar 

Ganaiem M et al (2023) NAP (davunetide): the neuroprotective ADNP drug candidate penetrates cell nuclei explaining pleiotropic mechanisms. Cells. https://doi.org/10.3390/cells12182251

Article  PubMed  PubMed Central  Google Scholar 

Georget M et al (2023) Loss of function of ADNP by an intragenic inversion. Eur J Hum Genet 31:967–970. https://doi.org/10.1038/s41431-023-01323-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ghasemi M, Turnbull T, Sebastian S, Kempson I (2021) The MTT assay: utility, limitations, pitfalls, and interpretation in bulk and single-cell analysis. Int J Mol Sci. https://doi.org/10.3390/ijms222312827

Article  PubMed  PubMed Central  Google Scholar 

Gozes I et al (2005) NAP: research and development of a peptide derived from activity-dependent neuroprotective protein (ADNP). CNS Drug Rev 11:353–368

Article  CAS  PubMed  Google Scholar 

Gozes I et al (2017) Premature primary tooth eruption in cognitive/motor-delayed ADNP-mutated children. Transl Psychiatry 7:e1043

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grigg I et al (2020) Tauopathy in the young autistic brain: novel biomarker and therapeutic target. Transl Psychiatry 10:228

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hacohen-Kleiman G et al (2018) Activity-dependent neuroprotective protein deficiency models synaptic and developmental phenotypes of autism-like syndrome. J Clin Invest 128:4956–4969

Article  PubMed  PubMed Central  Google Scholar 

Hadar A et al (2018) SIRT1, miR-132 and miR-212 link human longevity to Alzheimer’s disease. Sci Rep 8:8465

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hadar A et al (2016) RGS2 expression predicts amyloid-β sensitivity, MCI and Alzheimer’s disease: genome-wide transcriptomic profiling and bioinformatics data mining. Transl Psychiatry 6:e909

Article  CAS  PubMed  PubMed Central  Google Scholar 

Harris SJ, Wilce P, Bedi KS (2000) Exposure of rats to a high but not low dose of ethanol during early postnatal life increases the rate of loss of optic nerve axons and decreases the rate of myelination. J Anat 197(Pt 3):477–485

Article  CAS  PubMed  PubMed Central  Google Scholar 

Helsmoortel C et al (2014) A SWI/SNF-related autism syndrome caused by de novo mutations in ADNP. Nat Genet 46:380–384

Article  CAS  PubMed  PubMed Central  Google Scholar 

Karmon G et al (2022) Novel ADNP syndrome mice reveal dramatic sex-specific peripheral gene expression with brain synaptic and tau pathologies. Biol Psychiatry 92:81–95

Article  CAS  PubMed  Google Scholar 

Kolevzon A et al (2022) An open-label study evaluating the safety, behavioral, and electrophysiological outcomes of low-dose ketamine in children with ADNP syndrome. Hum Genet Genomics Adv 3:100138

Article  CAS  Google Scholar 

Magen I, Gozes I (2014) Davunetide: peptide therapeutic in neurological disorders. Curr Med Chem 21:2591–2598

Article  CAS  PubMed  Google Scholar 

Mandel S, Rechavi G, Gozes I (2007) Activity-dependent neuroprotective protein (ADNP) differentially interacts with chromatin to regulate genes essential for embryogenesis. Dev Biol 303:814–824

Article  CAS  PubMed  Google Scholar 

Mandel S, Gozes I (2007) Activity-dependent neuroprotective protein constitutes a novel element in the SWI/SNF chromatin remodeling complex. J Biol Chem 282:34448–34456

Article  CAS  PubMed