Bhattacharyya R, Barren C, Kovacs DM (2013) Palmitoylation of amyloid precursor protein regulates amyloidogenic processing in lipid rafts. J Neurosci 33:11169–11183
Article PubMed PubMed Central CAS Google Scholar
Borsche M, Pereira SL, Klein C, Grunewald A (2021) Mitochondria and Parkinson’s disease: clinical, molecular, and translational aspects. J Parkinsons Dis 11:45–60
Article PubMed PubMed Central CAS Google Scholar
Bose A, Burch M, Chowdhury A, Paschou P, Drineas P (2023) Structure-informed clustering for population stratification in association studies. BMC Bioinformatics 24:411
Article PubMed PubMed Central Google Scholar
Bowden J, Davey Smith G, Burgess S (2015) Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int J Epidemiol 44:512–525
Article PubMed PubMed Central Google Scholar
Burgess S, Butterworth A, Thompson SG (2013) Mendelian randomization analysis with multiple genetic variants using summarized data. Genet Epidemiol 37:658–665
Article PubMed PubMed Central Google Scholar
Cervilla-Martinez JF, Rodriguez-Gotor JJ, Wypijewski KJ, Fontan-Lozano A, Wang T, Santamaria E, Fuller W, Mejias R (2022) Altered Cortical Palmitoylation Induces Widespread Molecular Disturbances in Parkinson’s Disease. Int J Mol Sci 23:14018
Article PubMed PubMed Central CAS Google Scholar
Cho Y, Haycock PC, Sanderson E, Gaunt TR, Zheng J, Morris AP, Davey Smith G, Hemani G (2020) Exploiting horizontal pleiotropy to search for causal pathways within a Mendelian randomization framework. Nat Commun 11:1010
Article PubMed PubMed Central CAS Google Scholar
Gmitterova K, Heinemann U, Gawinecka J, Varges D, Ciesielczyk B, Valkovic P, Benetin J, Zerr I (2009) 8-OHdG in cerebrospinal fluid as a marker of oxidative stress in various neurodegenerative diseases. Neurodegener Dis 6:263–269
Article PubMed CAS Google Scholar
Hernandez LM, Montersino A, Niu J, Guo S, Faezov B, Sanders SS, Dunbrack RL, Thomas GM (2023) Palmitoylation-dependent control of JAK1 kinase signaling governs responses to neuropoietic cytokines and survival in DRG neurons. J Biol Chem 299:104965
Article PubMed PubMed Central CAS Google Scholar
Ho GPH, Ramalingam N, Imberdis T, Wilkie EC, Dettmer U, Selkoe DJ (2021) Upregulation of cellular palmitoylation mitigates alpha-synuclein accumulation and neurotoxicity. Mov Disord 36:348–359
Article PubMed CAS Google Scholar
Ho GPH, Wilkie EC, White AJ, Selkoe DJ (2023) Palmitoylation of the Parkinson’s disease-associated protein synaptotagmin-11 links its turnover to α-synuclein homeostasis. Sci Signal 16:7220
Jankovic J, Tan EK (2020) Parkinson’s disease: etiopathogenesis and treatment. J Neurol Neurosurg Psychiatry 91:795–808
Ji D, Chen WZ, Zhang L, Zhang ZH, Chen LJ (2024) Gut microbiota, circulating cytokines and dementia: a Mendelian randomization study. J Neuroinflammation 21:2
Article PubMed PubMed Central CAS Google Scholar
Jin J, Zhi X, Wang X, Meng D (2021) Protein palmitoylation and its pathophysiological relevance. J Cell Physiol 236:3220–3233
Article PubMed CAS Google Scholar
Klokkaris A, Migdalska-Richards A (2024) An Overview of Epigenetic Changes in the Parkinson’s Disease Brain. Int. J. Mol. Sci. 25:6168
Article PubMed PubMed Central CAS Google Scholar
Kolar D, Krajcovic B, Kleteckova L, Kuncicka D, Vales K, Brozka H (2023) Genes involved in mitochondrial physiology within 22q11.2 deleted region and their relevance to schizophrenia. Schizophr Bull 49:1637–1653
Article PubMed PubMed Central Google Scholar
Korycka J, Lach A, Heger E, Boguslawska DM, Wolny M, Toporkiewicz M, Augoff K, Korzeniewski J, Sikorski AF (2012) Human DHHC proteins: a spotlight on the hidden player of palmitoylation. Eur J Cell Biol 91:107–117
Article PubMed CAS Google Scholar
Kurki MI, Karjalainen J, Palta P, Sipila TP, Kristiansson K, Donner KM, Reeve MP, Laivuori H, Aavikko M, Kaunisto MA, Loukola A, Lahtela E, Mattsson H, Laiho P, Della Briotta Parolo P, Lehisto AA, Kanai M, Mars N, Ramo J, Kiiskinen T, Heyne HO, Veerapen K, Rueger S, Lemmela S, Zhou W, Ruotsalainen S, Parn K, Hiekkalinna T, Koskelainen S, Paajanen T, Llorens V, Gracia-Tabuenca J, Siirtola H, Reis K, Elnahas AG, Sun B, Foley CN, Aalto-Setala K, Alasoo K, Arvas M, Auro K, Biswas S, Bizaki-Vallaskangas A, Carpen O, Chen CY, Dada OA, Ding Z, Ehm MG, Eklund K, Farkkila M, Finucane H, Ganna A, Ghazal A, Graham RR, Green EM, Hakanen A, Hautalahti M, Hedman AK, Hiltunen M, Hinttala R, Hovatta I, Hu X, Huertas-Vazquez A, Huilaja L, Hunkapiller J, Jacob H, Jensen JN, Joensuu H, John S, Julkunen V, Jung M, Junttila J, Kaarniranta K, Kahonen M, Kajanne R, Kallio L, Kalviainen R, Kaprio J, FinnGen Kerimov N, Kettunen J, Kilpelainen E, Kilpi T, Klinger K, Kosma VM, Kuopio T, Kurra V, Laisk T, Laukkanen J, Lawless N, Liu A, Longerich S, Magi R, Makela J, Makitie A, Malarstig A, Mannermaa A, Maranville J, Matakidou A, Meretoja T, Mozaffari SV, Niemi MEK, Niemi M, Niiranen T, CJ OD, Obeidat ME, Okafo G, Ollila HM, Palomaki A, Palotie T, Partanen J, Paul DS, Pelkonen M, Pendergrass RK, Petrovski S, Pitkaranta A, Platt A, Pulford D, Punkka E, Pussinen P, Raghavan N, Rahimov F, Rajpal D, Renaud NA, Riley-Gillis B, Rodosthenous R, Saarentaus E, Salminen A, Salminen E, Salomaa V, Schleutker J, Serpi R, Shen HY, Siegel R, Silander K, Siltanen S, Soini S, Soininen H, Sul JH, Tachmazidou I, Tasanen K, Tienari P, Toppila-Salmi S, Tukiainen T, Tuomi T, Turunen JA, Ulirsch JC, Vaura F, Virolainen P, Waring J, Waterworth D, Yang R, Nelis M, Reigo A, Metspalu A, Milani L, Esko T, Fox C, Havulinna AS, Perola M, Ripatti S, Jalanko A, Laitinen T, Makela TP, Plenge R, McCarthy M, Runz H, Daly MJ, Palotie A (2023) FinnGen provides genetic insights from a well-phenotyped isolated population. Nature 613:508–518
Li W, Pang Y, Wang Y, Mei F, Guo M, Wei Y, Li X, Qin W, Wang W, Jia L, Jia J (2023) Aberrant palmitoylation caused by a ZDHHC21 mutation contributes to pathophysiology of Alzheimer’s disease. BMC Med 21:223
Article PubMed PubMed Central CAS Google Scholar
Li X, Fu Q, Guo M, Du Y, Cheng Y (2025) Unlocking Parkinson’s disease: the role of microRNAs in regulation, diagnosis, and therapy. Apoptosis 30:1272–1291
Article PubMed CAS Google Scholar
Liao D, Huang Y, Liu D, Zhang H, Shi X, Li X, Luo P (2023) The role of s-palmitoylation in neurological diseases: implication for zDHHC family. Front Pharmacol 14:1342830
Article PubMed CAS Google Scholar
Mehra S, Sahay S, Maji SK (2019) Alpha-synuclein misfolding and aggregation: implications in Parkinson’s disease pathogenesis. Biochim Biophys Acta Proteins Proteom 1867:890–908
Article PubMed CAS Google Scholar
Moutin E, Nikonenko I, Stefanelli T, Wirth A, Ponimaskin E, De Roo M, Muller D (2017) Palmitoylation of cdc42 Promotes Spine Stabilization and Rescues Spine Density Deficit in a Mouse Model of 22q11.2 Deletion Syndrome. Cereb Cortex 27:3618–3629
Mukai J, Liu H, Burt RA, Swor DE, Lai WS, Karayiorgou M, Gogos JA (2004) Evidence that the gene encoding ZDHHC8 contributes to the risk of schizophrenia. Nat Genet 36:725–731
Article PubMed CAS Google Scholar
Mukai J, Dhilla A, Drew LJ, Stark KL, Cao L, MacDermott AB, Karayiorgou M, Gogos JA (2008) Palmitoylation-dependent neurodevelopmental deficits in a mouse model of 22q11 microdeletion. Nat Neurosci 11:1302–1310
Article PubMed PubMed Central CAS Google Scholar
Nalls MA, Blauwendraat C, Vallerga CL, Heilbron K, Bandres-Ciga S, Chang D, Tan M, Kia DA, Noyce AJ, Xue A, Bras J, Young E, von Coelln R, Simon-Sanchez J, Schulte C, Sharma M, Krohn L, Pihlstrom L, Siitonen A, Iwaki H, Leonard H, Faghri F, Gibbs JR, Hernandez DG, Scholz SW, Botia JA, Martinez M, Corvol JC, Lesage S, Jankovic J, Shulman LM, Sutherland M, Tienari P, Majamaa K, Toft M, Andreassen OA, Bangale T, Brice A, Yang J, Gan-Or Z, Gasser T, Heutink P, Shulman JM, Wood NW, Hinds DA, Hardy JA, Morris HR, Gratten J, Visscher PM, Graham RR, Singleton AB, andMe Research T, System Genomics of Parkinson’s Disease C, International Parkinson’s Disease Genomics C (2019) Identification of novel risk loci, causal insights, and heritable risk for Parkinson’s disease: a meta-analysis of genome-wide association studies. Lancet Neurol 18:1091–1102
Noritake J, Fukata Y, Iwanaga T, Hosomi N, Tsutsumi R, Matsuda N, Tani H, Iwanari H, Mochizuki Y, Kodama T, Matsuura Y, Bredt DS, Hamakubo T, Fukata M (2009) Mobile DHHC palmitoylating enzyme mediates activity-sensitive synaptic targeting of PSD-95. J Cell Biol 186:147–160
Article PubMed PubMed Central CAS Google Scholar
Peng J, Liang D, Zhang Z (2024) Palmitoylation of synaptic proteins: roles in functional regulation and pathogenesis of neurodegenerative diseases. Cell Mol Biol Lett 29:108
Article PubMed PubMed Central CAS Google Scholar
Raymond FL, Tarpey PS, Edkins S, Tofts C, O’Meara S, Teague J, Butler A, Stevens C, Barthorpe S, Buck G, Cole J, Dicks E, Gray K, Halliday K, Hills K, Hinton J, Jones D, Menzies A, Perry J, Raine K, Shepherd R, Small A, Varian J, Widaa S, Mallya U, Moon J, Luo Y, Shaw M, Boyle J, Kerr B, Turner G, Quarrell O, Cole T, Easton DF, Wooster R, Bobrow M, Schwartz CE, Gecz J, Stratton MR, Futreal PA (2007) Mutations in ZDHHC9, which encodes a palmitoyltransferase of NRAS and HRAS, cause X-linked mental retardation associated with a Marfanoid habitus. Am J Hum Genet 80:982–987
Article PubMed PubMed Central CAS Google Scholar
Rocks O, Gerauer M, Vartak N, Koch S, Huang ZP, Pechlivanis M, Kuhlmann J, Brunsveld L, Chandra A, Ellinger B, Waldmann H, Bastiaens PI (2010) The palmitoylation machinery is a spatially organizing system for peripheral membrane proteins. Cell 141:458–471
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