Bao Y, Yu Y, Hong B, Lin Z, Qi G, Zhou J et al (2021) Hsa_Circ_0001947/MiR-661/DOK7 axis restrains non-small cell lung cancer development. J Microbiol Biotechnol 31(11):1508–1518. https://doi.org/10.4014/jmb.2106.06031

Article  CAS  PubMed  PubMed Central  Google Scholar 

Campo A, Aliquò F, Velletri T, Scuruchi M, Avenoso A, Campo GM et al (2024) Involvement of selected circulating ncRNAs in the regulation of cognitive dysfunction induced by anesthesia. Gene 928:148806. https://doi.org/10.1016/j.gene.2024.148806

Article  CAS  PubMed  Google Scholar 

Chi Y, Wang D, Wang J, Yu W, Yang J (2019) Long non-coding RNA in the pathogenesis of cancers. Cells. https://doi.org/10.3390/cells8091015

Article  PubMed  PubMed Central  Google Scholar 

Han S, Bian R, Chen Y, Liang J, Zhao P, Gu Y et al (2024) Dysregulation of the gut microbiota contributes to sevoflurane-induced cognitive dysfunction in aged mice by activating the NLRP3 inflammasome. Mol Neurobiol 61(12):10500–10516. https://doi.org/10.1007/s12035-024-04229-x

Article  CAS  PubMed  Google Scholar 

Hojati Z, Omidi F, Dehbashi M, Mohammad Soltani B (2021) The highlighted roles of metabolic and cellular response to stress pathways engaged in circulating hsa-miR-494-3p and hsa-miR-661 in Alzheimer’s disease. Iran Biomed J 25(1):62–67. https://doi.org/10.29252/ibj.25.1.62

Article  PubMed  Google Scholar 

Hu Y, Huang H, Jiang Y, Zhang J, Zhang Y, Tian Y et al (2024) Liraglutide improves sevoflurane-induced postoperative cognitive dysfunction via activating autophagy and inhibiting apoptosis. Aging 16(4):3763–3772. https://doi.org/10.18632/aging.205558

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang L, Tao W, Liu J, Yang A, Zhou J (2024) MicroRNA-637/661 ameliorate hypoxic-induced pulmonary arterial hypertension by targeting TRIM29 signaling pathway. Sci Rep 14(1):27971. https://doi.org/10.1038/s41598-024-79769-2

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jin T, Liu M, Liu Y, Li Y, Xu Z, He H et al (2020) Lcn2-derived circular RNA (hsa_circ_0088732) inhibits cell apoptosis and promotes EMT in Glioma via the miR-661/RAB3D axis. Front Oncol 10:170. https://doi.org/10.3389/fonc.2020.00170

Article  PubMed  PubMed Central  Google Scholar 

Li Z, Liu YH, Diao HY, Ma J, Yao YL (2015) MiR-661 inhibits glioma cell proliferation, migration and invasion by targeting hTERT. Biochem Biophys Res Commun 468(4):870–876. https://doi.org/10.1016/j.bbrc.2015.11.046

Article  CAS  PubMed  Google Scholar 

Lin J, Zhu X, Li X, Hong Y, Liang Y, Chen S et al (2025) Impaired hippocampal neurogenesis associated with regulatory ceRNA network in a mouse model of postoperative cognitive dysfunction. BMC Anesthesiol 25(1):60. https://doi.org/10.1186/s12871-025-02928-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin X, Zhong L, Wang N, Chu X, Liu B (2022) Hsa_circ_0103232 promotes melanoma cells proliferation and invasion via targeting miR-661/RAB3D. Cell Cycle 21(17):1811–1826. https://doi.org/10.1080/15384101.2022.2072636

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu C, Wu J, Li M, Gao R, Zhang X, Ye-Lehmann S et al (2023) Smad7 in the hippocampus contributes to memory impairment in aged mice after anesthesia and surgery. J Neuroinflammation 20(1):175. https://doi.org/10.1186/s12974-023-02849-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Matsumoto J, Dohgu S, Takata F, Machida T, Bölükbaşi Hatip FF, Hatip-Al-Khatib I et al (2018) TNF-α-sensitive brain pericytes activate microglia by releasing IL-6 through cooperation between IκB-NFκB and JAK-STAT3 pathways. Brain Res 1692:34–44. https://doi.org/10.1016/j.brainres.2018.04.023

Article  CAS  PubMed  Google Scholar 

Shu B, Gan H, Wang C, Cao C, Tong H, Liang D (2022) LINC01426 aggravates the malignant progression of glioma through miR-661/Mdm2 axis. Brain Res Bull 188:110–121. https://doi.org/10.1016/j.brainresbull.2022.06.012

Article  CAS  PubMed  Google Scholar 

Tan XX, Qiu LL, Sun J (2021) Research progress on the role of inflammatory mechanisms in the development of postoperative cognitive dysfunction. Biomed Res Int 2021:3883204. https://doi.org/10.1155/2021/3883204

Article  CAS  PubMed  PubMed Central  Google Scholar 

VatanIman R, Malekpour SH, Afshari A, Zare M (2021) MiR-770-5p, miR-661 and miR-571 expression level in serum and tissue samples of foot ulcer caused by diabetes mellitus type II in Iranian population. Mol Biol Rep 48(12):7811–7818. https://doi.org/10.1007/s11033-021-06798-9

Article  CAS  PubMed  Google Scholar 

Wang G, Shen J, Guan Q, Lin Y, Zhai L, Shen H (2024) LncRNA-AC020978 promotes metabolic reprogramming in M1 microglial cells in postoperative cognitive disorder via PKM2. Mol Neurobiol 61(4):2459–2467. https://doi.org/10.1007/s12035-023-03729-6

Article  CAS  PubMed  Google Scholar 

Wang YL, Zhang Y, Cai DS (2021) Dexmedetomidine ameliorates postoperative cognitive dysfunction via the MicroRNA-381-mediated EGR1/p53 axis. Mol Neurobiol 58(10):5052–5066. https://doi.org/10.1007/s12035-021-02417-7

Article  CAS  PubMed  Google Scholar 

Wei FS, Rao MW, Huang YL, Chen SB, Wu YQ, Yang L (2022) Mir-182-5p delivered by plasma exosomes promotes sevoflurane-induced neuroinflammation and cognitive dysfunction in aged rats with postoperative cognitive dysfunction by targeting brain-derived neurotrophic factor and activating NF-κB pathway. Neurotox Res 40(6):1902–1912. https://doi.org/10.1007/s12640-022-00597-1

Article  CAS  PubMed  Google Scholar 

Wei X, Xing F, Xu Y, Zhang F, Cheng D, Zhou Y et al (2024) Preoperative gut microbiota of POCD patients induces pre- and postoperative cognitive impairment and systemic inflammation in rats. J Neuroinflammation 21(1):221. https://doi.org/10.1186/s12974-024-03220-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu M, Shang X, Sun Y, Wu J, Liu G (2020) Integrated analysis of lymphocyte infiltration-associated lncRNA for ovarian cancer via TCGA, GTEx and GEO datasets. PeerJ 8:e8961. https://doi.org/10.7717/peerj.8961

Article  PubMed  PubMed Central  Google Scholar 

Wu S, Wu K, Yang Y, Ou Z, Lei X, Yang X (2025) LncRNA TUG1 and its molecular mechanisms in human cancer. Curr Mol Med 25(6):686–696. https://doi.org/10.2174/0115665240298173240427042624

Article  CAS  PubMed  Google Scholar 

Xiao QX, Cheng CX, Deng R, Liu Q, Ren YB, He L et al (2021) LncRNA-MYL2-2 and miR-124-3p are associated with perioperative neurocognitive disorders in patients after cardiac surgery. J Invest Surg 34(12):1297–1303. https://doi.org/10.1080/08941939.2020.1797949

Article  PubMed  Google Scholar 

Yang J, Huang Q, Cao R, Cui Y (2022) Effects of propofol and inhaled anesthetics on postoperative complications for the patients undergoing one lung ventilation: a meta-analysis. PLoS ONE 17(10):e0266988. https://doi.org/10.1371/journal.pone.0266988

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang Y, Yujiao W, Fang W, Linhui Y, Ziqi G, Zhichen W et al (2020) The roles of miRNA, lncRNA and circRNA in the development of osteoporosis. Biol Res 53(1):40. https://doi.org/10.1186/s40659-020-00309-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ye L, Cheng X, Shi Y, Liu Z, Xiong Y, Huang Y (2023) Long non-coding RNA MEG3 alleviates postoperative cognitive dysfunction by suppressing inflammatory response and oxidative stress via has-miR-106a-5p/SIRT3. NeuroReport 34(6):357–367. https://doi.org/10.1097/wnr.0000000000001901

Article  CAS  PubMed