Abdelnour E, Jansen MO, Gold JA (2022) Adhd diagnostic trends: increased recognition or overdiagnosis? Mo Med 119(5):467–473

PubMed  PubMed Central  Google Scholar 

Aitta-Aho T, Maksimovic M, Dahl K, Sprengel R, Korpi ER (2019) Attenuation of novelty-induced hyperactivity of gria1-/- mice by cannabidiol and hippocampal inhibitory chemogenetics. Front Pharmacol 10:309

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alexandre J, Carmo H, Carvalho F, Silva JP (2020) Synthetic cannabinoids and their impact on neurodevelopmental processes. Addict Biol 25(2):e12824

Article  PubMed  Google Scholar 

Alipour A, Patel PB, Shabbir Z, Gabrielson S (2019) Review of the many faces of synthetic cannabinoid toxicities. Ment Health Clin 9(2):93–99

Article  PubMed  PubMed Central  Google Scholar 

Amin MR, Ali DW (2019) Pharmacology of Medical Cannabis. Adv Exp Med Biol 1162:151–165

Article  CAS  PubMed  Google Scholar 

Bossong MG, van Berckel BN, Boellaard R, Zuurman L, Schuit RC, Windhorst AD, van Gerven JM, Ramsey NF, Lammertsma AA, Kahn RS (2009) Delta 9-tetrahydrocannabinol induces dopamine release in the human striatum. Neuropsychopharmacology 34(3):759–766

Article  CAS  PubMed  Google Scholar 

Bossong MG, Mehta MA, van Berckel BN, Howes OD, Kahn RS, Stokes PR (2015) Further human evidence for striatal dopamine release induced by administration of ∆9-tetrahydrocannabinol (THC): selectivity to limbic striatum. Psychopharmacology 232(15):2723–2729

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brennan AR, Arnsten AF (2008) Neuronal mechanisms underlying attention deficit hyperactivity disorder: the influence of arousal on prefrontal cortical function. Ann N Y Acad Sci 1129:236–245

Article  PubMed  PubMed Central  Google Scholar 

Castaneto MS, Gorelick DA, Desrosiers NA, Hartman RL, Pirard S, Huestis MA (2014) Synthetic cannabinoids: epidemiology, pharmacodynamics, and clinical implications. Drug Alcohol Depend 144:12–41

Article  CAS  PubMed  Google Scholar 

Cawkwell PB, Hong DS, Leikauf JE (2021) Neurodevelopmental effects of cannabis use in adolescents and emerging adults with ADHD: a systematic review. Harv Rev Psychiatry 29(4):251–261

Article  PubMed  PubMed Central  Google Scholar 

Caye A, Swanson JM, Coghill D, Rohde LA (2019) Treatment strategies for ADHD: an evidence-based guide to select optimal treatment. Mol Psychiatry 24(3):390–408

Article  CAS  PubMed  Google Scholar 

Clavenna, A. and M. Bonati (2016). Safety and tolerability of medications for ADHD: 233–253.

Coghill, D. (2013). Non-stimulant Drug Treatments for Adults with ADHD: 89–117.

Cohen K, Weinstein AM (2018) Synthetic and non-synthetic cannabinoid drugs and their adverse effects—a review from public health prospective. Front Public Health 6:162

Article  PubMed  PubMed Central  Google Scholar 

Cooper RE, Williams E, Seegobin S, Tye C, Kuntsi J, Asherson P (2017) Cannabinoids in attention-deficit/hyperactivity disorder: a randomised-controlled trial. Eur Neuropsychopharmacol 27(8):795–808

Article  CAS  PubMed  Google Scholar 

Cortese S, Coghill D (2018) Twenty years of research on attention-deficit/hyperactivity disorder (ADHD): looking back, looking forward. Evid Based Ment Health 21(4):173–176

Article  PubMed  PubMed Central  Google Scholar 

da Silva BS, Grevet EH, Silva LCF, Ramos JKN, Rovaris DL, Bau CHD (2023) An overview on neurobiology and therapeutics of attention-deficit/hyperactivity disorder. Discov Ment Health 3(1):2

Article  PubMed  PubMed Central  Google Scholar 

Darcq E, Kieffer BL (2015) PI3K signaling in the locus coeruleus: a new molecular pathway for ADHD research. EMBO Mol Med 7(7):859–861

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Souza B, Penna D, Gumiéro Costa S, Davis MP, da Costa Calaza K, Dos Santos Rodrigues A, Pandolfo P (2025) Chronic modulation of endocannabinoid receptors does not impact hyperactivity, risk behavior, and working memory in an animal model of attention-deficit/hyperactivity disorder. Pharmacol Biochem Behav 254:174059

Article  Google Scholar 

Di Marzo V (2018) New approaches and challenges to targeting the endocannabinoid system. Nat Rev Drug Discov 17(9):623–639

Article  CAS  PubMed  Google Scholar 

Drechsler R, Brem S, Brandeis D, Grünblatt E, Berger G, Walitza S (2020) ADHD: current concepts and treatments in children and adolescents. Neuropediatrics 51(5):315–335

Article  PubMed  PubMed Central  Google Scholar 

Elia J, Devoto M (2007) ADHD genetics: 2007 update. Curr Psychiatry Rep 9(5):434–439

Article  PubMed  Google Scholar 

Fabre LF, McLENDON D (1981) The efficacy and safety of nabilone (a synthetic cannabinoid) in the treatment of anxiety. J Clin Pharmacol 21(S1):377S-382S

Article  CAS  PubMed  Google Scholar 

Faraone SV (2018) The pharmacology of amphetamine and methylphenidate: relevance to the neurobiology of attention-deficit/hyperactivity disorder and other psychiatric comorbidities. Neurosci Biobehav Rev 87:255–270

Article  CAS  PubMed  PubMed Central  Google Scholar 

Garnock-Jones KP, Keating GM (2009) Atomoxetine: a review of its use in attention-deficit hyperactivity disorder in children and adolescents. Paediatr Drugs 11(3):203–226

Article  PubMed  Google Scholar 

Goodman S, Wadsworth E, Leos-Toro C, Hammond D (2020) Prevalence and forms of cannabis use in legal vs. illegal recreational cannabis markets. Int J Drug Policy 76:102658

Article  PubMed  Google Scholar 

Gorberg V, Harpaz T, Shamir EN, Karminsky OD, Fride E, Pertwee RG, Greig IR, McCaffery P, Anavi-Goffer S (2025) A Tourette syndrome/ADHD-like phenotype results from postnatal disruption of CB(1) and CB(2) receptor signalling. Int J Mol Sci. https://doi.org/10.3390/ijms26136052

Article  PubMed  PubMed Central  Google Scholar 

Grimm O, Kranz TM, Reif A (2020) Genetics of ADHD: what should the clinician know? Curr Psychiatry Rep 22(4):18

Article  PubMed  PubMed Central  Google Scholar 

Gujska JH, Silczuk A, Madejek R, Szulc A (2023) Exploring the link between attention-deficit hyperactivity disorder and cannabis use disorders: a review. Med Sci Monit 29:e939749

Article  PubMed  PubMed Central  Google Scholar 

Gunderson EW, Haughey HM, Ait-Daoud N, Joshi AS, Hart CL (2014) A survey of synthetic cannabinoid consumption by current cannabis users. Subst Abuse 35(2):184–189

Article  Google Scholar 

Haavik J, Halmøy A, Lundervold AJ, Fasmer OB (2010) Clinical assessment and diagnosis of adults with attention-deficit/hyperactivity disorder. Expert Rev Neurother 10(10):1569–1580

Article  PubMed  Google Scholar 

Henquet C, Kuepper R (2010) Does cannabidiol protect against the negative effects of THC? Br J Psychiatry 197(4):259–260

Article  PubMed  Google Scholar 

Henson JD, Vitetta L, Hall S (2022) Tetrahydrocannabinol and cannabidiol medicines for chronic pain and mental health conditions. Inflammopharmacology 30(4):1167–1178

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hergenrather JY, Aviram J, Vysotski Y, Campisi-Pinto S, Lewitus GM, Meiri D (2020) Cannabinoid and terpenoid doses are associated with adult ADHD status of medical cannabis patients. Rambam Maimonides Med J. https://doi.org/10.5041/RMMJ.10384

Article