Microglial Necroptosis Mediated by RIPK3 Leads to Retinal Ganglion Cell Apoptosis Through the Release of FGF2 After Ischemia/Reperfusion

Aghaei M, KhanAhmad H, Aghaei S, Ali Nilforoushzadeh M, Mohaghegh MA, Hejazi SH (2020) The role of Bax in the apoptosis of Leishmania-infected macrophages. Microb Pathog 139:103892

Article  PubMed  Google Scholar 

Almasieh M, Wilson AM, Morquette B, Cueva Vargas JL, Di Polo A (2012) The molecular basis of retinal ganglion cell death in glaucoma. Prog Retin Eye Res 31:152–181

Article  CAS  PubMed  Google Scholar 

Banasiak KJ, Xia Y, Haddad GG (2000) Mechanisms underlying hypoxia-induced neuronal apoptosis. Prog Neurobiol 62:215–249

Article  CAS  PubMed  Google Scholar 

Chen H, Fang Y, Wu J, Chen H, Zou Z, Zhang X, Shao J, Xu Y (2018) RIPK3-MLKL-mediated necroinflammation contributes to AKI progression to CKD. Cell Death Dis 9:878

Article  PubMed  PubMed Central  Google Scholar 

Chen W, Zhou Z, Li L, Zhong CQ, Zheng X, Wu X, Zhang Y, Ma H, Huang D, Li W, Xia Z, Han J (2013) Diverse sequence determinants control human and mouse receptor interacting protein 3 (RIP3) and mixed lineage kinase domain-like (MLKL) interaction in necroptotic signaling. J Biol Chem 288:16247–16261

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chipuk JE, Fisher JC, Dillon CP, Kriwacki RW, Kuwana T, Green DR (2008) Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins. Proc Natl Acad Sci U S A 105:20327–20332

Article  CAS  PubMed  PubMed Central  Google Scholar 

Choi ME, Price DR, Ryter SW, Choi AMK (2019) Necroptosis: a crucial pathogenic mediator of human disease. JCI Insight. https://doi.org/10.1172/jci.insight.128834

Article  PubMed  PubMed Central  Google Scholar 

Divya MS, Rasheed VA, Schmidt T, Lalitha S, Hattar S, James J (2017) Intraocular injection of ES cell-derived neural progenitors improve visual function in retinal ganglion cell-depleted mouse models. Front Cell Neurosci 11:295

Article  PubMed  PubMed Central  Google Scholar 

Dvoriantchikova G, Degterev A, Ivanov D (2014) Retinal ganglion cell (RGC) programmed necrosis contributes to ischemia-reperfusion-induced retinal damage. Exp Eye Res 123:1–7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Feng Y, Hu C, Cui K, Fan M, Xiang W, Ye D, Shi Y, Ye H, Bai X, Wei Y, Xu Y, Huang J (2023) GSK840 alleviates retinal neuronal injury by inhibiting RIPK3/MLKL-mediated RGC necroptosis after ischemia/reperfusion. Invest Ophthalmol vis Sci 64:42

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao S, Huang X, Zhang Y, Bao L, Wang X, Zhang M (2021) Investigation on the expression regulation of RIPK1/RIPK3 in the retinal ganglion cells (RGCs) cultured in high glucose. Bioengineered 12:3947–3956

Article  CAS  PubMed  PubMed Central  Google Scholar 

Garrido C, Galluzzi L, Brunet M, Puig PE, Didelot C, Kroemer G (2006) Mechanisms of cytochrome c release from mitochondria. Cell Death Differ 13:1423–1433

Article  CAS  PubMed  Google Scholar 

He C, Liu Y, Huang Z, Yang Z, Zhou T, Liu S, Hao Z, Wang J, Feng Q, Liu Y, Cao Y, Liu X (2021) A specific RIP3(+) subpopulation of microglia promotes retinopathy through a hypoxia-triggered necroptotic mechanism. Proc Natl Acad Sci U S A. https://doi.org/10.1073/pnas.2023290118

Article  PubMed  PubMed Central  Google Scholar 

Hollville E, Romero SE, Deshmukh M (2019) Apoptotic cell death regulation in neurons. FEBS J 286:3276–3298

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang Z, Liang J, Chen S, Ng TK, Brelén ME, Liu Q, Yang R, Xie B, Ke S, Chen W, Huang D (2023) RIP3-mediated microglial necroptosis promotes neuroinflammation and neurodegeneration in the early stages of diabetic retinopathy. Cell Death Dis 14:227

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang Z, Zhou T, Sun X, Zheng Y, Cheng B, Li M, Liu X, He C (2018) Necroptosis in microglia contributes to neuroinflammation and retinal degeneration through TLR4 activation. Cell Death Differ 25:180–189

Article  CAS  PubMed  Google Scholar 

Jagatha B, Divya MS, Sanalkumar R, Indulekha CL, Vidyanand S, Divya TS, Das AV, James J (2009) In vitro differentiation of retinal ganglion-like cells from embryonic stem cell derived neural progenitors. Biochem Biophys Res Commun 380:230–235

Article  CAS  PubMed  Google Scholar 

Karunakaran D, Geoffrion M, Wei L, Gan W, Richards L, Shangari P, DeKemp EM, Beanlands RA, Perisic L, Maegdefessel L, Hedin U, Sad S, Guo L, Kolodgie FD, Virmani R, Ruddy T, Rayner KJ (2016) Targeting macrophage necroptosis for therapeutic and diagnostic interventions in atherosclerosis. Sci Adv 2:e1600224

Article  PubMed  PubMed Central  Google Scholar 

Khoury MK, Gupta K, Franco SR, Liu B (2020) Necroptosis in the pathophysiology of disease. Am J Pathol 190:272–285

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim BK, Goncharov T, Archaimbault SA, Roudnicky F, Webster JD, Westenskow PD, Vucic D (2025) RIP1 inhibition protects retinal ganglion cells in glaucoma models of ocular injury. Cell Death Differ 32:353–368

Article  CAS  PubMed  Google Scholar 

Kim SK, Kim WJ, Yoon JH, Ji JH, Morgan MJ, Cho H, Kim YC, Kim YS (2015) Upregulated RIP3 expression potentiates MLKL phosphorylation-mediated programmed necrosis in toxic epidermal necrolysis. J Invest Dermatol 135:2021–2030

Article  CAS  PubMed  Google Scholar 

Kim SJ, Li J (2013) Caspase blockade induces RIP3-mediated programmed necrosis in Toll-like receptor-activated microglia. Cell Death Dis 4:e716

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li X, Ma N, Xu J, Zhang Y, Yang P, Su X, Xing Y, An N, Yang F, Zhang G, Zhang L, Xing Y (2021) Targeting ferroptosis: pathological mechanism and treatment of ischemia-reperfusion injury. Oxid Med Cell Longev 2021:1587922

Article  PubMed  PubMed Central  Google Scholar 

Linkermann A, Green DR (2014) Necroptosis. N Engl J Med 370:455–465

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu S, Joshi K, Denning MF, Zhang J (2021) RIPK3 signaling and its role in the pathogenesis of cancers. Cell Mol Life Sci 78:7199–7217

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu M, Li H, Yang R, Ji D, Xia X (2022) GSK872 and necrostatin-1 protect retinal ganglion cells against necroptosis through inhibition of RIP1/RIP3/MLKL pathway in glutamate-induced retinal excitotoxic model of glaucoma. J Neuroinflammation 19:262

Article  CAS  PubMed  PubMed Central  Google Scholar 

Maes ME, Schlamp CL, Nickells RW (2017) BAX to basics: how the BCL2 gene family controls the death of retinal ganglion cells. Prog Retin Eye Res 57:1–25

Article  CAS  PubMed  PubMed Central  Google Scholar 

McKenna S, García-Gutiérrez L, Matallanas D, Fey D (2021) BAX and SMAC regulate bistable properties of the apoptotic caspase system. Sci Rep 11:3272

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moriwaki K, Chan FK (2017) The inflammatory signal adaptor RIPK3: functions beyond necroptosis. Int Rev Cell Mol Biol 328:253–

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