Targeting the Gut-Brain Axis Through Insulin-like Growth Factors: Therapeutic Implications and Future Directions

Agis-Balboa RC, Arcos-Diaz D, Wittnam J, Govindarajan N, Blom K, Burkhardt S, Haladyniak U, Agbemenyah HY, Zovoilis A, Salinas-Riester G, Opitz L, Sananbenesi F, Fischer A (2011) A hippocampal insulin-growth factor 2 pathway regulates the extinction of fear memories. EMBO J 30:4071–4083. https://doi.org/10.1038/emboj.2011.293

Article  PubMed  PubMed Central  CAS  Google Scholar 

Anderson CD (2024) Therapeutic potential for mRNA-based IGF-I regenerative therapy. Mol Ther 35:102143. https://doi.org/10.1016/j.omtn.2024.102143

Article  CAS  Google Scholar 

Arcos J, Grunenwald F, Sepulveda D, Jerez C, Urbina V, Huerta T, Troncoso-Escudero P, Tirado D, Perez A, Diaz-Espinoza R, Nova E, Kubitscheck U, Rodriguez-Gatica JE, Hetz C, Toledo J, Ahumada P, Rojas-Rivera D, Martín-Montañez E, Garcia-Fernandez M, Vidal RL (2023) IGF2 prevents dopaminergic neuronal loss and decreases intracellular alpha-synuclein accumulation in parkinson’s disease models. Cell Death Discovery 9:401. https://doi.org/10.1038/s41420-023-01734-1

Article  CAS  Google Scholar 

Arjunan A, Sah DK, Woo M, Song J (2023) Identification of the molecular mechanism of insulin-like growth factor-1 (IGF-1): a promising therapeutic target for neurodegenerative diseases associated with metabolic syndrome. Cell Biosci 13:40. https://doi.org/10.1186/s13578-023-00966-z

Article  CAS  Google Scholar 

Bailey J, Oliveri A, Levin E (2013) Zebrafish model systems for developmental neurobehavioral toxicology. Birth Defects Research Part C: Embryo Today: Reviews 99:14–23. https://doi.org/10.1002/bdrc.21027

Article  PubMed  CAS  Google Scholar 

Bertucci JI, Blanco AM, Sundarrajan L, Ramasamy HS, Canosa LF, Unniappan S (2019) Nutrient regulation of endocrine factors influencing feeding and growth in fish. Front Endocrinol (Lausanne) 10:83. https://doi.org/10.3389/fendo.2019.00083

Article  PubMed  Google Scholar 

Bohin N, McGowan KP, Keeley TM, Carlson EA, Yan KS, Samuelson LC (2020) Insulin-like growth factor-1 and MTORC1 signaling promote the intestinal regenerative response after irradiation injury. Cell Mol Gastroenterol Hepatol 10:797–810. https://doi.org/10.1016/j.jcmgh.2020.05.013

Article  PubMed  PubMed Central  Google Scholar 

Bond AM, Ming G-L, Song H (2022) What is the relationship between hippocampal neurogenesis across different stages of the lifespan? Front Neurosci 16. https://doi.org/10.3389/fnins.2022.891713

Byrne TA, Wilmore DW, Iyer K, Dibaise J, Clancy K, Robinson MK, Chang P, Gertner JM, Lautz D (2005) Growth hormone, glutamine, and an optimal diet reduces parenteral nutrition in patients with short bowel syndrome. Ann Surg 242:655–661. https://doi.org/10.1097/01.sla.0000186479.53295.14

Article  PubMed  PubMed Central  Google Scholar 

Camacho-Hübner C, Rose S, Preece MA, Sleevi M, Storr HL, Miraki-Moud F, Minuto F, Frystyk J, Rogol A, Allan G, Sommer A, Savage MO (2006) Pharmacokinetic Studies of Recombinant Human Insulin-Like Growth Factor I (rhIGF-I)/rhIGF-Binding Protein-3 complex administered to patients with growth hormone insensitivity syndrome. J Clin Endocrinol Metab 91:1246–1253. https://doi.org/10.1210/jc.2005-1017

Article  PubMed  CAS  Google Scholar 

Carabotti M, Scirocco A, Maselli MA, Severi C (2015) The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Ann Gastroenterol 28:203–209

PubMed  PubMed Central  Google Scholar 

Carini C, Seyhan AA (2024) Tribulations and future opportunities for artificial intelligence in precision medicine. J Transl Med 22:108. https://doi.org/10.1186/s12967-024-05067-0

Article  Google Scholar 

Carro E, Trejo JL, Busiguina S, Torres-Aleman I (2001) Circulating insulin-like growth factor I mediates the protective effects of physical exercise against brain insults of different etiology and anatomy. J Neurosci 21:5678–5684

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chaudhari PR, Singla A, Vaidya VA (2022) Early adversity and accelerated brain aging: a Mini-Review. Front Mol Neurosci 15. https://doi.org/10.3389/fnmol.2022.822917

Chen T, Zheng F, Tao J, Tan S, Zeng L, Peng X, Wu B (2015a) Insulin-like growth factor-1 contributes to mucosal repair by β-arrestin2-mediated extracellular signal-related kinase signaling in experimental colitis. Am J Pathol 185:2441–2453. https://doi.org/10.1016/j.ajpath.2015.05.020

Article  PubMed  CAS  Google Scholar 

Chen Z, He P, Ding X, Huang Y, Gu H, Ni X (2015b) PPARγ stimulates expression of L-type amino acid and taurine transporters in human placentas: the evidence of PPARγ regulating fetal growth. Sci Rep 5:12650. https://doi.org/10.1038/srep12650

Article  PubMed  PubMed Central  CAS  Google Scholar 

Choteau L, Vancraeyneste H, Le Roy D, Dubuquoy L, Romani L, Jouault T, Poulain D, Sendid B (2017) Role of TLR1, TLR2 and TLR6 in the modulation of intestinal inflammation and Candida albicans elimination. Gut Pathog 9:9. https://doi.org/10.1186/s13099-017-0158-0

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cunningham AL, Stephens JW, Harris DA (2021) Gut microbiota influence in type 2 diabetes mellitus (T2DM). Gut Pathog 13:50. https://doi.org/10.1186/s13099-021-00446-0

Article  PubMed  PubMed Central  CAS  Google Scholar 

Dodge JC, Haidet AM, Yang W, Passini MA, Hester M, Clarke J, Roskelley EM, Treleaven CM, Rizo L, Martin H, Kim SH, Kaspar R, Taksir TV, Griffiths DA, Cheng SH, Shihabuddin LS, Kaspar BK (2008) Delivery of AAV-IGF-1 to the CNS extends survival in ALS mice through modification of aberrant glial cell activity. Mol Ther 16:1056–1064. https://doi.org/10.1038/mt.2008.60

Article  PubMed  CAS  Google Scholar 

Dong CX, Zhao W, Solomon C, Rowland KJ, Ackerley C, Robine S, Holzenberger M, Gonska T, Brubaker PL (2014) The intestinal epithelial insulin-like growth factor-1 receptor links glucagon-like peptide-2 action to gut barrier function. Endocrinology 155:370–379. https://doi.org/10.1210/en.2013-1871

Article  PubMed  CAS  Google Scholar 

Dubé PE, Forse CL, Bahrami J, Brubaker PL (2006) The essential role of Insulin-like growth factor-1 in the intestinal tropic effects of Glucagon-like peptide-2 in mice. Gastroenterology 131:589–605. https://doi.org/10.1053/j.gastro.2006.05.055

Article  PubMed  CAS  Google Scholar 

Dubreuil JD (2017) Enterotoxigenic Escherichia coli targeting intestinal epithelial tight junctions: an effective way to alter the barrier integrity. Microb Pathog 113:129–134. https://doi.org/10.1016/j.micpath.2017.10.037

Article  PubMed  CAS  Google Scholar 

Duysburgh C, Miclotte L, Green JB, Van den Abbeele P, Mattila H, Ghyselinck J, Marzorati M (2024) Saccharomyces cerevisiae derived postbiotic alters gut Microbiome metabolism in the human distal colon resulting in Immunomodulatory potential in vitro. Front Microbiol 15:1358456. https://doi.org/10.3389/fmicb.2024.1358456

Article  PubMed  PubMed Central  CAS  Google Scholar 

Dyer AH, Vahdatpour C, Sanfeliu A, Tropea D (2016) The role of insulin-like growth factor 1 (IGF-1) in brain development, maturation and neuroplasticity. Neuroscience 325:89–99. https://doi.org/10.1016/j.neuroscience.2016.03.056

Article  PubMed  CAS  Google Scholar 

Fernández de Sevilla ME, Pignatelli J, Zegarra-Valdivia JA, Nuñez A, Torres-Aleman I (2022) Insulin-like growth factor I mitigates post-traumatic stress by inhibiting AMP-kinase in orexin neurons. Mol Psychiatry 27:2182–2196. https://doi.org/10.1038/s41380-022-01442-9

Article  PubMed  PubMed Central  CAS  Google Scholar 

Fliesen T, Maiter D, Gerard G, Underwood LE, Maes M, Ketelslegers JM (1989) Reduction of serum Insulin-like growth Factor-I by dietary protein restriction is age dependent. J Clin Endocrinol Metab 69:1073–1077. https://doi.org/10.1210/jcem-69-5-1073

Article  Google Scholar 

Foster JA, Rinaman L, Cryan JF (2017) Stress & the gut-brain axis: Regulation by the microbiome. Neurobiol Stress 7:124–136. https://doi.org/10.1016/j.ynstr.2017.03.001

Article  PubMed  PubMed Central  Google Scholar 

Fujisaka S, Watanabe Y, Tobe K (2023) The gut microbiome: a core regulator of metabolism. J Endocrinol 256:e220111. https://doi.org/10.1530/JOE-22-0111

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gao T, Bogdanova N, Ghauri S, Zhang G, Lin J, Sheikh K (2018) Systemic IGF-1 gene delivery by rAAV9 improves spontaneous autoimmune peripheral polyneuropathy (SAPP). Sci Rep 8:4718. https://doi.org/10.1038/s41598-018-23607-9

Comments (0)

No login
gif