Integrated Bioinformatics Analyses of Peripheral Blood Transcriptomes Reveals Shared Molecular Features Underlying the Comorbidity of Schizophrenia and Metabolic Syndrome

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM et al (2000) Gene ontology: tool for the unification of biology. Nat Genet 25(1):25–29

Article  PubMed  PubMed Central  Google Scholar 

Bardou P, Mariette J, Escudié F, Djemiel C, Klopp C (2014) Jvenn: an interactive Venn diagram viewer. BMC Bioinformatics 15(1):293

Article  PubMed  PubMed Central  Google Scholar 

Barrett T, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky M et al (2013) Ncbi geo: archive for functional genomics data sets—update. Nucleic Acids Res 41(Database issue):D991–D995

PubMed  Google Scholar 

Bhusal A, Kim JH, Kim SC, Hwang EM, Ryu H, Ali MS (2024) The microglial innate immune protein PGLYRP1 mediates neuroinflammation and consequent behavioral changes. Cell Rep 43(3):113813

Article  PubMed  Google Scholar 

Broadbear JH, Kabel D, Tracy L, Mak P (2014) Oxytocinergic regulation of endogenous as well as drug-induced mood. Pharmacol Biochem Behav 119:61–71

Article  PubMed  Google Scholar 

Burley SK, Bhikadiya C, Bi C, Bittrich S, Chen L, Crichlow GV et al (2021) RCSB protein data bank: powerful new tools for exploring 3D structures of biological macromolecules for basic and applied research and education in fundamental biology, biomedicine, biotechnology, bioengineering and energy sciences. Nucleic Acids Res 49(D1):D437–D451

Article  PubMed  Google Scholar 

Chin CH, Chen SH, Wu HH, Ho CW, Ko MT, Lin CY (2014) cytoHubba: identifying hub objects and sub-networks from complex interactome. BMC Syst Biol 8(Suppl 4(Suppl 4)):S11

Article  PubMed  PubMed Central  Google Scholar 

Cordes J, Bechdolf A, Engelke C, Kahl KG, Balijepalli C, Lösch C et al (2017) Prevalence of metabolic syndrome in female and male patients at risk of psychosis. Schizophr Res 181:38–42

Article  PubMed  Google Scholar 

Dasgupta A, Singh OP, Rout JK, Saha T, Mandal S (2010) Insulin resistance and metabolic profile in antipsychotic naïve schizophrenia patients. Prog Neuropsychopharmacol Biol Psychiatry 34(7):1202–1207

Article  PubMed  Google Scholar 

De Hert M, Schreurs V, Vancampfort D, Van Winkel R (2009) Metabolic syndrome in people with schizophrenia: a review. World Psychiatry 8(1):15–22

Article  PubMed  PubMed Central  Google Scholar 

Doménech-Matamoros P (2020) Influence of the use of atypical antipsychotics in metabolic syndrome. Rev Esp Sanid Penit 22(2):80–86

Article  PubMed  PubMed Central  Google Scholar 

Feifel D, Shilling PD, MacDonald K (2016) A review of oxytocin’s effects on the positive, negative, and cognitive domains of schizophrenia. Biol Psychiatry 79(3):222–233

Article  PubMed  Google Scholar 

Feng Y, Sun L, Dang X et al (2024) Aberrant glycosylation in schizophrenia: insights into pathophysiological mechanisms and therapeutic potentials. Front Pharmacol 15:1457811

Article  PubMed  PubMed Central  Google Scholar 

Hjorthøj C, Stürup AE, McGrath JJ, Nordentoft M (2017) Years of potential life lost and life expectancy in schizophrenia: a systematic review and meta-analysis. Lancet Psychiatr 4(4):295–301

Article  Google Scholar 

Islam MS, Wei P, Suzauddula M et al (2024) The interplay of factors in metabolic syndrome: understanding its roots and complexity. Mol Med 30(1):279

Article  PubMed  PubMed Central  Google Scholar 

Jääskeläinen E, Juola P, Hirvonen N, McGrath JJ, Saha S, Isohanni M et al (2013) A systematic review and meta-analysis of recovery in schizophrenia. Schizophr Bull 39(6):1296–1306

Article  PubMed  Google Scholar 

Kalinowska S, Trześniowska-Drukała B, Kłoda K, Safranow K, Misiak B, Cyran A et al (2021) The association between lifestyle choices and schizophrenia symptoms. J Clin Med 10(1):165

Article  PubMed  PubMed Central  Google Scholar 

Kanehisa M, Goto S (2000) KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res 28(1):27–30

Article  PubMed  PubMed Central  Google Scholar 

Kim S, Chen J, Cheng T, Gindulyte A, He J, He S et al (2021) PubChem in 2021: new data content and improved web interfaces. Nucleic Acids Res 49(D1):D1388–D1395

Article  PubMed  Google Scholar 

Kritharides L, Chow V, Lambert TJ (2017) Cardiovascular disease in patients with schizophrenia. Med J Aust 206(2):91–95

Article  PubMed  Google Scholar 

Lago SG, Tomasik J, van Rees GF, Rubey M, Gonzalez-Vioque E, Ramsey JM et al (2021) Exploring cellular markers of metabolic syndrome in peripheral blood mononuclear cells across the neuropsychiatric spectrum. Brain Behav Immun 91:673–682

Article  PubMed  Google Scholar 

Langfelder P, Horvath S (2008) WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics 9:559

Article  PubMed  PubMed Central  Google Scholar 

Lappas AS, Ioannou M, Samara MT, Christodoulou NG (2025) Autophagy in schizophrenia: acontinuum from developmental vulnerability to progressive neuronal stress? a scoping review. Schizophrenia bulletin sbaf130. https://doi.org/10.1093/schbul/sbaf130

Li Z, Jiang YY, Long C et al (2024) Bridging metabolic syndrome and cognitive dysfunction: role of astrocytes. Front Endocrinol (Lausanne) 15:1393253

Article  PubMed  Google Scholar 

Lind L, Sundström J, Ärnlöv J, Risérus U, Lampa E (2021) A longitudinal study over 40 years to study the metabolic syndrome as a risk factor for cardiovascular diseases. Sci Rep 11(1):2978

Article  PubMed  PubMed Central  Google Scholar 

Liu Y, Yang X, Gan J, Chen S, Xiao ZX, Cao Y (2022) CB-dock2: improved protein-ligand blind docking by integrating cavity detection, docking and homologous template fitting. Nucleic Acids Res 50(W1):W159–W164

Article  PubMed  PubMed Central  Google Scholar 

Love MI, Huber W, Anders S (2014) Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol 15(12):550

Article  PubMed  PubMed Central  Google Scholar 

Lv H, Li J, Gao K, Zeng L, Xue R, Liu X et al (2022) Identification of genetic loci that overlap between schizophrenia and metabolic syndrome. Psychiatry Res 318:114947

Article  PubMed  Google Scholar 

Mairesse J, Zinni M, Pansiot J, Hassan-Abdi R, Demene C, Colella M et al (2019) Oxytocin receptor agonist reduces perinatal brain damage by targeting microglia. Glia 67(2):345–359

Article  PubMed  Google Scholar 

Manu P, Dima L, Shulman M, Vancampfort D, De Hert M, Correll CU (2015) Weight gain and obesity in schizophrenia: epidemiology, pathobiology, and management. Acta Psychiatr Scand 132(2):97–108

Article  PubMed  Google Scholar 

Marder SR, Cannon TD (2019) Schizophrenia. N Engl J Med 381(18):1753–1761

Article  PubMed  Google Scholar 

McGuire JL, Hammond JH, Yates SD et al (2014) Altered serine/threonine kinase activity in schizophrenia. Brain Res 1568:42–54

Article  PubMed  PubMed Central  Google Scholar 

Mohammadi A, Rashidi E, Amooeian VG (2018) Brain, blood, cerebrospinal fluid, and serum biomarkers in schizophrenia. Psychiatry Res 265:25–38

Article  PubMed  Google Scholar 

Morley-Fletcher S, Gaetano A, Gao V, Gatta E, Van Camp G, Bouwalerh H et al (2024) Postpartum oxytocin treatment via the mother reprograms long-term behavioral disorders induced by early life stress on the plasma and brain metabolome in the rat. Int J Mol Sci 25(5):3014

Article  PubMed  PubMed Central  Google Scholar 

Rawani NS, Chan AW, Todd KG, Baker GB, Dursun SM (2024) The role of neuroglia in the development and progression of schizophrenia. Biomolecules 15(1):10

Article  PubMed  PubMed Central 

Comments (0)

No login
gif