Bukowski K, Kciuk M, Kontek R (2020) Mechanisms of multidrug resistance in cancer chemotherapy. Int J Mol Sci 21(9):3233
Article PubMed PubMed Central CAS Google Scholar
Global Burden of Disease Cancer Collaboration, Fitzmaurice C, Allen C, Barber RM, Barregard L, Bhutta ZA et al (2017) Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: a systematic analysis for the global burden of disease study. JAMA Oncol 3(4):524
Article PubMed Central Google Scholar
Duan C, Yu M, Xu J, Li BY, Zhao Y, Kankala RK (2023) Overcoming cancer multi-drug resistance (MDR): reasons, mechanisms, nanotherapeutic solutions, and challenges. Biomed Pharmacother 162:114643
Article PubMed CAS Google Scholar
Loira-Pastoriza C, Todoroff J, Vanbever R (2014) Delivery strategies for sustained drug release in the lungs. Adv Drug Deliv Rev 75:81–91
Article PubMed CAS Google Scholar
Kankala RK, Liu CG, Chen AZ, Wang SB, Xu PY, Mende LK et al (2017) Overcoming multidrug resistance through the synergistic effects of hierarchical pH-sensitive ROS-generating nanoreactors. ACS Biomater Sci Eng 3(10):2431–2442
Article PubMed CAS Google Scholar
Neal RD, Tharmanathan P, France B, Din NU, Cotton S, Fallon-Ferguson J et al (2015) Is increased time to diagnosis and treatment in symptomatic cancer associated with poorer outcomes? Systematic review. Br J Cancer 112(S1):S92-107
Article PubMed PubMed Central Google Scholar
Li T, Li J, Chen Z, Zhang S, Li S, Wageh S et al (2022) Glioma diagnosis and therapy: current challenges and nanomaterial-based solutions. J Controlled Release 352:338–370
Husain A, Makadia V, Valicherla GR, Riyazuddin M, Gayen JR (2022) Approaches to minimize the effects of P-glycoprotein in drug transport: a review. Drug Dev Res 83(4):825–841
Article PubMed CAS Google Scholar
Wright SCE, Vasilevski N, Serra V, Rodon J, Eichhorn PJA (2021) Mechanisms of resistance to PI3K inhibitors in cancer: adaptive responses, drug tolerance and cellular plasticity. Cancers 13(7):1538
Article PubMed PubMed Central CAS Google Scholar
Karthika C, Sureshkumar R, Zehravi M, Akter R, Ali F, Ramproshad S et al (2022) Multidrug resistance of cancer cells and the vital role of P-glycoprotein. Life 12(6):897
Article PubMed PubMed Central CAS Google Scholar
Goyal R, Kaur G, Malik DS, Singh S, Dua K, Singh D et al (2025) Assessing anti-acne potentials via in vitro, ex vivo, and in vivo models: a comprehensive approach. Curr Drug Targets 26(7):435–453
Article PubMed CAS Google Scholar
Estevinho MM, Fernandes C, Silva JC, Gomes AC, Afecto E, Correia J et al (2022) Role of ATP-binding cassette transporters in sorafenib therapy for hepatocellular carcinoma: an overview. Curr Drug Targets 23(1):21–32
Article PubMed CAS Google Scholar
Davis LN, Sherbenou DW (2021) Emerging therapeutic strategies to overcome drug resistance in multiple myeloma. Cancers 13(7):1686
Article PubMed PubMed Central CAS Google Scholar
Kankala RK, Tsai PY, Kuthati Y, Wei PR, Liu CL, Lee CH (2017) Overcoming multidrug resistance through co-delivery of ROS-generating nano-machinery in cancer therapeutics. J Mater Chem B 5(7):1507–1517
Article PubMed CAS Google Scholar
Whittle EE, Orababa O, Osgerby A, Siasat P, Element SJ, Blair JMA et al (2024) Efflux pumps mediate changes to fundamental bacterial physiology via membrane potential. Wright GD, editor. mBio 15(10):e02370-24
Article PubMed PubMed Central Google Scholar
Engle K, Kumar G (2022) Cancer multidrug-resistance reversal by ABCB1 inhibition: a recent update. Eur J Med Chem 239(Sep):114542
Article PubMed CAS Google Scholar
Hu X, Zhang Z (2016) Understanding the genetic mechanisms of cancer drug resistance using genomic approaches. Trends Genet 32(2):127–137
Article PubMed CAS Google Scholar
Zhang A, Miao K, Sun H, Deng CX (2022) Tumor heterogeneity reshapes the tumor microenvironment to influence drug resistance. Int J Biol Sci 18(7):3019–3033
Article PubMed PubMed Central CAS Google Scholar
Long W, Zhang L, Wang Y, Xie H, Wang L, Yu H (2022) Research progress and prospects of autophagy in the mechanism of multidrug resistance in tumors. Zheng D, editor. J Oncol 2022:1–15
Vaidya FU, Sufiyan Chhipa A, Mishra V, Gupta VK, Rawat SG, Kumar A et al (2022) Molecular and cellular paradigms of multidrug resistance in cancer. Cancer Rep 5(12):e1291
Dong J, Yuan L, Hu C, Cheng X, Qin JJ (2023) Strategies to overcome cancer multidrug resistance (MDR) through targeting P-glycoprotein (ABCB1): an updated review. Pharmacol Ther 249:108488
Article PubMed CAS Google Scholar
Huang J, Ecker GF (2023) A structure-based view on ABC-transporter linked to multidrug resistance. Molecules 28(2):495
Article PubMed PubMed Central CAS Google Scholar
Wu CP, Hsiao SH, Wu YS (2023) Perspectives on drug repurposing to overcome cancer multidrug resistance mediated by ABCB1 and ABCG2. Drug Resist Updat 71:101011
Article PubMed CAS Google Scholar
Hanssen KM, Haber M, Fletcher JI (2021) Targeting multidrug resistance-associated protein 1 (MRP1)-expressing cancers: beyond pharmacological inhibition. Drug Resist Updat 59(Dec):100795
Article PubMed CAS Google Scholar
Di Virgilio F, Adinolfi E (2017) Extracellular purines, purinergic receptors and tumor growth. Oncogene 36(3):293–303
Burnstock G, Di Virgilio F (2013) Purinergic signalling and cancer. Purinergic Signal 9(4):491–540
Article PubMed PubMed Central CAS Google Scholar
Kroll T, Prescher M, Smits SHJ, Schmitt L (2021) Structure and function of hepatobiliary ATP binding cassette transporters. Chem Rev 121(9):5240–5288
Article PubMed CAS Google Scholar
Andreoletti P, Raas Q, Gondcaille C, Cherkaoui-Malki M, Trompier D, Savary S (2017) Predictive structure and topology of peroxisomal ATP-binding cassette (ABC) transporters. Int J Mol Sci 18(7):1593
Article PubMed PubMed Central Google Scholar
Mora Lagares L, Pérez-Castillo Y, Minovski N, Novič M (2021) Structure–function relationships in the human P-glycoprotein (ABCB1): insights from molecular dynamics simulations. Int J Mol Sci 23(1):362
Article PubMed PubMed Central Google Scholar
Alam A, Küng R, Kowal J, McLeod RA, Tremp N, Broude EV, et al. Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1. Proc Natl Acad Sci [Internet]. 2018 Feb 27 [cited 2025 Jun 26];115(9). Available from: https://pnas.org/doi/full/https://doi.org/10.1073/pnas.1717044115
Dunk CE, Pappas JJ, Lye P, Kibschull M, Javam M, Bloise E et al (2018) P-glycoprotein (P-gp)/ ABCB 1 plays a functional role in extravillous trophoblast ( EVT ) invasion and is decreased in the pre-eclamptic placenta. J Cell Mol Med 22(11):5378–5393
Article PubMed PubMed Central CAS Google Scholar
Gaohua L, Miao X, Dou L (2021) Crosstalk of physiological pH and chemical pKa under the umbrella of physiologically based pharmacokinetic modeling of drug absorption, distribution, metabolism, excretion, and toxicity. Expert Opin Drug Metab Toxicol 17(9):1103–1124
Comments (0)