Adair K, Meng X, Naisbitt DJ (2021) Drug hapten-specific T-cell activation: current status and unanswered questions. Proteomics 21(17–18):2000267
Alfirevic A, Gonzalez-Galarza F, Bell C et al (2012) In silico analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers. Genome Medicine 4:1–14
Andrade RJ, Aithal GP, Bjornsson ES et al (2019) EASL clinical practice guidelines: drug-induced liver injury. J Hepatol 70(6):1222–1261. https://doi.org/10.1016/j.jhep.2019.02.014
Byeon J-H, Kil J-H, Ahn Y-C, Son C-G (2019) Systematic review of published data on herb induced liver injury. J Ethnopharmacol 233:190–196
Chen Y, Wang C, Qi M, Wei Y, Jiang H, Du Z (2024) Molecular targets of cisplatin in HeLa cells explored through competitive activity-based protein profiling strategy. J Inorg Biochem 254:112518
Article PubMed CAS Google Scholar
Feng J, Ren H, Gou Q, Zhu L, Ji H, Yi T (2016) Comparative analysis of the major constituents in three related polygonaceous medicinal plants using pressurized liquid extraction and HPLC-ESI/MS. Anal Methods 8(7):1557–1564
Feng Y, Jin C, Lv S, Zhang H, Ren F, Wang J (2023) Molecular mechanisms and applications of polyphenol-protein complexes with antioxidant properties: a review. Antioxidants 12(8):1577
Article PubMed PubMed Central CAS Google Scholar
Hammond S, Thomson P, Meng X, Naisbitt D (2021) In-vitro approaches to predict and study T-cell mediated hypersensitivity to drugs. Front Immunol 12:630530
Article PubMed PubMed Central CAS Google Scholar
Hegazy UM, Tars K, Hellman U, Mannervik B (2008) Modulating catalytic activity by unnatural amino acid residues in a GSH-binding loop of GST P1–1. J Mol Biol 376(3):811–826
Article PubMed CAS Google Scholar
Huang J, Zhang J-P, Jun-Qi B et al (2018) Chemical profiles and metabolite study of raw and processed Polygoni Multiflori Radix in rats by UPLC-LTQ-Orbitrap MSn spectrometry. Chin J Nat Med 16(5):375–400
Huang J, Huang S, Zhang J et al (2022) A systematic strategy for the characterization of 2, 3, 5, 4′-tetrahydroxystilbene-2-O-β-D-glucoside metabolites in vivo by ultrahigh performance liquid chromatography coupled with a Q exactive-orbitrap mass system. J Agric Food Chem 70(25):7773–7785
Article PubMed CAS Google Scholar
Jenkins RE, Kitteringham NR, Goldring CE et al (2008) Glutathione-S-transferase pi as a model protein for the characterisation of chemically reactive metabolites. Proteomics 8(2):301–315
Article PubMed CAS Google Scholar
Le Bourvellec C, Renard CM (2012) Interactions between polyphenols and macromolecules: quantification methods and mechanisms. Crit Rev Food Sci 52(3):213–248
Li C, Rao T, Chen X et al (2019) HLA-B* 35: 01 allele is a potential biomarker for predicting polygonum multiflorum–induced liver injury in humans. Hepatology 70(1):346–357
Article PubMed CAS Google Scholar
Lin L, Ni B, Lin H et al (2015) Traditional usages, botany, phytochemistry, pharmacology and toxicology of Polygonum multiflorum Thunb.: a review. J Ethnopharmacol 159:158–183
Article PubMed CAS Google Scholar
Line J, Ali S-E, Grice S, Rao T, Naisbitt DJ (2023) Investigating the immune basis of green tea extract induced liver injury in healthy donors expressing HLA-B* 35: 01. Chem Res Toxicol 36(12):1872–1875
Article PubMed PubMed Central CAS Google Scholar
Liu J, Li T, Li R et al (2022) Hepatic organoid-based high-content imaging boosts evaluation of stereoisomerism-dependent hepatotoxicity of stilbenes in herbal medicines. Front Pharmacol 13:862830
Article PubMed PubMed Central CAS Google Scholar
Liu W, Zeng X, Wang X et al (2024) 2,3,5,4′- tetrahydroxystilbene-2-O-β-D- glucopyranoside (TSG)-driven immune response in the hepatotoxicity of Polygonum multiflorum. J Ethnopharmacol. https://doi.org/10.1016/j.jep.2024.117865
Ma J, Zheng L, He Y-S, Li H-J (2015) Hepatotoxic assessment of Polygoni Multiflori Radix extract and toxicokinetic study of stilbene glucoside and anthraquinones in rats. J Ethnopharmacol 162:61–68
Article PubMed CAS Google Scholar
Mak A, Uetrecht J (2017) Immune mechanisms of idiosyncratic drug-induced liver injury. J Clin Transl Res 3(1):145
PubMed PubMed Central CAS Google Scholar
Meng X, Al-Attar Z, Yaseen FS et al (2017a) Definition of the nature and hapten threshold of the β-lactam antigen required for T cell activation in vitro and in patients. J Immunol 198(11):4217–4227
Article PubMed CAS Google Scholar
Meng Y-k, Li C-y, Li R-y et al (2017b) Cis-stilbene glucoside in Polygonum multiflorum induces immunological idiosyncratic hepatotoxicity in LPS-treated rats by suppressing PPAR-γ. Acta Pharmacol Sin 38(10):1340–1352
Article PubMed PubMed Central CAS Google Scholar
Ogese MO, Lister A, Gardner J et al (2021) Deciphering adverse drug reactions: in vitro priming and characterization of vancomycin-specific T cells from healthy donors expressing HLA-A* 32: 01. Toxicol Sci 183(1):139–153
Article PubMed PubMed Central CAS Google Scholar
Pan R-Y, Chu M-T, Wang C-W et al (2019) Identification of drug-specific public TCR driving severe cutaneous adverse reactions. Nat Commun 10(1):3569
Article PubMed PubMed Central Google Scholar
Pan H, Zhai G, Jing Q, Fan Y, Fang C, Shi F (2025) Two-step metabolic activation to ortho-benzoquinone intermediate and its role in 2, 3, 5, 4′-tetrahydroxystilbene-2-O-β-D-glucoside-induced liver injury in mice. Drug Metab Dispos. https://doi.org/10.1016/j.dmd.2025.100047
Prigent SV, Voragen AG, Visser AJ, van Koningsveld GA, Gruppen H (2007) Covalent interactions between proteins and oxidation products of caffeoylquinic acid (chlorogenic acid). J Sci Food Agric 87(13):2502–2510
Rao T, Liu Y-t, Zeng X-c, Li C-p, Ou-Yang D-s (2021) The hepatotoxicity of Polygonum multiflorum: the emerging role of the immune-mediated liver injury. Acta Pharmacol Sin 42(1):27–35
Article PubMed CAS Google Scholar
Sun M, Yu Q-W, Xiang T, Jiang Z-Z, Zhang L-Y (2021) 2,3,5,4’-tetrahydroxystibane-2-O-β-D-glucoside induces liver injury by disrupting bile acid homeostasis and phospholipids efflux. Zhongguo Zhong Yao Za Zhi 46(1):139–145
Uetrecht J (2019) Mechanisms of idiosyncratic drug-induced liver injury. Adv Pharmacol 85:133–163
Article PubMed CAS Google Scholar
Wang Q, Wen H, Ma S, Zhang Y (2022a) Polygonum multiflorum Thunb. induces hepatotoxicity in SD rats and hepatocyte spheroids by disrupting the metabolism of bilirubin and bile acid. J Ethnopharmacol 296:115461
Article PubMed CAS Google Scholar
Wang X, Dong L, Zhao G, Li W, Peng Y, Zheng J (2022b) 2,3,5,4′-tetrahydroxy stilbene-2-Ο-β-D-glucoside, a mechanism-based inactivator of CYP2C19 and CYP3A4, potentiates hepatic protein adduction and hepatotoxicity induced by emodin in vivo. Chem Biol Interact 368:110234
Article PubMed CAS Google Scholar
Wang X, Zhao G, Ju C et al (2023) Reduction of emodin-8-O-ß-D-glucoside content participates in processing-based detoxification of polygoni multiflori radix. Phytomedicine 114:154750
Comments (0)