Revolutionizing toxicological risk assessment: integrative advances in new approach methodologies (NAMs) and precision toxicology

Benam KH, Novak R, Nawroth J et al (2016) Matched-comparative modeling of normal and diseased human airway responses using a microengineered breathing lung chip. Cell Syst 3(5):456-466.e4. https://doi.org/10.1016/j.cels.2016.10.003

Article  CAS  PubMed  Google Scholar 

Bertram MG, Ågerstrand M, Thoré ESJ et al (2024) Ethocred: a framework to guide reporting and evaluation of the relevance and reliability of behavioural ecotoxicity studies. Biol Rev Camb Philos Soc. https://doi.org/10.1111/brv.13154

Article  PubMed  PubMed Central  Google Scholar 

Bhatia SN, Ingber DE (2014) Microfluidic organs-on-chips. Nat Biotechnol 32(8):760–772. https://doi.org/10.1038/nbt.2989

Article  CAS  PubMed  Google Scholar 

Browne P, Paul Friedman K, Boekelheide K, Thomas RS (2024) Adverse effects in traditional and alternative toxicity tests. Regul Toxicol Pharmacol 148:105579. https://doi.org/10.1016/j.yrtph.2024.105579

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen J, Wu J, Bai Y, Yang C, Wang J (2024) Recent advances of single-cell RNA sequencing in toxicology research: insight into hepatotoxicity and nephrotoxicity. Curr Opin Toxicol 37:100462. https://doi.org/10.1016/j.cotox.2024.100462

Article  CAS  Google Scholar 

Cöllen E, Bartmann K, Blum J et al (2025) Mapping out strategies to further develop human-relevant, new approach methodology (NAM)-based developmental neurotoxicity (DNT) testing. Altex. https://doi.org/10.14573/altex.2501091

Article  PubMed  Google Scholar 

Debad S, Allen D, Bandele O et al (2024) Trust your gut: establishing confidence in gastrointestinal models - an overview of the state of the science and contexts of use. Altex. https://doi.org/10.14573/altex.2403261

Article  PubMed  PubMed Central  Google Scholar 

Dehghani S, Yunesian M (2024) Combining biomarkers of susceptibility with toxicodynamic models: a novel approach for assessing modifying factors. J Environ Health Sci Eng 22(1):361–364. https://doi.org/10.1007/s40201-024-00896-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Douziech M, Oginah SA, Golsteijn L et al (2024) Characterizing freshwater ecotoxicity of more than 9000 chemicals by combining different levels of available measured test data with in silico predictions. Environ Toxicol Chem. https://doi.org/10.1002/etc.5929

Article  PubMed  Google Scholar 

Durkin AM, Zou R, Boucher JM et al (2024) Investigating exposure and hazards of micro- and nanoplastics during pregnancy and early life (AURORA project): protocol for an interdisciplinary study. JMIR Res Protoc 13:e63176. https://doi.org/10.2196/63176

Article  PubMed  PubMed Central  Google Scholar 

ECHA.pdf.

Ehrlich D, Krishna S, Kleinstreuer N (2024) Data-driven derivation of an adverse outcome pathway linking vascular endothelial growth factor receptor (VEGFR), endocrine disruption, and atherosclerosis. Altex. https://doi.org/10.14573/altex.2403211

Article  PubMed  Google Scholar 

Eze C, Vinken M (2024) E-waste: mechanisms of toxicity and safety testing. FEBS Open Bio. https://doi.org/10.1002/2211-5463.13863

Article  PubMed  PubMed Central  Google Scholar 

Eze OO, Ogbuene EB, Ibraheem O, Küster E, Eze CT (2024) Novel Flame Retardants (NFRs) in E-waste: environmental burdens, health implications, and recommendations for safety assessment and sustainable management. Toxicology. https://doi.org/10.1016/j.tox.2024.154037

Article  PubMed  Google Scholar 

Flynn KM, Bush K, Cavallin J et al (2025) Transcriptomic response of an algal species (Raphidocelis subcapitata) exposed to 22 per- and polyfluoroalkyl substances. Environ Toxicol Chem. https://doi.org/10.1093/etojnl/vgaf022

Article  PubMed  Google Scholar 

Ford LC, Lin HC, Tsai HD et al (2024) Hazard and risk characterization and grouping of 56 structurally diverse PFAS using a targeted battery of broad coverage assays in six human cell types. Toxicology. https://doi.org/10.1016/j.tox.2024.153763

Article  PubMed  Google Scholar 

Fritsche E, Haarmann-Stemmann T, Kapr J et al (2021) Stem cells for next level toxicity testing in the 21st century. Small 17(15):e2006252. https://doi.org/10.1002/smll.202006252

Article  CAS  PubMed  Google Scholar 

Godderis L, De Ryck E, Baeyens W et al (2024) Towards a more effective reach legislation in protecting human health more effective reach in protecting human health. Toxicol Sci. https://doi.org/10.1093/toxsci/kfae025

Article  PubMed  Google Scholar 

Goetz A, Ryan N, Sauve-Ciencewicki A, Lord CC, Hilton GM, Wolf DC (2024) Assessing human carcinogenicity risk of agrochemicals without the rodent cancer bioassay. Front Toxicol 6:1394361. https://doi.org/10.3389/ftox.2024.1394361

Article  PubMed  PubMed Central  Google Scholar 

Guo Z, Xiao Q, Li T et al (2025) Co-exposure to polycyclic aromatic hydrocarbons and nicotine and their associations with cognitive impairment risk in older adults from southern China. Food Chem Toxicol 197:115255. https://doi.org/10.1016/j.fct.2025.115255

Article  CAS  PubMed  Google Scholar 

Hampton T (2017) Organoids reveal clues to gut-brain communication. JAMA 318(9):787–788. https://doi.org/10.1001/jama.2017.11545

Article  PubMed  Google Scholar 

Hartung T (2009) Toxicology for the twenty-first century. Nature 460(7252):208–212. https://doi.org/10.1038/460208a

Article  CAS  PubMed  Google Scholar 

Hartung T (2023) Artificial intelligence as the new frontier in chemical risk assessment. Front Artif Intell 6:1269932. https://doi.org/10.3389/frai.2023.1269932

Article  PubMed  PubMed Central  Google Scholar 

Hernandez AF, Buha A, Constantin C et al (2019) Critical assessment and integration of separate lines of evidence for risk assessment of chemical mixtures. Arch Toxicol 93(10):2741–2757. https://doi.org/10.1007/s00204-019-02547-x

Article  CAS  PubMed  Google Scholar 

Heusinkveld HJ, Zwart E, de Haan A, Braeuning A, Alarcan J, van der Ven LTM (2024) The zebrafish embryo as a model for chemically-induced steatosis: a case study with three pesticides. Toxicology. https://doi.org/10.1016/j.tox.2024.153927

Article  PubMed  Google Scholar 

Hirano T, Ikenaka Y, Nomiyama K et al (2023) An adverse outcome pathway-based approach to assess the neurotoxicity by combined exposure to current-use pesticides. Toxicology 500:153687. https://doi.org/10.1016/j.tox.2023.153687

Article  CAS  PubMed  Google Scholar 

Hopf NB, Suter-Dick L, Huwyler J et al (2024) Novel strategy to assess the neurotoxicity of organic solvents such as glycol ethers: protocol for combining in vitro and in silico methods with human-controlled exposure experiments. JMIR Res Protoc 13:e50300. https://doi.org/10.2196/50300

Article  PubMed  PubMed Central  Google Scholar 

Huh D, Matthews BD, Mammoto A, Montoya-Zavala M, Hsin HY, Ingber DE (2010) Reconstituting organ-level lung functions on a chip. Science 328(5986):1662–1668. https://doi.org/10.1126/science.1188302

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huh D, Leslie DC, Matthews BD et al (2012) A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice. Sci Transl Med 4(159):159ra147. https://doi.org/10.1126/scitranslmed.3004249

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jang KJ, Mehr AP, Hamilton GA et al (2013) Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment. Integr Biol (Camb) 5(9):1119–1129. https://doi.org/10.1039/c3ib40049b

Article  CAS  PubMed 

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